Abstract：
BACKGROUND:Almost 20 million people in the US have chronic kidney disease (CKD). Cardiovascular disease and arterial wall abnormalities are common in this population. Because angiotensin II may have adverse effects on the arterial wall, we hypothesized that an angiotensin receptor blocker (ARB) would improve arterial compliance as compared with placebo in subjects with CKD. METHODS:We performed a double-blinded, placebo-controlled pilot study in which 25 subjects with stages 2 or 3 CKD and proteinuria <1 g were randomized to either the ARB, eprosartan, or placebo and titrated to achieve a goal blood pressure (BP) <130/85 mm Hg. Arterial compliance was measured at baseline and at 8 weeks. RESULTS:Baseline characteristics were similar between the groups and included mean estimated glomerular filtration rate 63 +/- 14 ml/min/1.73 m(2), heart rate 76 +/- 10 beats/min, BP 142 +/- 12/81 +/- 8 mm Hg, 64% diabetic, 44% male, and 40% white, though subjects in the eprosartan group were younger (60 +/- 12 vs. 70 +/- 6 years, p = 0.01). There were no significant differences between the groups in large or small artery compliance measurements either at baseline or at 8 weeks, but there was a statistically significant improvement from baseline in small artery compliance in the eprosartan group (from median 2.5 ml/mm Hg x 100 [90% CI (1.1, 4.7)] to 4.0 ml/mm Hg x 100 [90% CI (1.9, 6.7)] (p = 0.01)) not seen in the placebo group. CONCLUSION:Use of an ARB to achieve recommended BP is associated with improved small artery compliance in people with CKD, though larger studies are needed to confirm these findings.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Garg JP,Ellis R,Elliott WJ,Hasabou N,Chua D,Chertow GM,Bakris GLdoi
10.1159/000087211subject
Has Abstractpub_date
2005-07-01 00:00:00pages
393-9issue
4eissn
0250-8095issn
1421-9670pii
87211journal_volume
25pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:Hyperoxaluria may result from increased endogenous production or overabsorption of dietary oxalate in the gastrointestinal tract leading to nephrolithiasis and, in some, to oxalate nephropathy and chronic kidney disease. ALLN-177 is an oral formulation of a recombinant, oxalate specific, microbial enzyme oxa...
journal_title：American journal of nephrology
pub_type： 杂志文章,随机对照试验
doi：10.1159/000448766
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Clinical indicators for accurately distinguishing diabetic nephropathy (DN) from non-diabetic renal disease in type 2 diabetes (T2D) are lacking. This study aimed to develop and validate a nomogram for predicting DN in T2D patients with kidney disease. METHODS:A total of 302 consecutive patients with T2D wh...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000505145
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Published reports examining the efficacy and safety of glucocorticoids for preserving renal function in immunoglobulin A nephropathy (IgAN) have yielded conflicting results. To systematically evaluate the efficacy and safety of glucocorticoids agents for IgAN, we conducted a meta-analysis of the published ra...
journal_title：American journal of nephrology
pub_type： 杂志文章,meta分析,评审
doi：10.1159/000226129
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND/AIMS:HFE protein controls iron absorption and cycling, and HFE mutations influence iron status. The aim was to evaluate the effect of the HFE genotype on the need for iron and erythropoietin in Italian hemodialysis patients. METHODS:Ninety-six prevalent patients were evaluated at the time of enrolment and p...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000111387
更新日期：2008-01-01 00:00:00
abstract：:The substitution of recombinant human erythropoietin (rhEPO) in chronic hemodialysis patients is often associated with the development of severe hypertension. In the present study, a systematical echocardiographic analysis was performed in 25 patients on maintenance hemodialysis during rhEPO therapy for at least 4 mon...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168273
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Death with a functioning graft (DWF) has been reported as a major cause of graft loss after renal transplantation. It has been reported to occur in 9-30%. METHODS:From March 1976 to January 2002, a total of 1400 living donor renal transplants were performed in our center. Out of 257 reported deaths among ou...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000070864
更新日期：2003-05-01 00:00:00
abstract：:Although the acute nephrotoxicity of cisplatin has been well documented, long-term follow-up studies are scanty. We have evaluated the renal function in 35 patients who have had completed therapy with cisplatin at least 3 months before the study. All patients had normal serum creatinine levels before chemotherapy. Eva...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168693
更新日期：1994-01-01 00:00:00
abstract：:Extraskeletal tumoral calcinosis occur in uremic patients with high calcium phosphorus (Ca x P) product and progressive secondary hyperparathyroidism. However, cases are also described in which this association cannot be confirmed. The influence of aluminum, vitamins D and K, alkalosis, magnesium and local lesions is ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000169078
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVES AND METHODS:Altered plasma high-sensitivity C-reactive protein (hs-CRP) and adiponectin (ADP) may contribute to increased vascular inflammation and accelerated atherosclerosis in patients with end-stage renal disease (ESRD) and co-morbid diabetes. Common carotid artery intima-media thickness (CCA-IMT) and at...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000094403
更新日期：2006-01-01 00:00:00
abstract：:Tuberculosis associated with dialysis was studied at the Artificial Kidney Unit (AKU) in Abha, Saudi Arabia. There were 13 tuberculosis patients out of 270 patients on maintenance hemodialysis from August 1986 to July 1993, a prevalence of 4.8%. Ten (77%) were female and 3 (23%) were male, mean age of 51.23 +/- 11.62 ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169068
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Chronic kidney disease (CKD) impairs intestinal barrier function which by allowing influx of noxious products causes systemic inflammation. We have recently shown that intestinal barrier dysfunction in CKD is due to degradation of epithelial tight junction (TJ) which is, in part, mediated by influx of urea a...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000351171
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND/AIMS:Patients with chronic renal failure (CRF) secondary to diabetes mellitus show a high incidence of atherosclerosis with its thrombotic complications. Both CRF and type 2 diabetes mellitus (DM2) results in fibrinolysis defects causally related to atherogenesis and thrombogenesis. It is not well known whet...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000065270
更新日期：2002-09-01 00:00:00
abstract：:Thymoglobulin (Thymoglobulin®; Genzyme, Cambridge, Mass., USA) is a polyclonal antibody which has been used in the field of transplantation over the last four decades. With an initial hesitancy, it is widely used now in the prevention and treatment of rejection following renal transplantation. Thymoglobulin's lack of ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000351643
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Although there is a very high mortality rate (>50%) with acute renal failure (ARF) in the intensive care unit (ICU), there is no general consensus on the best dialysis treatment for this condition. METHODS:We surveyed by mail questionnaire, all adult academic and community registered Canadian nephrology cen...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000046671
更新日期：2002-01-01 00:00:00
abstract：:This study was carried out to find out whether Ramadan fasting would affect the renal function in kidney transplant recipients with normal or impaired graft function. Twenty-three transplant recipients, 17 with a normal function and 6 with an impaired but stable function with plasma creatinine levels not exceeding 300...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013316
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND/AIMS:The long-term renal outcomes of patients with IgA nephropathy (IgAN) who present with recurrent macroscopic hematuria (RMH) have not been described in previous studies. METHODS:Patients with biopsy-proven primary IgAN in Jinling Hospital were divided into three groups according to different patterns of...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000364954
更新日期：2014-01-01 00:00:00
abstract：:The number of patients with end-stage renal disease undergoing kidney transplantation - both cadaveric and living-donor - continues to rise. With long-term graft survival relatively fixed, this trend means that increasing numbers of patients are returning to dialysis after graft loss. Most will never be retransplanted...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000342626
更新日期：2012-01-01 00:00:00
abstract：:To evaluate the therapeutic effect of recombinant human alpha-interferon (alpha-IFN) on hepatitis B virus associated glomerulonephritis (HBV-GN) and the relationship between the seroconversion of viral antigens and the change of proteinuria, the hepatitis B viral markers and urinary protein were monitored during alpha...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169083
更新日期：1997-01-01 00:00:00
abstract：:Ultramorphological images and details of an uremic echinocyte are shown. The images confirm the existence of uremic echinocytes and demonstrate that atomic force microscopy can provide high-resolution images of cell surfaces. ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168714
更新日期：1994-01-01 00:00:00
abstract：:Peritoneal sclerosis, a disorder similar to that previously identified in nonuremic patients, is being noted in peritoneal dialysis patients with increasing frequency. The etiology in dialysis patients remains unknown. An association with previous or ongoing peritoneal inflammation or irritation suggests that the inci...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166799
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:A poor nutritional state is associated with an increased risk of cardiovascular events in end-stage renal disease. It is unclear whether malnutrition itself can induce cardiovascular disease (CVD). We examined the impact of nutritional status on patients' arterial stiffness in peritoneal dialysis (PD) patien...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000206697
更新日期：2009-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167443
更新日期：1987-01-01 00:00:00
abstract：:This report reviews the features of 149 cases of renal allograft rupture, while adding a detailed description of 3 more cases to the English literature. From November, 1973 to November, 1979, 3 cases of renal allograft rupture occurred in 100 renal transplants performed at Research Medical Center, Kansas City, Mo., an...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166577
更新日期：1982-01-01 00:00:00
abstract：BACKGROUND:Estimating total body water (TBW) is crucial in determining dry weight and dialytic dose for hemodialysis patients. Several anthropometric equations have been used to predict TBW, but a more accurate method is needed. We developed an artificial neural network (ANN) to predict TBW in hemodialysis patients. M...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000088279
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND/AIMS:Hemodialysis treatment requires a well-functioning vascular access. Access patency is limited by the development of venous intimal hyperplasia, which predisposes to fistula stenosis and subsequent thrombosis. In animal models, the renin-angiotensin system has a major role in the development of intimal h...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000080464
更新日期：2004-07-01 00:00:00
abstract：:The terminal complement-inhibitor eculizumab has dramatically changed the management of patients with atypical hemolytic uremic syndrome (aHUS), and has also shown promise for treating certain forms of secondary HUS (sHUS), including that caused by drugs and solid-organ/hematopoietic stem cell transplant. While effect...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000492033
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:There is continued and significant debate regarding the salient etiologies associated with graft loss and racial disparities in kidney transplant recipients. METHODS:This was a longitudinal cohort study of all adult kidney transplant recipients, comparing patients with early graft loss (<5 years) to those w...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000363393
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Hypercholesterolemia is one of the major manifestations of nephrotic syndrome. We have previously shown that nephrotic hypercholesterolemia is associated with and, in part, due to dysregulation of hepatic HMG-CoA reductase, acyl-CoA:cholesterol acyltransferase (ACAT) and cholesterol 7alpha-hydroxylase, as we...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000082510
更新日期：2004-11-01 00:00:00
abstract：:A comparative clinicopathological study was retrospectively performed in 61 children and 51 adults with IgA nephropathy. Hematuria and/or proteinuria as a chance finding was the most common initial clinical sign, being observed in 82.0% of the children and in 52.9% of the adults. At renal biopsy, hypertension and seve...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168080
更新日期：1990-01-01 00:00:00
abstract：:The pathogenesis of calciphylaxis, a potentially life-threatening condition, is not well understood. Several factors such as end-stage renal disease (azotemia), hyperparathyroidism, hyperphosphatemia, hypercalcemia, a high calcium-phosphate product, and the use of steroids and cytotoxic drugs after kidney transplantat...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169021
更新日期：1996-01-01 00:00:00
