Severe calciphylaxis in a renal patient on long-term oral anticoagulant therapy.

Abstract:

:The pathogenesis of calciphylaxis, a potentially life-threatening condition, is not well understood. Several factors such as end-stage renal disease (azotemia), hyperparathyroidism, hyperphosphatemia, hypercalcemia, a high calcium-phosphate product, and the use of steroids and cytotoxic drugs after kidney transplantation are believed to interact in calciphylaxis. Recently, hypercoagulability due to functional protein C deficiency has been suggested to play a pathogenic role in this condition. Here, we present a renal transplant patient, with secondary hyperparathyroidism and on long-term oral anticoagulant therapy, who developed calciphylaxis with severe skin necrosis of her legs. The patient's condition improved dramatically after total parathyroidectomy. Hypercoagulability, therefore, does not appear to have played a significant role in this case of calciphylaxis.

journal_name

Am J Nephrol

authors

Rudwaleit M,Schwarz A,Trautmann C,Offermann G,Distler A

doi

10.1159/000169021

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

344-8

issue

4

eissn

0250-8095

issn

1421-9670

journal_volume

16

pub_type

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