Abstract：
BACKGROUND/AIMS:The long-term renal outcomes of patients with IgA nephropathy (IgAN) who present with recurrent macroscopic hematuria (RMH) have not been described in previous studies. METHODS:Patients with biopsy-proven primary IgAN in Jinling Hospital were divided into three groups according to different patterns of macroscopic hematuria (MH): RMH, isolated MH (IMH), and those without a history of MH (NMH). RESULTS:A total of 1,155 patients were enrolled in the study (158 in the RMH group, 256 in the IMH group, and 741 in the NMH group). At biopsy, patients with RMH were younger, had lower median proteinuria, a lower incidence of hypertension, and a higher estimated glomerular filtration rate than those in the NMH group. Pathologically, patients with RMH had a lower level of mesangial hypercellularity and segmental glomerulosclerosis as well as less tubular atrophy than those with NMH. The demographic and clinical features of patients with IMH fell between patients with RMH and those with NMH. During a median follow-up of 7.9 years, the 5-, 10- and 20-year cumulative renal survival after biopsy, as calculated by K-M methods, were 98, 91, and 91% in the RMH group, 95, 89, and 64% in the IMH group, and 95, 79, and 57% in the NMH group. The renal survival in patients with RMH was significantly better than patients with NMH or IMH. CONCLUSIONS:The long-term prognosis of patients who present with RMH is significantly better than patients with NMH or IMH.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Le W,Liang S,Chen H,Wang S,Zhang W,Wang X,Wang J,Zeng CH,Liu ZHdoi
10.1159/000364954subject
Has Abstractpub_date
2014-01-01 00:00:00pages
43-50issue
1eissn
0250-8095issn
1421-9670pii
000364954journal_volume
40pub_type
杂志文章abstract：AIM:To study the role of the caliceal system in urine flow. METHODS:Eight patients (6 men, 2 women; mean age 42.6 +/- 7.6 years) with an upper polar renal mass (6 renal cysts; 2 hypernephromas) which did not encroach on the pelvicaliceal system were studied. After mass removal, a manometric catheter was introduced int...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013391
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Hypertension often accompanies chronic kidney disease (CKD), and diuretics are widely prescribed to reduce blood pressure (BP). Chlorthalidone (CTD) is a thiazide-like diuretic and an effective antihypertensive drug, yet little data exist to support its use in treating hypertension in individuals with advanc...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000508700
更新日期：2020-01-01 00:00:00
abstract：:A renal transplant recipient with a remote history of end-stage renal disease due to postpartum hemolytic-uremic syndrome (HUS) presented with acute renal failure after having stable renal allograft function for 9 years. A diagnosis of thrombotic microangiopathy was made based on clinical and histologic findings at re...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169094
更新日期：1997-01-01 00:00:00
abstract：:This study was carried out to find out whether Ramadan fasting would affect the renal function in kidney transplant recipients with normal or impaired graft function. Twenty-three transplant recipients, 17 with a normal function and 6 with an impaired but stable function with plasma creatinine levels not exceeding 300...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013316
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) may lead to right heart failure and subsequently alter glomerular filtration rates (GFR). Chronic kidney disease (CKD, GFR <60 mL/min/1.73 m2) may also adversely affect PAH prognosis. This study aimed to assess how right heart hemodynamics was associated with reduced est...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000487198
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. The extent to which histopathologic features predicts prognostication is uncertain. METHODS:A single-center retrospective cohort with biopsy-proven TG was i...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000500043
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Clinical indicators for accurately distinguishing diabetic nephropathy (DN) from non-diabetic renal disease in type 2 diabetes (T2D) are lacking. This study aimed to develop and validate a nomogram for predicting DN in T2D patients with kidney disease. METHODS:A total of 302 consecutive patients with T2D wh...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000505145
更新日期：2020-01-01 00:00:00
abstract：:Two patients with a long-standing history of familial Mediterranean fever were found to have both microscopic hematuria and proteinuria during the acute attacks. Kidney biopsies from both patients revealed diffuse mesangial proliferative glomerulonephritis with intense mesangial IgA and C3 deposits and no evidence of ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167628
更新日期：1988-01-01 00:00:00
abstract：AIMS:This study investigated the protective effect of the angiotensin-converting enzyme inhibitor, enalapril, and the vitamin D analog, paricalcitol, alone or in combination, on cardiac oxidative stress in uremic rats. METHODS:Rats were made uremic by 5/6 nephrectomy and treated for 4 months as follows: (1) uremic + v...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000178251
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:The identification of nephrin and CD2AP, podocyte proteins which modulate the properties of glomerular barrier selectivity, has made it possible to unravel the mechanisms undergoing foot process effacement and proteinuria. Here we explored the role of nephrin and CD2AP together with the integrity of the slit...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000072281
更新日期：2003-07-01 00:00:00
abstract：:To elucidate the relationship between the renal regulation of sodium and calcium excretion at extremes of sodium intake, we studied 6 normal men ingesting a fixed, 400 mg/day calcium intake and four levels of sodium intake from 10 to 1,500 mEq/day. Serum ionized calcium was not influenced by sodium intake. Blood press...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166496
更新日期：1981-01-01 00:00:00
abstract：:In this paper, we analyze the collection of ancient Greek treatises ascribed to Hippocrates (460; between 371 and 350 BC), in order to determine whether or not edema can be traced. As a result of reading these works on the Greek text, we recognize some symptoms of edema in those called oidêma (swelling) and udrôps (dr...
journal_title：American journal of nephrology
pub_type： 传,历史文章,杂志文章
doi：10.1159/000013442
更新日期：1999-01-01 00:00:00
abstract：:A dramatic response was noted in a patient at our hospital who received hemodialysis therapy for severe acidosis secondary to an unknown toxin, subsequently identified as cyanide. We were unable to find any information concerning the hemodialysis clearance and extraction ratio of cyanide; thus, we studied the effect o...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166918
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:The use of complementary/alternative medicine has garnered rising interest in recent years. Natural products including herbs, vitamins, and minerals are the most popularly consumed. The Internet is a ubiquitous source of information/market for these supplements. AIM:To systematically evaluate the dietary an...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000368724
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Despite a previous study showing that PINCH-1 exerts an important role in regulating TGF-β1-mediated mesenchymal transition through its interaction with integrin-linked kinase, relatively little is known about the role of PINCH in the obstructive nephropathy. METHODS:To construct a rat model of renal inters...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000450838
更新日期：2016-01-01 00:00:00
abstract：:Chronic kidney disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importan...
journal_title：American journal of nephrology
pub_type： 社论
doi：10.1159/000486408
更新日期：2018-01-01 00:00:00
abstract：:Renal disease is a common complication in malaria infection. In acute falciparum malaria renal involvement is usually mild, but in severe disease acute renal failure is a major problem. Acute renal failure has been attributed to ischaemic tubular necrosis from hypovolaemia resulting from vasodilatation due to endothel...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013611
更新日期：2000-07-01 00:00:00
abstract：:Recent studies have focused attention on the possible role of zinc depletion in the pathogenesis of uremic symptoms such as dysgeusia and impotence. The present studies were undertaken to evaluate the prevalence of zinc deficiency and abnormalities of zinc metabolism in patients with end-stage renal disease. A total o...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167247
更新日期：1986-01-01 00:00:00
abstract：:To evaluate the therapeutic effect of recombinant human alpha-interferon (alpha-IFN) on hepatitis B virus associated glomerulonephritis (HBV-GN) and the relationship between the seroconversion of viral antigens and the change of proteinuria, the hepatitis B viral markers and urinary protein were monitored during alpha...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169083
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Patients with primary hyperoxaluria (PH) overproduce oxalate which is eliminated via the kidneys. If end-stage kidney disease develops they are at high risk for systemic oxalosis, unless adequate oxalate is removed during hemodialysis (HD) to equal or exceed ongoing oxalate production. The purpose of this st...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000360624
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Patients with diabetic nephropathy are at high risk for further progressive renal function loss. Treatments that decrease albuminuria have been linked with renal and cardiovascular protection. However, even when taking optimal treatment, residual renal and cardiovascular risk remains high which correlates wi...
journal_title：American journal of nephrology
pub_type： 杂志文章,随机对照试验
doi：10.1159/000225903
更新日期：2009-01-01 00:00:00
abstract：:Pasteurella multocida has been reported only once previously as a cause of peritonitis in a patient undergoing chronic peritoneal dialysis. The present report describes findings associated with a case of P. multocida peritonitis in a human immunodeficiency virus (HIV)-positive patient in which renal replacement therap...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168274
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Prolonged use of corticosteroids continues to be the mainstay in the management of most proteinuric glomerulopathies, but is limited by extensive side effects. Alternative medications such as adrenocorticotropic hormone (ACTH) have been recently used to treat refractory glomerulopathies and have shown superi...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000506854
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Health-related quality of life (HRQOL) reflects a patient's perceived disease burden, treatment effectiveness, and health status. Given the time burden and physiologic effects of hemodialysis, patients who spend dialysis time (9-15 h/week) physically or intellectually engaged may have better HRQOL. We charac...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000492623
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Chronic metabolic acidosis is a common metabolic disturbance and its clinical impact can be severe and extensive. The role and the change of the intrarenal renin-angiotensin system (RAS) during metabolic acidosis are uncertain, and whether acidosis can evoke inflammation remains unclear. METHODS:Male Spragu...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000328742
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:End-stage renal disease (ESRD) is a disease with an aging population and a high prevalence of cognitive impairment affecting quality of life, health care costs and mortality. Structural changes in the brain with decreased white matter integrity have been observed in ESRD. Understanding the changes in cogniti...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000444334
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND/AIMS:The elderly are the fastest growing subpopulation with end-stage renal disease. The goal of our study was to define characteristics of elderly patients who were considered ineligible for transplantation compared to those who were listed. METHODS:984 patients were referred for evaluation during a 2-year...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000354483
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Home dialysis patients may be at an increased risk of adverse events after transitional states. The home dialysis virtual ward (HDVW) trial was conducted in Canadian dialysis centers and aimed to evaluate potential care gaps and patient satisfaction during the HDVW. METHODS:The HDVW was a multicenter single...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1159/000503439
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Persons with chronic kidney disease (CKD) represent a population prone to cardiovascular disease (CVD) but vulnerable to adverse medication effects. We assessed the impact of intensive antihypertensive therapy on the cerebrovascular and other CVD outcomes in high-risk patients with type 2 diabetes and baseli...
journal_title：American journal of nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1159/000446122
更新日期：2016-01-01 00:00:00
abstract：:Bardoxolone methyl has been reported to cause detrimental cardiovascular events in the terminated BEACON Phase III human clinical trial via modulation of the renal endothelin pathway. However, the effects of bardoxolone methyl administration on the endothelin pathway in the heart are unknown. Our purpose in this persp...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000368563
更新日期：2014-01-01 00:00:00
