Zinc metabolism in patients on maintenance hemodialysis.

Abstract:

:Recent studies have focused attention on the possible role of zinc depletion in the pathogenesis of uremic symptoms such as dysgeusia and impotence. The present studies were undertaken to evaluate the prevalence of zinc deficiency and abnormalities of zinc metabolism in patients with end-stage renal disease. A total of 43 stable chronic hemodialysis patients were screened for evidence of zinc deficiency by measurement of fasting predialysis leukocyte and plasma zinc. The results were compared with those from 30 healthy volunteers. Seventeen of these 43 patients had 65Zn absorption measured, and in 9 the rate of disappearance of 65Zn from the body was also measured. The results were compared with those obtained in 20 healthy controls. The nutritional status of these 17 patients was estimated by global nutritional assessment and calculation of the Quetelet index while 9 of 17 had dietary zinc intake calculated from a diet history. The mean plasma zinc level was lower in the hemodialysis patients (11.7 +/- 2.3 mumol/l vs. 13.3 +/- 2.9 mumol/l in controls; p less than 0.05). The mean leukocyte zinc level was 0.81 +/- 0.27 mumol/g dry weight in dialysis patients and 0.81 +/- 0.22 mumol/g in controls (p greater than 0.2). The mean 65Zn absorption in the patients was 49 +/- 14% and in controls 53 +/- 12% (p greater than 0.2). Mean turnover of body 65Zn was 0.47 +/- 0.11%/day in patients and 0.43 +/- 0.18%/day in controls (p greater than 0.1). The mean 65Zn half-life was 154 +/- 29 days in patients and 187 +/- 75 days in controls (p greater than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Am J Nephrol

authors

Muirhead N,Kertesz A,Flanagan PR,Hodsman AB,Hollomby DJ,Valberg LS

doi

10.1159/000167247

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

422-6

issue

6

eissn

0250-8095

issn

1421-9670

journal_volume

6

pub_type

杂志文章
  • Effects of uremia, acetate and bicarbonate dialysis on beta-adrenergic responsiveness as assessed by epinephrine-stimulated adenylate cyclase.

    abstract::This study was designed to evaluate beta-adrenergic responsiveness as assessed by the generation of cyclic AMP after the subcutaneous administration of epinephrine in 31 subjects: normal controls, patients with chronic renal insufficiency, hemodynamically stable patients on chronic acetate dialysis and hemodynamically...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000167985

    authors: Fuiano G,Dal Canton A,Maj M,Testa A,Memoli B,Conte G,Ariano MG,Guarriello L,Russo D,Andreucci VE

    更新日期:1989-01-01 00:00:00

  • Association of Albuminuria and Estimated Glomerular Filtration Rate with Functional Performance Measures in Older Adults with Chronic Kidney Disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is increasingly common and disproportionately affects older adults. The contribution of kidney disease to the functional impairment noted in the elderly CKD population is unclear. METHODS:This is a cross-sectional analysis of a hypertensive cohort of people aged ≥75 years from t...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000455388

    authors: Wolfgram DF,Garcia K,Evans G,Zamanian S,Tang R,Wiegmann T,Sharma R,Campbell R,Whittle J,SPRINT Study Research Group.

    更新日期:2017-01-01 00:00:00

  • The endothelin pathway: a protective or detrimental target of bardoxolone methyl on cardiac function in patients with advanced chronic kidney disease?

    abstract::Bardoxolone methyl has been reported to cause detrimental cardiovascular events in the terminated BEACON Phase III human clinical trial via modulation of the renal endothelin pathway. However, the effects of bardoxolone methyl administration on the endothelin pathway in the heart are unknown. Our purpose in this persp...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000368563

    authors: Camer D,Huang XF

    更新日期:2014-01-01 00:00:00

  • Changes in atrial natriuretic peptide and plasma renin activity following changes in right atrial pressure in patients with chronic renal failure.

    abstract::Since it was first discovered in the early 1980s, the role of atrial natriuretic peptide (ANP) in the control of fluid and electrolyte balance and blood pressure has been extensively studied in both health and disease. We report here a study of ANP and its relationship to corresponding changes in right atrial pressure...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168797

    authors: Tan SY,Nolan J,Craig K,Swainson CP

    更新日期:1995-01-01 00:00:00

  • Plasma exchange in the treatment of early recurrent focal glomerulosclerosis after renal transplantation. Report and review.

    abstract::We report a 29-year-old female with recurrent focal glomerulosclerosis (FGS) presenting as heavy proteinuria immediately following renal transplantation. From day 13 after transplantation, daily plasma exchange was performed 6 times. Proteinuria decreased from 13 to 0.2 g/day after plasma exchange and remained to be l...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1159/000168637

    authors: Li PK,Lai FM,Leung CB,Lui SF,Wang A,Lai KN

    更新日期:1993-01-01 00:00:00

  • Incidence of stroke among chronic hemodialysis patients with nonrheumatic atrial fibrillation.

    abstract::In general, nonrheumatic atrial fibrillation is associated with a high risk of stroke. However, its impact on stroke in the setting of chronic hemodialysis treatment is insufficiently addressed in the literature. We assessed the incidence of stroke among 430 chronic hemodialysis patients and the impact of atrial fibri...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000046216

    authors: Wiesholzer M,Harm F,Tomasec G,Barbieri G,Putz D,Balcke P

    更新日期:2001-01-01 00:00:00

  • Skin tuberculosis with atypical mycobacteria 8 years after combined pancreas-kidney transplantation.

    abstract::We report on a Mycobacterium marinum infection in a diabetic woman 8 years after undergoing a combined pancreas-kidney transplantation. This is, to our knowledge, the first case report on an isolated skin infection with atypical mycobacteria after simultaneous pancreas-kidney transplantation. A genetic probe categoriz...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000065271

    authors: Schmekal B,Janko O,Zazgornik J,Schinko H,Bogner S,Syre G,Biesenbach G

    更新日期:2002-09-01 00:00:00

  • Primary renal hematuria presenting as unilateral gross hematuria.

    abstract::A patient with unilateral gross hematuria was found to have mesangial proliferation and IgM deposition on renal biopsy, consistent with the entity of primary renal hematuria. This case refutes previous assumptions that renal biopsy is normal in patients with unilateral hematuria. Glomerular lesions may be more common ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000167127

    authors: Tapp DC,Whitaker WR,Copley JB

    更新日期:1986-01-01 00:00:00

  • Determination of blood volume in nephrotic patients.

    abstract::We assessed blood volume (BV) in 20 edematous patients with nephrotic syndrome and in 32 subjects without renal or other disease liable to induce BV variation. Two methods were chosen, one using 131I-albumin and the other 51Cr red blood cells. Among the 20 patients, 11 presented minimal-change lesions, and 9 had histo...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000167967

    authors: Olmer M,Berland Y,Purgus R,Schultz G

    更新日期:1989-01-01 00:00:00

  • Universal Sustained Viral Response to the Combination of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with/without Ribavirin in Patients on Hemodialysis Infected with Hepatitis C Virus Genotypes 1 and 4.

    abstract:BACKGROUND:Hepatitis C virus (HCV) infection is highly prevalent among patients on hemodialysis (HD) and is associated with poor prognosis. Treatment with interferon and ribavirin is poorly tolerated, and few data are available on the impact of new direct-acting antivirals (DAAs). This study was intended to analyze the...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000454819

    authors: Abad S,Vega A,Hernández E,Mérida E,de Sequera P,Albalate M,Macías N,Milla M,López-Gómez JM

    更新日期:2017-01-01 00:00:00

  • Transglutaminase 2 accelerates vascular calcification in chronic kidney disease.

    abstract:BACKGROUND:Transglutaminase 2 (TGM2) is a calcium-dependent enzyme that can cross-link nearly all extracellular matrix (ECM) proteins and can facilitate cell-ECM interaction through integrins. Given the importance of the ECM in vascular calcification we tested the hypothesis that increased TGM2 activity may accelerate ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000347031

    authors: Chen NX,O'Neill K,Chen X,Kiattisunthorn K,Gattone VH,Moe SM

    更新日期:2013-01-01 00:00:00

  • Determinants of rhabdomyolysis in the diabetic state.

    abstract::To evaluate the determinants of rhabdomyolysis in the diabetic state, we compared biochemical and clinical features of diabetic patients with (group 1, 41 patients) and without (group 2, 36 patients) rhabdomyolysis. There was no difference in values for serum potassium, bicarbonate, phosphate and calcium between the t...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168357

    authors: Singhal PC,Abramovici M,Ayer S,Desroches L

    更新日期:1991-01-01 00:00:00

  • Novel methodology to evaluate renal cysts in polycystic kidney disease.

    abstract:AIM:To develop and assess a semiautomated method for segmenting and counting individual renal cysts from mid-slice MR images in patients with autosomal dominant polycystic kidney disease (ADPKD). METHODS:A semiautomated method was developed to segment and count individual renal cysts from mid-slice MR images in 241 su...

    journal_title:American journal of nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000358604

    authors: Bae KT,Sun H,Lee JG,Bae K,Wang J,Tao C,Chapman AB,Torres VE,Grantham JJ,Mrug M,Bennett WM,Flessner MF,Landsittel DP,Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease.

    更新日期:2014-01-01 00:00:00

  • Left ventricular hypertrophy in hypertensive patients with autosomal dominant polycystic kidney disease: influence of blood pressure and humoral and neurohormonal factors.

    abstract::Left ventricular hypertrophy (LVH) is a common finding in hypertensive autosomal dominant polycystic kidney disease (ADPKD) patients. There are few studies on the influence of blood pressure (BP) and nonhemodynamic factors on LVH in these patients. The aim of this study was to evaluate the relationship between BP, hum...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000013583

    authors: Martinez-Vea A,Valero FA,Bardaji A,Gutierrez C,Broch M,Garcia C,Richart C,Oliver JA

    更新日期:2000-05-01 00:00:00

  • Reversible hepatic dysfunction associated with rhabdomyolysis.

    abstract::Hepatic dysfunction was observed in 34 patients with nontraumatic rhabdomyolysis. The serum levels of lactic dehydrogenase were markedly elevated in all patients. The peak values occurred within 72 h of hospitalization. There was no significant difference among patients with (9,044 +/- 1,154 U/l) and without acute ren...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168053

    authors: Akmal M,Massry SG

    更新日期:1990-01-01 00:00:00

  • Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer.

    abstract::The development of new therapies for chronic diseases, such as diabetic kidney disease (DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights and will be responsive to treatment interventions. The recent application of metabolomic technologies, such as nuclear magnetic resonanc...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1159/000447954

    authors: Darshi M,Van Espen B,Sharma K

    更新日期:2016-01-01 00:00:00

  • 2009 influenza A infection and acute kidney injury: incidence, risk factors, and complications.

    abstract:BACKGROUND:2009 influenza A has spread globally. Respiratory complications and renal failure have been the leading causes for hospitalization and critical illness. We describe the risk factors and complications of acute kidney injury (AKI) in patients with influenza A. METHODS:Observational study of adult patients tes...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000328386

    authors: Demirjian SG,Raina R,Bhimraj A,Navaneethan SD,Gordon SM,Schreiber MJ Jr,Guzman JA

    更新日期:2011-01-01 00:00:00

  • Acquired renal cystic disease in end-stage renal disease: an autopsy study of 155 cases.

    abstract::Autopsy reports on 155 successive end-stage renal disease (ESRD) patients and 147 control patients without ESRD, matched for age, race and gender, were collected. Cystic transformation of the kidneys was noted in 58% of the ESRD patients and 13.6% of the control patients. There were 25 ESRD patients with renal adenoma...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000167988

    authors: Miller LR,Soffer O,Nassar VH,Kutner MH

    更新日期:1989-01-01 00:00:00

  • Use of Renin-Angiotensin System Blockers Increases Serum Potassium in Anuric Hemodialysis Patients.

    abstract:BACKGROUND:Angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) are increasingly used in uremic patients (pts). However, their effect on serum potassium (sK) concentrations in anuric pts on chronic hemodialysis treatment (HD) is controversial. The aim of the study was to evaluate sK b...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000491552

    authors: Movilli E,Camerini C,Gaggia P,Zubani R,Cancarini G

    更新日期:2018-01-01 00:00:00

  • Relapses of idiopathic diffuse crescentic glomerulonephritis without immune deposits: report of 6 cases.

    abstract::Idiopathic diffuse crescentic glomerulonephritis without immune deposits is a variant of rapidly progressive glomerulonephritis which can account for up to 40% of crescentic nephritis. The prognosis may depend on both the severity of histological injury at presentation and the efficacy of treatment. Recent advances in...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000167424

    authors: Belghiti D,Levy Y,Rifle G,Ottavioli JN,Rickelynck JP,Wolf C,Chalopin JM,Sobel A

    更新日期:1987-01-01 00:00:00

  • Peritoneal sclerosis in peritoneal dialysis patients.

    abstract::Peritoneal sclerosis, a disorder similar to that previously identified in nonuremic patients, is being noted in peritoneal dialysis patients with increasing frequency. The etiology in dialysis patients remains unknown. An association with previous or ongoing peritoneal inflammation or irritation suggests that the inci...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000166799

    authors: Ing TS,Daugirdas JT,Gandhi VC

    更新日期:1984-01-01 00:00:00

  • Prevention of myelinolysis in rats by dexamethasone or colchicine.

    abstract::The purpose of the present investigation was to determine whether dexamethasone, an agent known to preserve the blood-brain barrier, and colchicine, an agent that impairs mobilization of macrophages, can prevent demyelinating lesions associated with rapid correction of hyponatremia in the experimental animal. Hyponatr...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168071

    authors: Oh MS,Choi KC,Uribarri J,Sher J,Rao C,Carroll HJ

    更新日期:1990-01-01 00:00:00

  • Right ventricular dysfunction in patients with end-stage renal disease.

    abstract:BACKGROUND:While chronic dialysis treatment has been suggested to increase pulmonary pressure values, right ventricular dysfunction (RVD) is a major cause of death in patients with end-stage renal disease. We investigated the impact of different dialysis treatments on right ventricular function. METHODS:We examined 22...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000320755

    authors: Paneni F,Gregori M,Ciavarella GM,Sciarretta S,De Biase L,Marino L,Tocci G,Principe F,Domenici A,Luciani R,Punzo G,Menè P,Volpe M

    更新日期:2010-01-01 00:00:00

  • John Bostock MD FRS (1773-1846): physician and chemist in the shadow of a genius.

    abstract::John Bostock has a reasonable claim to being one of the first chemical pathologists. Most of his work was done before that of William Prout, with whom both he and Bright were in contact. Bostock's work was done about the same time as that of his friends and colleagues Marcet and Wollaston. Although other, notably Crui...

    journal_title:American journal of nephrology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000168749

    authors: Cameron JS

    更新日期:1994-01-01 00:00:00

  • Chronic metabolic alkalosis: not uncommon in young children with severe cystic fibrosis.

    abstract::The acid-base balance of 199 patients with cystic fibrosis, seen from 1987 through 1992 at the Bern Outpatient Clinic, were evaluated. Simple metabolic alkalosis was demonstrated in 16 and mixed metabolic alkalosis and respiratory acidosis in 9 patients. When compared with 10 patients with simple respiratory acidosis ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168839

    authors: Pedroli G,Liechti-Gallati S,Mauri S,Birrer P,Kraemer R,Foletti-Jäggi C,Bianchetti MG

    更新日期:1995-01-01 00:00:00

  • Right-sided bacterial endocarditis due to Flavobacterium odoratum in a patient on chronic hemodialysis.

    abstract::Bacterial endocarditis, particularly involving the left side, has been shown to occur in patients in regular hemodialysis. We report a case of right-sided endocarditis characterized by a very torpid evolution. Although the diagnosis was suspected early in the course, confirmation was obtained 2 months after the onset....

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168806

    authors: Ferrer C,Jakob E,Pastorino G,Juncos LI

    更新日期:1995-01-01 00:00:00

  • The Cytochrome P450 3A5 Non-Expressor Kidney Allograft as a Risk Factor for Calcineurin Inhibitor Nephrotoxicity.

    abstract:BACKGROUND:Tacrolimus is mainly metabolized by cytochrome P450 3A5 (CYP3A5), which is expressed in the liver. However, CYP3A5 is also expressed in the kidney tissue and may contribute to local tacrolimus clearance in the kidney allograft. We aimed to evaluate the association between the allograft CYP3A5 genotype and tr...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000487857

    authors: Udomkarnjananun S,Townamchai N,Chariyavilaskul P,Iampenkhae K,Pongpirul K,Sirichindakul B,Panumatrassamee K,Vanichanan J,Avihingsanon Y,Eiam-Ong S,Praditpornsilpa K

    更新日期:2018-01-01 00:00:00

  • Morphologic variants of light-chain deposition disease in the kidney.

    abstract::A variety of histologic changes have been observed in the kidneys of patients with light-chain deposition disease. We report 3 cases with kappa light chain deposition who presented with diverse clinical, histological, and ultrastructural features. All the cases were diagnosed by the presence of monoclonal kappa light ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000167600

    authors: Venkataseshan VS,Faraggiana T,Hughson MD,Buchwald D,Olesnicky L,Goldstein MH

    更新日期:1988-01-01 00:00:00

  • Severe calciphylaxis in a renal patient on long-term oral anticoagulant therapy.

    abstract::The pathogenesis of calciphylaxis, a potentially life-threatening condition, is not well understood. Several factors such as end-stage renal disease (azotemia), hyperparathyroidism, hyperphosphatemia, hypercalcemia, a high calcium-phosphate product, and the use of steroids and cytotoxic drugs after kidney transplantat...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000169021

    authors: Rudwaleit M,Schwarz A,Trautmann C,Offermann G,Distler A

    更新日期:1996-01-01 00:00:00

  • Current Canadian approaches to dialysis for acute renal failure in the ICU.

    abstract:BACKGROUND:Although there is a very high mortality rate (>50%) with acute renal failure (ARF) in the intensive care unit (ICU), there is no general consensus on the best dialysis treatment for this condition. METHODS:We surveyed by mail questionnaire, all adult academic and community registered Canadian nephrology cen...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000046671

    authors: Hyman A,Mendelssohn DC

    更新日期:2002-01-01 00:00:00