Novel methodology to evaluate renal cysts in polycystic kidney disease.

Abstract:

AIM:To develop and assess a semiautomated method for segmenting and counting individual renal cysts from mid-slice MR images in patients with autosomal dominant polycystic kidney disease (ADPKD). METHODS:A semiautomated method was developed to segment and count individual renal cysts from mid-slice MR images in 241 subjects with ADPKD from the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease. For each subject, a mid-slice MR image was selected from each set of coronal T2-weighted MR images covering the entire kidney. The selected mid-slice image was processed with the semiautomated method to segment and count individual renal cysts. The number of cysts from the mid-slice image of each kidney was also measured by manual counting. The level of agreement between the semiautomated and manual cyst counts was compared using intraclass correlation (ICC) and a Bland-Altman plot. RESULTS:Individual renal cysts were successfully segmented using the semiautomated method in all 241 cases. The number of cysts in each kidney measured with the semiautomated and manual counting methods correlated well (ICC = 0.96 for the right or left kidney), with a small average difference (-0.52, with higher semiautomated counts, for the right kidney, and 0.13, with higher manual counts, for the left kidney) in the semiautomated method. However, there was substantial variation in a small number of subjects; 6 of 241 participants (2.5%) had a difference in the total cyst count of more than 15. CONCLUSION:We have developed a semiautomated method to segment individual renal cysts from mid-slice MR images in ADPKD kidneys as a quantitative indicator of characterization and disease progression of ADPKD.

journal_name

Am J Nephrol

authors

Bae KT,Sun H,Lee JG,Bae K,Wang J,Tao C,Chapman AB,Torres VE,Grantham JJ,Mrug M,Bennett WM,Flessner MF,Landsittel DP,Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease.

doi

10.1159/000358604

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

210-7

issue

3

eissn

0250-8095

issn

1421-9670

pii

000358604

journal_volume

39

pub_type

临床试验,杂志文章
  • Glomerulopathy in acute and chronic rejection: relationship of ultrastructure to graft survival.

    abstract::The glomerular ultrastructure was retrospectively reviewed from 45 renal transplant biopsies with the clinical and light microscopic diagnosis of acute rejection (25 cases) and chronic rejection (20 cases). Three grades of morphologic alteration were ultrastructurally defined. In acute rejection, capillary lumenal obl...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000166725

    authors: Verani RR,Bergman D,Kerman RH

    更新日期:1983-09-01 00:00:00

  • Current Canadian approaches to dialysis for acute renal failure in the ICU.

    abstract:BACKGROUND:Although there is a very high mortality rate (>50%) with acute renal failure (ARF) in the intensive care unit (ICU), there is no general consensus on the best dialysis treatment for this condition. METHODS:We surveyed by mail questionnaire, all adult academic and community registered Canadian nephrology cen...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000046671

    authors: Hyman A,Mendelssohn DC

    更新日期:2002-01-01 00:00:00

  • Changes of lymphocyte populations in pediatric steroid-sensitive nephrotic syndrome are more pronounced in remission than in relapse.

    abstract:BACKGROUND/AIM:Although clinical and immunological findings in steroid-sensitive nephrotic syndrome (SSNS) favor an immunopathogenesis, many issues remain unsolved. Comprehensive studies analyzing cellular and humoral immunity in SSNS are scarce, and few studies addressed the effect of steroids on immunological factors...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000085357

    authors: Kemper MJ,Zepf K,Klaassen I,Link A,Muller-Wiefel DE

    更新日期:2005-03-01 00:00:00

  • Effect of pioglitazone on survival and renal function in a mouse model of polycystic kidney disease.

    abstract:BACKGROUND/AIMS:Cystic epithelia in polycystic kidney disease display features similar to malignant cells. Thiazolidinediones have been shown to have anti-neoplastic properties, therefore we tested the hypothesis that pioglitazone reduces cyst formation, improves renal function, and prolongs survival in a mouse model o...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000242432

    authors: Raphael KL,Strait KA,Stricklett PK,Baird BC,Piontek K,Germino GG,Kohan DE

    更新日期:2009-01-01 00:00:00

  • Association of Albuminuria and Estimated Glomerular Filtration Rate with Functional Performance Measures in Older Adults with Chronic Kidney Disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is increasingly common and disproportionately affects older adults. The contribution of kidney disease to the functional impairment noted in the elderly CKD population is unclear. METHODS:This is a cross-sectional analysis of a hypertensive cohort of people aged ≥75 years from t...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000455388

    authors: Wolfgram DF,Garcia K,Evans G,Zamanian S,Tang R,Wiegmann T,Sharma R,Campbell R,Whittle J,SPRINT Study Research Group.

    更新日期:2017-01-01 00:00:00

  • Care of the patient after renal allograft failure: managing the present and planning for the future.

    abstract::The number of patients with end-stage renal disease undergoing kidney transplantation - both cadaveric and living-donor - continues to rise. With long-term graft survival relatively fixed, this trend means that increasing numbers of patients are returning to dialysis after graft loss. Most will never be retransplanted...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1159/000342626

    authors: Fuquay R,Teitelbaum I

    更新日期:2012-01-01 00:00:00

  • Berengario da Carpi.

    abstract::Berengario da Carpi was magister of anatomy and surgery at the University of Bologna from 1502 to 1527. Eustachio and Falloppia defined him as 'the restaurator of anatomy'. He was a great surgeon, anatomist and physician of illustrious patients including Lorenzo II dei Medici, Giovanni dalle Bande Nere, Galeazzo Palla...

    journal_title:American journal of nephrology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000013452

    authors: De Santo NG,Bisaccia C,De Santo LS,De Santo RM,Di Leo VA,Papalia T,Cirillo M,Touwaide A

    更新日期:1999-01-01 00:00:00

  • Renal allograft rupture: a report of three cases and review of the literature.

    abstract::This report reviews the features of 149 cases of renal allograft rupture, while adding a detailed description of 3 more cases to the English literature. From November, 1973 to November, 1979, 3 cases of renal allograft rupture occurred in 100 renal transplants performed at Research Medical Center, Kansas City, Mo., an...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000166577

    authors: Thukral R,Mir AR,Jacobson MP

    更新日期:1982-01-01 00:00:00

  • Measurement of glomerular filtration rate using nonradioactive Iohexol: comparison of two one-compartment models.

    abstract::Radioisotopic methods for the determination of the glomerular filtration rate (GFR) are highly accurate but require the collection of multiple blood and urine samples and are costly to perform due to personnel, material, and analysis costs. Nonradioactive methods of GFR determination have the potential of minimizing p...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168985

    authors: Rocco MV,Buckalew VM Jr,Moore LC,Shihabi ZK

    更新日期:1996-01-01 00:00:00

  • Early Activation of PINCH/ Glycogen-Synthase Kinase 3β/ERK Pathway in Obstructive Nephropathy Rat Model.

    abstract:BACKGROUND:Despite a previous study showing that PINCH-1 exerts an important role in regulating TGF-β1-mediated mesenchymal transition through its interaction with integrin-linked kinase, relatively little is known about the role of PINCH in the obstructive nephropathy. METHODS:To construct a rat model of renal inters...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000450838

    authors: Jia L,Li X,Gu Y,Cui W

    更新日期:2016-01-01 00:00:00

  • Proteomic analysis of whole glomeruli in patients with IgA nephropathy using microsieving.

    abstract:BACKGROUND:To promote understanding of immunoglobulin A nephropathy (IgAN) pathophysiology, we tried to elucidate glomerular protein profiles in IgAN, using microsieving that we established recently to isolate glomeruli from renal biopsy samples and proteomic approaches. METHODS:Glomeruli were isolated from renal biop...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000357788

    authors: Kojima S,Koitabashi K,Iizuka N,Okamoto K,Arito M,Sato T,Kurokawa MS,Suematsu N,Shibagaki Y,Yasuda T,Kimura K,Kato T

    更新日期:2014-01-01 00:00:00

  • Treatment of digoxin intoxication in a renal failure patient with digoxin-specific antibody fragments and plasmapheresis.

    abstract::A patient with renal failure due to myeloma kidney and coincident digitalis intoxication due to prescribed daily digoxin administration was treated with digoxin-specific antibody fragments and plasmapheresis. Rapid response to therapy was noted, removal of digoxin-antidigoxin antibody complexes was confirmed, and prev...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168179

    authors: Rabetoy GM,Price CA,Findlay JW,Sailstad JM

    更新日期:1990-01-01 00:00:00

  • Progressive systemic sclerosis with the nephrotic syndrome and acquired factor X deficiency.

    abstract::A patient with progressive systemic sclerosis (PSS) involving skin, digit, esophagus, and lung developed the nephrotic syndrome and rapidly progressive renal insufficiency. Renal pathology revealed capillary collapse, cellular crescents, arteriolar hyaline deposition, and mesangial proliferation. On immunofluorescence...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000167055

    authors: Eiser AR,Zilversmit R,Neff MS,Grishman E,Slifkin RF

    更新日期:1986-01-01 00:00:00

  • Effects of simvastatin and pravastatin on hyperlipidemia and cyclosporin blood levels in renal transplant recipients.

    abstract::Thirty-one renal transplant recipients, submitted to treatment with cyclosporin in association with other immunosuppressive agents, were also treated for 9 months with two hydroxymethylglutaryl coenzyme A reductase inhibitors, simvastatin (10 mg/day) or pravastatin (20 mg/day), for concomitant hypercholesterolemia and...

    journal_title:American journal of nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000013487

    authors: Capone D,Stanziale P,Gentile A,Imperatore P,Pellegrino T,Basile V

    更新日期:1999-01-01 00:00:00

  • Association between kidney function and telomere length: the heart and soul study.

    abstract:BACKGROUND:Telomere attrition is a novel risk factor for cardiovascular disease. Studies of telomere length in relation to kidney function are limited. We explored the association of kidney function with telomere length and telomere shortening. METHODS:The Heart and Soul Study is a longitudinal study of patients with ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000343495

    authors: Bansal N,Whooley MA,Regan M,McCulloch CE,Ix JH,Epel E,Blackburn E,Lin J,Hsu CY

    更新日期:2012-01-01 00:00:00

  • Impact of Diabetes on Extracellular Volume Status in Patients Initiating Peritoneal Dialysis.

    abstract:BACKGROUND:Recent reports have highlighted that diabetic patients with kidney failure are at increased risk of technique failure and transfer to haemodialysis within 90 days of initiating peritoneal dialysis (PD). We wished to determine whether there were differences between diabetic and non-diabetic patients within th...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000477326

    authors: Udo A,Goodlad C,Davenport A

    更新日期:2017-01-01 00:00:00

  • Development of an outpatient native kidney biopsy service in low-risk patients: a multidisciplinary approach.

    abstract:BACKGROUND:In the US, native kidney biopsies are usually inpatient procedures. We developed an outpatient biopsy protocol for low-risk patients and assessed its safety and efficacy. METHODS:Patients with an SBP <140 mm Hg and a BMI ≤35 who were not taking anticoagulants, ASA and NSAIDS in the preceding week were inclu...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000337359

    authors: McMahon GM,McGovern ME,Bijol V,Benson CB,Foley R,Munkley K,Schnipper J,Franz C,Lin J

    更新日期:2012-01-01 00:00:00

  • Cultural links between Salerno and Montecassino.

    abstract::A meeting on the History of Nephrology is an opportunity to discuss the links between science and faith which were split until the 6th century. However, this was changed by Cassiodorus and monasticism. From the times of Abbot Bertario (died 883 AD) in Montecassino, medicine was regarded as an art and a science. Codex ...

    journal_title:American journal of nephrology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000168769

    authors: D'Onorio B

    更新日期:1994-01-01 00:00:00

  • Albuminuria Regression and All-Cause Mortality among Insulin-Treated Patients with Type 2 Diabetes: Analysis of a Large UK Primary Care Cohort.

    abstract:BACKGROUND:Overt albuminuria (urinary albumin-creatinine ratio [ACR] > 300 mg/g) is an established risk factor for progression of nephropathy and total mortality. However, whether a reduction in ACR translates into a reduction in mortality and/or cardiovascular (CV) events among insulin-treated patients with type 2 dia...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000496276

    authors: Anyanwagu U,Donnelly R,Idris I

    更新日期:2019-01-01 00:00:00

  • Outbreak of gram-negative bacteremia and pyrogenic reactions in a hemodialysis center.

    abstract::During the period from April 4, 1988, to April 20, 1988, nine pyrogenic reactions and five gram-negative bacteremias occurred in 11 patients undergoing dialysis. All pyrogenic reactions and gram-negative bacteremias occurred among patients in whom a reprocessed dialyzer was used. The rate of pyrogenic reactions or bac...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168155

    authors: Beck-Sague CM,Jarvis WR,Bland LA,Arduino MJ,Aguero SM,Verosic G

    更新日期:1990-01-01 00:00:00

  • Insights from Screening a Racially and Ethnically Diverse Population for Chronic Kidney Disease.

    abstract:BACKGROUND:The value of chronic kidney disease (CKD) screening in the general population remains unclear but may be beneficial in populations with high disease prevalence. We examined risk factors for albuminuria among participants in a state-wide CKD screening program in Hawaii. METHODS:The National Kidney Foundation...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000455389

    authors: Wong LL,Kalantar-Zadeh K,Page V,Hayashida G,You AS,Rhee CM

    更新日期:2017-01-01 00:00:00

  • Vitalism and synthesis of urea. From Friedrich Wöhler to Hans A. Krebs.

    abstract::In 1828, Friedrich Wöhler, a German physician and chemist by training, published a paper that describes the formation of urea, known since 1773 to be a major component of mammalian urine, by combining cyanic acid and ammonium in vitro. In these experiments the synthesis of an organic compound from two inorganic molecu...

    journal_title:American journal of nephrology

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000013463

    authors: Kinne-Saffran E,Kinne RK

    更新日期:1999-01-01 00:00:00

  • Incidence of stroke among chronic hemodialysis patients with nonrheumatic atrial fibrillation.

    abstract::In general, nonrheumatic atrial fibrillation is associated with a high risk of stroke. However, its impact on stroke in the setting of chronic hemodialysis treatment is insufficiently addressed in the literature. We assessed the incidence of stroke among 430 chronic hemodialysis patients and the impact of atrial fibri...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000046216

    authors: Wiesholzer M,Harm F,Tomasec G,Barbieri G,Putz D,Balcke P

    更新日期:2001-01-01 00:00:00

  • Elevated Circulating Cell-Free DNA in Hemodialysis-Treated Patients Is Associated with Increased Mortality.

    abstract:BACKGROUND:Predicting the mortality risk of patients un-dergoing hemodialysis (HD) is challenging. Cell-free DNA (cfDNA) is released into circulation from dying cells, and its elevation is predictive of unfavorable outcome. In a pilot study, we found post-HD cfDNA level to be a predictor of all-cause mortality. Thus, t...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000510771

    authors: Einbinder Y,Shnaider A,Ghanayem K,Basok A,Rogachev B,Lior Y,Haviv YS,Cohen-Hagai K,Nacasch N,Rozenberg I,Benchetrit S,Zitman-Gal T,Douvdevani A

    更新日期:2020-01-01 00:00:00

  • Seasonal maintenance of influenza vaccine-induced antibody response in kidney transplant recipients.

    abstract:BACKGROUND/AIMS:Although annual influenza vaccination is recommended for kidney transplant recipients, efficacy as reflected by serum antibody titers has not been well studied beyond 1 month in kidney transplant recipients. METHODS:We performed a single-center prospective cohort study of 51 kidney transplant recipient...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000341653

    authors: Birdwell KA,Ikizler MR,Wang L,Byrne DW,Sannella EC,Wright PF,Ikizler TA

    更新日期:2012-01-01 00:00:00

  • Serum Potassium Levels and Mortality in Hemodialysis Patients: A Retrospective Cohort Study.

    abstract:BACKGROUND:Hyperkalemia is common in patients receiving maintenance hemodialysis. However, few studies have examined the association between serum potassium level and mortality. METHODS:This study used annual cohorts of hemodialysis patients during 2007-2010. To determine hyperkalemia prevalence, monthly hyperkalemia ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000448341

    authors: Yusuf AA,Hu Y,Singh B,Menoyo JA,Wetmore JB

    更新日期:2016-01-01 00:00:00

  • Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer.

    abstract::The development of new therapies for chronic diseases, such as diabetic kidney disease (DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights and will be responsive to treatment interventions. The recent application of metabolomic technologies, such as nuclear magnetic resonanc...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1159/000447954

    authors: Darshi M,Van Espen B,Sharma K

    更新日期:2016-01-01 00:00:00

  • Autonomic nervous system dysfunction and impotence in uremia.

    abstract::The relationship between abnormalities in nocturnal penile tumescence (NPT) and autonomic function, measured by the Valsalva maneuver, was evaluated in 25 uremic patients and 22 normal subjects. NPT in uremic patients (45 +/- 6.8 min/night) was lower (p less than 0.01) than in normals (85 +/- 10.4 min/night). Valsalva...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000166629

    authors: Campese VM,Procci WR,Levitan D,Romoff MS,Goldstein DA,Massry SG

    更新日期:1982-01-01 00:00:00

  • Effect of high-flux hemodialysis on quality of life and neuropsychological function in chronic hemodialysis patients.

    abstract::The objective was to evaluate the effect of high-flux hemodialysis on quality of life, intra- and interdialytic symptoms and neuropsychological function. The study was double-blind single cross-over with random allocation to order of treatment. The patients were stable adult hospital hemodialysis patients. Both the co...

    journal_title:American journal of nephrology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000168491

    authors: Churchill DN,Bird DR,Taylor DW,Beecroft ML,Gorman J,Wallace JE

    更新日期:1992-01-01 00:00:00

  • Plasma exchange in the treatment of early recurrent focal glomerulosclerosis after renal transplantation. Report and review.

    abstract::We report a 29-year-old female with recurrent focal glomerulosclerosis (FGS) presenting as heavy proteinuria immediately following renal transplantation. From day 13 after transplantation, daily plasma exchange was performed 6 times. Proteinuria decreased from 13 to 0.2 g/day after plasma exchange and remained to be l...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1159/000168637

    authors: Li PK,Lai FM,Leung CB,Lui SF,Wang A,Lai KN

    更新日期:1993-01-01 00:00:00