Universal Sustained Viral Response to the Combination of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with/without Ribavirin in Patients on Hemodialysis Infected with Hepatitis C Virus Genotypes 1 and 4.

Abstract:

BACKGROUND:Hepatitis C virus (HCV) infection is highly prevalent among patients on hemodialysis (HD) and is associated with poor prognosis. Treatment with interferon and ribavirin is poorly tolerated, and few data are available on the impact of new direct-acting antivirals (DAAs). This study was intended to analyze the efficacy and safety of treatment with a combination of ombitasvir/paritaprevir/ritonavir and dasabuvir with/without ribavirin in HCV-infected patients on HD from 3 hospitals. METHODS:This is a multicentric study. We analyze the clinical course of all patients on HD with HCV infection who had been treated with the combination of ombitasvir/paritaprevir/ritonavir and dasabuvir in 3 hospitals in Madrid, Spain. All patients under treatment had undergone Transient elastography (FibroScan®) and HCV RNA (PCR) and HCV genotype were determined simultaneously. RESULTS:Thirty-five patients aged 53.3 ± 8.9 years (68.6% males) and with genotypes 1 and 4 were treated with the DAA regimen, and 17 were also given ribavirin. The most common etiology was glomerular disease. Sustained viral response was achieved in 100% of patients. Adverse effects were negligible, and no patient had to discontinue treatment. The most significant side effect was anemia, which led to a significant increase in the dose of erythropoiesis-stimulating agents. Anemia was more marked in patients receiving ribavirin. No patients required transfusions. CONCLUSION:A combination of ombitasvir/paritaprevir/ritonavir and dasabuvir with/without ribavirin for the treatment of HCV in patients on HD is highly effective and causes minimal side effects. This regimen represents a major advance in disease management. A considerable improvement in prognosis seems likely.

journal_name

Am J Nephrol

authors

Abad S,Vega A,Hernández E,Mérida E,de Sequera P,Albalate M,Macías N,Milla M,López-Gómez JM

doi

10.1159/000454819

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

267-272

issue

3

eissn

0250-8095

issn

1421-9670

pii

000454819

journal_volume

45

pub_type

杂志文章,多中心研究
  • CYP3A4 and CYP3A5 polymorphisms and blood pressure response to amlodipine among African-American men and women with early hypertensive renal disease.

    abstract:PURPOSE:To explore the association between CYP3A4 and CYP3A5 gene polymorphisms and blood pressure response to amlodipine among participants from the African-American Study of Kidney Disease and Hypertension Trial randomized to amlodipine (n = 164). METHODS:Cox proportional hazards models were used to determine the ri...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000258688

    authors: Bhatnagar V,Garcia EP,O'Connor DT,Brophy VH,Alcaraz J,Richard E,Bakris GL,Middleton JP,Norris KC,Wright J,Hiremath L,Contreras G,Appel LJ,Lipkowitz MS,AASK Study Investigators.

    更新日期:2010-01-01 00:00:00

  • Seasonal blood pressure and body weight variation in patients on chronic hemodialysis.

    abstract:AIM:The relation of ambient temperature (AMT) and relative humidity to systolic blood pressure (SBP), diastolic blood pressure (DBP), body weight (BW), and body weight gain between dialysis sessions (DeltaBW) was examined in hemodialysis patients by Fourier analysis. METHODS AND RESULTS:The authors recruited 144 dialy...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000013538

    authors: Tozawa M,Iseki K,Iseki C,Morita O,Yoshi S,Fukiyama K

    更新日期:1999-01-01 00:00:00

  • Proteomic analysis of whole glomeruli in patients with IgA nephropathy using microsieving.

    abstract:BACKGROUND:To promote understanding of immunoglobulin A nephropathy (IgAN) pathophysiology, we tried to elucidate glomerular protein profiles in IgAN, using microsieving that we established recently to isolate glomeruli from renal biopsy samples and proteomic approaches. METHODS:Glomeruli were isolated from renal biop...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000357788

    authors: Kojima S,Koitabashi K,Iizuka N,Okamoto K,Arito M,Sato T,Kurokawa MS,Suematsu N,Shibagaki Y,Yasuda T,Kimura K,Kato T

    更新日期:2014-01-01 00:00:00

  • The combination of mycophenolate mofetil with corticosteroids induces remission of Henoch-Schönlein purpura nephritis.

    abstract:BACKGROUND:Henoch-Schönlein purpura (HSP) is a form of systemic vasculitis that can progress to Henoch-Schönlein purpura nephritis (HSPN), and the most effective treatment remains controversial. Our aim was to compare the effects of oral mycophenolate mofetil (MMF) with low-dose prednisone and the full-dose corticoster...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000341914

    authors: Ren P,Han F,Chen L,Xu Y,Wang Y,Chen J

    更新日期:2012-01-01 00:00:00

  • Polymorphic genes for kinin receptors, nephropathy and blood pressure in type 2 diabetic patients.

    abstract:BACKGROUND/AIMS:There is evidence that hereditary predisposition contributes to the development of diabetic nephropathy and hypertension. Polymorphisms in the genes for bradykinin receptors (B(1)R and B(2)R) were found to be associated with decreased risk of the development of end-stage renal disease. This study examin...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000068035

    authors: Zychma MJ,Gumprecht J,Trautsolt W,Szydlowska I,Grzeszczak W

    更新日期:2003-03-01 00:00:00

  • Right ventricular dysfunction in patients with end-stage renal disease.

    abstract:BACKGROUND:While chronic dialysis treatment has been suggested to increase pulmonary pressure values, right ventricular dysfunction (RVD) is a major cause of death in patients with end-stage renal disease. We investigated the impact of different dialysis treatments on right ventricular function. METHODS:We examined 22...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000320755

    authors: Paneni F,Gregori M,Ciavarella GM,Sciarretta S,De Biase L,Marino L,Tocci G,Principe F,Domenici A,Luciani R,Punzo G,Menè P,Volpe M

    更新日期:2010-01-01 00:00:00

  • Novel methodology to evaluate renal cysts in polycystic kidney disease.

    abstract:AIM:To develop and assess a semiautomated method for segmenting and counting individual renal cysts from mid-slice MR images in patients with autosomal dominant polycystic kidney disease (ADPKD). METHODS:A semiautomated method was developed to segment and count individual renal cysts from mid-slice MR images in 241 su...

    journal_title:American journal of nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000358604

    authors: Bae KT,Sun H,Lee JG,Bae K,Wang J,Tao C,Chapman AB,Torres VE,Grantham JJ,Mrug M,Bennett WM,Flessner MF,Landsittel DP,Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease.

    更新日期:2014-01-01 00:00:00

  • Significant racial differences in the key factors associated with early graft loss in kidney transplant recipients.

    abstract:BACKGROUND:There is continued and significant debate regarding the salient etiologies associated with graft loss and racial disparities in kidney transplant recipients. METHODS:This was a longitudinal cohort study of all adult kidney transplant recipients, comparing patients with early graft loss (<5 years) to those w...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000363393

    authors: Taber DJ,Douglass K,Srinivas T,McGillicuddy JW,Bratton CF,Chavin KD,Baliga PK,Egede LE

    更新日期:2014-01-01 00:00:00

  • Histopathologic Features that Predict Transplant Glomerulopathy Progression in a Chinese Cohort.

    abstract:BACKGROUND:Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. The extent to which histopathologic features predicts prognostication is uncertain. METHODS:A single-center retrospective cohort with biopsy-proven TG was i...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000500043

    authors: Li X,Chen J,Cheng D,Wang W,Xie K,Zhang M,Xu F,Wen J,Tang Z

    更新日期:2019-01-01 00:00:00

  • Early Activation of PINCH/ Glycogen-Synthase Kinase 3β/ERK Pathway in Obstructive Nephropathy Rat Model.

    abstract:BACKGROUND:Despite a previous study showing that PINCH-1 exerts an important role in regulating TGF-β1-mediated mesenchymal transition through its interaction with integrin-linked kinase, relatively little is known about the role of PINCH in the obstructive nephropathy. METHODS:To construct a rat model of renal inters...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000450838

    authors: Jia L,Li X,Gu Y,Cui W

    更新日期:2016-01-01 00:00:00

  • Red blood cell membrane lipid peroxidation in continuous ambulatory peritoneal dialysis patients.

    abstract::We have recently described that in the erythrocytes from uremic patients on chronic hemodialysis, the pentose-phosphate shunt is defective, the membrane concentrations of malonyldialdehyde, resulting from peroxidation of polyunsaturated fatty acids in the membranes themselves, are increased, and the concentrations of ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000167061

    authors: Taccone-Gallucci M,Giardini O,Lubrano R,Mazzarella V,Bandino D,Khashan S,Mannarino O,Elli M,Cozzari M,Buoncristiani U

    更新日期:1986-01-01 00:00:00

  • Autonomic nervous system dysfunction and impotence in uremia.

    abstract::The relationship between abnormalities in nocturnal penile tumescence (NPT) and autonomic function, measured by the Valsalva maneuver, was evaluated in 25 uremic patients and 22 normal subjects. NPT in uremic patients (45 +/- 6.8 min/night) was lower (p less than 0.01) than in normals (85 +/- 10.4 min/night). Valsalva...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000166629

    authors: Campese VM,Procci WR,Levitan D,Romoff MS,Goldstein DA,Massry SG

    更新日期:1982-01-01 00:00:00

  • Association between circulating thrombopoietin levels and cardiovascular risk prediction scores in renal transplant recipients.

    abstract:BACKGROUND/AIMS:The 7-year Major Adverse Cardiovascular Events Calculator (CRCRTR-MACE) predicts cardiovascular events (CVE) in renal transplant recipients (RTR), and thrombopoietin (TPO) is a humoral inflammatory factor implicated in cardiovascular disease (CVD). The aim of the study was to determine if circulating TP...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000377641

    authors: Mansell H,Elmoselhi H,Shoker A

    更新日期:2015-01-01 00:00:00

  • Calcium-channel-blocking drugs and renal sodium excretion.

    abstract::The administration of calcium-blocking drugs exerts a natriuretic response. Acute studies in isolated perfused kidneys and in experimental animals, as well as in man, consistently demonstrate diuresis, natriuresis, calciuresis, and generally kaliuresis, even in the face of arterial blood pressure reduction. Clearance ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1159/000167541

    authors: Luft FC

    更新日期:1987-01-01 00:00:00

  • Intradialytic exercise in hemodialysis patients: a systematic review and meta-analysis.

    abstract:BACKGROUND AND OBJECTIVE:Hemodialysis (HD) patients are more inactive, leading to poor functional capacity and quality of life; this may be reversed with intradialytic exercise training. To systematically evaluate the efficacy and safety of intradialytic exercise for HD patients, we conducted a meta-analysis of the pub...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000368722

    authors: Sheng K,Zhang P,Chen L,Cheng J,Wu C,Chen J

    更新日期:2014-01-01 00:00:00

  • Cardiovascular Outcomes in Action to Control Cardiovascular Risk in Diabetes: Impact of Blood Pressure Level and Presence of Kidney Disease.

    abstract:BACKGROUND:Persons with chronic kidney disease (CKD) represent a population prone to cardiovascular disease (CVD) but vulnerable to adverse medication effects. We assessed the impact of intensive antihypertensive therapy on the cerebrovascular and other CVD outcomes in high-risk patients with type 2 diabetes and baseli...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000446122

    authors: Papademetriou V,Zaheer M,Doumas M,Lovato L,Applegate WB,Tsioufis C,Mottle A,Punthakee Z,Cushman WC,ACCORD Study Group.

    更新日期:2016-01-01 00:00:00

  • A case of acute tubulointerstitial nephritis and uveitis syndrome with a dramatic response to corticosteroid therapy.

    abstract::A 23-year-old female with acute renal failure associated with acute tubulointerstitial nephritis and uveitis is reported. Renal tubular acidosis and inflammatory reactions consisting of markedly increased erythrocyte sedimentation rate and high serum immunoglobulin levels were seen on admission. Light microscopy revea...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168020

    authors: Hirano K,Tomino Y,Mikami H,Ota K,Aikawa Y,Shirato I,Koide H

    更新日期:1989-01-01 00:00:00

  • Is AV fistula patency associated with angiotensin-converting enzyme (ACE) polymorphism and ACE inhibitor intake?

    abstract:BACKGROUND/AIMS:Hemodialysis treatment requires a well-functioning vascular access. Access patency is limited by the development of venous intimal hyperplasia, which predisposes to fistula stenosis and subsequent thrombosis. In animal models, the renin-angiotensin system has a major role in the development of intimal h...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000080464

    authors: Heine GH,Ulrich C,Köhler H,Girndt M

    更新日期:2004-07-01 00:00:00

  • Coronary Artery Calcification in Hemodialysis and Peritoneal Dialysis.

    abstract:BACKGROUND:Vascular calcification is seen in most patients on dialysis and is strongly associated with cardiovascular mortality. Vascular calcification is promoted by phosphate, which generally reaches higher levels in hemodialysis than in peritoneal dialysis. However, whether vascular calcification develops less in pe...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000494665

    authors: Jansz TT,van Reekum FE,Özyilmaz A,de Jong PA,Boereboom FTJ,Hoekstra T,Verhaar MC,van Jaarsveld BC

    更新日期:2018-01-01 00:00:00

  • Hemolytic-uremic syndrome associated with ingestion of quinine.

    abstract::Hemolytic-uremic syndrome following quinine ingestion is a newly described phenomenon, with just two previous descriptions of 4 cases in the literature. We describe a 5th case. The reaction may be mediated by the presence of antibodies reactive against platelets in the presence of quinine. Treatment has included use o...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168444

    authors: Hagley MT,Hosney IA,Hulisz DT,Davis HH

    更新日期:1992-01-01 00:00:00

  • Increasing Medical Student Interest in Nephrology.

    abstract:BACKGROUND:Interest in nephrology careers is declining, possibly due to perceptions of the field and/or training aspects. Understanding practices of medical schools successfully instilling nephrology interest could inform efforts to attract leading candidates to the specialty. METHODS:The American Society of Nephrolog...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000501058

    authors: Sozio SM,Pivert KA,Shah HH,Chakkera HA,Asmar AR,Varma MR,Morrow BD,Patel AB,Leight K,Parker MG

    更新日期:2019-01-01 00:00:00

  • Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis.

    abstract:BACKGROUND:The objective of this study was to investigate the role of bone morphogenetic protein (BMP) signal transduction in the pathogenesis of calciphylaxis. METHODS:Skin biopsy specimens were obtained from 18 patients with, and 12 patients without, calciphylaxis. Tissue sections were stained with antibodies direct...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000484418

    authors: Nigwekar SU,Jiramongkolchai P,Wunderer F,Bloch E,Ichinose R,Nazarian RM,Thadhani RI,Malhotra R,Bloch DB

    更新日期:2017-01-01 00:00:00

  • Applying an artificial neural network to predict total body water in hemodialysis patients.

    abstract:BACKGROUND:Estimating total body water (TBW) is crucial in determining dry weight and dialytic dose for hemodialysis patients. Several anthropometric equations have been used to predict TBW, but a more accurate method is needed. We developed an artificial neural network (ANN) to predict TBW in hemodialysis patients. M...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000088279

    authors: Chiu JS,Chong CF,Lin YF,Wu CC,Wang YF,Li YC

    更新日期:2005-09-01 00:00:00

  • Distal nephron function in Bartter's syndrome: abnormal conductance to chloride in the cortical collecting tubule?

    abstract::Five patients with the clinical patterns of Bartter's syndrome underwent a series of clearance studies in order to characterize the underlying tubule defect. Free water generation during maximal water diuresis (CH2O), expressed as percentage of the distal delivery (CH2O + CCl), was lower in the patients (72.5 +/- 3.2%...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168451

    authors: Colussi G,Rombolà G,Verde G,Airaghi C,Loli P,Minetti L

    更新日期:1992-01-01 00:00:00

  • Inhibition of cytokine synthesis by peritoneal dialysate persists throughout the CAPD cycle.

    abstract::The current study focused on the effect of continuous ambulatory peritoneal dialysis (CAPD) dialysate obtained following different intraperitoneal dwell periods on the release of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha) from mononuclear leukocytes (PBMC). Aliquots of 5 x 10(6)/ml healthy periph...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168422

    authors: Jörres A,Topley N,Steenweg L,Müller C,Köttgen E,Gahl GM

    更新日期:1992-01-01 00:00:00

  • Imaging uremic red blood cells with the atomic force microscope.

    abstract::Ultramorphological images and details of an uremic echinocyte are shown. The images confirm the existence of uremic echinocytes and demonstrate that atomic force microscopy can provide high-resolution images of cell surfaces. ...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168714

    authors: Zachée P,Boogaerts M,Snauwaert J,Hellemans L

    更新日期:1994-01-01 00:00:00

  • Association of co-occurring serious mental illness with emergency hospitalization in people with chronic kidney disease.

    abstract:BACKGROUND/AIMS:Chronic kidney disease (CKD) and serious mental illness (SMI) are both associated with an increased risk for repeated hospitalization. The objective of this study was to determine if co-occurring SMI exacerbates the risk for subsequent hospitalization, particularly through the emergency department (ED),...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000360095

    authors: McPherson S,Barbosa-Leiker C,Daratha K,Short R,McDonell MG,Alicic R,Roll J,Tuttle K

    更新日期:2014-01-01 00:00:00

  • D-penicillamine-induced crescentic glomerulonephritis and antimyeloperoxidase antibodies in a patient with scleroderma. Case report and review of the literature.

    abstract::Therapeutic use of D-penicillamine has been associated with a range of adverse effects. We present a patient with scleroderma, treated with D-penicillamine for 5 years, who developed severe renal failure due to rapidly progressive glomerulonephritis with both crescents and subepithelial immune deposits on renal biopsy...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1159/000169183

    authors: Karpinski J,Jothy S,Radoux V,Levy M,Baran D

    更新日期:1997-01-01 00:00:00

  • Immunotactoid glomerulopathy and cutaneous vasculitis.

    abstract::A 22-year-old woman presented glomerulonephritis with Schönlein-Henoch-like syndrome and monoclonal abnormality. One month later, she developed a rapidly progressive glomerulonephritis with hypertension and persistent purpura. In the two renal biopsies performed during the first and the second attack, mesangial expans...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000168276

    authors: Orfila C,Meeus F,Bernadet P,Lepert JC,Suc JM

    更新日期:1991-01-01 00:00:00

  • The significance of atherogenic indices in patients on hemodialysis.

    abstract::Atherosclerotic diseases (ASD) are the major cause of mortality and morbidity in patients on hemodialysis (HD). To evaluate the significance and usefulness of atherogenic indices, we examined lipoprotein(a) (Lp(a)), remnant-like particles cholesterol (RLP.C), homocysteine (Hcy), cardiac troponin T (TnT), and ankle-arm...

    journal_title:American journal of nephrology

    pub_type: 杂志文章

    doi:10.1159/000013566

    authors: Oishi K,Nagake Y,Yamasaki H,Fukuda S,Ichikawa H,Ota K,Makino H

    更新日期:2000-03-01 00:00:00