Polymorphic genes for kinin receptors, nephropathy and blood pressure in type 2 diabetic patients.

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in the atherosclerosis. Recombinant human erythropoietin (EPO) has become widely used to treat anemic hemodialyzed (HD) patients; however, an increased mortality has been reported for HD patients with cardiovascular d...

journal_title：American journal of nephrology

authors： Pawlak K,Pawlak D,Mysliwiec M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:It is uncertain whether kidneys from marginal donors are suitable for live kidney transplantation. In deceased donor kidneys, tubular cell senescence affects allograft function. However, the degree of cell senescence in a living donor kidney with marginal factors has not been reported. In this study, we asse...

journal_title：American journal of nephrology

authors： Sofue T,Kushida Y,Ozaki T,Moritoki M,Nishijima Y,Ohsaki H,Ueda N,Kakehi Y,Nishiyama A,Minamino T

更新日期：2018-01-01 00:00:00

abstract：:Serum levels of vitamin A (VA) were measured in 71 hemodialysis (HD) patients and in 30 normal controls. 65 of the 71 patients were taking multivitamin preparations (MP) containing VA. The HD patients had significantly greater values: 7.81 +/- 2.86 mumol/l (224 +/- 82 micrograms/dl) versus 3.97 +/- 0.97 mumol/l (114 +...

journal_title：American journal of nephrology

authors： Praga M,Diaz Rubio P,Morales JM,Cañizares F,Ruilope LM,Gutierrez-Millet V,Nieto J,Rodicio JL

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND/AIMS:The shortage in organ supply has required the use of expanded criteria donors (ECD) for kidney transplantation. Current pre-transplant evaluations of ECD organs are based on histological, clinical or mixed criteria. This monocentric study investigates the predictivity of Karpinski's histological score o...

journal_title：American journal of nephrology

authors： La Manna G,Comai G,Cappuccilli ML,Liviano D'Arcangelo G,Fabbrizio B,Valentini C,Carretta E,Ravaioli M,Scolari MP,Ridolfi L,Feliciangeli G,Grigioni FW,Pinna AD,Stefoni S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Transglutaminase 2 (TGM2) is a calcium-dependent enzyme that can cross-link nearly all extracellular matrix (ECM) proteins and can facilitate cell-ECM interaction through integrins. Given the importance of the ECM in vascular calcification we tested the hypothesis that increased TGM2 activity may accelerate ...

journal_title：American journal of nephrology

authors： Chen NX,O'Neill K,Chen X,Kiattisunthorn K,Gattone VH,Moe SM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Placental growth factor (PlGF), a member of the vascular endothelial growth factor (VEGF) family, has recently emerged as a predictor of survival and cardiovascular risk. Along with others, we have shown an independent association between PlGF and cardiovascular events in CKD patients, but not much is known ...

journal_title：American journal of nephrology

authors： Matsui M,Samejima K,Takeda Y,Tanabe K,Morimoto K,Okamoto K,Tagawa M,Onoue K,Okayama S,Kawata H,Kawakami R,Akai Y,Saito Y

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:In autosomal dominant polycystic kidney disease, renoprotective treatment with a vasopressin V2 receptor antagonist (V2RA) is given in a fixed dose (FD). Disease progression and drug habituation could diminish treatment efficacy. We investigated whether the renoprotective effect of the V2RA can be improved b...

journal_title：American journal of nephrology

authors： Zittema D,Versteeg IB,Gansevoort RT,van Goor H,de Heer E,Veraar KA,Peters DJ,Meijer E

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Health-related quality of life (HRQOL) reflects a patient's perceived disease burden, treatment effectiveness, and health status. Given the time burden and physiologic effects of hemodialysis, patients who spend dialysis time (9-15 h/week) physically or intellectually engaged may have better HRQOL. We charac...

journal_title：American journal of nephrology

authors： Warsame F,Ying H,Haugen CE,Thomas AG,Crews DC,Shafi T,Jaar B,Chu NM,Segev DL,McAdams-DeMarco MA

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:African Americans (AAs) suffer the widest gaps in chronic kidney disease (CKD) outcomes compared to Caucasian Americans (CAs) and this is because of the disparities that exist in both health and healthcare. In fact, the prevalence of CKD is 3.5 times higher in AAs compared to CAs. The disparities exist at al...

journal_title：American journal of nephrology

authors： Harding K,Mersha TB,Vassalotti JA,Webb FA,Nicholas SB

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Recent retrospective studies suggest an association of therapy with erythropoiesis-stimulating agents (ESAs) and increased mortality in renal transplant recipients (RTR). Large artery structure and function are significantly impaired in RTR which contributes to their high cardiovascular morbidity and co...

journal_title：American journal of nephrology

authors： Bartels V,Hillebrand U,Kosch M,Hausberg M,Kisters K,Di Marco GS,Reiermann S,Pavenstaedt H,Lang D

更新日期：2012-01-01 00:00:00

abstract：:Vascular access thrombosis is more common with polytetrafluoroethylene (PTFE) grafts than with native arteriovenous fistulae (AVF). Recent studies report an unexplained excess vascular access morbidity in women on hemodialysis. We studied 92 consecutive end-stage renal disease (ESRD) patients receiving their first per...

journal_title：American journal of nephrology

authors： Ifudu O,Macey LJ,Homel P,Hyppolite JC,Hong J,Sumrani N,Distant D,Sommer BG,Friedman EA

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:In the US, native kidney biopsies are usually inpatient procedures. We developed an outpatient biopsy protocol for low-risk patients and assessed its safety and efficacy. METHODS:Patients with an SBP <140 mm Hg and a BMI ≤35 who were not taking anticoagulants, ASA and NSAIDS in the preceding week were inclu...

journal_title：American journal of nephrology

authors： McMahon GM,McGovern ME,Bijol V,Benson CB,Foley R,Munkley K,Schnipper J,Franz C,Lin J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:Insulin is synthesised as a pro-hormone with an interconnecting C-peptide, cleaved during post-translational modification. This review discusses growing evidence which indicates that C-peptide is biologically active, benefiting microvascular complications associated with diabetes. METHODS:To explore th...

journal_title：American journal of nephrology

authors： Hills CE,Brunskill NJ,Squires PE

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Protein-energy wasting (PEW) is common and associated with poor outcome in hemodialysis patients. In hemodialysis patients, geriatric nutritional risk index (GNRI) and decoy receptor 3 (DcR3) have been shown as the nutritional and inflammatory markers, respectively. The present study aimed to assess the pred...

journal_title：American journal of nephrology

authors： Tsai MT,Hu FH,Lien TJ,Chen PJ,Huang TP,Tarng DC

更新日期：2014-01-01 00:00:00

abstract：:A noninvasive method for the diagnosis of cardiac calcinosis, a life-threatening complication in hemodialysis patients with end-stage renal disease (ESRD), has not, as yet, been firmly established. We tested whether whole body scanning with 99m-technetium methylene diphosphonate (MDP) might visualize cardiac calcinosi...

journal_title：American journal of nephrology

authors： Eguchi M,Tsuchihashi K,Takizawa H,Nakahara N,Hagiwara M,Ohnishi H,Torii T,Hashimoto A,Marusaki S,Nakata T,Ura N,Shimamoto K

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND/AIMS:Intradialytic hypotension is the most common complication of modern day haemodialysis (HD). Convective modalities, including haemodiafiltration (HDF) are reported to result in greater cardiovascular stability compared to standard HD, which has been suggested to be due to improved solute transport betwee...

journal_title：American journal of nephrology

authors： Kumar S,Khosravi M,Massart A,Potluri M,Davenport A

更新日期：2013-01-01 00:00:00

abstract：:To elucidate the prevalence and clinical implications of antineutrophil cytoplasmic antibody (ANCA) in lupus nephritis (LN), we examined ANCA by indirect immunofluorescence and by ELISA against antilactoferrin (anti-LF) and antimyeloperoxidase (anti-MPO) antibody. To discriminate perinuclear ANCA (pANCA) with antinucl...

journal_title：American journal of nephrology

authors： Chin HJ,Ahn C,Lim CS,Chung HK,Lee JG,Song YW,Lee HS,Han JS,Kim S,Lee JS

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:While the etiology of idiopathic nephrotic syndrome (idiopathic nephrotic syndrome [INS]; characterized by repeated relapses and comorbid allergic conditions) remains unknown, recent evidence suggests that dysfunction in regulatory T cells (Tregs) plays an important role in the development of INS as well as ...

journal_title：American journal of nephrology

authors： Tsuji S,Suruda C,Hashiyada M,Kimata T,Yamanouchi S,Kitao T,Kino J,Akane A,Kaneko K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) are increasingly used in uremic patients (pts). However, their effect on serum potassium (sK) concentrations in anuric pts on chronic hemodialysis treatment (HD) is controversial. The aim of the study was to evaluate sK b...

journal_title：American journal of nephrology

authors： Movilli E,Camerini C,Gaggia P,Zubani R,Cancarini G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Persons with chronic kidney disease (CKD) represent a population prone to cardiovascular disease (CVD) but vulnerable to adverse medication effects. We assessed the impact of intensive antihypertensive therapy on the cerebrovascular and other CVD outcomes in high-risk patients with type 2 diabetes and baseli...

journal_title：American journal of nephrology

authors： Papademetriou V,Zaheer M,Doumas M,Lovato L,Applegate WB,Tsioufis C,Mottle A,Punthakee Z,Cushman WC,ACCORD Study Group.

更新日期：2016-01-01 00:00:00

abstract：:Forty-eight chronic hemodialysis patients were divided comparably into two groups (24 patients in each). Two micrograms of 1 alpha(OH)D3 was administered to one group for 3 months and its placebo to the other group. In the 1 alpha(OH)D3-treated group, serum total calcium increased from 7.82 +/- 0.11 (mean +/- SEM) to ...

journal_title：American journal of nephrology

authors： Shimamatsu K,Onoyama K,Fujimi S,Iseki K,Fujishima M

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Patients with primary hyperoxaluria (PH) overproduce oxalate which is eliminated via the kidneys. If end-stage kidney disease develops they are at high risk for systemic oxalosis, unless adequate oxalate is removed during hemodialysis (HD) to equal or exceed ongoing oxalate production. The purpose of this st...

journal_title：American journal of nephrology

authors： Tang X,Voskoboev NV,Wannarka SL,Olson JB,Milliner DS,Lieske JC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cisplatin (CIS) induces nephrotoxicity partly through renal vasoconstriction and decreased glomerular filtration effects thought to involve adenosine acting on adenosine A(1) receptors (A1Rs). We studied the effect of the orally active, A1R antagonist tonapofylline (BG9928) on biochemical measures of re...

journal_title：American journal of nephrology

authors： Gill A,Wortham K,Costa D,Davis W,Ticho B,Whalley E

更新日期：2009-01-01 00:00:00

abstract：:To evaluate the determinants of rhabdomyolysis in the diabetic state, we compared biochemical and clinical features of diabetic patients with (group 1, 41 patients) and without (group 2, 36 patients) rhabdomyolysis. There was no difference in values for serum potassium, bicarbonate, phosphate and calcium between the t...

journal_title：American journal of nephrology

authors： Singhal PC,Abramovici M,Ayer S,Desroches L

更新日期：1991-01-01 00:00:00

abstract：:In hypoaldosteronemic patients with chronic renal insufficiency, administration of a mineralocorticoid steroid such as fludrocortisone can ameliorate hyperkalemia and metabolic acidosis, but this therapy is not always safe owing to the deleterious consequences of extracellular fluid volume expansion resulting from min...

journal_title：American journal of nephrology

authors： Sebastian A,Schambelan M,Sutton JM

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Predicting the mortality risk of patients un-dergoing hemodialysis (HD) is challenging. Cell-free DNA (cfDNA) is released into circulation from dying cells, and its elevation is predictive of unfavorable outcome. In a pilot study, we found post-HD cfDNA level to be a predictor of all-cause mortality. Thus, t...

journal_title：American journal of nephrology

authors： Einbinder Y,Shnaider A,Ghanayem K,Basok A,Rogachev B,Lior Y,Haviv YS,Cohen-Hagai K,Nacasch N,Rozenberg I,Benchetrit S,Zitman-Gal T,Douvdevani A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. The extent to which histopathologic features predicts prognostication is uncertain. METHODS:A single-center retrospective cohort with biopsy-proven TG was i...

journal_title：American journal of nephrology

authors： Li X,Chen J,Cheng D,Wang W,Xie K,Zhang M,Xu F,Wen J,Tang Z

更新日期：2019-01-01 00:00:00

abstract：:A patient with progressive systemic sclerosis (PSS) involving skin, digit, esophagus, and lung developed the nephrotic syndrome and rapidly progressive renal insufficiency. Renal pathology revealed capillary collapse, cellular crescents, arteriolar hyaline deposition, and mesangial proliferation. On immunofluorescence...

journal_title：American journal of nephrology

authors： Eiser AR,Zilversmit R,Neff MS,Grishman E,Slifkin RF

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:There is a higher risk of gastrointestinal (GI) bleeding in patients treated with dabigatran versus warfarin. We analyzed the impact of renal function on the relative risk of bleeding in patients converted to dabigatran. METHODS:Patients aged ≥65 years who received anticoagulation with warfarin for a minimu...

journal_title：American journal of nephrology

authors： Kalil RS,Kaboli PJ,Liu X,Vaughan-Sarrazin M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Fibrillary glomerulonephritis is characterized by randomly arranged fibrils, approximately 20 nm in diameter by electron microscopy. Patients present with proteinuria, hematuria and kidney insufficiency, and about half of the reported patients progress to end-stage kidney disease within 4 years. The dependen...

journal_title：American journal of nephrology

authors： Payan Schober F,Jobson MA,Poulton CJ,Singh HK,Nickeleit V,Falk RJ,Jennette JC,Nachman PH,Pendergraft Iii WF

更新日期：2017-01-01 00:00:00