Abstract:
BACKGROUND/AIMS:Intradialytic hypotension is the most common complication of modern day haemodialysis (HD). Convective modalities, including haemodiafiltration (HDF) are reported to result in greater cardiovascular stability compared to standard HD, which has been suggested to be due to improved solute transport between compartments. We therefore investigated the effect of treatment on body water by bioimpedance. METHODS:We measured the change in extracellular water (ECW) and intracellular water (ICW) in 263 outpatients attending for HD using cooled dialysate and 134 patients for HDF. RESULTS:Patient cohorts were matched for demographics, dialysate composition, ultrafiltration rate, and session duration. The fall in systolic blood pressure following HD was -11.8 mm Hg (-25.3 to 2.3) and not different from that following HDF -12 mm Hg (-27 to 6). Similarly there were no differences in pretreatment serum sodium and dialysate sodium gradient [HD 1 mmol/l (-1 to 3) vs. HDF 2 mmol/l (1 to 4)], or change in serum sodium posttreatment [HD 0 mmol/l (-2 to 2) vs. HDF 1 mmol/l (-1 to 3)]. There were no differences in ICW or ECW pretreatment, and following treatment the reduction in ICW and ECW did not differ [ICW HD -3.5% (-5.7 to -1.8) vs. -4.1% (-6.0 to -1.7), ECW HD -7.1% (-9.4 to -4.7) vs. HDF -7.1% (-9.7 to -4.9)]. CONCLUSION:We were unable to demonstrate any advantage for HDF over HD using cooled dialysate in terms of changes in blood pressure during a treatment session, or differences in the relative changes in ICW or ECW volumes.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Kumar S,Khosravi M,Massart A,Potluri M,Davenport Adoi
10.1159/000349925subject
Has Abstractpub_date
2013-01-01 00:00:00pages
320-4issue
4eissn
0250-8095issn
1421-9670pii
000349925journal_volume
37pub_type
杂志文章abstract::Investigations of biopsy material from human kidneys with different forms of glomerulonephritis (n = 1,240) and with diabetic glomerulosclerosis (n = 406) performed in order to find changes caused by hyperperfusion of the kidney tissue gave the following results: (1) Hyperperfusion injury occurs in the different forms...
journal_title:American journal of nephrology
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journal_title:American journal of nephrology
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doi:10.1159/000013391
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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pub_type: 传,历史文章,杂志文章
doi:10.1159/000168749
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000357787
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
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