Dose-Titrated Vasopressin V2 Receptor Antagonist Improves Renoprotection in a Mouse Model for Autosomal Dominant Polycystic Kidney Disease.

abstract：BACKGROUND:Fibrillary glomerulonephritis is characterized by randomly arranged fibrils, approximately 20 nm in diameter by electron microscopy. Patients present with proteinuria, hematuria and kidney insufficiency, and about half of the reported patients progress to end-stage kidney disease within 4 years. The dependen...

journal_title：American journal of nephrology

authors： Payan Schober F,Jobson MA,Poulton CJ,Singh HK,Nickeleit V,Falk RJ,Jennette JC,Nachman PH,Pendergraft Iii WF

更新日期：2017-01-01 00:00:00

abstract：:This study describes 10 cases of IgM nephropathy in whom the main morphological findings consisted of diffuse mesangial deposition of IgM and varying degrees of mesangial cell proliferation. In addition, focal segmental sclerosis was present in 1 patient and global sclerosis in another. An ill-defined electron-dense d...

journal_title：American journal of nephrology

authors： Kopolovic J,Shvil Y,Pomeranz A,Ron N,Rubinger D,Oren R

更新日期：1987-01-01 00:00:00

abstract：:The development of new therapies for chronic diseases, such as diabetic kidney disease (DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights and will be responsive to treatment interventions. The recent application of metabolomic technologies, such as nuclear magnetic resonanc...

journal_title：American journal of nephrology

authors： Darshi M,Van Espen B,Sharma K

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:We previously reported that patients with chronic kidney disease (CKD) receiving warfarin therapy and whose international normalized ratio increases to >3.0 may develop acute kidney injury (AKI) as a result of glomerular hemorrhage and formation of obstructive red blood cell (RBC) casts. We named this c...

journal_title：American journal of nephrology

authors： Ozcan A,Ware K,Calomeni E,Nadasdy T,Forbes R,Satoskar AA,Nadasdy G,Rovin BH,Hebert LA,Brodsky SV

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Evidence using real-world data is sparse regarding the effects of oral anticoagulants (OACs) among patients with kidney disease. The aim of this study was to investigate the effects of kidney disease on ischemic stroke (IS) or systemic embolism (SE) among patients taking OAC, using large-scale real-world d...

journal_title：American journal of nephrology

authors： Maeda T,Nishi T,Funakoshi S,Tada K,Tsuji M,Satoh A,Kawazoe M,Yoshimura C,Arima H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Treatment of metabolic acidosis to target the higher serum bicarbonate level than guideline recommendation may downregulate muscle protein degradation and improve renal function among chronic kidney disease (CKD) patients. We conducted a study to test the effects of increased serum bicarbonate level on muscl...

journal_title：American journal of nephrology

authors： Kittiskulnam P,Srijaruneruang S,Chulakadabba A,Thokanit NS,Praditpornsilpa K,Tungsanga K,Eiam-Ong S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:Living donor nephrectomy can be associated with increases in blood pressure several years following the procedure, but the best method to assess blood pressure during the living donor evaluation process is unclear. METHODS:Living kidney donors underwent casual clinic and ambulatory blood pressure monit...

journal_title：American journal of nephrology

authors： DeLoach SS,Meyers KE,Townsend RR

更新日期：2012-01-01 00:00:00

abstract：:We have demonstrated considerable variability in the volumes of different glomeruli in given individuals (individual glomerular volume: IGV) in a stereologic study of kidneys at forensic autopsy performed to investigate sudden or unexpected death in people without manifest kidney disease. We review some important asso...

journal_title：American journal of nephrology

authors： Hoy WE,Hughson MD,Diouf B,Zimanyi M,Samuel T,McNamara BJ,Douglas-Denton RN,Holden L,Mott SA,Bertram JF

更新日期：2011-01-01 00:00:00

abstract：:Both the Old Testament and the Talmud contain a great deal of information on medicine, nephrology, health and disease. The basic premise of early Jewish medicine is based on the notion that disease is due to structural changes in internal organs. This is in contrast to the mythical dogma of humoralism as the basis of ...

journal_title：American journal of nephrology

authors： Massry SG,Smogorzewski M,Hazani E,Shasha SM

更新日期：1997-01-01 00:00:00

abstract：:A dramatic response was noted in a patient at our hospital who received hemodialysis therapy for severe acidosis secondary to an unknown toxin, subsequently identified as cyanide. We were unable to find any information concerning the hemodialysis clearance and extraction ratio of cyanide; thus, we studied the effect o...

journal_title：American journal of nephrology

authors： Wesson DE,Foley R,Sabatini S,Wharton J,Kapusnik J,Kurtzman NA

更新日期：1985-01-01 00:00:00

abstract：:Most pretransplant malignancies require a tumor-free waiting period before transplantation. End-stage renal disease (ESRD) patients have an increased risk of renal cell carcinoma (RCC), which is mostly detected from routine screening during pre-kidney transplant evaluation. RCC must be quiescent prior to kidney transp...

journal_title：American journal of nephrology

authors： Tantisattamo E,Elam A,Cobb J,Ellis CL,Bailey JL

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) may lead to right heart failure and subsequently alter glomerular filtration rates (GFR). Chronic kidney disease (CKD, GFR <60 mL/min/1.73 m2) may also adversely affect PAH prognosis. This study aimed to assess how right heart hemodynamics was associated with reduced est...

journal_title：American journal of nephrology

authors： Bitker L,Sens F,Payet C,Turquier S,Duclos A,Cottin V,Juillard L

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a prevalent condition; however, little is known about healthcare resource utilization (HRU) by CKD patients. METHODS:This analysis included NHANES participants aged > or =18 years, with serum creatinine, urine protein, and hemoglobin measurements. We assessed the association ...

journal_title：American journal of nephrology

authors： Alexander M,Bradbury BD,Kewalramani R,Barlev A,Mohanty SA,Globe D

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:Although HIV-infected persons are at higher risk for acute kidney injury (AKI) during hospitalization compared with their uninfected counterparts, risk factors for AKI are not well-defined. We aimed to describe the evolving incidence of AKI among HIV-infected individuals and to identify important AKI ri...

journal_title：American journal of nephrology

authors： Li Y,Shlipak MG,Grunfeld C,Choi AI

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Vitamin D deficiency, sympathetic activation and endothelial dysfunction are associated with increased cardiovascular risk in patients with chronic kidney disease (CKD). Studies have so far failed to establish the role of vitamin D and vitamin D receptor activator (VDRA) treatment in moderate CKD. This trial...

journal_title：American journal of nephrology

authors： Lundwall K,Jörneskog G,Jacobson SH,Spaak J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The prognostic value of the anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN) classification has been demonstrated in several cohorts with sclerotic class having the worst renal outcome. Relevant published data on factors predicting outcomes in sclerotic ANCA GN is limited. METH...

journal_title：American journal of nephrology

authors： Menez S,Hruskova Z,Scott J,Cormican S,Chen M,Salama AD,Alasfar S,Little MA,Safrankova H,Honsova E,Tesar V,Geetha D

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cisplatin (CIS) induces nephrotoxicity partly through renal vasoconstriction and decreased glomerular filtration effects thought to involve adenosine acting on adenosine A(1) receptors (A1Rs). We studied the effect of the orally active, A1R antagonist tonapofylline (BG9928) on biochemical measures of re...

journal_title：American journal of nephrology

authors： Gill A,Wortham K,Costa D,Davis W,Ticho B,Whalley E

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The use of complementary/alternative medicine has garnered rising interest in recent years. Natural products including herbs, vitamins, and minerals are the most popularly consumed. The Internet is a ubiquitous source of information/market for these supplements. AIM:To systematically evaluate the dietary an...

journal_title：American journal of nephrology

authors： Vamenta-Morris H,Dreisbach A,Shoemaker-Moyle M,Abdel-Rahman EM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in the atherosclerosis. Recombinant human erythropoietin (EPO) has become widely used to treat anemic hemodialyzed (HD) patients; however, an increased mortality has been reported for HD patients with cardiovascular d...

journal_title：American journal of nephrology

authors： Pawlak K,Pawlak D,Mysliwiec M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Hyperoxaluria may result from increased endogenous production or overabsorption of dietary oxalate in the gastrointestinal tract leading to nephrolithiasis and, in some, to oxalate nephropathy and chronic kidney disease. ALLN-177 is an oral formulation of a recombinant, oxalate specific, microbial enzyme oxa...

journal_title：American journal of nephrology

authors： Langman CB,Grujic D,Pease RM,Easter L,Nezzer J,Margolin A,Brettman L

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Published reports examining the efficacy and safety of glucocorticoids for preserving renal function in immunoglobulin A nephropathy (IgAN) have yielded conflicting results. To systematically evaluate the efficacy and safety of glucocorticoids agents for IgAN, we conducted a meta-analysis of the published ra...

journal_title：American journal of nephrology

authors： Cheng J,Zhang X,Zhang W,He Q,Tao X,Chen J

更新日期：2009-01-01 00:00:00

abstract：:To evaluate the determinants of rhabdomyolysis in the diabetic state, we compared biochemical and clinical features of diabetic patients with (group 1, 41 patients) and without (group 2, 36 patients) rhabdomyolysis. There was no difference in values for serum potassium, bicarbonate, phosphate and calcium between the t...

journal_title：American journal of nephrology

authors： Singhal PC,Abramovici M,Ayer S,Desroches L

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is increasingly common and disproportionately affects older adults. The contribution of kidney disease to the functional impairment noted in the elderly CKD population is unclear. METHODS:This is a cross-sectional analysis of a hypertensive cohort of people aged ≥75 years from t...

journal_title：American journal of nephrology

authors： Wolfgram DF,Garcia K,Evans G,Zamanian S,Tang R,Wiegmann T,Sharma R,Campbell R,Whittle J,SPRINT Study Research Group.

更新日期：2017-01-01 00:00:00

abstract：:To verify if exogenous prostaglandin E2 (PGE2) is able to release antidiuretic hormone (ADH) and if endogenous angiotensin II plays a role in this eventual PGE2-induced stimulation of vasopressin, increasing doses of PGE2 were infused in 6 normal volunteers before (PGE2 study) and after the administration of 100 mg of...

journal_title：American journal of nephrology

authors： Usberti M,Gargiulo A,Comberti E,Campisi S,Poiesi C,Brognoli M,Doregatti C,Rondina M,Zaneboni A,Ghielmi S

更新日期：1989-01-01 00:00:00

abstract：:To elucidate the relationship between the renal regulation of sodium and calcium excretion at extremes of sodium intake, we studied 6 normal men ingesting a fixed, 400 mg/day calcium intake and four levels of sodium intake from 10 to 1,500 mEq/day. Serum ionized calcium was not influenced by sodium intake. Blood press...

journal_title：American journal of nephrology

authors： McCarron DA,Rankin LI,Bennett WM,Krutzik S,McClung MR,Luft FC

更新日期：1981-01-01 00:00:00

abstract：:We analyzed routine serum potassium concentration measurements and conditions temporally associated with abnormalities in potassium concentration in outpatients on chronic hemodialysis (136 nondiabetics, 36 diabetics) and continuous ambulatory peritoneal dialysis (16 nondiabetics, 10 diabetics). The following potassiu...

journal_title：American journal of nephrology

authors： Tzamaloukas AH,Avasthi PS

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND/AIMS:Vitamin D insufficiency drives secondary hyperparathyroidism (SHPT) and is associated with increased cardiovascular mortality in patients with chronic kidney disease (CKD). SHPT is poorly addressed by current vitamin D repletion options. The present study evaluated a novel investigational vitamin D repl...

journal_title：American journal of nephrology

authors： Sprague SM,Silva AL,Al-Saghir F,Damle R,Tabash SP,Petkovich M,Messner EJ,White JA,Melnick JZ,Bishop CW

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Tacrolimus is mainly metabolized by cytochrome P450 3A5 (CYP3A5), which is expressed in the liver. However, CYP3A5 is also expressed in the kidney tissue and may contribute to local tacrolimus clearance in the kidney allograft. We aimed to evaluate the association between the allograft CYP3A5 genotype and tr...

journal_title：American journal of nephrology

authors： Udomkarnjananun S,Townamchai N,Chariyavilaskul P,Iampenkhae K,Pongpirul K,Sirichindakul B,Panumatrassamee K,Vanichanan J,Avihingsanon Y,Eiam-Ong S,Praditpornsilpa K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:The present study tested the hypothesis that chronic hypoxia adversely affects renal development in the ovine fetus. METHODS:Kidneys were collected from near-term fetuses of pregnant ewes maintained at sea level or high altitude (3,801 m, PaO(2): approx. 60 mm Hg) for 110 days (n = 6 for each group). ...

journal_title：American journal of nephrology

authors： Mao C,Hou J,Ge J,Hu Y,Ding Y,Zhou Y,Zhang H,Xu Z,Zhang L

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:Three different apo E alleles (E2, E3 and E4) produce apo E isoproteins, which regulate the metabolism of lipoproteins. This study investigated the apo E polymorphisms as a prognostic factor for the development of diabetic nephropathy (DN). METHODS:A total of 525 type 2 diabetic patients were enrolled ...

journal_title：American journal of nephrology

authors： Tien KJ,Tu ST,Chou CW,Yang CY,Hsiao JY,Shin SJ,Chen HC,Hsieh MC

更新日期：2011-01-01 00:00:00