Abstract:
BACKGROUND/AIMS:The present study tested the hypothesis that chronic hypoxia adversely affects renal development in the ovine fetus. METHODS:Kidneys were collected from near-term fetuses of pregnant ewes maintained at sea level or high altitude (3,801 m, PaO(2): approx. 60 mm Hg) for 110 days (n = 6 for each group). RESULTS:Long-term high altitude hypoxia reduced the fetal kidney/body weight ratio. Histological analysis showed a significant enlargement in the Bowman's space and swelling of tubule epithelial cells in the kidney of the hypoxic fetus. The histological alterations were limited to the cortical, but not medullary, zone. These alterations were associated with an increase in serum creatinine and a decrease in the BUN-to-creatinine ratio in hypoxic fetuses. Angiotensin II receptors (AT(1)R and AT(2)R) were detected in the glomerular and tubular regions of the kidney. Chronic hypoxia caused a significant increase in AT(1)R and a decrease in AT(2)R protein and mRNA abundance, resulting in a large increase in the AT(1)R/AT(2)R ratio in the fetal kidney. CONCLUSION:The results demonstrate an adverse effect of chronic hypoxia on renal AT(1)R and AT(2)R expression and functions in the fetus, suggesting a possible role of fetal hypoxia in the programming of renal diseases in fetal origins.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Mao C,Hou J,Ge J,Hu Y,Ding Y,Zhou Y,Zhang H,Xu Z,Zhang Ldoi
10.1159/000259901subject
Has Abstractpub_date
2010-01-01 00:00:00pages
141-50issue
2eissn
0250-8095issn
1421-9670pii
000259901journal_volume
31pub_type
杂志文章abstract:BACKGROUND:The prognostic value of the anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN) classification has been demonstrated in several cohorts with sclerotic class having the worst renal outcome. Relevant published data on factors predicting outcomes in sclerotic ANCA GN is limited. METH...
journal_title:American journal of nephrology
pub_type: 杂志文章,多中心研究
doi:10.1159/000494840
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Oxidative stress (OS) and asymmetric dimethylarginine (ADMA) are accepted as nonclassical cardiovascular risk factors in end-stage renal disease patients. To clarify the role of these factors in the atherosclerotic process, we investigated if OS and ADMA are associated with common carotid artery intima media...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000109397
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIM:Slc26a6 (PAT1, CFEX) is a major chloride/base exchanger located on the apical membrane of the kidney proximal tubule. The purpose of the present study was to examine the effect of Slc26a6 deletion on the apical Na+/H+ exchanger 3 (NHE3) in the straight segment (S3) of the proximal tubule, which is the ma...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000111826
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Tacrolimus (FK) is currently widely used in transplant immunosuppression and the treatment of autoimmune diseases. However, FK induces nephrotoxicity which is characterized by functional and structural renal injury. The ubiquitous protein annexin A1 (ANXA1) has potent anti-inflammatory effects and protects a...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000309756
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:Ischemia/reperfusion (I/R) injury is characterized by cytoskeletal reorganization and loss of polarity in proximal tubule epithelial cells. Previously, we showed that myofibrillogenesis regulator (MR)-1 promoted actin organization in cardiomyocytes. MR-1 is also expressed in the kidney. METHODS:In this...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000360141
更新日期:2014-01-01 00:00:00
abstract::We report a 29-year-old female with recurrent focal glomerulosclerosis (FGS) presenting as heavy proteinuria immediately following renal transplantation. From day 13 after transplantation, daily plasma exchange was performed 6 times. Proteinuria decreased from 13 to 0.2 g/day after plasma exchange and remained to be l...
journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000168637
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Conditionally immortalized podocytes are valuable research tools but are difficult to efficiently transfect and do not provide graded transgene expression. METHODS:Conditionally immortalized mouse podocyte cell lines were established employing a tetracycline-inducible system. Glomerular cells, isolated from...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000151770
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Prolonged use of corticosteroids continues to be the mainstay in the management of most proteinuric glomerulopathies, but is limited by extensive side effects. Alternative medications such as adrenocorticotropic hormone (ACTH) have been recently used to treat refractory glomerulopathies and have shown superi...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000506854
更新日期:2020-01-01 00:00:00
abstract::Skin ulceration is a well-characterized thrombotic complication of the heparin-induced thrombocytopenia (HIT) syndrome. We present the case of a 73-year-old diabetic woman nearing end-stage renal failure who developed extensive upper thigh, abdominal and buttock ulceration following initiation of subcutaneous heparin ...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000046263
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Vascular calcification is seen in most patients on dialysis and is strongly associated with cardiovascular mortality. Vascular calcification is promoted by phosphate, which generally reaches higher levels in hemodialysis than in peritoneal dialysis. However, whether vascular calcification develops less in pe...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000494665
更新日期:2018-01-01 00:00:00
abstract::The purpose of the present investigation was to determine whether dexamethasone, an agent known to preserve the blood-brain barrier, and colchicine, an agent that impairs mobilization of macrophages, can prevent demyelinating lesions associated with rapid correction of hyponatremia in the experimental animal. Hyponatr...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000168071
更新日期:1990-01-01 00:00:00
abstract::A 22-year-old woman presented glomerulonephritis with Schönlein-Henoch-like syndrome and monoclonal abnormality. One month later, she developed a rapidly progressive glomerulonephritis with hypertension and persistent purpura. In the two renal biopsies performed during the first and the second attack, mesangial expans...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000168276
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Recent reports have highlighted that diabetic patients with kidney failure are at increased risk of technique failure and transfer to haemodialysis within 90 days of initiating peritoneal dialysis (PD). We wished to determine whether there were differences between diabetic and non-diabetic patients within th...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000477326
更新日期:2017-01-01 00:00:00
abstract::Renal function and life expectancy can be improved by aggressive antihypertensive therapy in severe hypertension. However, most reports of severe hypertension and renal failure concern primary hypertensive states. 3 cases of primary renal disease, 1 glomerular, 1 obstructive and 1 of chronic pyelonephritis, are descri...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000166576
更新日期:1982-01-01 00:00:00
abstract::The administration of calcium-blocking drugs exerts a natriuretic response. Acute studies in isolated perfused kidneys and in experimental animals, as well as in man, consistently demonstrate diuresis, natriuresis, calciuresis, and generally kaliuresis, even in the face of arterial blood pressure reduction. Clearance ...
journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000167541
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Living donor liver transplantation (LDLT) patients run the risk of developing acute kidney injury (AKI) and subsequent chronic kidney disease, affecting morbidity and mortality. Sevoflurane has anti-inflammation properties, and renal ischemia/reperfusion under sevoflurane anesthesia resulted in drastic impro...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000319623
更新日期:2010-01-01 00:00:00
abstract::The use of Dacron cuff double-lumen permanent catheters for hemodialysis has become more common in the dialysis unit as patients await for creation or maturation of a permanent hemoaccess for various reasons. Placement of these catheters is often done by surgeons. Nephrologists skilled in the placement of temporary ce...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000013425
更新日期:1999-01-01 00:00:00
abstract::The objective was to evaluate the effect of high-flux hemodialysis on quality of life, intra- and interdialytic symptoms and neuropsychological function. The study was double-blind single cross-over with random allocation to order of treatment. The patients were stable adult hospital hemodialysis patients. Both the co...
journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000168491
更新日期:1992-01-01 00:00:00
abstract::We describe an elderly women who died of renal failure secondary to spontaneous renal atheroembolic disease. The sole clinical clue to this diagnosis was a profound eosinophilia up to 19,100/mm3 and a relative eosinophil count of 80%. Renal atheroembolic disease should be a prominent consideration in any patient with ...
journal_title:American journal of nephrology
pub_type: 杂志文章,评审
doi:10.1159/000168476
更新日期:1992-01-01 00:00:00
abstract::We analyzed routine serum potassium concentration measurements and conditions temporally associated with abnormalities in potassium concentration in outpatients on chronic hemodialysis (136 nondiabetics, 36 diabetics) and continuous ambulatory peritoneal dialysis (16 nondiabetics, 10 diabetics). The following potassiu...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000167443
更新日期:1987-01-01 00:00:00
abstract::We describe a 78-year-old patient with nephrotic syndrome due to minimal-change glomerulopathy, associated with a renal adenocarcinoma. Oliguric acute renal failure requiring hemodialysis was also observed. Surgical removal of the tumor and corticosteroid therapy resulted in resolution of the nephrotic state and impro...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000013365
更新日期:1998-01-01 00:00:00
abstract::Renal disease is a common complication in malaria infection. In acute falciparum malaria renal involvement is usually mild, but in severe disease acute renal failure is a major problem. Acute renal failure has been attributed to ischaemic tubular necrosis from hypovolaemia resulting from vasodilatation due to endothel...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000013611
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND/AIMS:Upregulation of transforming growth factor beta (TGF-beta)/Smad signaling has been implicated in the primary pathogenesis of renal fibrosis. The ubiquitin-proteasome pathway has an important influence on TGF-beta signaling through regulating Smad degradation. As E3 ubiquitin ligases, both Arkadia and Sm...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000100518
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in the atherosclerosis. Recombinant human erythropoietin (EPO) has become widely used to treat anemic hemodialyzed (HD) patients; however, an increased mortality has been reported for HD patients with cardiovascular d...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000101191
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Adherence is paramount in treating hypertension; however, no gold standard method is available for non-adherence screening, delineating high-risk patients. An International Classification of Diseases 9th Edition non-adherence diagnostic code (V15.81) has been available for decades; but, its utility is poorly...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000440685
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:The elderly are the fastest growing subpopulation with end-stage renal disease. The goal of our study was to define characteristics of elderly patients who were considered ineligible for transplantation compared to those who were listed. METHODS:984 patients were referred for evaluation during a 2-year...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000354483
更新日期:2013-01-01 00:00:00
abstract::The present study evaluated thyroid hormone indices of patients with acute renal failure without other systemic illnesses (n = 12), as compared to patients with critical illnesses in the presence (n = 16) and absence (n = 6) of acute renal failure. Abnormalities in the group with acute renal failure alone included dec...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000166531
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. The extent to which histopathologic features predicts prognostication is uncertain. METHODS:A single-center retrospective cohort with biopsy-proven TG was i...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000500043
更新日期:2019-01-01 00:00:00
abstract::To evaluate the determinants of rhabdomyolysis in the diabetic state, we compared biochemical and clinical features of diabetic patients with (group 1, 41 patients) and without (group 2, 36 patients) rhabdomyolysis. There was no difference in values for serum potassium, bicarbonate, phosphate and calcium between the t...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000168357
更新日期:1991-01-01 00:00:00
abstract::The platelet content of adenosine triphosphate (ATP), adenosine diphosphate (ADP), serotonin and ouabain-insensitive, magnesium-dependent adenosine triphosphatase (ATPase) was determined in patients with chronic renal failure, patients on chronic hemodialysis, and kidney transplant recipients. Platelet ATP content was...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000166482
更新日期:1981-01-01 00:00:00