Abstract:
BACKGROUND:Living donor liver transplantation (LDLT) patients run the risk of developing acute kidney injury (AKI) and subsequent chronic kidney disease, affecting morbidity and mortality. Sevoflurane has anti-inflammation properties, and renal ischemia/reperfusion under sevoflurane anesthesia resulted in drastic improvements in renal function. Extrahepatic metabolism of sevoflurane has been reported in patients undergoing liver transplantation, and might lead to nephrotoxicity. However, whether sevoflurane anesthesia is safe with regard to renal function in small-size liver transplantation needs further investigation. As neutrophil gelatinase-associated lipocalin (NGAL) is an early predictive biomarker of AKI, we looked at the renal effects of sevoflurane in a rat liver transplantation model using small-for-size grafts to investigate the changes of NGAL level and kidney histology. METHODS:Sixty male Sprague-Dawley rats were randomly divided into 2 groups after 50% size liver transplantation. Rats were anesthetized with chloral hydrate or with sevoflurane and subjected to liver transplantation. Twelve rats in each group were used for the survival study and 6 rats were used for the hemodynamic study. Six rats in each group were sacrificed 2 or 24 h after reperfusion. We harvested kidneys and serum for further analysis, including histological and functional parameters; TNF-α, IL-6 and NGAL immunoassay; expressions of myeloperoxidase (MPO) activity; and NF-κB in renal tissues. RESULTS:Rats in the sevoflurane group had significantly lower Scr 24 h after reperfusion compared with those in the chloral hydrate group. Rats in the sevoflurane group demonstrated significantly reduced NGAL concentrations compared with rats in the chloral hydrate group 2 h after reperfusion. Epithelial necrosis in the chloral hydrate group (3.2 ± 0.8) was greater than that in the sevoflurane group (1.5 ± 1.1; p < 0.05). Sevoflurane anesthesia resulted in significantly lower plasma TNF-α and IL-6 concentrations and reduced MPO concentrations 2 h after reperfusion (p < 0.05). NF-κB protein levels 2 h after reperfusion increased by at least 110% in the chloral hydrate group relative to the sevoflurane group 2 h after reperfusion (p < 0.05). However, the urine inorganic fluoride concentrations increased significantly (p < 0.001) 2 h after reperfusion in the sevoflurane group (6.1 ± 1.5 μmol·l⁻¹) compared with the chloral hydrate group. CONCLUSIONS:Sevoflurane anesthesia can attenuate renal injury and modulate inflammatory cascades in small-size liver transplantation using rat models.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Kong HY,Zhu SM,Wang LQ,He Y,Xie HY,Zheng SSdoi
10.1159/000319623subject
Has Abstractpub_date
2010-01-01 00:00:00pages
347-55issue
4eissn
0250-8095issn
1421-9670pii
000319623journal_volume
32pub_type
杂志文章abstract::The present study evaluated thyroid hormone indices of patients with acute renal failure without other systemic illnesses (n = 12), as compared to patients with critical illnesses in the presence (n = 16) and absence (n = 6) of acute renal failure. Abnormalities in the group with acute renal failure alone included dec...
journal_title:American journal of nephrology
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doi:10.1159/000166531
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abstract:BACKGROUND/AIMS:Hemodialysis treatment requires a well-functioning vascular access. Access patency is limited by the development of venous intimal hyperplasia, which predisposes to fistula stenosis and subsequent thrombosis. In animal models, the renin-angiotensin system has a major role in the development of intimal h...
journal_title:American journal of nephrology
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更新日期:2018-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 临床试验,杂志文章
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journal_title:American journal of nephrology
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journal_title:American journal of nephrology
pub_type: 杂志文章
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000166914
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000166931
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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