Abstract:
BACKGROUND:We investigated the gender differences in the effect of ACE I/D and AGT M235T polymorphisms on the prognosis of diabetic nephropathy (DN). METHODS:A total of 525 type 2 diabetics were enrolled to participate in this prospective observational study. ACE and AGT gene polymorphisms were analyzed by polymerase chain reaction. The progression of DN was defined as a shift to a higher stage of DN or a doubling of the baseline serum creatinine level by the end of the study. RESULTS:The baseline biophysical parameters show no gender differences in progression and non-progression of DN. The women who were ACE D allele carriers were found to be at an increased risk of DN progression compared to those with II genotypes (p = 0.024, OR 2.176). No such difference was seen in male patients (p = 0.619, OR 0.833). After adjusting for confounding factors (age, SBP, DBP, BMI, HbA1c, total cholesterol, TG, HDL-C, LDL-C, ACEI, and ARB) in our multiple regression analysis, these women were still found to be at increased risk of progressing to more severe DN (p = 0.008, OR 3.082) but not the men (p = 0.183, OR 0.586). Neither the AGT TT genotype nor the T allele were associated with the progression of DN in either sex after adjusting for confounding factors. CONCLUSION:Our follow-up study suggests that female diabetic carriers of the ACE D allele might be at an increased risk of DN progression.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Tien KJ,Hsiao JY,Hsu SC,Liang HT,Lin SR,Chen HC,Hsieh MCdoi
10.1159/000163592subject
Has Abstractpub_date
2009-01-01 00:00:00pages
299-308issue
4eissn
0250-8095issn
1421-9670pii
000163592journal_volume
29pub_type
杂志文章abstract:BACKGROUND/AIMS:Recent retrospective studies suggest an association of therapy with erythropoiesis-stimulating agents (ESAs) and increased mortality in renal transplant recipients (RTR). Large artery structure and function are significantly impaired in RTR which contributes to their high cardiovascular morbidity and co...
journal_title:American journal of nephrology
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND/AIMS:The elderly are the fastest growing subpopulation with end-stage renal disease. The goal of our study was to define characteristics of elderly patients who were considered ineligible for transplantation compared to those who were listed. METHODS:984 patients were referred for evaluation during a 2-year...
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journal_title:American journal of nephrology
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doi:10.1159/000324561
更新日期:2011-01-01 00:00:00
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journal_title:American journal of nephrology
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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