Abstract：
:Obese Zucker rats spontaneously develop lipoprotein abnormalities, proteinuria, mesangial expansion and glomerulosclerosis. Previous studies have implicated these lipoprotein abnormalities in the pathogenesis of the progressive renal injury which these rats develop. The present study was designed to examine the chronological development of very-low-density lipoprotein (VLDL) abnormalities and renal injury. Obese and lean Zucker rats were maintained on a standard rat diet and sacrificed at 6, 11, 17, 23, 28, and 34 weeks of age. Renal tissue was examined histologically, serum was assayed for lipoproteins, and 24-hour urinary protein excretion determined. Hypertriglyceridemia, elevated VLDL-cholesterol and VLDL-triglycerides were seen at as early as 6 weeks of age in obese rats at a time when other lipoprotein fractions were normal. By 23 weeks, proteinuria developed in obese animals and renal tissue showed increased mesangial matrix, hypercellularity and glomerulosclerosis with lipid deposition noted in the mesangium. All of these abnormalities worsened during the 34 weeks of study at a time when almost all of the total circulating cholesterol was carried by VLDL rather than low-density lipoprotein (LDL), the predominant carrier of circulating cholesterol. These data suggest that increased lipoproteins with atherogenic potential, specifically cholesterol-rich VLDL and triglyceride-rich VLDL particles, correlated positively with the development of renal injury and glomerulosclerosis in obese Zucker rats. They further support a hypothesis that the increased appearance of atherogenic lipoproteins, particularly cholesterol-rich VLDL, may be associated with proteinuria and progressive glomerular injury.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Kamanna VS,Kirschenbaum MAdoi
10.1159/000168588subject
Has Abstractpub_date
1993-01-01 00:00:00pages
53-8issue
1eissn
0250-8095issn
1421-9670journal_volume
13pub_type
杂志文章abstract：:Nutrition has been shown to predict clinical outcome in continuous ambulatory peritoneal dialysis (CAPD) patients. However, despite the positive relationship between KT/V (urea) and the normalised protein catabolic rate, the ability of urea kinetic modelling to predict clinical outcome or nutrition remains inconclusiv...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168663
更新日期：1993-01-01 00:00:00
abstract：:The acid-base balance of 199 patients with cystic fibrosis, seen from 1987 through 1992 at the Bern Outpatient Clinic, were evaluated. Simple metabolic alkalosis was demonstrated in 16 and mixed metabolic alkalosis and respiratory acidosis in 9 patients. When compared with 10 patients with simple respiratory acidosis ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168839
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND/AIMS:The elderly are the fastest growing subpopulation with end-stage renal disease. The goal of our study was to define characteristics of elderly patients who were considered ineligible for transplantation compared to those who were listed. METHODS:984 patients were referred for evaluation during a 2-year...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000354483
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Health-related quality of life (HRQOL) reflects a patient's perceived disease burden, treatment effectiveness, and health status. Given the time burden and physiologic effects of hemodialysis, patients who spend dialysis time (9-15 h/week) physically or intellectually engaged may have better HRQOL. We charac...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000492623
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in the atherosclerosis. Recombinant human erythropoietin (EPO) has become widely used to treat anemic hemodialyzed (HD) patients; however, an increased mortality has been reported for HD patients with cardiovascular d...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000101191
更新日期：2007-01-01 00:00:00
abstract：:We describe an elderly women who died of renal failure secondary to spontaneous renal atheroembolic disease. The sole clinical clue to this diagnosis was a profound eosinophilia up to 19,100/mm3 and a relative eosinophil count of 80%. Renal atheroembolic disease should be a prominent consideration in any patient with ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000168476
更新日期：1992-01-01 00:00:00
abstract：:Radioisotopic methods for the determination of the glomerular filtration rate (GFR) are highly accurate but require the collection of multiple blood and urine samples and are costly to perform due to personnel, material, and analysis costs. Nonradioactive methods of GFR determination have the potential of minimizing p...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168985
更新日期：1996-01-01 00:00:00
abstract：:Maimonides (Moses ben Maimon) was born in 1135 in Cordoba, the son of a Jewish rabbi. After a seminomadic upbringing in Spain and North Africa during the rule of the Almohades, Maimonides settled in Fostate (Old Cairo), where he became renowned as a physician, eventually being appointed as court physician to Saladin a...
journal_title：American journal of nephrology
pub_type： 传,历史文章,杂志文章
doi：10.1159/000168739
更新日期：1994-01-01 00:00:00
abstract：:One hundred twenty-eight hemodialysis patients and 64 medical personnel consisting of dialysis nurses and technicians, hemodialysis access surgeons and nephrologists were surveyed about their preferences and concerns in regard to the hemodialysis vascular access. The access preferred by physicians was the A-V fistula ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013380
更新日期：1998-01-01 00:00:00
abstract：:Man-made or massive natural disasters may be followed by 'epidemics' of the muscle crush syndrome. The first descriptions of the crush syndrome were in the German-language literature following the earthquake of Messina in 1909 and World War II. On the threshold of World War II, the English-language literature was stil...
journal_title：American journal of nephrology
pub_type： 历史文章,杂志文章
doi：10.1159/000169127
更新日期：1997-01-01 00:00:00
abstract：:Bicarbonate dialysate is claimed to be superior to acetate for both chronic and acute hemodialysis. We compared acetate and bicarbonate dialysates in 30 acute renal failure patients during 120 dialyses. 4 patients were diabetic and 2 had liver failure. Patients were dialyzed alternating acetate and bicarbonate dialysa...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
doi：10.1159/000166484
更新日期：1981-01-01 00:00:00
abstract：BACKGROUND:Dietary sodium may influence cognitive function through its effects on cerebrovascular function and cerebral blood flow. METHODS:The aim of this study was to evaluate the association of dietary sodium intake with cognitive decline in community-dwelling older adults. We also evaluated the associations of die...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000486580
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:It is uncertain whether kidneys from marginal donors are suitable for live kidney transplantation. In deceased donor kidneys, tubular cell senescence affects allograft function. However, the degree of cell senescence in a living donor kidney with marginal factors has not been reported. In this study, we asse...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000485845
更新日期：2018-01-01 00:00:00
abstract：:Whole plasma from 6 normolipidemic chronic renal failure (CRF) patients undergoing hemodialysis treatment was passed through the anti-apolipoprotein (Apo) AI immunosorbent column connected to the anti-Apo B immunoaffinity column. Apo AI and B containing particles were analyzed for lipid and Apo contents. The results w...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169011
更新日期：1996-01-01 00:00:00
abstract：:We analyzed routine serum potassium concentration measurements and conditions temporally associated with abnormalities in potassium concentration in outpatients on chronic hemodialysis (136 nondiabetics, 36 diabetics) and continuous ambulatory peritoneal dialysis (16 nondiabetics, 10 diabetics). The following potassiu...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167443
更新日期：1987-01-01 00:00:00
abstract：INTRODUCTION:Evidence using real-world data is sparse regarding the effects of oral anticoagulants (OACs) among patients with kidney disease. The aim of this study was to investigate the effects of kidney disease on ischemic stroke (IS) or systemic embolism (SE) among patients taking OAC, using large-scale real-world d...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000509567
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Three million people in the United States are estimated to have chronic kidney disease (CKD). Management of these CKD patients in the outpatient primary care clinic setting has not been well studied. HYPOTHESIS:Primary care management of CKD can be assessed and opportunities for improvement can be identifie...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000066296
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Increased mortality and morbidity are reported in association with high ultrafiltration rate (UFR) and with long dialysis recovery time (DRT). We studied the association between UFR and DRT. METHODS:This is a cross-sectional, observational study was conducted. Patients on thrice-weekly hemodialysis (HD) wit...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000476076
更新日期：2017-01-01 00:00:00
abstract：:This study was carried out to find out whether Ramadan fasting would affect the renal function in kidney transplant recipients with normal or impaired graft function. Twenty-three transplant recipients, 17 with a normal function and 6 with an impaired but stable function with plasma creatinine levels not exceeding 300...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013316
更新日期：1998-01-01 00:00:00
abstract：:We retrospectively reviewed the course of 1,000 renal transplants performed in 835 recipients (758 nondiabetics) to assess the incidence of new onset posttransplant diabetes in former nondiabetics. A total of 119 (15.7%) recipients manifested posttransplant diabetes, of whom 64 (53.8%) became hyperglycemic within 3 we...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166932
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:Fatigue is an important symptom to patients with advanced chronic kidney disease (CKD). The aim of this study is to examine the prevalence and severity of fatigue among non-dialysis-dependent CKD and end-stage renal disease (ESRD) patients, to examine the association of fatigue with subjective and objective ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000356939
更新日期：2013-01-01 00:00:00
abstract：:We have recently described that in the erythrocytes from uremic patients on chronic hemodialysis, the pentose-phosphate shunt is defective, the membrane concentrations of malonyldialdehyde, resulting from peroxidation of polyunsaturated fatty acids in the membranes themselves, are increased, and the concentrations of ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167061
更新日期：1986-01-01 00:00:00
abstract：:The review focuses on biochemical metabolisms of conventional buffers and emphasizes advantages of sodium pyruvate (Pyr) in the correction of intracellular acidosis. Exogenous lactate (Lac) as an alternative of natural buffer, bicarbonate, consumes intracellular protons on an equimolar basis, regenerating bicarbonate ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000084141
更新日期：2005-01-01 00:00:00
abstract：:The platelet content of adenosine triphosphate (ATP), adenosine diphosphate (ADP), serotonin and ouabain-insensitive, magnesium-dependent adenosine triphosphatase (ATPase) was determined in patients with chronic renal failure, patients on chronic hemodialysis, and kidney transplant recipients. Platelet ATP content was...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166482
更新日期：1981-01-01 00:00:00
abstract：:The terminal complement-inhibitor eculizumab has dramatically changed the management of patients with atypical hemolytic uremic syndrome (aHUS), and has also shown promise for treating certain forms of secondary HUS (sHUS), including that caused by drugs and solid-organ/hematopoietic stem cell transplant. While effect...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000492033
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:We investigated the gender differences in the effect of ACE I/D and AGT M235T polymorphisms on the prognosis of diabetic nephropathy (DN). METHODS:A total of 525 type 2 diabetics were enrolled to participate in this prospective observational study. ACE and AGT gene polymorphisms were analyzed by polymerase ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000163592
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:The objective of this study was to investigate the role of bone morphogenetic protein (BMP) signal transduction in the pathogenesis of calciphylaxis. METHODS:Skin biopsy specimens were obtained from 18 patients with, and 12 patients without, calciphylaxis. Tissue sections were stained with antibodies direct...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000484418
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/AIMS:Pseudotumors of the craniovertebral junction (PTCVJ) are observed in long-term hemodialysis (HD) patients. There are neither criteria for diagnosis nor guidelines for screening. We attempted to determine magnetic resonance imaging (MRI) findings that could be used to detect PTCVJ, to determine the preva...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013516
更新日期：1999-01-01 00:00:00
abstract：:The effects of cisplatin (5 mg/kg BW given intraperitoneally) on renal concentration mechanism were evaluated initially by clearance studies in rats 5-7 days after cisplatin administration and compared to normal rats. During hypotonic saline infusion, cisplatin rats showed a lower inulin clearance (0.56 +/- 0.07 vs. 1...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167938
更新日期：1989-01-01 00:00:00
abstract：AIM:To develop and assess a semiautomated method for segmenting and counting individual renal cysts from mid-slice MR images in patients with autosomal dominant polycystic kidney disease (ADPKD). METHODS:A semiautomated method was developed to segment and count individual renal cysts from mid-slice MR images in 241 su...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
doi：10.1159/000358604
更新日期：2014-01-01 00:00:00
