Abstract：
:A comparative clinicopathological study was retrospectively performed in 61 children and 51 adults with IgA nephropathy. Hematuria and/or proteinuria as a chance finding was the most common initial clinical sign, being observed in 82.0% of the children and in 52.9% of the adults. At renal biopsy, hypertension and severe proteinuria were found in 9.8 and 33.3% of the adults and in 0 and 14.8% of the children (both p less than 0.05), respectively. Elevations of blood urea nitrogen and serum creatinine were found at this time of biopsy in 21.6 and 9.8% of the adults, but in none of the children (p less than 0.001 and p less than 0.05, respectively). Histologically, focal glomerulosclerosis and tubular atrophy were found in 52.9% of the adults and in 32.8% of the children (p less than 0.05). However, some features of the disease seen in both groups were similar, including the incidences of IgA nephropathy, sex ratio, the mode of onset, incidences of gross hematuria, and high IgA levels in the sera. Furthermore, the relationships between the severity of proteinuria and renal lesions were similar: mesangial proliferation, glomerulosclerosis, and tubular atrophy increased with the degree of the severity of proteinuria. These results suggest that IgA nephropathy is essentially identical in children and adults, although adult patients tend to be further advanced in their disease course at the time of diagnosis, and that focal glomerulosclerosis with tubular atrophy is correlated with deterioration of renal function.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Okada K,Funai M,Kawakami K,Kagami S,Yano I,Kuroda Ydoi
10.1159/000168080subject
Has Abstractpub_date
1990-01-01 00:00:00pages
191-7issue
3eissn
0250-8095issn
1421-9670journal_volume
10pub_type
杂志文章abstract：BACKGROUND/AIMS:In chronic hemodialysis patients, we evaluated determinants of repetitive ventricular tachyarrhythmias which included late potentials and heart rate variability. METHODS:We compared the presence of late potentials and heart rate variability obtained by ambulatory electrocardiogram (ECG), findings of ec...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013351
更新日期：1998-01-01 00:00:00
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journal_title：American journal of nephrology
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更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Evidence suggests that recombinant human erythropoietin (rHuEPO) protects neurons and cardiomyocytes from acute insults. We investigated the protective effect of rHuEPO on cyclosporine (CsA)-induced renal injury. METHODS:CsA (15 mg/kg/day) was given to rats for 1 or 4 weeks, and rHuEPO was concurrently admi...
journal_title：American journal of nephrology
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更新日期：2005-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000341862
更新日期：2012-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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更新日期：1993-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000088491
更新日期：2005-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168276
更新日期：1991-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章,评审
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更新日期：1997-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000206697
更新日期：2009-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000446848
更新日期：2016-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 历史文章,杂志文章
doi：10.1159/000063771
更新日期：2002-07-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
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更新日期：1988-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：American journal of nephrology
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更新日期：1993-01-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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journal_title：American journal of nephrology
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更新日期：2004-03-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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更新日期：2015-01-01 00:00:00
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更新日期：2014-01-01 00:00:00
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