Abstract：
BACKGROUND:The value of chronic kidney disease (CKD) screening in the general population remains unclear but may be beneficial in populations with high disease prevalence. We examined risk factors for albuminuria among participants in a state-wide CKD screening program in Hawaii. METHODS:The National Kidney Foundation of Hawaii Kidney Early Detection Screening (NKFH-KEDS) program held 19 CKD screening events from 2006 to 2012. Participants rotated through 5 stations during which sociodemographic, blood glucose, urine albumin-to-creatinine ratio (ACR), and spot urine albumin data were collected. Multivariate logistic regression analyses (adjusted for age, sex, race/ethnicity, body mass index [BMI]) were used to identify clinical predictors of abnormal ACR (≥30 μg/mg) and abnormal spot urine albumin (>20 mg/L) levels. RESULTS:Among 1,190 NKFH-KEDS participants who met eligibility criteria, 13 and 49% had abnormal ACR and urine albumin levels, respectively. In multivariate logistic regression analyses, participants of older age (>65 years), Asian and Pacific Islander race/ethnicity, BMI ≥30 kg/m2, and with hypertension had higher risk of abnormal ACR. Being of older age; Asian, Pacific Islander, and Mixed race/ethnicity; and having diabetes was associated with higher risk of abnormal urine albumin levels in adjusted analyses. CONCLUSIONS:NKFH-KEDS participants of older age; Asian and Pacific Islander race/ethnicity; and with obesity, hypertension, and diabetes had higher risk of kidney damage defined by elevated ACR and urine albumin levels. Further studies are needed to determine whether targeted screening programs can result in timely identification of CKD and implementation of interventions that reduce cardiovascular disease, death, and progression to end-stage renal disease.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Wong LL,Kalantar-Zadeh K,Page V,Hayashida G,You AS,Rhee CMdoi
10.1159/000455389subject
Has Abstractpub_date
2017-01-01 00:00:00pages
200-208issue
3eissn
0250-8095issn
1421-9670pii
000455389journal_volume
45pub_type
杂志文章abstract：:The development of new therapies for chronic diseases, such as diabetic kidney disease (DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights and will be responsive to treatment interventions. The recent application of metabolomic technologies, such as nuclear magnetic resonanc...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000447954
更新日期：2016-01-01 00:00:00
abstract：:Man-made or massive natural disasters may be followed by 'epidemics' of the muscle crush syndrome. The first descriptions of the crush syndrome were in the German-language literature following the earthquake of Messina in 1909 and World War II. On the threshold of World War II, the English-language literature was stil...
journal_title：American journal of nephrology
pub_type： 历史文章,杂志文章
doi：10.1159/000169127
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Various medications are cleared by the kidneys, therefore patients with impaired renal function, especially dialysis patients are at risk for adverse drug events (ADEs). There are limited studies on ADEs in maintenance dialysis patients. METHODS:We utilized a nationally representative database, the Nationwi...
journal_title：American journal of nephrology
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更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Serum protein profiling patterns can reflect the pathological state of a patient and therefore may be useful for clinical diagnostics. Here, we present results from a pilot study of proteomic expression patterns in hemodialysis patients designed to evaluate the range of serum proteomic alterations in this po...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000077409
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND/AIMS:There is a critical need for more noninvasive biomarkers to identify nephritis in patients with systemic lupus erythematosus (SLE). Recent studies in a model mouse and an adult SLE patient cohort suggest that anti-basement membrane antibody levels correlate well with lupus activity and kidney injury. Th...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000381965
更新日期：2015-01-01 00:00:00
abstract：:To elucidate the prevalence and clinical implications of antineutrophil cytoplasmic antibody (ANCA) in lupus nephritis (LN), we examined ANCA by indirect immunofluorescence and by ELISA against antilactoferrin (anti-LF) and antimyeloperoxidase (anti-MPO) antibody. To discriminate perinuclear ANCA (pANCA) with antinucl...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013557
更新日期：2000-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000360141
更新日期：2014-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000098150
更新日期：2006-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167967
更新日期：1989-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168422
更新日期：1992-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 传,历史文章,杂志文章
doi：10.1159/000168739
更新日期：1994-01-01 00:00:00
abstract：:An 18-year-old woman complained of fever and edema and was admitted to Showa University Hospital for treatment of thrombocytopenia and deteriorating renal function. Laboratory studies demonstrated the presence of lupus anticoagulant (LA), prolongation of prothrombin time, hemolytic anemia, a negative Coombs' test, the...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013526
更新日期：1999-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000046647
更新日期：2001-11-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169011
更新日期：1996-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000357133
更新日期：2013-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
doi：10.1159/000167515
更新日期：1987-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000346712
更新日期：2013-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000111826
更新日期：2008-01-01 00:00:00
abstract：:Alcaligenes xylosoxidans is an uncommon cause of peritonitis in patients on maintenance continuous ambulatory peritoneal dialysis (CAPD). Peritonitis caused by A. xylosoxidans usually carries a poor prognosis because of the pathogen's virulence and its universal resistance to most antimicrobial agents. Even after earl...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000046657
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:The outcome-predictability of baseline and instantaneously changing serum calcium in hemodialysis patients has been examined. We investigated the mortality-predictability of time-averaged calcium values to reflect the 'cumulative' effect of calcium burden over time. METHODS:We employed a Cox model using up-...
journal_title：American journal of nephrology
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：American journal of nephrology
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更新日期：2010-01-01 00:00:00
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journal_title：American journal of nephrology
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doi：10.1159/000070864
更新日期：2003-05-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000484418
更新日期：2017-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013400
更新日期：1998-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168080
更新日期：1990-01-01 00:00:00
abstract：:Left ventricular hypertrophy (LVH) is a common finding in hypertensive autosomal dominant polycystic kidney disease (ADPKD) patients. There are few studies on the influence of blood pressure (BP) and nonhemodynamic factors on LVH in these patients. The aim of this study was to evaluate the relationship between BP, hum...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013583
更新日期：2000-05-01 00:00:00
abstract：:To determine the effect of multiple dialyzer use on intradialytic symptoms, data from 26,592 successive dialyses on 147 patients were analyzed. Over the 26-month period of study 4,933 new dialyzers were used. All symptoms, considered together, occurred 1.3 times more frequently during the initial than during the subse...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167063
更新日期：1986-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168985
更新日期：1996-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000484903
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Overt albuminuria (urinary albumin-creatinine ratio [ACR] > 300 mg/g) is an established risk factor for progression of nephropathy and total mortality. However, whether a reduction in ACR translates into a reduction in mortality and/or cardiovascular (CV) events among insulin-treated patients with type 2 dia...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000496276
更新日期：2019-01-01 00:00:00
