HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-β via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells.

abstract：BACKGROUND:In the US, native kidney biopsies are usually inpatient procedures. We developed an outpatient biopsy protocol for low-risk patients and assessed its safety and efficacy. METHODS:Patients with an SBP <140 mm Hg and a BMI ≤35 who were not taking anticoagulants, ASA and NSAIDS in the preceding week were inclu...

journal_title：American journal of nephrology

authors： McMahon GM,McGovern ME,Bijol V,Benson CB,Foley R,Munkley K,Schnipper J,Franz C,Lin J

更新日期：2012-01-01 00:00:00

abstract：:A patient with renal failure due to myeloma kidney and coincident digitalis intoxication due to prescribed daily digoxin administration was treated with digoxin-specific antibody fragments and plasmapheresis. Rapid response to therapy was noted, removal of digoxin-antidigoxin antibody complexes was confirmed, and prev...

journal_title：American journal of nephrology

authors： Rabetoy GM,Price CA,Findlay JW,Sailstad JM

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIMS:There is a critical need for more noninvasive biomarkers to identify nephritis in patients with systemic lupus erythematosus (SLE). Recent studies in a model mouse and an adult SLE patient cohort suggest that anti-basement membrane antibody levels correlate well with lupus activity and kidney injury. Th...

journal_title：American journal of nephrology

authors： Orjuela A,Suwanichkul A,Canter D,Minard CG,Devaraj S,Hicks MJ,Muscal E,Wenderfer SE

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Although rhabdomyolysis has been associated with acute kidney injury and mortality in the short term, the long-term consequences of an episode of rhabdomyolysis remain unknown. We sought to identify the long-term outcomes of rhabdomyolysis, including mortality, renal function, and incidence of hypertension (...

journal_title：American journal of nephrology

authors： Faulk T,Walker LE,Howard JT,Janak JC,Sosnov JA,Stewart IJ

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIM:While the familial nature of chronic kidney disease (CKD) has been recognized, it has primarily been defined from studies of first-degree relatives of selected sets of cases. The goal of this study is an evaluation of the familial clustering of end-stage renal disease (ESRD) and CKD mortality using a pop...

journal_title：American journal of nephrology

authors： Goldfarb-Rumyantzev AS,Cheung AK,Habib AN,Wang BJ,Lin SJ,Baird BC,Naiman N,Cannon-Albright L

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Health-related quality of life (HRQOL) reflects a patient's perceived disease burden, treatment effectiveness, and health status. Given the time burden and physiologic effects of hemodialysis, patients who spend dialysis time (9-15 h/week) physically or intellectually engaged may have better HRQOL. We charac...

journal_title：American journal of nephrology

authors： Warsame F,Ying H,Haugen CE,Thomas AG,Crews DC,Shafi T,Jaar B,Chu NM,Segev DL,McAdams-DeMarco MA

更新日期：2018-01-01 00:00:00

abstract：:A 50-year-old woman presented with thrombocytopenia, microangiopathic hemolytic anemia, and nephrotic syndrome. Although a high level of circulating immune complexes, mild hypocomplementemia, and the antinuclear antibody also were present, the criteria for collagen disease were not fulfilled. Renal biopsy demonstrated...

journal_title：American journal of nephrology

authors： Kimura M,Fujigaki Y,Ohtake T,Furuya R,Hishida A,Kaneko E

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Malnutrition-inflammation score (MIS) is a comprehensive and quantitative system to assess malnutrition-inflammation complex syndrome, and a strong correlation between MIS and morbidity/mortality in maintenance hemodialysis (MHD) patients had been demonstrated. However, there is no cut-off value of MIS to ca...

journal_title：American journal of nephrology

authors： Ho LC,Wang HH,Peng YS,Chiang CK,Huang JW,Hung KY,Hu FC,Wu KD

更新日期：2008-01-01 00:00:00

abstract：:Renal disease is a common complication in malaria infection. In acute falciparum malaria renal involvement is usually mild, but in severe disease acute renal failure is a major problem. Acute renal failure has been attributed to ischaemic tubular necrosis from hypovolaemia resulting from vasodilatation due to endothel...

journal_title：American journal of nephrology

authors： Sinniah R,Lye W

更新日期：2000-07-01 00:00:00

abstract：:The number of patients with end-stage renal disease undergoing kidney transplantation - both cadaveric and living-donor - continues to rise. With long-term graft survival relatively fixed, this trend means that increasing numbers of patients are returning to dialysis after graft loss. Most will never be retransplanted...

journal_title：American journal of nephrology

authors： Fuquay R,Teitelbaum I

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Recent reports have highlighted that diabetic patients with kidney failure are at increased risk of technique failure and transfer to haemodialysis within 90 days of initiating peritoneal dialysis (PD). We wished to determine whether there were differences between diabetic and non-diabetic patients within th...

journal_title：American journal of nephrology

authors： Udo A,Goodlad C,Davenport A

更新日期：2017-01-01 00:00:00

abstract：:This report reviews the features of 149 cases of renal allograft rupture, while adding a detailed description of 3 more cases to the English literature. From November, 1973 to November, 1979, 3 cases of renal allograft rupture occurred in 100 renal transplants performed at Research Medical Center, Kansas City, Mo., an...

journal_title：American journal of nephrology

authors： Thukral R,Mir AR,Jacobson MP

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Various medications are cleared by the kidneys, therefore patients with impaired renal function, especially dialysis patients are at risk for adverse drug events (ADEs). There are limited studies on ADEs in maintenance dialysis patients. METHODS:We utilized a nationally representative database, the Nationwi...

journal_title：American journal of nephrology

authors： Chan L,Saha A,Poojary P,Chauhan K,Naik N,Coca S,Garimella PS,Nadkarni GN

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:It is uncertain whether kidneys from marginal donors are suitable for live kidney transplantation. In deceased donor kidneys, tubular cell senescence affects allograft function. However, the degree of cell senescence in a living donor kidney with marginal factors has not been reported. In this study, we asse...

journal_title：American journal of nephrology

authors： Sofue T,Kushida Y,Ozaki T,Moritoki M,Nishijima Y,Ohsaki H,Ueda N,Kakehi Y,Nishiyama A,Minamino T

更新日期：2018-01-01 00:00:00

abstract：:Heavy proteinuria in patients with essential hypertension raises the question of underlying primary renal disease. While malignant hypertension may be associated with proteinuria in the nephrotic range, it is generally held that protein excretion in benign nephrosclerosis is almost invariably less than 0.5-1.0 g/24 h....

journal_title：American journal of nephrology

authors： Mujais SK,Emmanouel DS,Kasinath BS,Spargo BH

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Estimating total body water (TBW) is crucial in determining dry weight and dialytic dose for hemodialysis patients. Several anthropometric equations have been used to predict TBW, but a more accurate method is needed. We developed an artificial neural network (ANN) to predict TBW in hemodialysis patients. M...

journal_title：American journal of nephrology

authors： Chiu JS,Chong CF,Lin YF,Wu CC,Wang YF,Li YC

更新日期：2005-09-01 00:00:00

abstract：:Ultramorphological images and details of an uremic echinocyte are shown. The images confirm the existence of uremic echinocytes and demonstrate that atomic force microscopy can provide high-resolution images of cell surfaces. ...

journal_title：American journal of nephrology

authors： Zachée P,Boogaerts M,Snauwaert J,Hellemans L

更新日期：1994-01-01 00:00:00

abstract：:The platelet content of adenosine triphosphate (ATP), adenosine diphosphate (ADP), serotonin and ouabain-insensitive, magnesium-dependent adenosine triphosphatase (ATPase) was determined in patients with chronic renal failure, patients on chronic hemodialysis, and kidney transplant recipients. Platelet ATP content was...

journal_title：American journal of nephrology

authors： Eknoyan G,Brown CH 3rd

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:To explore the association between CYP3A4 and CYP3A5 gene polymorphisms and blood pressure response to amlodipine among participants from the African-American Study of Kidney Disease and Hypertension Trial randomized to amlodipine (n = 164). METHODS:Cox proportional hazards models were used to determine the ri...

journal_title：American journal of nephrology

authors： Bhatnagar V,Garcia EP,O'Connor DT,Brophy VH,Alcaraz J,Richard E,Bakris GL,Middleton JP,Norris KC,Wright J,Hiremath L,Contreras G,Appel LJ,Lipkowitz MS,AASK Study Investigators.

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The proinflammatory cytokine S100A12 (also known as EN-RAGE) is associated with cardiovascular morbidity and mortality in hemodialysis patients. In the current study, we tested the hypothesis that S100A12 expressed in vascular smooth muscle in nonatherosclerosis-prone C57BL/6J mice on normal rodent chow diet...

journal_title：American journal of nephrology

authors： Gawdzik J,Mathew L,Kim G,Puri TS,Hofmann Bowman MA

更新日期：2011-01-01 00:00:00

abstract：:To evaluate the therapeutic effect of recombinant human alpha-interferon (alpha-IFN) on hepatitis B virus associated glomerulonephritis (HBV-GN) and the relationship between the seroconversion of viral antigens and the change of proteinuria, the hepatitis B viral markers and urinary protein were monitored during alpha...

journal_title：American journal of nephrology

authors： Chung DR,Yang WS,Kim SB,Yu E,Chung YH,Lee Y,Park JS

更新日期：1997-01-01 00:00:00

abstract：:The review focuses on biochemical metabolisms of conventional buffers and emphasizes advantages of sodium pyruvate (Pyr) in the correction of intracellular acidosis. Exogenous lactate (Lac) as an alternative of natural buffer, bicarbonate, consumes intracellular protons on an equimolar basis, regenerating bicarbonate ...

journal_title：American journal of nephrology

authors： Zhou FQ

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia is one of the major manifestations of nephrotic syndrome. We have previously shown that nephrotic hypercholesterolemia is associated with and, in part, due to dysregulation of hepatic HMG-CoA reductase, acyl-CoA:cholesterol acyltransferase (ACAT) and cholesterol 7alpha-hydroxylase, as we...

journal_title：American journal of nephrology

authors： Vaziri ND,Liang K

更新日期：2004-11-01 00:00:00

abstract：:We analyzed routine serum potassium concentration measurements and conditions temporally associated with abnormalities in potassium concentration in outpatients on chronic hemodialysis (136 nondiabetics, 36 diabetics) and continuous ambulatory peritoneal dialysis (16 nondiabetics, 10 diabetics). The following potassiu...

journal_title：American journal of nephrology

authors： Tzamaloukas AH,Avasthi PS

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cystic epithelia in polycystic kidney disease display features similar to malignant cells. Thiazolidinediones have been shown to have anti-neoplastic properties, therefore we tested the hypothesis that pioglitazone reduces cyst formation, improves renal function, and prolongs survival in a mouse model o...

journal_title：American journal of nephrology

authors： Raphael KL,Strait KA,Stricklett PK,Baird BC,Piontek K,Germino GG,Kohan DE

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Serum creatinine (SCr) levels are decreased following traumatic amputation, leading to the overestimation of glomerular filtration rate (GFR). β-Trace protein (BTP) and β2-microglobulin (B2M) strongly correlate with measured GFR and have not been studied following amputation. We hypothesized that BTP and B2M...

journal_title：American journal of nephrology

authors： Little DJ,Yuan CM,Thurlow JS,Gounden V,Doi SQ,Pruziner A,Abbott KC,Theeler BJ,Olson SW

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:To determine the association of vancomycin with acute kidney injury (AKI) in relation to its serum concentration value and to examine the risk of AKI in patients treated with vancomycin when compared with a matched cohort of patients receiving non-glycopeptide antibiotics (linezolid/daptomycin). METHODS:Fro...

journal_title：American journal of nephrology

authors： Gyamlani G,Potukuchi PK,Thomas F,Akbilgic O,Soohoo M,Streja E,Naseer A,Sumida K,Molnar MZ,Kalantar-Zadeh K,Kovesdy CP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:We investigated the gender differences in the effect of ACE I/D and AGT M235T polymorphisms on the prognosis of diabetic nephropathy (DN). METHODS:A total of 525 type 2 diabetics were enrolled to participate in this prospective observational study. ACE and AGT gene polymorphisms were analyzed by polymerase ...

journal_title：American journal of nephrology

authors： Tien KJ,Hsiao JY,Hsu SC,Liang HT,Lin SR,Chen HC,Hsieh MC

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Patients with diabetic nephropathy are at high risk for further progressive renal function loss. Treatments that decrease albuminuria have been linked with renal and cardiovascular protection. However, even when taking optimal treatment, residual renal and cardiovascular risk remains high which correlates wi...

journal_title：American journal of nephrology

authors： Lambers Heerspink HJ,Agarwal R,Coyne DW,Parving HH,Ritz E,Remuzzi G,Audhya P,Amdahl MJ,Andress DL,de Zeeuw D

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:We examined the correlations between renal biopsy findings in Wegener's granulomatosis and renal function at baseline and 1 year in 22 patients who presented between 1988 and 1999. METHODS:Renal histology was independently reviewed by 2 pathologists who were masked to the clinical data. The primary out...

journal_title：American journal of nephrology

authors： Haroun MK,Stone JH,Nair R,Racusen L,Hellmann DB,Eustace JA

更新日期：2002-09-01 00:00:00