Abstract:
BACKGROUND/AIMS:We examined the correlations between renal biopsy findings in Wegener's granulomatosis and renal function at baseline and 1 year in 22 patients who presented between 1988 and 1999. METHODS:Renal histology was independently reviewed by 2 pathologists who were masked to the clinical data. The primary outcome was the relationship of the percentage of normal glomeruli to reciprocal serum creatinine at baseline and 1 year. Other histologic data were collected using a series of ordinal rating scales. Acute and chronic sum scores were calculated. RESULTS:The median serum creatinine (SCr) at baseline was 3.9 mg/dl (0.8-14 mg/dl). Seven patients initially required hemodialysis, of whom 4 subsequently regained independent renal function. By 1 year of follow-up, the median (SCr) for patients with independent renal function was 1.9 mg/dl (0.9-6.8 mg/dl). Reciprocal SCr at baseline correlated with the percentage of normal glomeruli (r = 0.584, p = 0.005), crescent score (r = -0.595, p = 0.003), interstitial fibrosis as a percentage of cortical surface area (r = -0.669, p = 0.002), interstitial inflammation (r = -0.439, p = 0.041), eosinophil (r = -0.495, p = 0.019), neutrophil score (r = -0.557, p = 0.005), and acute sum score (r = -0.499, p = 0.018). However, only the percentage of normal glomeruli (r = 0.493, p = 0.023), the crescent score (r = -0.452, p = 0.035), and interstitial fibrosis as a percentage of cortical surface area (r = -0.466, p = 0.052) correlated with reciprocal SCr at 1 year of follow-up. CONCLUSION:In this relatively small data set, the percentage of normal glomeruli, the crescent score, and interstitial fibrosis as a percentage of cortical surface area correlated with renal function at both baseline and 1 year of follow-up.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Haroun MK,Stone JH,Nair R,Racusen L,Hellmann DB,Eustace JAdoi
10.1159/000065283subject
Has Abstractpub_date
2002-09-01 00:00:00pages
497-503issue
5-6eissn
0250-8095issn
1421-9670pii
65283journal_volume
22pub_type
杂志文章abstract:BACKGROUND:C-reactive protein (CRP), which reflects chronic inflammation, is a strong predictor of cardiovascular mortality in hemodialysis patients. We investigated whether persistent elevation of CRP is associated with cardiac function and morphology in patients maintained on hemodialysis. METHODS:Predialysis high-s...
journal_title:American journal of nephrology
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doi:10.1159/000085585
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. The extent to which histopathologic features predicts prognostication is uncertain. METHODS:A single-center retrospective cohort with biopsy-proven TG was i...
journal_title:American journal of nephrology
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journal_title:American journal of nephrology
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更新日期:1986-01-01 00:00:00
abstract::To evaluate the determinants of rhabdomyolysis in the diabetic state, we compared biochemical and clinical features of diabetic patients with (group 1, 41 patients) and without (group 2, 36 patients) rhabdomyolysis. There was no difference in values for serum potassium, bicarbonate, phosphate and calcium between the t...
journal_title:American journal of nephrology
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journal_title:American journal of nephrology
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journal_title:American journal of nephrology
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journal_title:American journal of nephrology
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更新日期:2010-01-01 00:00:00
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journal_title:American journal of nephrology
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journal_title:American journal of nephrology
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更新日期:2020-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章,评审
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更新日期:2003-07-01 00:00:00
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journal_title:American journal of nephrology
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doi:10.1159/000167061
更新日期:1986-01-01 00:00:00
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journal_title:American journal of nephrology
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doi:10.1159/000046671
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Fibrillary glomerulonephritis is characterized by randomly arranged fibrils, approximately 20 nm in diameter by electron microscopy. Patients present with proteinuria, hematuria and kidney insufficiency, and about half of the reported patients progress to end-stage kidney disease within 4 years. The dependen...
journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000455390
更新日期:2017-01-01 00:00:00
abstract::Two patients who developed bilateral renal cortical necrosis as a consequence of Neisseria meningitidis infections are described: 1 patient had meningococcemia and the other had meningococcal meningitis. Both patients developed a Shwartzman-like reaction, disseminated intravascular coagulation and irreversible renal f...
journal_title:American journal of nephrology
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000046647
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Hyperkalemia is common in patients receiving maintenance hemodialysis. However, few studies have examined the association between serum potassium level and mortality. METHODS:This study used annual cohorts of hemodialysis patients during 2007-2010. To determine hyperkalemia prevalence, monthly hyperkalemia ...
journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章,随机对照试验
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更新日期:2015-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:American journal of nephrology
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更新日期:2000-07-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-01-01 00:00:00