Abstract：
BACKGROUND:Various medications are cleared by the kidneys, therefore patients with impaired renal function, especially dialysis patients are at risk for adverse drug events (ADEs). There are limited studies on ADEs in maintenance dialysis patients. METHODS:We utilized a nationally representative database, the Nationwide Emergency Department Sample, from 2008 to 2013, to compare emergency department (ED) visits for dialysis and propensity matched non-dialysis patients. Log binomial regression was used to calculate relative risk of hospital admission and logistic regression to calculate ORs for in-hospital mortality while adjusting for patient and hospital characteristics. RESULTS:While ED visits for ADEs decreased in both groups, they were over 10-fold higher in dialysis patients than non-dialysis patients (65.8-88.5 per 1,000 patients vs. 4.6-5.4 per 1,000 patients respectively, p < 0.001). The top medication category associated with ED visits for ADEs in dialysis patients is agents primarily affecting blood constituents, which has increased. After propensity matching, patient admission was higher in dialysis patients than non-dialysis patients, (88 vs. 76%, p < 0.001). Dialysis was associated with a 3% increase in risk of admission and 3 times the odds of in-hospital mortality (adjusted OR 3, 95% CI 2.7-2.3.3). CONCLUSIONS:ED visits for ADEs are substantially higher in dialysis patients than non-dialysis patients. In dialysis patients, ADEs associated with agents primarily affecting blood constituents are on the rise. ED visits for ADEs in dialysis patients have higher inpatient admissions and in-hospital mortality. Further studies are needed to identify and implement measures aimed at reducing ADEs in dialysis patients.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Chan L,Saha A,Poojary P,Chauhan K,Naik N,Coca S,Garimella PS,Nadkarni GNdoi
10.1159/000489703subject
Has Abstractpub_date
2018-01-01 00:00:00pages
441-449issue
6eissn
0250-8095issn
1421-9670pii
000489703journal_volume
47pub_type
杂志文章abstract：:Left ventricular hypertrophy (LVH) is a common finding in hypertensive autosomal dominant polycystic kidney disease (ADPKD) patients. There are few studies on the influence of blood pressure (BP) and nonhemodynamic factors on LVH in these patients. The aim of this study was to evaluate the relationship between BP, hum...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013583
更新日期：2000-05-01 00:00:00
abstract：:Ultramorphological images and details of an uremic echinocyte are shown. The images confirm the existence of uremic echinocytes and demonstrate that atomic force microscopy can provide high-resolution images of cell surfaces. ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168714
更新日期：1994-01-01 00:00:00
abstract：:The development of new therapies for chronic diseases, such as diabetic kidney disease (DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights and will be responsive to treatment interventions. The recent application of metabolomic technologies, such as nuclear magnetic resonanc...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000447954
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) may lead to right heart failure and subsequently alter glomerular filtration rates (GFR). Chronic kidney disease (CKD, GFR <60 mL/min/1.73 m2) may also adversely affect PAH prognosis. This study aimed to assess how right heart hemodynamics was associated with reduced est...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000487198
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND/AIMS:Serum phosphorus levels have been associated with adverse long-term outcome in several populations, however, no prior studies evaluated short-term postoperative outcome. The present study evaluated the predictive value of phosphorus levels on 30-day outcome after vascular surgery. METHODS:The study inc...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000315856
更新日期：2010-01-01 00:00:00
abstract：:Thymoglobulin (Thymoglobulin®; Genzyme, Cambridge, Mass., USA) is a polyclonal antibody which has been used in the field of transplantation over the last four decades. With an initial hesitancy, it is widely used now in the prevention and treatment of rejection following renal transplantation. Thymoglobulin's lack of ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000351643
更新日期：2013-01-01 00:00:00
abstract：:We retrospectively reviewed the course of 1,000 renal transplants performed in 835 recipients (758 nondiabetics) to assess the incidence of new onset posttransplant diabetes in former nondiabetics. A total of 119 (15.7%) recipients manifested posttransplant diabetes, of whom 64 (53.8%) became hyperglycemic within 3 we...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166932
更新日期：1985-01-01 00:00:00
abstract：:A dramatic response was noted in a patient at our hospital who received hemodialysis therapy for severe acidosis secondary to an unknown toxin, subsequently identified as cyanide. We were unable to find any information concerning the hemodialysis clearance and extraction ratio of cyanide; thus, we studied the effect o...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166918
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:Apolipoprotein A1 (APOL1) gene variants occurring in people of West African descent contribute to the greater burden of kidney disease among African Americans. These variants are associated with increased risk of nondiabetic nephropathy, more rapid progression of chronic kidney disease, and shorter survival ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000502675
更新日期：2019-01-01 00:00:00
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journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167982
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:It has been demonstrated that phosphate uptake through the type III sodium-dependent phosphate co-transporter, Pit-1, induced apoptosis of aortic vascular smooth muscle cells and endothelial cells in vitro. However, the apoptotic effects of high phosphate (HP) level in human peritoneal mesothelial cells (HPM...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000329081
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Serum protein profiling patterns can reflect the pathological state of a patient and therefore may be useful for clinical diagnostics. Here, we present results from a pilot study of proteomic expression patterns in hemodialysis patients designed to evaluate the range of serum proteomic alterations in this po...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000077409
更新日期：2004-03-01 00:00:00
abstract：:A patient with unilateral gross hematuria was found to have mesangial proliferation and IgM deposition on renal biopsy, consistent with the entity of primary renal hematuria. This case refutes previous assumptions that renal biopsy is normal in patients with unilateral hematuria. Glomerular lesions may be more common ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167127
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Vascular calcification is seen in most patients on dialysis and is strongly associated with cardiovascular mortality. Vascular calcification is promoted by phosphate, which generally reaches higher levels in hemodialysis than in peritoneal dialysis. However, whether vascular calcification develops less in pe...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000494665
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:C-reactive protein (CRP), which reflects chronic inflammation, is a strong predictor of cardiovascular mortality in hemodialysis patients. We investigated whether persistent elevation of CRP is associated with cardiac function and morphology in patients maintained on hemodialysis. METHODS:Predialysis high-s...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000085585
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND:The use of complementary/alternative medicine has garnered rising interest in recent years. Natural products including herbs, vitamins, and minerals are the most popularly consumed. The Internet is a ubiquitous source of information/market for these supplements. AIM:To systematically evaluate the dietary an...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000368724
更新日期：2014-01-01 00:00:00
abstract：:Hyperkalemia is a commonly encountered problem in dialysis patients with end-stage renal disease. In this study we evaluated the effect of mineralocorticoid therapy (MCT; fludrocortisone 0.1-0.3 mg per os daily) on serum potassium of hyperkalemic end-stage renal disease patients. Consecutive monthly clinical and bioch...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168604
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Hepatitis C virus (HCV) infection is highly prevalent among patients on hemodialysis (HD) and is associated with poor prognosis. Treatment with interferon and ribavirin is poorly tolerated, and few data are available on the impact of new direct-acting antivirals (DAAs). This study was intended to analyze the...
journal_title：American journal of nephrology
pub_type： 杂志文章,多中心研究
doi：10.1159/000454819
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Malnutrition-inflammation score (MIS) is a comprehensive and quantitative system to assess malnutrition-inflammation complex syndrome, and a strong correlation between MIS and morbidity/mortality in maintenance hemodialysis (MHD) patients had been demonstrated. However, there is no cut-off value of MIS to ca...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000137684
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND/AIMS:Upregulation of transforming growth factor beta (TGF-beta)/Smad signaling has been implicated in the primary pathogenesis of renal fibrosis. The ubiquitin-proteasome pathway has an important influence on TGF-beta signaling through regulating Smad degradation. As E3 ubiquitin ligases, both Arkadia and Sm...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000100518
更新日期：2007-01-01 00:00:00
abstract：:An 18-year-old woman complained of fever and edema and was admitted to Showa University Hospital for treatment of thrombocytopenia and deteriorating renal function. Laboratory studies demonstrated the presence of lupus anticoagulant (LA), prolongation of prothrombin time, hemolytic anemia, a negative Coombs' test, the...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013526
更新日期：1999-01-01 00:00:00
abstract：:Hemolytic-uremic syndrome following quinine ingestion is a newly described phenomenon, with just two previous descriptions of 4 cases in the literature. We describe a 5th case. The reaction may be mediated by the presence of antibodies reactive against platelets in the presence of quinine. Treatment has included use o...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168444
更新日期：1992-01-01 00:00:00
abstract：:We carried out a prospective 2-year study on the transmission of human immunodeficiency virus (HIV) infection in a chronic dialysis unit with a high prevalence (11%) of the infection. Only 1 of 45 HIV-negative patients seroconverted, and this was related to the administration of contaminated blood. We conclude that cu...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167570
更新日期：1988-01-01 00:00:00
abstract：:Angiotensin-converting enzyme (ACE) inhibitor therapy has recently been shown to be effective in the treatment of post-renal transplant erythrocytosis (PTE). In an attempt to assess the effect of drug treatment on serum erythropoietin level, glomerular filtration rate, and urinary protein excretion, we prospectively e...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168856
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND/AIMS:Gastrointestinal (GI) symptoms in renal transplant recipients may be caused due to mycophenolic acid (MPA) toxicity. Using small bowel capsule endoscopy (SBCE) we examined the impact of conversion from Mycophenolate Mofetil (MMF) to enteric-coated formulation of Mycophenolate Sodium (EC-MPS) given to tr...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
doi：10.1159/000365360
更新日期：2014-01-01 00:00:00
abstract：:A variety of histologic changes have been observed in the kidneys of patients with light-chain deposition disease. We report 3 cases with kappa light chain deposition who presented with diverse clinical, histological, and ultrastructural features. All the cases were diagnosed by the presence of monoclonal kappa light ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167600
更新日期：1988-01-01 00:00:00
abstract：:We describe an elderly women who died of renal failure secondary to spontaneous renal atheroembolic disease. The sole clinical clue to this diagnosis was a profound eosinophilia up to 19,100/mm3 and a relative eosinophil count of 80%. Renal atheroembolic disease should be a prominent consideration in any patient with ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000168476
更新日期：1992-01-01 00:00:00
abstract：:Both the Old Testament and the Talmud contain a great deal of information on medicine, nephrology, health and disease. The basic premise of early Jewish medicine is based on the notion that disease is due to structural changes in internal organs. This is in contrast to the mythical dogma of humoralism as the basis of ...
journal_title：American journal of nephrology
pub_type： 传,历史文章,杂志文章
doi：10.1159/000169107
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Transglutaminase 2 (TGM2) is a calcium-dependent enzyme that can cross-link nearly all extracellular matrix (ECM) proteins and can facilitate cell-ECM interaction through integrins. Given the importance of the ECM in vascular calcification we tested the hypothesis that increased TGM2 activity may accelerate ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000347031
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Older adults with advanced non-dialysis-dependent chronic kidney disease (NDD-CKD) face a high risk of hospitalization and related adverse events. METHODS:This prospective cohort study followed nephrology clinic patients ≥60 years old with NDD-CKD stages 4-5. After an eligible patient's office visit, study ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000509046
更新日期：2020-01-01 00:00:00
