Abstract:
BACKGROUND/AIM:Although clinical and immunological findings in steroid-sensitive nephrotic syndrome (SSNS) favor an immunopathogenesis, many issues remain unsolved. Comprehensive studies analyzing cellular and humoral immunity in SSNS are scarce, and few studies addressed the effect of steroids on immunological factors. METHODS:We therefore performed a cross-sectional study of T and B lymphocyte populations in 89 children during the different stages of the disease and related the findings to parameters of humoral immunity and treatment with steroids. RESULTS:In untreated relapse, an increase in the proportion of activated CD3+ lymphocytes with a concomitant reduction of CD19+ B cells was noted compared to healthy controls. Conversely, patients with steroid dependency, relapsing on alternate-day steroids, showed a decline of the absolute numbers as well as proportion of CD4+ lymphocytes but a relative increase in CD19+ B cells, compared to healthy controls. Also untreated remission was characterized by an absolute and relative decrease in CD4+ lymphocytes compared to healthy controls which was accompanied by a significant increase in the proportion of CD8+ and also activated CD3+ lymphocytes. Steroid-induced remission resulted in suppression of absolute and relative CD4+, while absolute and relative B cells were upregulated in this group compared to untreated remission. SUMMARY AND CONCLUSION:Alterations of lymphocyte populations in SSNS are not limited to relapse but seem to be more pronounced in remission and show a different profile with steroid treatment. Changes of lymphocyte populations do not only affect T but also B lymphocytes, which may be of relevance in the pathogenesis of this disorder.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Kemper MJ,Zepf K,Klaassen I,Link A,Muller-Wiefel DEdoi
10.1159/000085357subject
Has Abstractpub_date
2005-03-01 00:00:00pages
132-7issue
2eissn
0250-8095issn
1421-9670pii
85357journal_volume
25pub_type
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journal_title:American journal of nephrology
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000119742
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pub_type: 杂志文章,随机对照试验
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000342794
更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1990-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000346712
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000339752
更新日期:2012-01-01 00:00:00
abstract::Most pretransplant malignancies require a tumor-free waiting period before transplantation. End-stage renal disease (ESRD) patients have an increased risk of renal cell carcinoma (RCC), which is mostly detected from routine screening during pre-kidney transplant evaluation. RCC must be quiescent prior to kidney transp...
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pub_type: 杂志文章,评审
doi:10.1159/000365201
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:American journal of nephrology
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000178251
更新日期:2009-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000238824
更新日期:2009-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000448766
更新日期:2016-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000111826
更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:American journal of nephrology
pub_type: 杂志文章
doi:10.1159/000510771
更新日期:2020-01-01 00:00:00