Proteinuria and progression in human glomerular diseases.

abstract：BACKGROUND:Published reports examining the efficacy and safety of glucocorticoids for preserving renal function in immunoglobulin A nephropathy (IgAN) have yielded conflicting results. To systematically evaluate the efficacy and safety of glucocorticoids agents for IgAN, we conducted a meta-analysis of the published ra...

journal_title：American journal of nephrology

authors： Cheng J,Zhang X,Zhang W,He Q,Tao X,Chen J

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Older adults with advanced non-dialysis-dependent chronic kidney disease (NDD-CKD) face a high risk of hospitalization and related adverse events. METHODS:This prospective cohort study followed nephrology clinic patients ≥60 years old with NDD-CKD stages 4-5. After an eligible patient's office visit, study ...

journal_title：American journal of nephrology

authors： Ramer SJ,Baddour NA,Siew ED,Salat H,Bian A,Stewart TG,Wong SPY,Jhamb M,Abdel-Kader K

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Health-related quality of life (HRQOL) reflects a patient's perceived disease burden, treatment effectiveness, and health status. Given the time burden and physiologic effects of hemodialysis, patients who spend dialysis time (9-15 h/week) physically or intellectually engaged may have better HRQOL. We charac...

journal_title：American journal of nephrology

authors： Warsame F,Ying H,Haugen CE,Thomas AG,Crews DC,Shafi T,Jaar B,Chu NM,Segev DL,McAdams-DeMarco MA

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:End-stage renal disease (ESRD) is a disease with an aging population and a high prevalence of cognitive impairment affecting quality of life, health care costs and mortality. Structural changes in the brain with decreased white matter integrity have been observed in ESRD. Understanding the changes in cogniti...

journal_title：American journal of nephrology

authors： Gupta A,Lepping RJ,Yu AS,Perea RD,Honea RA,Johnson DK,Brooks WM,Burns JM

更新日期：2016-01-01 00:00:00

abstract：:The medical history of salt begins in ancient times and is closely related to different aspects of human history. Salt may be extracted from sea water, mineral deposits, surface encrustations, saline lakes and brine springs. In many inland areas, wood was used as a fuel source for evaporation of brine and this practic...

journal_title：American journal of nephrology

authors： Cirillo M,Capasso G,Di Leo VA,De Santo NG

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:A poor nutritional state is associated with an increased risk of cardiovascular events in end-stage renal disease. It is unclear whether malnutrition itself can induce cardiovascular disease (CVD). We examined the impact of nutritional status on patients' arterial stiffness in peritoneal dialysis (PD) patien...

journal_title：American journal of nephrology

authors： Tang W,Cheng LT,Lu XH,Wang T

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND AIM:Robust evidence about dialyzer reuse effects on mortality is not available. Our aim was to summarize the evidence for the effectiveness of dialyzer reuse compared to single use in patients with end-stage renal disease. METHODS:We searched MEDLINE, Embase, CINAHL, SciELO, LILACS, USRDS ADR, universit...

journal_title：American journal of nephrology

authors： Galvao TF,Silva MT,Araujo ME,Bulbol WS,Cardoso AL

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:There is a critical need for more noninvasive biomarkers to identify nephritis in patients with systemic lupus erythematosus (SLE). Recent studies in a model mouse and an adult SLE patient cohort suggest that anti-basement membrane antibody levels correlate well with lupus activity and kidney injury. Th...

journal_title：American journal of nephrology

authors： Orjuela A,Suwanichkul A,Canter D,Minard CG,Devaraj S,Hicks MJ,Muscal E,Wenderfer SE

更新日期：2015-01-01 00:00:00

abstract：:Peritoneal sclerosis, a disorder similar to that previously identified in nonuremic patients, is being noted in peritoneal dialysis patients with increasing frequency. The etiology in dialysis patients remains unknown. An association with previous or ongoing peritoneal inflammation or irritation suggests that the inci...

journal_title：American journal of nephrology

authors： Ing TS,Daugirdas JT,Gandhi VC

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:To determine the association of vancomycin with acute kidney injury (AKI) in relation to its serum concentration value and to examine the risk of AKI in patients treated with vancomycin when compared with a matched cohort of patients receiving non-glycopeptide antibiotics (linezolid/daptomycin). METHODS:Fro...

journal_title：American journal of nephrology

authors： Gyamlani G,Potukuchi PK,Thomas F,Akbilgic O,Soohoo M,Streja E,Naseer A,Sumida K,Molnar MZ,Kalantar-Zadeh K,Kovesdy CP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:A recent study suggests that inflammation and malnutrition are strongly associated with cardiovascular disease in dialysis patients. Endothelial lipase (EL) is a newly cloned physiological regulator of high-density lipoprotein cholesterol (HDL), which is associated with the progression of atherosclerosi...

journal_title：American journal of nephrology

authors： Fujii H,Fukuda A,Tanaka M,Kojima Y,Ishida T,Hirata K,Fukagawa M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIM:Slc26a6 (PAT1, CFEX) is a major chloride/base exchanger located on the apical membrane of the kidney proximal tubule. The purpose of the present study was to examine the effect of Slc26a6 deletion on the apical Na+/H+ exchanger 3 (NHE3) in the straight segment (S3) of the proximal tubule, which is the ma...

journal_title：American journal of nephrology

authors： Petrovic S,Barone S,Wang Z,McDonough AA,Amlal H,Soleimani M

更新日期：2008-01-01 00:00:00

abstract：:Hepatic dysfunction was observed in 34 patients with nontraumatic rhabdomyolysis. The serum levels of lactic dehydrogenase were markedly elevated in all patients. The peak values occurred within 72 h of hospitalization. There was no significant difference among patients with (9,044 +/- 1,154 U/l) and without acute ren...

journal_title：American journal of nephrology

authors： Akmal M,Massry SG

更新日期：1990-01-01 00:00:00

abstract：:Five patients with the clinical patterns of Bartter's syndrome underwent a series of clearance studies in order to characterize the underlying tubule defect. Free water generation during maximal water diuresis (CH2O), expressed as percentage of the distal delivery (CH2O + CCl), was lower in the patients (72.5 +/- 3.2%...

journal_title：American journal of nephrology

authors： Colussi G,Rombolà G,Verde G,Airaghi C,Loli P,Minetti L

更新日期：1992-01-01 00:00:00

abstract：:We report a 29-year-old female with recurrent focal glomerulosclerosis (FGS) presenting as heavy proteinuria immediately following renal transplantation. From day 13 after transplantation, daily plasma exchange was performed 6 times. Proteinuria decreased from 13 to 0.2 g/day after plasma exchange and remained to be l...

journal_title：American journal of nephrology

authors： Li PK,Lai FM,Leung CB,Lui SF,Wang A,Lai KN

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) impairs intestinal barrier function which by allowing influx of noxious products causes systemic inflammation. We have recently shown that intestinal barrier dysfunction in CKD is due to degradation of epithelial tight junction (TJ) which is, in part, mediated by influx of urea a...

journal_title：American journal of nephrology

authors： Vaziri ND,Yuan J,Khazaeli M,Masuda Y,Ichii H,Liu S

更新日期：2013-01-01 00:00:00

abstract：:A comparative clinicopathological study was retrospectively performed in 61 children and 51 adults with IgA nephropathy. Hematuria and/or proteinuria as a chance finding was the most common initial clinical sign, being observed in 82.0% of the children and in 52.9% of the adults. At renal biopsy, hypertension and seve...

journal_title：American journal of nephrology

authors： Okada K,Funai M,Kawakami K,Kagami S,Yano I,Kuroda Y

更新日期：1990-01-01 00:00:00

abstract：:We assessed blood volume (BV) in 20 edematous patients with nephrotic syndrome and in 32 subjects without renal or other disease liable to induce BV variation. Two methods were chosen, one using 131I-albumin and the other 51Cr red blood cells. Among the 20 patients, 11 presented minimal-change lesions, and 9 had histo...

journal_title：American journal of nephrology

authors： Olmer M,Berland Y,Purgus R,Schultz G

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND/AIMS:Vitamin D insufficiency drives secondary hyperparathyroidism (SHPT) and is associated with increased cardiovascular mortality in patients with chronic kidney disease (CKD). SHPT is poorly addressed by current vitamin D repletion options. The present study evaluated a novel investigational vitamin D repl...

journal_title：American journal of nephrology

authors： Sprague SM,Silva AL,Al-Saghir F,Damle R,Tabash SP,Petkovich M,Messner EJ,White JA,Melnick JZ,Bishop CW

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Interest in nephrology careers is declining, possibly due to perceptions of the field and/or training aspects. Understanding practices of medical schools successfully instilling nephrology interest could inform efforts to attract leading candidates to the specialty. METHODS:The American Society of Nephrolog...

journal_title：American journal of nephrology

authors： Sozio SM,Pivert KA,Shah HH,Chakkera HA,Asmar AR,Varma MR,Morrow BD,Patel AB,Leight K,Parker MG

更新日期：2019-01-01 00:00:00

abstract：:The development of new therapies for chronic diseases, such as diabetic kidney disease (DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights and will be responsive to treatment interventions. The recent application of metabolomic technologies, such as nuclear magnetic resonanc...

journal_title：American journal of nephrology

authors： Darshi M,Van Espen B,Sharma K

更新日期：2016-01-01 00:00:00

abstract：:There is evidence to suggest that a renal embryogenesis disorder, with an associated deficit of nephrons, may be the cause of nephropathy later in the lives of patients with Balkan endemic nephropathy (BEN). This evidence includes the renal dysplasia or hypoplasia observed in BEN patients, the high incidence of renal ...

journal_title：American journal of nephrology

authors： Nenov VD,Nenov DS

更新日期：2002-07-01 00:00:00

abstract：:Most pretransplant malignancies require a tumor-free waiting period before transplantation. End-stage renal disease (ESRD) patients have an increased risk of renal cell carcinoma (RCC), which is mostly detected from routine screening during pre-kidney transplant evaluation. RCC must be quiescent prior to kidney transp...

journal_title：American journal of nephrology

authors： Tantisattamo E,Elam A,Cobb J,Ellis CL,Bailey JL

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Current status of primary hyperoxaluria (PH) has not been surveyed in Japan. METHODS:Japanese patients with PH were reviewed in the published literature. RESULTS:Fifty-nine patients were diagnosed as PH from 1962 to 2003. The median ages both at diagnosis and at the onset of initial symptoms were 17 (...

journal_title：American journal of nephrology

authors： Takayama T,Nagata M,Ichiyama A,Ozono S

更新日期：2005-05-01 00:00:00

abstract：:We have compared the renal effects of ioxitalamate, ioxaglate, and iopamidol in patients with chronic renal failure. Sixty consecutive patients with an estimated creatinine clearance (ECRCl) less than 60 ml/min were randomly assigned to receive either ioxitalamate, iopamidol, or ioxaglate. All patients received 500 cm...

journal_title：American journal of nephrology

authors： Deray G,Bellin MF,Boulechfar H,Baumelou B,Koskas F,Baumelou A,Grellet J,Jacobs C

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Various medications are cleared by the kidneys, therefore patients with impaired renal function, especially dialysis patients are at risk for adverse drug events (ADEs). There are limited studies on ADEs in maintenance dialysis patients. METHODS:We utilized a nationally representative database, the Nationwi...

journal_title：American journal of nephrology

authors： Chan L,Saha A,Poojary P,Chauhan K,Naik N,Coca S,Garimella PS,Nadkarni GN

更新日期：2018-01-01 00:00:00

abstract：:Resistance to the action of PTH is encountered in chronic renal failure (CRF). This was attributed to downregulation of PTH receptor due to the state of secondary hyperparathyroidism of CRF. The present study examined whether the amount of PTH-PTH-related peptide (PTH-PTHrP) mRNA in a traditional (kidney) and a nontra...

journal_title：American journal of nephrology

authors： Tian J,Smogorzewski M,Kedes L,Massry SG

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cystic epithelia in polycystic kidney disease display features similar to malignant cells. Thiazolidinediones have been shown to have anti-neoplastic properties, therefore we tested the hypothesis that pioglitazone reduces cyst formation, improves renal function, and prolongs survival in a mouse model o...

journal_title：American journal of nephrology

authors： Raphael KL,Strait KA,Stricklett PK,Baird BC,Piontek K,Germino GG,Kohan DE

更新日期：2009-01-01 00:00:00

abstract：:In this paper, we analyze the collection of ancient Greek treatises ascribed to Hippocrates (460; between 371 and 350 BC), in order to determine whether or not edema can be traced. As a result of reading these works on the Greek text, we recognize some symptoms of edema in those called oidêma (swelling) and udrôps (dr...

journal_title：American journal of nephrology

authors： Touwaide A,De Santo NG

更新日期：1999-01-01 00:00:00

abstract：:A 50-year-old woman presented with thrombocytopenia, microangiopathic hemolytic anemia, and nephrotic syndrome. Although a high level of circulating immune complexes, mild hypocomplementemia, and the antinuclear antibody also were present, the criteria for collagen disease were not fulfilled. Renal biopsy demonstrated...

journal_title：American journal of nephrology

authors： Kimura M,Fujigaki Y,Ohtake T,Furuya R,Hishida A,Kaneko E

更新日期：1998-01-01 00:00:00