Prolonged endoplasmic reticulum stress induces apoptotic cell death in an experimental model of chronic cyclosporine nephropathy.

abstract：PURPOSE:To explore the association between CYP3A4 and CYP3A5 gene polymorphisms and blood pressure response to amlodipine among participants from the African-American Study of Kidney Disease and Hypertension Trial randomized to amlodipine (n = 164). METHODS:Cox proportional hazards models were used to determine the ri...

journal_title：American journal of nephrology

authors： Bhatnagar V,Garcia EP,O'Connor DT,Brophy VH,Alcaraz J,Richard E,Bakris GL,Middleton JP,Norris KC,Wright J,Hiremath L,Contreras G,Appel LJ,Lipkowitz MS,AASK Study Investigators.

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Hyperoxaluria may result from increased endogenous production or overabsorption of dietary oxalate in the gastrointestinal tract leading to nephrolithiasis and, in some, to oxalate nephropathy and chronic kidney disease. ALLN-177 is an oral formulation of a recombinant, oxalate specific, microbial enzyme oxa...

journal_title：American journal of nephrology

authors： Langman CB,Grujic D,Pease RM,Easter L,Nezzer J,Margolin A,Brettman L

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the role of bone morphogenetic protein (BMP) signal transduction in the pathogenesis of calciphylaxis. METHODS:Skin biopsy specimens were obtained from 18 patients with, and 12 patients without, calciphylaxis. Tissue sections were stained with antibodies direct...

journal_title：American journal of nephrology

authors： Nigwekar SU,Jiramongkolchai P,Wunderer F,Bloch E,Ichinose R,Nazarian RM,Thadhani RI,Malhotra R,Bloch DB

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Data concerning long-term mortality predictors among large, purely diabetic hemodialysis collectives are scarce. METHODS:We used data from a multicenter, prospective, randomized trial among 1,255 hemodialysis patients with type 2 diabetes mellitus (T2DM) and its observational follow-up study. The associatio...

journal_title：American journal of nephrology

authors： Triebswetter S,Gutjahr-Lengsfeld LJ,Schmidt KR,Drechsler C,Wanner C,Krane V

更新日期：2018-01-01 00:00:00

abstract：:A dramatic response was noted in a patient at our hospital who received hemodialysis therapy for severe acidosis secondary to an unknown toxin, subsequently identified as cyanide. We were unable to find any information concerning the hemodialysis clearance and extraction ratio of cyanide; thus, we studied the effect o...

journal_title：American journal of nephrology

authors： Wesson DE,Foley R,Sabatini S,Wharton J,Kapusnik J,Kurtzman NA

更新日期：1985-01-01 00:00:00

abstract：:A renal transplant recipient with a remote history of end-stage renal disease due to postpartum hemolytic-uremic syndrome (HUS) presented with acute renal failure after having stable renal allograft function for 9 years. A diagnosis of thrombotic microangiopathy was made based on clinical and histologic findings at re...

journal_title：American journal of nephrology

authors： Gohh RY,Williams ME,Crosson AW,Federman M,Zambetti FX

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIMS:There is a critical need for more noninvasive biomarkers to identify nephritis in patients with systemic lupus erythematosus (SLE). Recent studies in a model mouse and an adult SLE patient cohort suggest that anti-basement membrane antibody levels correlate well with lupus activity and kidney injury. Th...

journal_title：American journal of nephrology

authors： Orjuela A,Suwanichkul A,Canter D,Minard CG,Devaraj S,Hicks MJ,Muscal E,Wenderfer SE

更新日期：2015-01-01 00:00:00

abstract：:Renal disease is a common complication in malaria infection. In acute falciparum malaria renal involvement is usually mild, but in severe disease acute renal failure is a major problem. Acute renal failure has been attributed to ischaemic tubular necrosis from hypovolaemia resulting from vasodilatation due to endothel...

journal_title：American journal of nephrology

authors： Sinniah R,Lye W

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Elderly patients with cardiovascular comorbidities are more likely to die before progressing to the need for undergoing hemodialysis; so deferring their predialysis vascular access (VA) surgery has been suggested. However, recent declines in cardiovascular mortality in the US population may have changed this...

journal_title：American journal of nephrology

authors： Lee T,Thamer M,Zhang Q,Zhang Y,Allon M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Intradialytic hypotension is the most common complication of modern day haemodialysis (HD). Convective modalities, including haemodiafiltration (HDF) are reported to result in greater cardiovascular stability compared to standard HD, which has been suggested to be due to improved solute transport betwee...

journal_title：American journal of nephrology

authors： Kumar S,Khosravi M,Massart A,Potluri M,Davenport A

更新日期：2013-01-01 00:00:00

abstract：:Idiopathic diffuse crescentic glomerulonephritis without immune deposits is a variant of rapidly progressive glomerulonephritis which can account for up to 40% of crescentic nephritis. The prognosis may depend on both the severity of histological injury at presentation and the efficacy of treatment. Recent advances in...

journal_title：American journal of nephrology

authors： Belghiti D,Levy Y,Rifle G,Ottavioli JN,Rickelynck JP,Wolf C,Chalopin JM,Sobel A

更新日期：1987-01-01 00:00:00

abstract：:We have recently described that in the erythrocytes from uremic patients on chronic hemodialysis, the pentose-phosphate shunt is defective, the membrane concentrations of malonyldialdehyde, resulting from peroxidation of polyunsaturated fatty acids in the membranes themselves, are increased, and the concentrations of ...

journal_title：American journal of nephrology

authors： Taccone-Gallucci M,Giardini O,Lubrano R,Mazzarella V,Bandino D,Khashan S,Mannarino O,Elli M,Cozzari M,Buoncristiani U

更新日期：1986-01-01 00:00:00

abstract：:Resistance to the action of PTH is encountered in chronic renal failure (CRF). This was attributed to downregulation of PTH receptor due to the state of secondary hyperparathyroidism of CRF. The present study examined whether the amount of PTH-PTH-related peptide (PTH-PTHrP) mRNA in a traditional (kidney) and a nontra...

journal_title：American journal of nephrology

authors： Tian J,Smogorzewski M,Kedes L,Massry SG

更新日期：1994-01-01 00:00:00

abstract：:Ion-selective electrodes have been designed for determining the ionized concentration of magnesium in blood, the biologically active form of this ion. The effect of acute acidosis induced by ammonium loading on circulating and urinary magnesium was investigated in 11 volunteers. No changes in plasma total and ionized ...

journal_title：American journal of nephrology

authors： Blumberg D,Bonetti A,Jacomella V,Capillo S,Truttmann AC,Lüthy CM,Colombo JP,Bianchetti MG

更新日期：1998-01-01 00:00:00

abstract：:Clinical and pathologic findings are described in 14 patients whose main abnormality was an excessively thin glomerular basement membrane (GBM). The subjects were aged 11-51 years, the majority males: most were referred because of hematuria, but proteinuria was the main problem in 2, while hypertension or renal functi...

journal_title：American journal of nephrology

authors： Dische FE,Weston MJ,Parsons V

更新日期：1985-01-01 00:00:00

abstract：:In general, nonrheumatic atrial fibrillation is associated with a high risk of stroke. However, its impact on stroke in the setting of chronic hemodialysis treatment is insufficiently addressed in the literature. We assessed the incidence of stroke among 430 chronic hemodialysis patients and the impact of atrial fibri...

journal_title：American journal of nephrology

authors： Wiesholzer M,Harm F,Tomasec G,Barbieri G,Putz D,Balcke P

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Malnutrition-inflammation score (MIS) is a comprehensive and quantitative system to assess malnutrition-inflammation complex syndrome, and a strong correlation between MIS and morbidity/mortality in maintenance hemodialysis (MHD) patients had been demonstrated. However, there is no cut-off value of MIS to ca...

journal_title：American journal of nephrology

authors： Ho LC,Wang HH,Peng YS,Chiang CK,Huang JW,Hung KY,Hu FC,Wu KD

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Health-related quality of life (HRQOL) reflects a patient's perceived disease burden, treatment effectiveness, and health status. Given the time burden and physiologic effects of hemodialysis, patients who spend dialysis time (9-15 h/week) physically or intellectually engaged may have better HRQOL. We charac...

journal_title：American journal of nephrology

authors： Warsame F,Ying H,Haugen CE,Thomas AG,Crews DC,Shafi T,Jaar B,Chu NM,Segev DL,McAdams-DeMarco MA

更新日期：2018-01-01 00:00:00

abstract：:To determine the effect of multiple dialyzer use on intradialytic symptoms, data from 26,592 successive dialyses on 147 patients were analyzed. Over the 26-month period of study 4,933 new dialyzers were used. All symptoms, considered together, occurred 1.3 times more frequently during the initial than during the subse...

journal_title：American journal of nephrology

authors： Robson MD,Charoenpanich R,Kant KS,Peterson DW,Flynn J,Cathey M,Pollak VE

更新日期：1986-01-01 00:00:00

abstract：:A patient with unilateral gross hematuria was found to have mesangial proliferation and IgM deposition on renal biopsy, consistent with the entity of primary renal hematuria. This case refutes previous assumptions that renal biopsy is normal in patients with unilateral hematuria. Glomerular lesions may be more common ...

journal_title：American journal of nephrology

authors： Tapp DC,Whitaker WR,Copley JB

更新日期：1986-01-01 00:00:00

abstract：:The terminal complement-inhibitor eculizumab has dramatically changed the management of patients with atypical hemolytic uremic syndrome (aHUS), and has also shown promise for treating certain forms of secondary HUS (sHUS), including that caused by drugs and solid-organ/hematopoietic stem cell transplant. While effect...

journal_title：American journal of nephrology

authors： Olson SR,Lu E,Sulpizio E,Shatzel JJ,Rueda JF,DeLoughery TG

更新日期：2018-01-01 00:00:00

abstract：:There is evidence to suggest that a renal embryogenesis disorder, with an associated deficit of nephrons, may be the cause of nephropathy later in the lives of patients with Balkan endemic nephropathy (BEN). This evidence includes the renal dysplasia or hypoplasia observed in BEN patients, the high incidence of renal ...

journal_title：American journal of nephrology

authors： Nenov VD,Nenov DS

更新日期：2002-07-01 00:00:00

abstract：:The influence of fluvastatin, a liver-selective, competitive inhibitor of the 3-hydroxymethyl-glutaryl-coenzyme A reductase, on the lipoprotein metabolism was investigated in 9 patients with nephrotic syndrome. All patients had biopsy-proven renal disease as cause of their nephrotic syndrome and exhibited severe hyper...

journal_title：American journal of nephrology

authors： Matzkies FK,Bahner U,Teschner M,Hohage H,Heidland A,Schaefer RM

更新日期：1999-01-01 00:00:00

abstract：:A 22-year-old woman presented glomerulonephritis with Schönlein-Henoch-like syndrome and monoclonal abnormality. One month later, she developed a rapidly progressive glomerulonephritis with hypertension and persistent purpura. In the two renal biopsies performed during the first and the second attack, mesangial expans...

journal_title：American journal of nephrology

authors： Orfila C,Meeus F,Bernadet P,Lepert JC,Suc JM

更新日期：1991-01-01 00:00:00

abstract：:A patient with renal failure due to myeloma kidney and coincident digitalis intoxication due to prescribed daily digoxin administration was treated with digoxin-specific antibody fragments and plasmapheresis. Rapid response to therapy was noted, removal of digoxin-antidigoxin antibody complexes was confirmed, and prev...

journal_title：American journal of nephrology

authors： Rabetoy GM,Price CA,Findlay JW,Sailstad JM

更新日期：1990-01-01 00:00:00

abstract：:We analyzed routine serum potassium concentration measurements and conditions temporally associated with abnormalities in potassium concentration in outpatients on chronic hemodialysis (136 nondiabetics, 36 diabetics) and continuous ambulatory peritoneal dialysis (16 nondiabetics, 10 diabetics). The following potassiu...

journal_title：American journal of nephrology

authors： Tzamaloukas AH,Avasthi PS

更新日期：1987-01-01 00:00:00

abstract：:The relationship between abnormalities in nocturnal penile tumescence (NPT) and autonomic function, measured by the Valsalva maneuver, was evaluated in 25 uremic patients and 22 normal subjects. NPT in uremic patients (45 +/- 6.8 min/night) was lower (p less than 0.01) than in normals (85 +/- 10.4 min/night). Valsalva...

journal_title：American journal of nephrology

authors： Campese VM,Procci WR,Levitan D,Romoff MS,Goldstein DA,Massry SG

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND/AIMS:Gastrointestinal (GI) symptoms in renal transplant recipients may be caused due to mycophenolic acid (MPA) toxicity. Using small bowel capsule endoscopy (SBCE) we examined the impact of conversion from Mycophenolate Mofetil (MMF) to enteric-coated formulation of Mycophenolate Sodium (EC-MPS) given to tr...

journal_title：American journal of nephrology

authors： Bunnapradist S,Sampaio MS,Wilkinson AH,Pham PT,Huang E,Kuo HT,Anastasi B,Danovitch GM,Lo SK

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hemodialysis (HD) patients are more inactive, leading to poor functional capacity and quality of life; this may be reversed with intradialytic exercise training. To systematically evaluate the efficacy and safety of intradialytic exercise for HD patients, we conducted a meta-analysis of the pub...

journal_title：American journal of nephrology

authors： Sheng K,Zhang P,Chen L,Cheng J,Wu C,Chen J

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Intravenous (IV) iron preparations are widely used in the management of anemia in ESRD populations. Recent changes in reimbursement policy have dramatically increased the use of IV iron to lower the use of costly erythropoiesis-stimulating agents. These preparations are frequently administered with insu...

journal_title：American journal of nephrology

authors： Kamanna VS,Ganji SH,Shelkovnikov S,Norris K,Vaziri ND

更新日期：2012-01-01 00:00:00