Genetic risk factors of amyloidogenesis in familial Mediterranean fever.

abstract：BACKGROUND:We determined the familial aggregation of end-stage renal disease (ESRD) in a large, population-based sample of incident ESRD cases to assess the feasibility of developing a targeted screening and prevention program directed at members of families at high risk for kidney disease. METHODS:Between January 1, ...

journal_title：American journal of nephrology

authors： Freedman BI,Volkova NV,Satko SG,Krisher J,Jurkovitz C,Soucie JM,McClellan WM

更新日期：2005-11-01 00:00:00

abstract：:The relationship of the duration of anuria to the recovery in glomerular filtration rate (GFR) was studied in 71 children with diarrhea-associated hemolytic uremic syndrome. A significant relationship was found, and regression analysis revealed that y = 114.61 - 5.68 x, where y is predicted GFR (ml/min/1.73 m2) and x ...

journal_title：American journal of nephrology

authors： Robson WL,Leung AK,Brant R

更新日期：1993-01-01 00:00:00

abstract：:The relationship between abnormalities in nocturnal penile tumescence (NPT) and autonomic function, measured by the Valsalva maneuver, was evaluated in 25 uremic patients and 22 normal subjects. NPT in uremic patients (45 +/- 6.8 min/night) was lower (p less than 0.01) than in normals (85 +/- 10.4 min/night). Valsalva...

journal_title：American journal of nephrology

authors： Campese VM,Procci WR,Levitan D,Romoff MS,Goldstein DA,Massry SG

更新日期：1982-01-01 00:00:00

abstract：:Hepatic dysfunction was observed in 34 patients with nontraumatic rhabdomyolysis. The serum levels of lactic dehydrogenase were markedly elevated in all patients. The peak values occurred within 72 h of hospitalization. There was no significant difference among patients with (9,044 +/- 1,154 U/l) and without acute ren...

journal_title：American journal of nephrology

authors： Akmal M,Massry SG

更新日期：1990-01-01 00:00:00

abstract：:The treatment of the bleeding diathesis of renal failure remains unsatisfactory. 1-Deamino-8-D-arginine vasopressin (DDAVP) has recently been shown to shorten the prolonged bleeding time of renal failure and may as a result diminish the risk of clinical hemorrhage. We describe 2 cases where DDAVP was used successfully...

journal_title：American journal of nephrology

authors： Watson AJ,Keogh JA

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The prognostic value of the anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN) classification has been demonstrated in several cohorts with sclerotic class having the worst renal outcome. Relevant published data on factors predicting outcomes in sclerotic ANCA GN is limited. METH...

journal_title：American journal of nephrology

authors： Menez S,Hruskova Z,Scott J,Cormican S,Chen M,Salama AD,Alasfar S,Little MA,Safrankova H,Honsova E,Tesar V,Geetha D

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Growth hormone (GH) resistance in CKD is partly due to increased expression of SOCS2, a GH signaling negative regulator. In SOCS2 absence, body growth is exaggerated. However, GH overexpression in mice causes glomerulosclerosis. Accordingly, we tested whether lack of SOCS2 improves body growth, but accelerat...

journal_title：American journal of nephrology

authors： Landau D,Assadi MH,Abu Hilal R,Chen Y,Rabkin R,Segev Y

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. The extent to which histopathologic features predicts prognostication is uncertain. METHODS:A single-center retrospective cohort with biopsy-proven TG was i...

journal_title：American journal of nephrology

authors： Li X,Chen J,Cheng D,Wang W,Xie K,Zhang M,Xu F,Wen J,Tang Z

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Estimating total body water (TBW) is crucial in determining dry weight and dialytic dose for hemodialysis patients. Several anthropometric equations have been used to predict TBW, but a more accurate method is needed. We developed an artificial neural network (ANN) to predict TBW in hemodialysis patients. M...

journal_title：American journal of nephrology

authors： Chiu JS,Chong CF,Lin YF,Wu CC,Wang YF,Li YC

更新日期：2005-09-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a common finding in hypertensive autosomal dominant polycystic kidney disease (ADPKD) patients. There are few studies on the influence of blood pressure (BP) and nonhemodynamic factors on LVH in these patients. The aim of this study was to evaluate the relationship between BP, hum...

journal_title：American journal of nephrology

authors： Martinez-Vea A,Valero FA,Bardaji A,Gutierrez C,Broch M,Garcia C,Richart C,Oliver JA

更新日期：2000-05-01 00:00:00

abstract：:The objective was to evaluate the effect of high-flux hemodialysis on quality of life, intra- and interdialytic symptoms and neuropsychological function. The study was double-blind single cross-over with random allocation to order of treatment. The patients were stable adult hospital hemodialysis patients. Both the co...

journal_title：American journal of nephrology

authors： Churchill DN,Bird DR,Taylor DW,Beecroft ML,Gorman J,Wallace JE

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Death with a functioning graft (DWF) has been reported as a major cause of graft loss after renal transplantation. It has been reported to occur in 9-30%. METHODS:From March 1976 to January 2002, a total of 1400 living donor renal transplants were performed in our center. Out of 257 reported deaths among ou...

journal_title：American journal of nephrology

authors： El-Agroudy AE,Bakr MA,Shehab El-Dein AB,Ghoneim MA

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:We hypothesized that the difference between the prescribed end-dialysis body weight, defined end-dialysis over-weight (edOW; kg), and the body weight which is actually attained could impact survival in hemodialysis (HD) patients. The aim of this prospective observational study was to evaluate if edOW could i...

journal_title：American journal of nephrology

authors： Movilli E,Camerini C,Gaggia P,Zubani R,Feller P,Poiatti P,Pola A,Carli O,Cancarini G

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Tacrolimus has been reported to be effective in refractory nephrotic syndrome, such as focal segmental glomerulosclerosis and membranous nephropathy. Some IgA nephropathy (IgAN) patients with massive proteinuria showed resistance to steroids and/or cytotoxic immunosuppressants based on the supportive therapy...

journal_title：American journal of nephrology

authors： Zhang Q,Shi SF,Zhu L,Lv JC,Liu LJ,Chen YQ,Zhang H,Wang HY

更新日期：2012-01-01 00:00:00

abstract：:A 50-year-old woman presented with thrombocytopenia, microangiopathic hemolytic anemia, and nephrotic syndrome. Although a high level of circulating immune complexes, mild hypocomplementemia, and the antinuclear antibody also were present, the criteria for collagen disease were not fulfilled. Renal biopsy demonstrated...

journal_title：American journal of nephrology

authors： Kimura M,Fujigaki Y,Ohtake T,Furuya R,Hishida A,Kaneko E

更新日期：1998-01-01 00:00:00

abstract：:We studied plasma, dialysate, and muscle carnitine levels in patients with stable chronic renal failure on hemodialysis, and intermittent peritoneal, or continuous ambulatory peritoneal dialysis (CAPD). In patients on hemodialysis, plasma carnitine levels fell from 46.2 +/- 4.5 mumol/l (mean +/- SEM) to 18.8 +/- 2.7 m...

journal_title：American journal of nephrology

authors： Moorthy AV,Rosenblum M,Rajaram R,Shug AL

更新日期：1983-07-01 00:00:00

abstract：:A multicentre trial (11 nephrology centres) was carried out to test the effects of ibopamine, an orally active dopamine-like drug, on the progression of chronic renal failure. For a 2-year period 189 chronic renal failure patients (serum creatinine level 1.5-4.0 mg/dl) were observed. They were homogeneous for basic ne...

journal_title：American journal of nephrology

authors： Stefoni S,Mosconi G,La Manna G,Bonomini V,Mioli V,Fanciulli E,Feletti C,Docci D,Cappelli P,Bonomini M,Locatelli F,Marai P,Bazzato G,Fracasso A,Brancaccio D,Galmozzi C,Scarpioni L,Sverzellati E,Sorba GB,Cossu M,Pic

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Serum creatinine (SCr) levels are decreased following traumatic amputation, leading to the overestimation of glomerular filtration rate (GFR). β-Trace protein (BTP) and β2-microglobulin (B2M) strongly correlate with measured GFR and have not been studied following amputation. We hypothesized that BTP and B2M...

journal_title：American journal of nephrology

authors： Little DJ,Yuan CM,Thurlow JS,Gounden V,Doi SQ,Pruziner A,Abbott KC,Theeler BJ,Olson SW

更新日期：2015-01-01 00:00:00

abstract：:Nutrition has been shown to predict clinical outcome in continuous ambulatory peritoneal dialysis (CAPD) patients. However, despite the positive relationship between KT/V (urea) and the normalised protein catabolic rate, the ability of urea kinetic modelling to predict clinical outcome or nutrition remains inconclusiv...

journal_title：American journal of nephrology

authors： Harty J,Boulton H,Heelis N,Uttley L,Venning M,Gokal R

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:Ischemia/reperfusion (I/R) injury is characterized by cytoskeletal reorganization and loss of polarity in proximal tubule epithelial cells. Previously, we showed that myofibrillogenesis regulator (MR)-1 promoted actin organization in cardiomyocytes. MR-1 is also expressed in the kidney. METHODS:In this...

journal_title：American journal of nephrology

authors： Wang X,Tao T,Ding R,Song D,Liu M,Xie Y,Liu X

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Studies have shown that kidney injury molecule-1 (KIM-1) is upregulated in damaged renal proximal tubules. In this study, we examined KIM-1 expression in glomerular epithelial cells in diabetic glomerulopathy. METHODS:Renal histology, immunostaining and Western blot for protein level, and real-time PCR...

journal_title：American journal of nephrology

authors： Zhao X,Zhang Y,Li L,Mann D,Imig JD,Emmett N,Gibbons G,Jin LM

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:Three different apo E alleles (E2, E3 and E4) produce apo E isoproteins, which regulate the metabolism of lipoproteins. This study investigated the apo E polymorphisms as a prognostic factor for the development of diabetic nephropathy (DN). METHODS:A total of 525 type 2 diabetic patients were enrolled ...

journal_title：American journal of nephrology

authors： Tien KJ,Tu ST,Chou CW,Yang CY,Hsiao JY,Shin SJ,Chen HC,Hsieh MC

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Transglutaminase 2 (TGM2) is a calcium-dependent enzyme that can cross-link nearly all extracellular matrix (ECM) proteins and can facilitate cell-ECM interaction through integrins. Given the importance of the ECM in vascular calcification we tested the hypothesis that increased TGM2 activity may accelerate ...

journal_title：American journal of nephrology

authors： Chen NX,O'Neill K,Chen X,Kiattisunthorn K,Gattone VH,Moe SM

更新日期：2013-01-01 00:00:00

abstract：:Hepcidin is a key regulator of iron metabolism. In this study, we examined whether measurement of hepcidin is useful in assessing recombinant human erythropoietin (rHuEPO) responsiveness in regular hemodialysis (HD) patients in a cross-sectional fashion. We examined the association between serum prohepcidin, a prohorm...

journal_title：American journal of nephrology

authors： Kato A,Tsuji T,Luo J,Sakao Y,Yasuda H,Hishida A

更新日期：2008-01-01 00:00:00

abstract：:In hypoaldosteronemic patients with chronic renal insufficiency, administration of a mineralocorticoid steroid such as fludrocortisone can ameliorate hyperkalemia and metabolic acidosis, but this therapy is not always safe owing to the deleterious consequences of extracellular fluid volume expansion resulting from min...

journal_title：American journal of nephrology

authors： Sebastian A,Schambelan M,Sutton JM

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:This study aimed at evaluating the after effects of a single bout of aerobic exercise on muscle sympathetic nerve activity (MSNA), peripheral vascular resistance and blood pressure (BP) in stages 2-3 chronic kidney disease (CKD) patients. We hypothesized that CKD patients present a greater decline in these v...

journal_title：American journal of nephrology

authors： Aprile DC,Oneda B,Gusmão JL,Costa LA,Forjaz CL,Mion D Jr,Tinucci T

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Home dialysis patients may be at an increased risk of adverse events after transitional states. The home dialysis virtual ward (HDVW) trial was conducted in Canadian dialysis centers and aimed to evaluate potential care gaps and patient satisfaction during the HDVW. METHODS:The HDVW was a multicenter single...

journal_title：American journal of nephrology

authors： Nadeau-Fredette AC,Chan CT,Bargman JM,Copland MA,Finkle SN,Oliver MJ,Pauly RP,Perl J,Shah NA,Zimmerman DL,Tennankore KK

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:It is uncertain whether kidneys from marginal donors are suitable for live kidney transplantation. In deceased donor kidneys, tubular cell senescence affects allograft function. However, the degree of cell senescence in a living donor kidney with marginal factors has not been reported. In this study, we asse...

journal_title：American journal of nephrology

authors： Sofue T,Kushida Y,Ozaki T,Moritoki M,Nishijima Y,Ohsaki H,Ueda N,Kakehi Y,Nishiyama A,Minamino T

更新日期：2018-01-01 00:00:00

abstract：:Renal function and life expectancy can be improved by aggressive antihypertensive therapy in severe hypertension. However, most reports of severe hypertension and renal failure concern primary hypertensive states. 3 cases of primary renal disease, 1 glomerular, 1 obstructive and 1 of chronic pyelonephritis, are descri...

journal_title：American journal of nephrology

authors： Friedlaender MM,Rubinger D,Popovtzer MM

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Fibrillary glomerulonephritis is characterized by randomly arranged fibrils, approximately 20 nm in diameter by electron microscopy. Patients present with proteinuria, hematuria and kidney insufficiency, and about half of the reported patients progress to end-stage kidney disease within 4 years. The dependen...

journal_title：American journal of nephrology

authors： Payan Schober F,Jobson MA,Poulton CJ,Singh HK,Nickeleit V,Falk RJ,Jennette JC,Nachman PH,Pendergraft Iii WF

更新日期：2017-01-01 00:00:00