Abstract：
:45 bone biopsies from patients with chronic uremia were reviewed to define which noninvasive investigations were of value in predicting the histological diagnosis and to quantify the spectrum of uremic bone disease at a center that has consistently used an aluminum-free dialysis bath. 17 biopsies were taken postmortem. 15 patients received conservative treatment, the rest were on maintenance dialysis. 13 patients had symptomatic bone disease. Virtually all patients with a uremia duration greater than 3 years had uremic osteodystrophy. All patients with clinical bone disease, hypercalcemia or raised alkaline phosphatase activity had osteodystrophy, but the specific histology was not indicated. Greatly raised parathyroid levels suggested secondary hyperparathyroidism, but the test was only 100% specific when 20 times normal. Total aluminum consumption was highly indicative of bone aluminum concentration (p less than 0.0001) and aluminum-related osteomalacia (5 cases), suggesting that a considerable proportion of uremic bone disease is iatrogenic. Serum aluminum was of some use in the diagnosis of aluminum-related osteomalacia, but was not wholly reliable. Bone mineral content (BMC) using both forearm measurements and total body bone mineral levels (TBBM) were assessed in 32 patients and were found to be reduced in 12, with a preponderance of secondary hyperparathyroidism. BMC and TBBM were negatively correlated to resorbing surfaces and bone formation rate, suggesting that secondary hyperparathyroidism is the uremic bone disease that represents the greatest threat to bone mass. It is concluded that while noninvasive investigations give considerable information, reliable diagnosis requires the use of histological methods.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Heaf JG,Joffe P,Pødenphant J,Andersen JRdoi
10.1159/000167465subject
Has Abstractpub_date
1987-01-01 00:00:00pages
203-11issue
3eissn
0250-8095issn
1421-9670journal_volume
7pub_type
杂志文章abstract：:The effects of cisplatin (5 mg/kg BW given intraperitoneally) on renal concentration mechanism were evaluated initially by clearance studies in rats 5-7 days after cisplatin administration and compared to normal rats. During hypotonic saline infusion, cisplatin rats showed a lower inulin clearance (0.56 +/- 0.07 vs. 1...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167938
更新日期：1989-01-01 00:00:00
abstract：:Autopsy reports on 155 successive end-stage renal disease (ESRD) patients and 147 control patients without ESRD, matched for age, race and gender, were collected. Cystic transformation of the kidneys was noted in 58% of the ESRD patients and 13.6% of the control patients. There were 25 ESRD patients with renal adenoma...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167988
更新日期：1989-01-01 00:00:00
abstract：:The acid-base balance of 199 patients with cystic fibrosis, seen from 1987 through 1992 at the Bern Outpatient Clinic, were evaluated. Simple metabolic alkalosis was demonstrated in 16 and mixed metabolic alkalosis and respiratory acidosis in 9 patients. When compared with 10 patients with simple respiratory acidosis ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168839
更新日期：1995-01-01 00:00:00
abstract：:Bacterial endocarditis, particularly involving the left side, has been shown to occur in patients in regular hemodialysis. We report a case of right-sided endocarditis characterized by a very torpid evolution. Although the diagnosis was suspected early in the course, confirmation was obtained 2 months after the onset....
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168806
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Apolipoprotein A1 (APOL1) gene variants occurring in people of West African descent contribute to the greater burden of kidney disease among African Americans. These variants are associated with increased risk of nondiabetic nephropathy, more rapid progression of chronic kidney disease, and shorter survival ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000502675
更新日期：2019-01-01 00:00:00
abstract：:The influence of fluvastatin, a liver-selective, competitive inhibitor of the 3-hydroxymethyl-glutaryl-coenzyme A reductase, on the lipoprotein metabolism was investigated in 9 patients with nephrotic syndrome. All patients had biopsy-proven renal disease as cause of their nephrotic syndrome and exhibited severe hyper...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
doi：10.1159/000013504
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:The objective of this study was to investigate the role of bone morphogenetic protein (BMP) signal transduction in the pathogenesis of calciphylaxis. METHODS:Skin biopsy specimens were obtained from 18 patients with, and 12 patients without, calciphylaxis. Tissue sections were stained with antibodies direct...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000484418
更新日期：2017-01-01 00:00:00
abstract：:The administration of calcium-blocking drugs exerts a natriuretic response. Acute studies in isolated perfused kidneys and in experimental animals, as well as in man, consistently demonstrate diuresis, natriuresis, calciuresis, and generally kaliuresis, even in the face of arterial blood pressure reduction. Clearance ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000167541
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:Treatment of metabolic acidosis to target the higher serum bicarbonate level than guideline recommendation may downregulate muscle protein degradation and improve renal function among chronic kidney disease (CKD) patients. We conducted a study to test the effects of increased serum bicarbonate level on muscl...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000504557
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Increased mortality and morbidity are reported in association with high ultrafiltration rate (UFR) and with long dialysis recovery time (DRT). We studied the association between UFR and DRT. METHODS:This is a cross-sectional, observational study was conducted. Patients on thrice-weekly hemodialysis (HD) wit...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000476076
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/AIMS:Evaluation of the risk factors, and phenotype-genotype correlation of familial Mediterranean fever (FMF) gene (MEFV) and serum amyloid A1 (SAA1) gene polymorphisms in renal amyloidosis. METHODS:We investigated MEFV and SAA1 genotypes (alpha, beta, and gamma isoforms) in 50 FMF patients and 50 healthy c...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000087824
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Conditionally immortalized podocytes are valuable research tools but are difficult to efficiently transfect and do not provide graded transgene expression. METHODS:Conditionally immortalized mouse podocyte cell lines were established employing a tetracycline-inducible system. Glomerular cells, isolated from...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000151770
更新日期：2009-01-01 00:00:00
abstract：:Peritoneal sclerosis, a disorder similar to that previously identified in nonuremic patients, is being noted in peritoneal dialysis patients with increasing frequency. The etiology in dialysis patients remains unknown. An association with previous or ongoing peritoneal inflammation or irritation suggests that the inci...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166799
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND/AIMS:The susceptibility of patients on maintenance hemodialysis (MHD) to infections is a major cause of mortality and morbidity. Natural resistance-associated macrophage protein 1 (Nramp1) regulates intracellular pathogen proliferation, and its mRNA expression is highest in polymorphonuclear leukocytes (PMNL...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000337742
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND/AIM:Although clinical and immunological findings in steroid-sensitive nephrotic syndrome (SSNS) favor an immunopathogenesis, many issues remain unsolved. Comprehensive studies analyzing cellular and humoral immunity in SSNS are scarce, and few studies addressed the effect of steroids on immunological factors...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000085357
更新日期：2005-03-01 00:00:00
abstract：:Thymoglobulin (Thymoglobulin®; Genzyme, Cambridge, Mass., USA) is a polyclonal antibody which has been used in the field of transplantation over the last four decades. With an initial hesitancy, it is widely used now in the prevention and treatment of rejection following renal transplantation. Thymoglobulin's lack of ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000351643
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Growth hormone (GH) resistance in CKD is partly due to increased expression of SOCS2, a GH signaling negative regulator. In SOCS2 absence, body growth is exaggerated. However, GH overexpression in mice causes glomerulosclerosis. Accordingly, we tested whether lack of SOCS2 improves body growth, but accelerat...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000508224
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Death with a functioning graft (DWF) has been reported as a major cause of graft loss after renal transplantation. It has been reported to occur in 9-30%. METHODS:From March 1976 to January 2002, a total of 1400 living donor renal transplants were performed in our center. Out of 257 reported deaths among ou...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000070864
更新日期：2003-05-01 00:00:00
abstract：:Both the Old Testament and the Talmud contain a great deal of information on medicine, nephrology, health and disease. The basic premise of early Jewish medicine is based on the notion that disease is due to structural changes in internal organs. This is in contrast to the mythical dogma of humoralism as the basis of ...
journal_title：American journal of nephrology
pub_type： 传,历史文章,杂志文章
doi：10.1159/000169107
更新日期：1997-01-01 00:00:00
abstract：:A patient with progressive systemic sclerosis (PSS) involving skin, digit, esophagus, and lung developed the nephrotic syndrome and rapidly progressive renal insufficiency. Renal pathology revealed capillary collapse, cellular crescents, arteriolar hyaline deposition, and mesangial proliferation. On immunofluorescence...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167055
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Clinical indicators for accurately distinguishing diabetic nephropathy (DN) from non-diabetic renal disease in type 2 diabetes (T2D) are lacking. This study aimed to develop and validate a nomogram for predicting DN in T2D patients with kidney disease. METHODS:A total of 302 consecutive patients with T2D wh...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000505145
更新日期：2020-01-01 00:00:00
abstract：AIM:To develop and assess a semiautomated method for segmenting and counting individual renal cysts from mid-slice MR images in patients with autosomal dominant polycystic kidney disease (ADPKD). METHODS:A semiautomated method was developed to segment and count individual renal cysts from mid-slice MR images in 241 su...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
doi：10.1159/000358604
更新日期：2014-01-01 00:00:00
abstract：:We report on a Mycobacterium marinum infection in a diabetic woman 8 years after undergoing a combined pancreas-kidney transplantation. This is, to our knowledge, the first case report on an isolated skin infection with atypical mycobacteria after simultaneous pancreas-kidney transplantation. A genetic probe categoriz...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000065271
更新日期：2002-09-01 00:00:00
abstract：:This study was carried out to find out whether Ramadan fasting would affect the renal function in kidney transplant recipients with normal or impaired graft function. Twenty-three transplant recipients, 17 with a normal function and 6 with an impaired but stable function with plasma creatinine levels not exceeding 300...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000013316
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND/AIMS:Apoptosis contributes to cyclosporine (CsA)-induced renal cell death. This study tested the effects of CsA-induced endoplasmic reticulum (ER) stress on apoptotic cell death in an experimental model of chronic CsA nephropathy. METHODS:CsA (15 mg/kg per day) was given to rats for 7 or 28 days. The ER str...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000127432
更新日期：2008-01-01 00:00:00
abstract：:Whole plasma from 6 normolipidemic chronic renal failure (CRF) patients undergoing hemodialysis treatment was passed through the anti-apolipoprotein (Apo) AI immunosorbent column connected to the anti-Apo B immunoaffinity column. Apo AI and B containing particles were analyzed for lipid and Apo contents. The results w...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169011
更新日期：1996-01-01 00:00:00
abstract：:Several medical inventors in Europe and North America brought the artificial kidney (hemodialysis) to practical usefulness in the late 1940s, but there were very few early successes. It was used at first for only desperate cases of acute renal failure. Renal authorities in the 'metabolic' tradition favored newly quant...
journal_title：American journal of nephrology
pub_type： 历史文章,杂志文章
doi：10.1159/000169117
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Chronic kidney disease (CKD) is a prevalent condition; however, little is known about healthcare resource utilization (HRU) by CKD patients. METHODS:This analysis included NHANES participants aged > or =18 years, with serum creatinine, urine protein, and hemoglobin measurements. We assessed the association ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000178816
更新日期：2009-01-01 00:00:00
abstract：:Bicarbonate dialysate is claimed to be superior to acetate for both chronic and acute hemodialysis. We compared acetate and bicarbonate dialysates in 30 acute renal failure patients during 120 dialyses. 4 patients were diabetic and 2 had liver failure. Patients were dialyzed alternating acetate and bicarbonate dialysa...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
doi：10.1159/000166484
更新日期：1981-01-01 00:00:00
abstract：BACKGROUND/AIMS:The present study tested the hypothesis that chronic hypoxia adversely affects renal development in the ovine fetus. METHODS:Kidneys were collected from near-term fetuses of pregnant ewes maintained at sea level or high altitude (3,801 m, PaO(2): approx. 60 mm Hg) for 110 days (n = 6 for each group). ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000259901
更新日期：2010-01-01 00:00:00
