Abstract：
:Hyperlipidemia is common in patients with glomerular proteinuria. It may contribute to atherosclerotic complications and accelerate glomerular damage. Early trials of the fibric acid derivative clofibrate led to a myositis syndrome causing many nephrologists to abandon attempts at treatment of nephrotic hyperlipidemia. Recent trials with lipid-lowering medications have been successful without major side effects. The bile acid sequestrants colestipol and cholestyramine bind bile acids in the gut and deplete the hepatic cholesterol pool, thus inducing LDL hepatocyte receptors. Recent studies showed a reduction of total cholesterol of 8-20% and LDL cholesterol of 19-31% without significant changes in HDL cholesterol. Probucol has reduced total cholesterol 23-30% and LDL cholesterol 23-25% in nephrotic patients. Although HDL cholesterol was reduced, the LDL/HDL ratio remains favorably changed. The fibric acid derivative gemfibrozil inhibits adipose lipolysis and enhances lipoprotein lipase activity thus decreasing LDL synthesis and increasing its removal. It caused a large decrease in triglycerides with a 13-15% decrease in total and LDL cholesterol in a recent trial. HDL cholesterol increased 18%. The HMG-CoA reductase inhibitors inhibit the rate-limiting step in cholesterol biosynthesis hence inducing an increase in LDL receptors on hepatocytes. Trials have shown decreases of 18-36% in total cholesterol and 18-47% in LDL cholesterol, while HDL cholesterol was either increased or unchanged. The use of lipid-lowering agents of several classes has been effective in ameliorating the progression of glomerular damage in a number of different models of glomerulosclerosis. Nevertheless, so far in humans lipid lowering drugs have not been established to have an effect on either the degree of proteinuria or the progression of glomerulosclerosis.
journal_name
Am J Nephroljournal_title
American journal of nephrologyauthors
Appel GB,Appel ASdoi
10.1159/000168204subject
Has Abstractpub_date
1990-01-01 00:00:00pages
110-5eissn
0250-8095issn
1421-9670journal_volume
10 Suppl 1pub_type
临床试验,杂志文章,评审abstract：:To evaluate the therapeutic effect of recombinant human alpha-interferon (alpha-IFN) on hepatitis B virus associated glomerulonephritis (HBV-GN) and the relationship between the seroconversion of viral antigens and the change of proteinuria, the hepatitis B viral markers and urinary protein were monitored during alpha...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169083
更新日期：1997-01-01 00:00:00
abstract：:Recent studies have focused attention on the possible role of zinc depletion in the pathogenesis of uremic symptoms such as dysgeusia and impotence. The present studies were undertaken to evaluate the prevalence of zinc deficiency and abnormalities of zinc metabolism in patients with end-stage renal disease. A total o...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167247
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Despite the significant morbidity and mortality attributable to cardiovascular disease (CVD), risk stratification remains an important challenge in the chronic kidney disease (CKD) population. We examined the discriminative ability of noninvasive measures of atherosclerosis, including carotid intima-media th...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000342794
更新日期：2012-01-01 00:00:00
abstract：:A patient with progressive systemic sclerosis (PSS) involving skin, digit, esophagus, and lung developed the nephrotic syndrome and rapidly progressive renal insufficiency. Renal pathology revealed capillary collapse, cellular crescents, arteriolar hyaline deposition, and mesangial proliferation. On immunofluorescence...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167055
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:To promote understanding of immunoglobulin A nephropathy (IgAN) pathophysiology, we tried to elucidate glomerular protein profiles in IgAN, using microsieving that we established recently to isolate glomeruli from renal biopsy samples and proteomic approaches. METHODS:Glomeruli were isolated from renal biop...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000357788
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:End-stage renal disease (ESRD) is a disease with an aging population and a high prevalence of cognitive impairment affecting quality of life, health care costs and mortality. Structural changes in the brain with decreased white matter integrity have been observed in ESRD. Understanding the changes in cogniti...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000444334
更新日期：2016-01-01 00:00:00
abstract：:To determine the prevalence and type of glomerulonephritis (GN) associated with hepatitis C virus (HCV) cirrhosis, we prospectively evaluated 28 consecutive Saudi patients with HCV cirrhosis for liver transplantation. Six patients (21%) underwent kidney biopsies for proteinuria, unexplained elevated serum creatinine o...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168874
更新日期：1995-01-01 00:00:00
abstract：:A meeting on the History of Nephrology is an opportunity to discuss the links between science and faith which were split until the 6th century. However, this was changed by Cassiodorus and monasticism. From the times of Abbot Bertario (died 883 AD) in Montecassino, medicine was regarded as an art and a science. Codex ...
journal_title：American journal of nephrology
pub_type： 历史文章,杂志文章
doi：10.1159/000168769
更新日期：1994-01-01 00:00:00
abstract：:Nutrition has been shown to predict clinical outcome in continuous ambulatory peritoneal dialysis (CAPD) patients. However, despite the positive relationship between KT/V (urea) and the normalised protein catabolic rate, the ability of urea kinetic modelling to predict clinical outcome or nutrition remains inconclusiv...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168663
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:We investigated the gender differences in the effect of ACE I/D and AGT M235T polymorphisms on the prognosis of diabetic nephropathy (DN). METHODS:A total of 525 type 2 diabetics were enrolled to participate in this prospective observational study. ACE and AGT gene polymorphisms were analyzed by polymerase ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000163592
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Older adults with advanced non-dialysis-dependent chronic kidney disease (NDD-CKD) face a high risk of hospitalization and related adverse events. METHODS:This prospective cohort study followed nephrology clinic patients ≥60 years old with NDD-CKD stages 4-5. After an eligible patient's office visit, study ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000509046
更新日期：2020-01-01 00:00:00
abstract：:The prejunctional beta-adrenoceptors present in the isolated perfused kidney of normotensive rats (NR) and spontaneously hypertensive rats (SHR) were compared and the effects of tertatolol on these receptors were investigated. Kidneys of NR (Wistar + Wistar-Kyoto [WKY]) and SHR, were continuously perfused with Tyrode ...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000167330
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND/AIMS:Intravenous (IV) iron preparations are widely used in the management of anemia in ESRD populations. Recent changes in reimbursement policy have dramatically increased the use of IV iron to lower the use of costly erythropoiesis-stimulating agents. These preparations are frequently administered with insu...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000334939
更新日期：2012-01-01 00:00:00
abstract：:Accelerated atherosclerosis is both a cause and a consequence of chronic renal failure. Vascular smooth muscle cells (VSMCs) are an important component of atherosclerotic plaques, responsible for promoting plaque stability in advanced lesions. In contrast, VSMC apoptosis has been implicated in a number of deleterious ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000097815
更新日期：2006-01-01 00:00:00
abstract：:Collapsing glomerulopathy is a pattern of renal injury that is seen in association with human immunodeficiency virus (HIV) infection. Patients with this HIV-associated nephropathy (HIVAN) present nephrotic syndrome and rapid deterioration of the renal function. There is no proven effective therapy for HIVAN, and the m...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000065229
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND/AIMS:Upregulation of transforming growth factor beta (TGF-beta)/Smad signaling has been implicated in the primary pathogenesis of renal fibrosis. The ubiquitin-proteasome pathway has an important influence on TGF-beta signaling through regulating Smad degradation. As E3 ubiquitin ligases, both Arkadia and Sm...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000100518
更新日期：2007-01-01 00:00:00
abstract：:The glomerular ultrastructure was retrospectively reviewed from 45 renal transplant biopsies with the clinical and light microscopic diagnosis of acute rejection (25 cases) and chronic rejection (20 cases). Three grades of morphologic alteration were ultrastructurally defined. In acute rejection, capillary lumenal obl...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166725
更新日期：1983-09-01 00:00:00
abstract：BACKGROUND:Henoch-Schönlein purpura (HSP) is a form of systemic vasculitis that can progress to Henoch-Schönlein purpura nephritis (HSPN), and the most effective treatment remains controversial. Our aim was to compare the effects of oral mycophenolate mofetil (MMF) with low-dose prednisone and the full-dose corticoster...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000341914
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Increased mortality and morbidity are reported in association with high ultrafiltration rate (UFR) and with long dialysis recovery time (DRT). We studied the association between UFR and DRT. METHODS:This is a cross-sectional, observational study was conducted. Patients on thrice-weekly hemodialysis (HD) wit...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000476076
更新日期：2017-01-01 00:00:00
abstract：:We have demonstrated considerable variability in the volumes of different glomeruli in given individuals (individual glomerular volume: IGV) in a stereologic study of kidneys at forensic autopsy performed to investigate sudden or unexpected death in people without manifest kidney disease. We review some important asso...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000327044
更新日期：2011-01-01 00:00:00
abstract：:The purpose of our study was to investigate the feasibility of using lactate as a complete or partial substitute for acetate in hemodialysis solutions. Six patients, each serving as his own control, were dialyzed once against a dialysis solution containing 40 mM acetate, once against a dialysis solution containing 40 ...
journal_title：American journal of nephrology
pub_type： 临床试验,杂志文章
doi：10.1159/000167515
更新日期：1987-01-01 00:00:00
abstract：:Hemolytic-uremic syndrome following quinine ingestion is a newly described phenomenon, with just two previous descriptions of 4 cases in the literature. We describe a 5th case. The reaction may be mediated by the presence of antibodies reactive against platelets in the presence of quinine. Treatment has included use o...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168444
更新日期：1992-01-01 00:00:00
abstract：:A young woman presented with nephrotic syndrome due to membranous nephropathy and a localized form of giant lymph node hyperplasia (Castleman's disease) occurring as a large intra-abdominal mass. Five months after surgical removal of the mass, only mild proteinuria persisted. Twenty months later a second kidney biopsy...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000168127
更新日期：1990-01-01 00:00:00
abstract：:The pathogenesis of calciphylaxis, a potentially life-threatening condition, is not well understood. Several factors such as end-stage renal disease (azotemia), hyperparathyroidism, hyperphosphatemia, hypercalcemia, a high calcium-phosphate product, and the use of steroids and cytotoxic drugs after kidney transplantat...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000169021
更新日期：1996-01-01 00:00:00
abstract：:A dramatic response was noted in a patient at our hospital who received hemodialysis therapy for severe acidosis secondary to an unknown toxin, subsequently identified as cyanide. We were unable to find any information concerning the hemodialysis clearance and extraction ratio of cyanide; thus, we studied the effect o...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000166918
更新日期：1985-01-01 00:00:00
abstract：:In this paper, we analyze the collection of ancient Greek treatises ascribed to Hippocrates (460; between 371 and 350 BC), in order to determine whether or not edema can be traced. As a result of reading these works on the Greek text, we recognize some symptoms of edema in those called oidêma (swelling) and udrôps (dr...
journal_title：American journal of nephrology
pub_type： 传,历史文章,杂志文章
doi：10.1159/000013442
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Evidence suggests that recombinant human erythropoietin (rHuEPO) protects neurons and cardiomyocytes from acute insults. We investigated the protective effect of rHuEPO on cyclosporine (CsA)-induced renal injury. METHODS:CsA (15 mg/kg/day) was given to rats for 1 or 4 weeks, and rHuEPO was concurrently admi...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000084275
更新日期：2005-01-01 00:00:00
abstract：:To evaluate the determinants of rhabdomyolysis in the diabetic state, we compared biochemical and clinical features of diabetic patients with (group 1, 41 patients) and without (group 2, 36 patients) rhabdomyolysis. There was no difference in values for serum potassium, bicarbonate, phosphate and calcium between the t...
journal_title：American journal of nephrology
pub_type： 杂志文章
doi：10.1159/000168357
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Patients with diabetic nephropathy are at high risk for further progressive renal function loss. Treatments that decrease albuminuria have been linked with renal and cardiovascular protection. However, even when taking optimal treatment, residual renal and cardiovascular risk remains high which correlates wi...
journal_title：American journal of nephrology
pub_type： 杂志文章,随机对照试验
doi：10.1159/000225903
更新日期：2009-01-01 00:00:00
abstract：:Proteinuria is characteristic of many glomerular conditions, and often exceeds 2-3 g/24 h. There are several possible routes by which such profuse proteinuria might contribute to progression of the underlying pathology, whatever its type. First, proteinuria leads to a transit of protein through glomerular structures, ...
journal_title：American journal of nephrology
pub_type： 杂志文章,评审
doi：10.1159/000168199
更新日期：1990-01-01 00:00:00
