The emerging role of vascular smooth muscle cell apoptosis in atherosclerosis and plaque stability.


:Accelerated atherosclerosis is both a cause and a consequence of chronic renal failure. Vascular smooth muscle cells (VSMCs) are an important component of atherosclerotic plaques, responsible for promoting plaque stability in advanced lesions. In contrast, VSMC apoptosis has been implicated in a number of deleterious consequences of atherosclerosis, including plaque rupture, vessel remodelling, co- agulation, inflammation and calcification. Although VSMC apoptosis occurs in association with these processes, its precise contribution to these diseases is unknown, given that apoptosis frequently accompanies vessel injury or alterations to flow. Using transgenic mice with selective induction of VSMC apoptosis, a recent study has precisely determined the direct consequences of VSMC apoptosis in both normal vessels and atherosclerotic plaques. Surprisingly, normal arteries can withstand huge cell losses with little change in active or passive properties. Normal vessels demonstrate highly efficient clearance of apoptotic bodies, even in the absence of professional phagocytes. In contrast, VSMC apoptosis alone is sufficient to induce multiple features of vulnerability to rupture in plaques. This study identifies VSMC apoptosis as a critical process determining plaque stability and thus the most important consequence of atherosclerosis, plaque rupture.


Am J Nephrol


Clarke M,Bennett M




Has Abstract


2006-01-01 00:00:00














  • A Double-Blind, Placebo Controlled, Randomized Phase 1 Cross-Over Study with ALLN-177, an Orally Administered Oxalate Degrading Enzyme.

    abstract:BACKGROUND:Hyperoxaluria may result from increased endogenous production or overabsorption of dietary oxalate in the gastrointestinal tract leading to nephrolithiasis and, in some, to oxalate nephropathy and chronic kidney disease. ALLN-177 is an oral formulation of a recombinant, oxalate specific, microbial enzyme oxa...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,随机对照试验


    authors: Langman CB,Grujic D,Pease RM,Easter L,Nezzer J,Margolin A,Brettman L

    更新日期:2016-01-01 00:00:00

  • Effects of Traumatic Amputation on β-Trace Protein and β2-Microglobulin Concentrations in Male Soldiers.

    abstract:BACKGROUND:Serum creatinine (SCr) levels are decreased following traumatic amputation, leading to the overestimation of glomerular filtration rate (GFR). β-Trace protein (BTP) and β2-microglobulin (B2M) strongly correlate with measured GFR and have not been studied following amputation. We hypothesized that BTP and B2M...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Little DJ,Yuan CM,Thurlow JS,Gounden V,Doi SQ,Pruziner A,Abbott KC,Theeler BJ,Olson SW

    更新日期:2015-01-01 00:00:00

  • Aldosterone promotes fibronectin synthesis in rat mesangial cells via ERK1/2-stimulated Na-H+ exchanger isoform 1.

    abstract:BACKGROUND:Aldosterone plays an important role in fibrosis. Recent studies showed that Na(+)-H(+) exchanger isoform 1 (NHE1) is involved in mineralocorticoid-induced organ fibrosis. In this study, we examined the role of NHE1 in aldosterone-induced fibronectin accumulation in rat mesangial cells and the signaling pathw...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Zhang M,Chen J,Lai L,You L,Lin S,Hao C,Gu Y

    更新日期:2010-01-01 00:00:00

  • A case of acute tubulointerstitial nephritis and uveitis syndrome with a dramatic response to corticosteroid therapy.

    abstract::A 23-year-old female with acute renal failure associated with acute tubulointerstitial nephritis and uveitis is reported. Renal tubular acidosis and inflammatory reactions consisting of markedly increased erythrocyte sedimentation rate and high serum immunoglobulin levels were seen on admission. Light microscopy revea...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Hirano K,Tomino Y,Mikami H,Ota K,Aikawa Y,Shirato I,Koide H

    更新日期:1989-01-01 00:00:00

  • Association between Renal Function and Bleeding Risk for Dabigatran after Switching from Warfarin.

    abstract:BACKGROUND:There is a higher risk of gastrointestinal (GI) bleeding in patients treated with dabigatran versus warfarin. We analyzed the impact of renal function on the relative risk of bleeding in patients converted to dabigatran. METHODS:Patients aged ≥65 years who received anticoagulation with warfarin for a minimu...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Kalil RS,Kaboli PJ,Liu X,Vaughan-Sarrazin M

    更新日期:2016-01-01 00:00:00

  • Tubular Cell Senescence in the Donated Kidney Predicts Allograft Function, but Not Donor Remnant Kidney Function, in Living Donor Kidney Transplantation.

    abstract:BACKGROUND:It is uncertain whether kidneys from marginal donors are suitable for live kidney transplantation. In deceased donor kidneys, tubular cell senescence affects allograft function. However, the degree of cell senescence in a living donor kidney with marginal factors has not been reported. In this study, we asse...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Sofue T,Kushida Y,Ozaki T,Moritoki M,Nishijima Y,Ohsaki H,Ueda N,Kakehi Y,Nishiyama A,Minamino T

    更新日期:2018-01-01 00:00:00

  • High titer anti-basement membrane antibodies in a subset of patients with pediatric systemic lupus erythematosus.

    abstract:BACKGROUND/AIMS:There is a critical need for more noninvasive biomarkers to identify nephritis in patients with systemic lupus erythematosus (SLE). Recent studies in a model mouse and an adult SLE patient cohort suggest that anti-basement membrane antibody levels correlate well with lupus activity and kidney injury. Th...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Orjuela A,Suwanichkul A,Canter D,Minard CG,Devaraj S,Hicks MJ,Muscal E,Wenderfer SE

    更新日期:2015-01-01 00:00:00

  • Angiotensin II-mediated constriction of afferent and efferent arterioles involves T-type Ca2+ channel activation.

    abstract:BACKGROUND/AIMS:Previous studies have shown that L-type Ca2+ channel (LCC) blockers prevent the afferent arteriolar (AA) vasoconstriction elicited by angiotensin II (Ang II), but do not influence its vasoconstrictor effect on efferent arterioles (EA). The present study tested the hypothesis that Ang II-mediated constri...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Feng MG,Navar LG

    更新日期:2004-11-01 00:00:00

  • Improvement in prognosis of patients with acute renal failure over a period of 15 years: an analysis of 710 cases in a dialysis center.

    abstract::In order to evaluate the changes in causes and outcome of acute renal failure (ARF) during the years 1975-1989, 710 patients treated in our dialysis center were analyzed. We compared the etiology, the severity and catabolic state of ARF, the techniques of renal replacement therapy, which were employed and the ages and...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Biesenbach G,Zazgornik J,Kaiser W,Grafinger P,Stuby U,Necek S

    更新日期:1992-01-01 00:00:00

  • Hypotension during acetate and bicarbonate dialysis in patients with acute renal failure.

    abstract::Bicarbonate dialysate is claimed to be superior to acetate for both chronic and acute hemodialysis. We compared acetate and bicarbonate dialysates in 30 acute renal failure patients during 120 dialyses. 4 patients were diabetic and 2 had liver failure. Patients were dialyzed alternating acetate and bicarbonate dialysa...

    journal_title:American journal of nephrology

    pub_type: 临床试验,杂志文章


    authors: Borges HF,Fryd DS,Rosa AA,Kjellstrand CM

    更新日期:1981-01-01 00:00:00

  • Obesity, anthropometric measures and chronic kidney disease complications.

    abstract:BACKGROUND/AIMS:Anthropometric measures such as body mass index (BMI) and waist circumference (WC) have differential associations with incident chronic kidney disease (CKD) and mortality. We examined the associations of BMI and WC with various CKD complications. METHODS:We conducted a cross-sectional analysis of 2,853...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Navaneethan SD,Kirwan JP,Arrigain S,Schreiber MJ,Sarnak MJ,Schold JD

    更新日期:2012-01-01 00:00:00

  • Low levels of serum ferritin lead to adequate hemoglobin levels and good survival in hemodialysis patients.

    abstract:BACKGROUND:The optimal level of serum ferritin (s-ft) for anemia control and good survival in hemodialysis (HD) patients remains unclear. A 10-year survey was performed to clarify the appropriate quantities of s-ft and investigate the relationships among s-ft, transferrin saturation (TSAT), and mortality in HD patients...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Ogawa C,Tsuchiya K,Kanda F,Maeda T

    更新日期:2014-01-01 00:00:00

  • The antioxidant EPC-K1 attenuates renal ischemia-reperfusion injury in a rat model.

    abstract:BACKGROUND:Acute kidney injury (AKI) occurs frequently in the intensive care unit. A primary cause is renal ischemia/reperfusion (I/R) injury, during which excess reactive oxygen species (ROS) are produced. ROS subsequently damage renal cells, leading to the development of AKI. Here, we investigated whether renal I/R i...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Yamamoto S,Hagiwara S,Hidaka S,Shingu C,Goto K,Kashima K,Noguchi T

    更新日期:2011-01-01 00:00:00

  • Intradialytic exercise in hemodialysis patients: a systematic review and meta-analysis.

    abstract:BACKGROUND AND OBJECTIVE:Hemodialysis (HD) patients are more inactive, leading to poor functional capacity and quality of life; this may be reversed with intradialytic exercise training. To systematically evaluate the efficacy and safety of intradialytic exercise for HD patients, we conducted a meta-analysis of the pub...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,meta分析,评审


    authors: Sheng K,Zhang P,Chen L,Cheng J,Wu C,Chen J

    更新日期:2014-01-01 00:00:00

  • Josep Trueta (1897-1977): military surgeon and pioneer investigator of acute renal failure.

    abstract::The great Spanish military and orthopedic surgeon J. Trueta gained his field and clinical experience in the Spanish civil war (1936-1939) and in Britain during World War II. As part of his major contribution to traumatology, he searched for the causes of the characteristic oliguria of combat casualties. For this purpo...

    journal_title:American journal of nephrology

    pub_type: 传,历史文章,杂志文章


    authors: Better OS

    更新日期:1999-01-01 00:00:00

  • Angiotensin receptor blockade and arterial compliance in chronic kidney disease: a pilot study.

    abstract:BACKGROUND:Almost 20 million people in the US have chronic kidney disease (CKD). Cardiovascular disease and arterial wall abnormalities are common in this population. Because angiotensin II may have adverse effects on the arterial wall, we hypothesized that an angiotensin receptor blocker (ARB) would improve arterial c...

    journal_title:American journal of nephrology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Garg JP,Ellis R,Elliott WJ,Hasabou N,Chua D,Chertow GM,Bakris GL

    更新日期:2005-07-01 00:00:00

  • Internet claims on dietary and herbal supplements in advanced nephropathy: truth or myth.

    abstract:BACKGROUND:The use of complementary/alternative medicine has garnered rising interest in recent years. Natural products including herbs, vitamins, and minerals are the most popularly consumed. The Internet is a ubiquitous source of information/market for these supplements. AIM:To systematically evaluate the dietary an...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Vamenta-Morris H,Dreisbach A,Shoemaker-Moyle M,Abdel-Rahman EM

    更新日期:2014-01-01 00:00:00

  • Presence of Kidney Disease as an Outcome Predictor in Patients with Pulmonary Arterial Hypertension.

    abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) may lead to right heart failure and subsequently alter glomerular filtration rates (GFR). Chronic kidney disease (CKD, GFR <60 mL/min/1.73 m2) may also adversely affect PAH prognosis. This study aimed to assess how right heart hemodynamics was associated with reduced est...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Bitker L,Sens F,Payet C,Turquier S,Duclos A,Cottin V,Juillard L

    更新日期:2018-01-01 00:00:00

  • Correlation of percentage of normal glomeruli with renal outcome in Wegener's granulomatosis.

    abstract:BACKGROUND/AIMS:We examined the correlations between renal biopsy findings in Wegener's granulomatosis and renal function at baseline and 1 year in 22 patients who presented between 1988 and 1999. METHODS:Renal histology was independently reviewed by 2 pathologists who were masked to the clinical data. The primary out...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Haroun MK,Stone JH,Nair R,Racusen L,Hellmann DB,Eustace JA

    更新日期:2002-09-01 00:00:00

  • Effects of HMG-CoA reductase inhibition on hepatic expression of key cholesterol-regulatory enzymes and receptors in nephrotic syndrome.

    abstract:BACKGROUND:Hypercholesterolemia is one of the major manifestations of nephrotic syndrome. We have previously shown that nephrotic hypercholesterolemia is associated with and, in part, due to dysregulation of hepatic HMG-CoA reductase, acyl-CoA:cholesterol acyltransferase (ACAT) and cholesterol 7alpha-hydroxylase, as we...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Vaziri ND,Liang K

    更新日期:2004-11-01 00:00:00

  • Seasonal maintenance of influenza vaccine-induced antibody response in kidney transplant recipients.

    abstract:BACKGROUND/AIMS:Although annual influenza vaccination is recommended for kidney transplant recipients, efficacy as reflected by serum antibody titers has not been well studied beyond 1 month in kidney transplant recipients. METHODS:We performed a single-center prospective cohort study of 51 kidney transplant recipient...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Birdwell KA,Ikizler MR,Wang L,Byrne DW,Sannella EC,Wright PF,Ikizler TA

    更新日期:2012-01-01 00:00:00

  • IgM nephropathy: morphological study related to clinical findings.

    abstract::This study describes 10 cases of IgM nephropathy in whom the main morphological findings consisted of diffuse mesangial deposition of IgM and varying degrees of mesangial cell proliferation. In addition, focal segmental sclerosis was present in 1 patient and global sclerosis in another. An ill-defined electron-dense d...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Kopolovic J,Shvil Y,Pomeranz A,Ron N,Rubinger D,Oren R

    更新日期:1987-01-01 00:00:00

  • Applying an artificial neural network to predict total body water in hemodialysis patients.

    abstract:BACKGROUND:Estimating total body water (TBW) is crucial in determining dry weight and dialytic dose for hemodialysis patients. Several anthropometric equations have been used to predict TBW, but a more accurate method is needed. We developed an artificial neural network (ANN) to predict TBW in hemodialysis patients. M...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Chiu JS,Chong CF,Lin YF,Wu CC,Wang YF,Li YC

    更新日期:2005-09-01 00:00:00

  • Right-sided bacterial endocarditis due to Flavobacterium odoratum in a patient on chronic hemodialysis.

    abstract::Bacterial endocarditis, particularly involving the left side, has been shown to occur in patients in regular hemodialysis. We report a case of right-sided endocarditis characterized by a very torpid evolution. Although the diagnosis was suspected early in the course, confirmation was obtained 2 months after the onset....

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Ferrer C,Jakob E,Pastorino G,Juncos LI

    更新日期:1995-01-01 00:00:00

  • Autosomal dominant polycystic kidney disease complicated by primary aldosteronism. Case report and review of the literature.

    abstract::We report the case of a 42-year-old woman with autosomal dominant polycystic kidney disease complicated by primary aldosteronism. She had a history of hypertension for 12 years and was found to have hypokalemia and polycystic renal and hepatic disease. Endocrinological tests revealed hyporeninemia and hyperaldosterone...

    journal_title:American journal of nephrology

    pub_type: 杂志文章,评审


    authors: Gejyo F,Ishida K,Arakawa M

    更新日期:1994-01-01 00:00:00

  • Albuminuria Regression and All-Cause Mortality among Insulin-Treated Patients with Type 2 Diabetes: Analysis of a Large UK Primary Care Cohort.

    abstract:BACKGROUND:Overt albuminuria (urinary albumin-creatinine ratio [ACR] > 300 mg/g) is an established risk factor for progression of nephropathy and total mortality. However, whether a reduction in ACR translates into a reduction in mortality and/or cardiovascular (CV) events among insulin-treated patients with type 2 dia...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Anyanwagu U,Donnelly R,Idris I

    更新日期:2019-01-01 00:00:00

  • Abnormally thin glomerular basement membranes associated with hematuria, proteinuria or renal failure in adults.

    abstract::Clinical and pathologic findings are described in 14 patients whose main abnormality was an excessively thin glomerular basement membrane (GBM). The subjects were aged 11-51 years, the majority males: most were referred because of hematuria, but proteinuria was the main problem in 2, while hypertension or renal functi...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Dische FE,Weston MJ,Parsons V

    更新日期:1985-01-01 00:00:00

  • Prevalence of Chronic Kidney Disease, Thrombotic Cardiovascular Events, and Use of Oral P2Y12 Inhibitors among Veterans.

    abstract:BACKGROUND:Contemporary prevalence of chronic kidney disease (CKD) and thrombotic cardiovascular (CV) events remains unclear in Veterans enrolled in the Veterans Affairs Health Care System (VA) care. Although oral P2Y12 inhibitors (P2Y12i) are increasingly being prescribed to this patient population, the overall prescr...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Singh M,Raghavan D,Williams JS,Martin BC,Hudson TJ,Owen RR,Jain N

    更新日期:2018-01-01 00:00:00

  • Prevention of myelinolysis in rats by dexamethasone or colchicine.

    abstract::The purpose of the present investigation was to determine whether dexamethasone, an agent known to preserve the blood-brain barrier, and colchicine, an agent that impairs mobilization of macrophages, can prevent demyelinating lesions associated with rapid correction of hyponatremia in the experimental animal. Hyponatr...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Oh MS,Choi KC,Uribarri J,Sher J,Rao C,Carroll HJ

    更新日期:1990-01-01 00:00:00

  • Waist circumference is strongly associated with renal resistive index in normoalbuminuric patients with type 2 diabetes.

    abstract:OBJECTIVE:Anthropometric parameters may play a role in modulating the risk of kidney dysfunction. The aim of this study was to evaluate whether anthropometric indices and the metabolic syndrome are associated with alterations of the renal resistive index (RI) in normoalbuminuric type 2 diabetic (T2DM) patients. METHOD...

    journal_title:American journal of nephrology

    pub_type: 杂志文章


    authors: Lamacchia O,Nicastro V,Camarchio D,Stallone G,Gesualdo L,Cignarelli M

    更新日期:2008-01-01 00:00:00