Behavioral alterations in response to fear-provoking stimuli and tranylcypromine induced by perinatal exposure to bisphenol A and nonylphenol in male rats.

Abstract:

:The purpose of this study was to examine whether perinatal exposure to two major environmental endocrine-disrupting chemicals, bisphenol A (BPA; 0.1 mg/kg/day orally) and nonylphenol [NP; 0.1 mg/kg/day (low dose) and 10 mg/kg/day (high dose) orally] daily from gestational day 3 to postnatal day 20 (transplacental and lactational exposures) would lead to behavioral alterations in the male offspring of F344 rats. Neither BPA nor NP exposure affected behavioral characteristics in an open-field test (8 weeks of age), in a measurement of spontaneous motor activity (12 weeks of age), or in an elevated plus-maze test (14 weeks of age). A passive avoidance test (13 weeks of age) showed that both BPA- and NP-treated offspring tended to delay entry into a dark compartment. An active avoidance test at 15 weeks of age revealed that BPA-treated offspring showed significantly fewer avoidance responses and low-dose NP-treated offspring exhibited slightly fewer avoidance responses. Furthermore, BPA-treated offspring significantly increased the number of failures to avoid electrical unconditioned stimuli within 5-sec electrical shock presentation compared with the control offspring. In a monoamine-disruption test using 5 mg/kg (intraperitoneal) tranylcypromine (Tcy), a monoamine oxidase inhibitor, both BPA-treated and low-dose NP-treated offspring at 22-24 weeks of age failed to show a significant increment in locomotion in response to Tcy, whereas control and high-dose NP-treated offspring significantly increased locomotion behavior after Tcy injection. In addition, when only saline was injected during a monoamine-disruption test, low-dose NP-treated offspring showed frequent rearing compared with the control offspring. The present results indicate that perinatal low-dose BPA or NP exposure irreversibly influenced the reception of fear-provoking stimuli (e.g., electrical shock), as well as monoaminergic neural pathways. Key words: behavior, bisphenol A, fear, learning, monoamine, nonylphenol.

authors

Negishi T,Kawasaki K,Suzaki S,Maeda H,Ishii Y,Kyuwa S,Kuroda Y,Yoshikawa Y

doi

10.1289/ehp.6961

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

1159-64

issue

11

eissn

0091-6765

issn

1552-9924

journal_volume

112

pub_type

杂志文章
  • Evaluation criteria for publishing in top-tier journals in environmental health sciences and toxicology.

    abstract:BACKGROUND:Trying to publish a paper in a top-rated peer-reviewed journal can be a difficult and frustrating experience for authors. It is important that authors understand the general review process before submitting manuscripts for publication. OBJECTIVES:Editors-in-chief and associate editors from top-tier journals...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1003280

    authors: Lee BM

    更新日期:2011-07-01 00:00:00

  • Dioxins and endometriosis: a plausible hypothesis.

    abstract::A potential connection exists between exposure to organochlorine chemicals and the increasing prevalence of endometriosis. Evidence shows that dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) can increase the incidence and severity of the disease in monkeys and can promote the growth or survival of endometrial tissue impl...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.0211015

    authors: Birnbaum LS,Cummings AM

    更新日期:2002-01-01 00:00:00

  • GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study.

    abstract:BACKGROUND:Genetics may partially explain observed heterogeneity in associations between traffic-related air pollution and incident asthma. OBJECTIVE:Our aim was to investigate the impact of gene variants associated with oxidative stress and inflammation on associations between air pollution and incident childhood ast...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1307459

    authors: MacIntyre EA,Brauer M,Melén E,Bauer CP,Bauer M,Berdel D,Bergström A,Brunekreef B,Chan-Yeung M,Klümper C,Fuertes E,Gehring U,Gref A,Heinrich J,Herbarth O,Kerkhof M,Koppelman GH,Kozyrskyj AL,Pershagen G,Postma DS,Th

    更新日期:2014-04-01 00:00:00

  • Bacterial mutagenicity of pyrolysis tars produced from chloro-organic fuels.

    abstract::Droplets of toluene and three chlorinated organics, ortho-dichlorobenzene, 1,2-dichloroethane, and trichloroethylene, were pyrolyzed in pure nitrogen. The composition and bacterial mutagenicity of the product tars were measured. The presence of organic chlorine was found to affect both pyrolysis product tar compositio...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.94102s1283

    authors: Mulholland JA,Sarofim AF,Longwell JP,Lafleur AL,Thilly WG

    更新日期:1994-01-01 00:00:00

  • Expanded operational concept of high risk groups and its role in standard setting.

    abstract::The role of the knowledge of high risk groups in the standard-setting process is examined. The overall conclusion is that many potential high risk segments of the population have not been studied adequately and that this deficiency in our knowledge markedly reduces the ability of decision makers to derive appropriate ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8352257

    authors: Calabrese EJ

    更新日期:1983-10-01 00:00:00

  • Mechanisms underlying Children's susceptibility to environmental toxicants.

    abstract::An important public health challenge has been the need to protect children's health. To accomplish this goal, the scientific community needs scientifically based child-specific risk assessment methods. Critical to their development is the need to understand mechanisms underlying children's sensitivity to environmental...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.00108s113

    authors: Faustman EM,Silbernagel SM,Fenske RA,Burbacher TM,Ponce RA

    更新日期:2000-03-01 00:00:00

  • Potential molecular mechanisms of oxidant-induced carcinogenesis.

    abstract::Chronic exposure to oxidants is associated with an increased incidence of malignancy; however, the mechanism(s) by which oxidants contribute to carcinogenesis is unknown. Since oncogene activation plays an important role in carcinogenesis, we hypothesized that hydroxyl radical-induced DNA damage might contribute to ca...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.94102s10155

    authors: Jackson JH

    更新日期:1994-12-01 00:00:00

  • Angiotensin-converting enzyme: II. Pulmonary endothelial cells in culture.

    abstract::Direct studies of the function of a given cell type often require that the cell type be obtained in pure culture. A number of different specific metabolic activities have been attributed to pulmonary endothelial cells, yet with few exceptions the conclusions were based on indirect evidence. Thus, to improve our abilit...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8035171

    authors: Ryan US,Ryan JW

    更新日期:1980-04-01 00:00:00

  • The biological exposure indices: a key component in protecting workers from toxic chemicals.

    abstract::Biological monitoring of exposure to chemicals in the workplace is an important component of exposure assessment and prevention of adverse health effects. It should be employed in conjunction with ambient air monitoring to provide information on the absorbed dose of a chemical agent and the effect of all routes of exp...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.97105s1105

    authors: Morgan MS

    更新日期:1997-02-01 00:00:00

  • Prenatal lead levels, plasma amyloid β levels, and gene expression in young adulthood.

    abstract:BACKGROUND:Animal studies suggest that early-life lead exposure influences gene expression and production of proteins associated with Alzheimer's disease (AD). OBJECTIVES:We attempted to assess the relationship between early-life lead exposure and potential biomarkers for AD among young men and women. We also attempte...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1104474

    authors: Mazumdar M,Xia W,Hofmann O,Gregas M,Ho Sui S,Hide W,Yang T,Needleman HL,Bellinger DC

    更新日期:2012-05-01 00:00:00

  • Setting a new syllabus: environmental health science in the classroom.

    abstract::Environmental health is a subject that has only relatively recently become prominent in the social consciousness. Even as its significance becomes known, finding ways to integrate the subject into education for primary and secondary students is difficult because of federal testing requirements under the No Child Left ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.112-a814

    authors: Brown VJ

    更新日期:2004-10-01 00:00:00

  • The Salmonella mutagenicity assay: the stethoscope of genetic toxicology for the 21st century.

    abstract:OBJECTIVES:According to the 2007 National Research Council report Toxicology for the Twenty-First Century, modern methods (e.g., "omics," in vitro assays, high-throughput testing, computational methods) will lead to the emergence of a new approach to toxicology. The Salmonella mammalian microsome mutagenicity assay has...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.1002336

    authors: Claxton LD,Umbuzeiro Gde A,DeMarini DM

    更新日期:2010-11-01 00:00:00

  • Use of the land snail Helix aspersa as sentinel organism for monitoring ecotoxicologic effects of urban pollution: an integrated approach.

    abstract::Atmospheric pollution from vehicular traffic is a matter of growing interest, often leading to temporary restrictions in urban areas. Although guidelines indicate limits for several parameters, the real toxicologic impacts remain largely unexplored in field conditions. In this study our aim was to validate an ecotoxic...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8397

    authors: Regoli F,Gorbi S,Fattorini D,Tedesco S,Notti A,Machella N,Bocchetti R,Benedetti M,Piva F

    更新日期:2006-01-01 00:00:00

  • Airborne particles of the california central valley alter the lungs of healthy adult rats.

    abstract::Epidemiologic studies have shown that airborne particulate matter (PM) with a mass median aerodynamic diameter < 10 microm (PM10) is associated with an increase in respiratory-related disease. However, there is a growing consensus that particles < 2.5 microm (PM2.5), including many in the ultrafine (< 0.1 microm) size...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.5964

    authors: Smith KR,Kim S,Recendez JJ,Teague SV,Ménache MG,Grubbs DE,Sioutas C,Pinkerton KE

    更新日期:2003-06-01 00:00:00

  • Cord serum cotinine as a biomarker of fetal exposure to cigarette smoke at the end of pregnancy.

    abstract::This study investigated the association between biomarkers of fetal exposure to cigarette smoke at the end of pregnancy, cotinine in cord serum and in maternal and newborn urine samples, and quantitative measurement of smoking intake and exposure evaluated by maternal self-reported questionnaire. Study subjects were 4...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.001081079

    authors: Pichini S,Basagaña XB,Pacifici R,Garcia O,Puig C,Vall O,Harris J,Zuccaro P,Segura J,Sunyer J

    更新日期:2000-11-01 00:00:00

  • United Kingdom Beryllium Registry: mortality and autopsy study.

    abstract::This report is based on 30 deaths from chronic beryllium disease (CBD) in the United Kingdom with details of 19 autopsies. The majority were fluorescent lamp workers and machinists who died from respiratory failure. There were no cases of lung cancer. The survival times ranged from less than 1 to 29 years and was long...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.96104s5949

    authors: Williams WJ

    更新日期:1996-10-01 00:00:00

  • Predicting children's short-term exposure to pesticides: results of a questionnaire screening approach.

    abstract::The ability of questionnaires to predict children's exposure to pesticides was examined as part of the Minnesota Children's Pesticide Exposure Study (MNCPES). The MNCPES focused on a probability sample of 102 children between the ages of 3 and 13 years living in either urban (Minneapolis and St. Paul, MN) or nonurban ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.5823

    authors: Sexton K,Adgate JL,Eberly LE,Clayton CA,Whitmore RW,Pellizzari ED,Lioy PJ,Quackenboss JJ

    更新日期:2003-01-01 00:00:00

  • Methods for and approaches to evaluating susceptibility of ecological systems to hazardous chemicals.

    abstract::Differences in genetic susceptibility to hazardous chemicals affect individuals of both human and nonhuman populations. In both cases, differences in response to chemicals or general ill health result as a function of these differences in genetic susceptibility. However, ecological systems are a compilation of hundred...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.97105s4843

    authors: Burger J

    更新日期:1997-06-01 00:00:00

  • Lead exposure, B vitamins, and plasma homocysteine in men 55 years of age and older: the VA normative aging study.

    abstract:BACKGROUND:Lead (Pb) exposure may influence the plasma concentration of homocysteine, a one-carbon metabolite associated with cardiovascular and neurodegenerative diseases. Little is known about the associations between Pb and homocysteine over time, or the potential influence of dietary factors. OBJECTIVES:We examine...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1306931

    authors: Bakulski KM,Park SK,Weisskopf MG,Tucker KL,Sparrow D,Spiro A 3rd,Vokonas PS,Nie LH,Hu H,Weuve J

    更新日期:2014-10-01 00:00:00

  • Recommendations for medical management of adult lead exposure.

    abstract::Research conducted in recent years has increased public health concern about the toxicity of lead at low dose and has supported a reappraisal of the levels of lead exposure that may be safely tolerated in the workplace. In this article, which appears as part of a mini-monograph on adult lead exposure, we summarize a b...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.9784

    authors: Kosnett MJ,Wedeen RP,Rothenberg SJ,Hipkins KL,Materna BL,Schwartz BS,Hu H,Woolf A

    更新日期:2007-03-01 00:00:00

  • Residential Road Traffic Noise and High Depressive Symptoms after Five Years of Follow-up: Results from the Heinz Nixdorf Recall Study.

    abstract:BACKGROUND:Traffic noise affects a large number of people, particularly in urbanized areas. Noise causes stress and annoyance, but less is known about the relationship between noise and depression. OBJECTIVE:We investigated the association of residential road traffic noise with depressive symptoms using 5-year follow-...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1409400

    authors: Orban E,McDonald K,Sutcliffe R,Hoffmann B,Fuks KB,Dragano N,Viehmann A,Erbel R,Jöckel KH,Pundt N,Moebus S

    更新日期:2016-05-01 00:00:00

  • Health effects of gasoline exposure. II. Mortality patterns of distribution workers in the United States.

    abstract::In this study, the cohort consisted of 18,135 distribution employees with potential exposure to gasoline for at least one year at land-based terminals (n = 9,026) or on marine vessels (n = 9,109) between 1946 and 1985. The primary objective of the study was to determine the relationship, if any, between exposure to ga...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.93101s663

    authors: Wong O,Harris F,Smith TJ

    更新日期:1993-12-01 00:00:00

  • Long-term, low-dose lead exposure alters the gonadotropin-releasing hormone system in the male rat.

    abstract::Lead is a male reproductive toxicant. Data suggest that rats dosed with relatively high levels of lead acetate for short periods of time induced changes in the hypothalamic gonadotropin-releasing hormone (GnRH) at the molecular level, but these changes were attenuated with increased concentration of exposure. The curr...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.02110871

    authors: Sokol RZ,Wang S,Wan YJ,Stanczyk FZ,Gentzschein E,Chapin RE

    更新日期:2002-09-01 00:00:00

  • Respiratory involvement and immune status in yusho patients.

    abstract::Clinical and experimental studies on respiratory involvement and alterations in immune status were carried out. Respiratory distress occurring in these patients has improved gradually for 14 years but still remains. Copious expectoration at an early stage of the disease may be related to the fact that a number of disc...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.59-1568074

    authors: Nakanishi Y,Shigematsu N,Kurita Y,Matsuba K,Kanegae H,Ishimaru S,Kawazoe Y

    更新日期:1985-02-01 00:00:00

  • Measurement methods for human exposure analysis.

    abstract::The general methods used to complete measurements of human exposures are identified and illustrations are provided for the cases of indirect and direct methods used for exposure analysis. The application of the techniques for external measurements of exposure, microenvironmental and personal monitors, are placed in th...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.95103s335

    authors: Lioy PJ

    更新日期:1995-04-01 00:00:00

  • Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia.

    abstract:BACKGROUND:Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia. OBJECTIVES:In this case-control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children. ME...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.11927

    authors: Scélo G,Metayer C,Zhang L,Wiemels JL,Aldrich MC,Selvin S,Month S,Smith MT,Buffler PA

    更新日期:2009-01-01 00:00:00

  • Evaluation of mutagenicity testing with Salmonella typhimurium TA102 in three different laboratories.

    abstract::Thirty compounds of various chemical classes were investigated for mutagenicity in a collaborative study (three laboratories) using Salmonella typhimurium TA102. With five compounds, hydrazine sulfate, phenylhydrazine, hydralazine, glutardialdehyde, and glyoxal, mutagenicity was detected by all laboratories. Formaldeh...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.101-1521147

    authors: Müller W,Engelhart G,Herbold B,Jäckh R,Jung R

    更新日期:1993-10-01 00:00:00

  • Particulate Air Pollution, Exceptional Aging, and Rates of Centenarians: A Nationwide Analysis of the United States, 1980-2010.

    abstract:BACKGROUND:Exceptional aging, defined as reaching age 85 years, shows geographic inequalities that may depend on local environmental conditions. Links between particulate pollution-a well-recognized environmental risk factor-and exceptional aging have not been investigated. OBJECTIVES:We conducted a nationwide analysi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP197

    authors: Baccarelli AA,Hales N,Burnett RT,Jerrett M,Mix C,Dockery DW,Pope CA

    更新日期:2016-11-01 00:00:00

  • Estimating Time-Varying PCB Exposures Using Person-Specific Predictions to Supplement Measured Values: A Comparison of Observed and Predicted Values in Two Cohorts of Norwegian Women.

    abstract:BACKGROUND:Studies on the health effects of polychlorinated biphenyls (PCBs) call for an understanding of past and present human exposure. Time-resolved mechanistic models may supplement information on concentrations in individuals obtained from measurements and/or statistical approaches if they can be shown to reprodu...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1409191

    authors: Nøst TH,Breivik K,Wania F,Rylander C,Odland JØ,Sandanger TM

    更新日期:2016-03-01 00:00:00

  • Home and allergic characteristics of children with asthma in seven U.S. urban communities and design of an environmental intervention: the Inner-City Asthma Study.

    abstract::Most published environmental remediation interventions have been directed at single allergens and have employed demanding strategies; few have been performed in the homes of inner-city children disproportionately burdened by asthma. Our objective was a) to describe the allergen sensitivities, environmental tobacco smo...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.02110939

    authors: Crain EF,Walter M,O'Connor GT,Mitchell H,Gruchalla RS,Kattan M,Malindzak GS,Enright P,Evans R 3rd,Morgan W,Stout JW

    更新日期:2002-09-01 00:00:00