Localization of PDGF A and PDGFR alpha mRNA in Xenopus embryos suggests signalling from neural ectoderm and pharyngeal endoderm to neural crest cells.

abstract：:A key role for phosphorylation of Smad2 by TGFβ superfamily ligands in the axial patterning of early embryos is well established. The regulation and role of Smad2 signaling in post-neurula embryonic patterning, however, is less well understood. While a variety of TGFβ superfamily ligands are implicated in various stag...

journal_title：Mechanisms of development

authors： Ho DM,Yeo CY,Whitman M

更新日期：2010-09-01 00:00:00

abstract：:Avian neural crest cells migrate on precise pathways to their target areas where they form a wide variety of cellular derivatives, including neurons, glia, pigment cells and skeletal components. In one portion of their pathway, trunk neural crest cells navigate in the somitic mesoderm in a segmental fashion, invading ...

journal_title：Mechanisms of development

authors： Krull CE

更新日期：2001-07-01 00:00:00

abstract：:X-chromosome inactivation (XCI) is an epigenetic mechanism that occurs in the eutherian embryo development to equalize the dosage of X-linked genes between males and females. This event is regulated by various factors, and the genes located in the X-chromosome inactivation center (XIC), which is known to be an evoluti...

journal_title：Mechanisms of development

authors： Hwang JY,Oh JN,Park CH,Lee DK,Lee CK

更新日期：2015-11-01 00:00:00

abstract：:Myogenin and CMD1, the chicken homologue of MyoD, transactivate the promoter of the alpha-subunit of the acetylcholine receptor (AChR) in chicken fibroblasts. The expression of these three genes was followed by in situ hybridization. In two-day-old embryos the CMD1 gene is expressed shortly before the AChR alpha-subun...

journal_title：Mechanisms of development

authors： Piette J,Huchet M,Duclert A,Fujisawa-Sehara A,Changeux JP

更新日期：1992-03-01 00:00:00

abstract：:In Drosophila melanogaster, the patterning of dorsal appendages on the eggshell is strictly controlled by EGFR signaling. However, the number of dorsal appendages is remarkably diverse among Drosophila species. For example, D. melanogaster and D. virilis have two and four dorsal appendages, respectively. Here we show ...

journal_title：Mechanisms of development

authors： Nakamura Y,Matsuno K

更新日期：2003-08-01 00:00:00

abstract：:By means of subtractive and differential hybridization techniques we have identified a novel murine gene (1A13) the expression of which is developmentally regulated in the mouse brain. Comparison of the nucleotide and predicted protein sequence revealed closest relationship of 1A13 to human CoREST, a transcriptional c...

journal_title：Mechanisms of development

authors： Tontsch S,Zach O,Bauer HC

更新日期：2001-10-01 00:00:00

abstract：:Hair cell (HC) and supporting cell (SC) productions are completed during early embryonic development of the mammalian cochlea. This study shows that acutely dissociated cells from the newborn rat organ of Corti, developed into so-called otospheres consisting of 98% nestin (+) cells when plated on a non-adherent substr...

journal_title：Mechanisms of development

authors： Malgrange B,Belachew S,Thiry M,Nguyen L,Rogister B,Alvarez ML,Rigo JM,Van De Water TR,Moonen G,Lefebvre PP

更新日期：2002-03-01 00:00:00

abstract：:Endoreduplication cycles that lead to an increase of DNA ploidy and cell size occur in distinct spatial and temporal patterns during Drosophila development. Only little is known about the regulation of these modified cell cycles. We have investigated fore- and hindgut development and we present evidence that the Droso...

journal_title：Mechanisms of development

authors： Fuss B,Meissner T,Bauer R,Lehmann C,Eckardt F,Hoch M

更新日期：2001-01-01 00:00:00

abstract：:The embryonic fins and the tip of adult fins of teleost fish are supported by rows of straight, unmineralized fibrils called actinotrichia. The proximal ends of the actinotrichia are bundled and the mineralized bones called lepidotrichia are made along them. Since malformation in actinotrichia causes wavy fin bones, t...

journal_title：Mechanisms of development

authors： Kuroda J,Iwane AH,Kondo S

更新日期：2018-10-01 00:00:00

abstract：:Terminal portions of the Drosophila body pattern are specified by an extracellular ligand generated at each end of the early syncytial embryo. This ligand triggers the localized transcription of two gap segmentation genes, tailles (tll) and huckebein (hkb) through a signal transduction cascade involving the receptor t...

journal_title：Mechanisms of development

authors： Casanova J,Llimargas M,Greenwood S,Struhl G

更新日期：1994-10-01 00:00:00

abstract：:Egr1 is a highly conserved zinc finger protein which plays important roles in many aspects of vertebrate development and in the adult. The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization. Egr1 mRNA is first detec...

journal_title：Mechanisms of development

authors： Close R,Toro S,Martial JA,Muller M

更新日期：2002-10-01 00:00:00

abstract：:The actin cytoskeleton is implicated in many cellular processes, such as cell adhesion, locomotion, contraction and cytokinesis, which are central to any development. The extent of polymerization, cross-linking, and bundling of actin is regulated by several actin-binding proteins. Knock-out mutations in these proteins...

journal_title：Mechanisms of development

authors： Ponte E,Rivero F,Fechheimer M,Noegel A,Bozzaro S

更新日期：2000-03-01 00:00:00

abstract：:When an amphibian limb, cockroach leg or Drosophila imaginal disc is subjected to a surgical operation, it is capable of regenerating or duplicating certain parts. Although the structure of the regenerated tissue varies depending on the location and mass of the amputated or transplanted part, it can be predicted from ...

journal_title：Mechanisms of development

authors： Kondo S

更新日期：1992-12-01 00:00:00

abstract：:ADAM19 is a member of the meltrin subfamily of ADAM metalloproteases. In Xenopus, ADAM19 is present as a maternal transcript. Zygotic expression starts during gastrulation and is apparent in the dorsal blastopore lip. ADAM19 expression through neurulation and tailbud formation becomes enriched in dorsal structures suc...

journal_title：Mechanisms of development

authors： Neuner R,Cousin H,McCusker C,Coyne M,Alfandari D

更新日期：2009-03-01 00:00:00

abstract：:We analyse the role of the empty spiracles (ems) gene in embryonic brain and ventral nerve cord development. ems is differentially expressed in the neurectoderm of the anterior head versus the trunk region of early embryos. A distal enhancer region drives expression in the deutocerebral brain anlage and a proximal enh...

journal_title：Mechanisms of development

authors： Hartmann B,Hirth F,Walldorf U,Reichert H

更新日期：2000-02-01 00:00:00

abstract：:The existence of a common endodermal progenitor cell to both pancreas and liver is suggested by anatomy of the development of pancreatic and liver buds in embryogenesis. Here we review the large body of evidence that pancreas to liver and liver to pancreas cell differentiation can also occur in adult life. The publish...

journal_title：Mechanisms of development

authors： Grompe M

更新日期：2003-01-01 00:00:00

abstract：:Using a Drosophila cell-free system, we have analyzed the regulation of alternative splicing of Drosophila muscle myosin heavy chain (MHC) transcripts. Splicing of MHC 3' end transcripts results in exclusion of adult-specific alternative exon 18, as is observed in embryonic and larval muscle in vivo. Mutations that st...

journal_title：Mechanisms of development

authors： Hodges D,Bernstein SI

更新日期：1992-05-01 00:00:00

abstract：:dkk-1 has recently been identified as a secreted protein in Xenopus laevis which is sufficient and necessary to cause head induction by antagonizing Wnt signalling (Glinka et al., 1998, Nature 391, 357-362). Consistent with such a role dkk-1 is expressed in the Spemann organizer of the early frog gastrula. Later, expr...

journal_title：Mechanisms of development

authors： Grotewold L,Theil T,Rüther U

更新日期：1999-12-01 00:00:00

abstract：:During early vertebrate development, a series of neuromeres divides the central nervous system from the forebrain to the spinal cord. Here we examine in more detail the expression of Wnt-3, a member of the Wnt gene family of secreted proteins, in the developing diencephalon, in comparison to the expression of the home...

journal_title：Mechanisms of development

authors： Salinas PC,Nusse R

更新日期：1992-12-01 00:00:00

abstract：:Active repression of gene expression mediated by unliganded nuclear receptors plays crucial roles in early development of vertebrates. N-CoR (nuclear receptor co-repressor) is the first identified co-repressor that can repress retinoic acid (RA) inducible gene transcription in the absence of RA. Previously, N-CoR was ...

journal_title：Mechanisms of development

authors： Xu F,Li K,Tian M,Hu P,Song W,Chen J,Gao X,Zhao Q

更新日期：2009-10-01 00:00:00

abstract：:The segmentation of vertebrate embryos depends on a complex genetic network that generates highly dynamic gene expression. Many of the elements of the network have been identified, but their interaction and their influence on segmentation remain poorly understood. A few mathematical models have been proposed to explai...

journal_title：Mechanisms of development

authors： Cinquin O

更新日期：2007-08-01 00:00:00

abstract：:We report the expression pattern of a murine homolog of the Xenopus laevis T-box gene Eomesodermin. mEomes expression is first detected in the extra-embryonic ectoderm prior to gastrulation, and persists there until head-fold stages. In the embryo proper, mEomes is expressed throughout the early primitive streak, nasc...

journal_title：Mechanisms of development

authors： Ciruna BG,Rossant J

更新日期：1999-03-01 00:00:00

abstract：:The transgenic sequences in the mouse line TKZ751 are demethylated on a DBA/2 inbred strain background but become highly methylated at postimplantation stages in offspring of a cross with a BALB/c female. In the reciprocal cross the transgene remains demethylated suggesting that imprinted BALB/c methylation modifiers ...

journal_title：Mechanisms of development

authors： Pickard B,Dean W,Engemann S,Bergmann K,Fuermann M,Jung M,Reis A,Allen N,Reik W,Walter J

更新日期：2001-05-01 00:00:00

abstract：:Although the molecular mechanisms directing anteroposterior patterning of the Drosophila embryo (long-germband mode) are well understood, how these mechanisms were evolved from an ancestral mode of insect embryogenesis remains largely unknown. In order to gain insight into mechanisms of evolution in insect embryogenes...

journal_title：Mechanisms of development

authors： Shinmyo Y,Mito T,Matsushita T,Sarashina I,Miyawaki K,Ohuchi H,Noji S

更新日期：2005-02-01 00:00:00

abstract：:We describe the structural organization of a gene, termed XFDL 141/156, that is transiently activated during early Xenopus development. XFDL 141/156 is first transcribed at the midblastula transition (MBT) and during early gastrulation events. A roughly 200 nucleotide fragment immediately 5' to the transcription start...

journal_title：Mechanisms of development

authors： Bellefroid E,Bourguignon C,Bouwmeester T,Rausch O,Blumberg B,Pieler T

更新日期：1997-04-01 00:00:00

abstract：:Mammalian embryos develop in coordination with extraembryonic tissues, which support embryonic development by implanting embryos into the uterus, supplying nutrition, providing a confined niche, and also providing patterning signals to embryos. Here, we show that in mouse embryos, the expansion of the amniotic cavity ...

journal_title：Mechanisms of development

authors： Imuta Y,Koyama H,Shi D,Eiraku M,Fujimori T,Sasaki H

更新日期：2014-05-01 00:00:00

abstract：:We have identified ramshackle (ram) as a dominant suppressor of hedgehog loss-of-function in the developing Drosophila eye. We have characterized the gene and it encodes a double bromodomain protein with eight WD40 repeats. The Ram protein is localized predominantly to polytene chromosome interbands and is required fo...

journal_title：Mechanisms of development

authors： D'Costa A,Reifegerste R,Sierra S,Moses K

更新日期：2006-08-01 00:00:00

abstract：:The spatial and temporal analysis of GATA-3 expression pattern in the human embryo revealed its expression in new anatomical sites. These include the endoderm of the primitive foregut, pharynx and allantois, the branchial arches and the mesenchymal cells surrounding the stomach and dorsal aorta. On the other hand, hum...

journal_title：Mechanisms of development

authors： Debacker C,Catala M,Labastie MC

更新日期：1999-07-01 00:00:00

abstract：:The Bar homeobox genes play an essential role during nervous system and eye development in Drosophila. We isolated a medaka Bar gene closely related to the Drosophila and mammalian Bar genes. In the medaka embryo, OlBar is expressed from gastrula stages onwards, in a region demarcating the presumptive prosencephalic-m...

journal_title：Mechanisms of development

authors： Poggi L,Carl M,Vignali R,Barsacchi G,Wittbrodt J

更新日期：2002-06-01 00:00:00

abstract：:The foot of the simple metazoan Hydra is a highly dynamic body region of constant tissue movement, cell proliferation, determination and differentiation. Previously, two genes have been shown to participate in the development and differentiation of this body region: homeodomain factor CnNK-2 and signal peptide pedibin...

journal_title：Mechanisms of development

authors： Thomsen S,Till A,Wittlieb J,Beetz C,Khalturin K,Bosch TC

更新日期：2004-02-01 00:00:00