Abstract:
:Mammalian embryos develop in coordination with extraembryonic tissues, which support embryonic development by implanting embryos into the uterus, supplying nutrition, providing a confined niche, and also providing patterning signals to embryos. Here, we show that in mouse embryos, the expansion of the amniotic cavity (AC), which is formed between embryonic and extraembryonic tissues, provides the mechanical forces required for a type of morphogenetic movement of the notochord known as convergent extension (CE) in which the cells converge to the midline and the tissue elongates along the antero-posterior (AP) axis. The notochord is stretched along the AP axis, and the expansion of the AC is required for CE. Both mathematical modeling and physical simulation showed that a rectangular morphology of the early notochord caused the application of anisotropic force along the AP axis to the notochord through the isotropic expansion of the AC. AC expansion acts upstream of planar cell polarity (PCP) signaling, which regulates CE movement. Our results highlight the importance of extraembryonic tissues as a source of the forces that control the morphogenesis of embryos.
journal_name
Mech Devjournal_title
Mechanisms of developmentauthors
Imuta Y,Koyama H,Shi D,Eiraku M,Fujimori T,Sasaki Hdoi
10.1016/j.mod.2014.01.004subject
Has Abstractpub_date
2014-05-01 00:00:00pages
44-58eissn
0925-4773issn
1872-6356pii
S0925-4773(14)00006-9journal_volume
132pub_type
杂志文章abstract::Mutations in the CFTR gene cause cystic fibrosis (CF) with myocardial dysfunction. However, it remains unknown whether CF-related heart disease is a secondary effect of pulmonary disease, or an intrinsic primary defect in the heart. Here, we used zebrafish, which lack lung tissue, to investigate the role of CFTR in ca...
journal_title:Mechanisms of development
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journal_title:Mechanisms of development
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journal_title:Mechanisms of development
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pub_type: 杂志文章
doi:10.1016/s0925-4773(99)00221-x
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pub_type: 杂志文章,评审
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更新日期:2004-10-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章,评审
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更新日期:2003-11-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
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journal_title:Mechanisms of development
pub_type: 杂志文章
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