Abstract：
:The Drosophila wing is a classical model for studying the generation of developmental patterns. Previous studies have suggested that vein primordia form at boundaries between discrete sectors of gene expression along the antero-posterior (A/P) axis in the larval wing imaginal disc. Observation that the vein marker rhomboid (rho) is expressed at the centre of wider vein-competent domains led to propose that narrow vein primordia form first, and produce secondary short-range signals activating provein genes in neighbouring cells (see Curr. Opin. Genet. Dev. 10 (2000) 393). Here, we examined how the central L3 and L4 veins are positioned relative to the limits of expression of Collier (Col), a dose-dependent Hedgehog (Hh) target activated in the wing A/P organiser. We found that rho expression is first activated in broad domains adjacent to Col-expressing cells and secondarily restricted to the centre of these domains. This restriction which depends upon Notch (N) signaling sets the L3 and L4 vein primordia off the boundaries of Col expression. N activity is also required to fix the anterior limit of Col expression by locally antagonising Hh activation, thus precisely positioning the L3 vein primordium relative to the A/P compartment boundary. Experiments using Nts mutants further indicated that these two activities of N could be temporally uncoupled. Together, these observations highlight new roles of N in topologically linking the position of veins to prepattern gene expression.
journal_name
Mech Devjournal_title
Mechanisms of developmentauthors
Crozatier M,Glise B,Khemici V,Vincent Adoi
10.1016/s0925-4773(03)00041-8subject
Has Abstractpub_date
2003-05-01 00:00:00pages
529-35issue
5eissn
0925-4773issn
1872-6356pii
S0925477303000418journal_volume
120pub_type
杂志文章abstract：:Nemo-like kinases define a novel family of serine/threonine kinases that are involved in integrating multiple signaling pathways. They are conserved regulators of Wnt/Wingless pathways, which may coordinate Wnt with TGFbeta-mediated signaling. Drosophila nemo was identified through its involvement in epithelial planar...
journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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journal_title：Mechanisms of development
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