Expression of Drosophila trithorax-group homologues in chick embryos.

abstract：:Cell-cell interactions during embryogenesis have been shown to be important for establishing developmental fates in a number of organisms such as Drosophila and Caenorhabditis. One class of genes shown to mediate this process are receptor-protein tyrosine kinases (R-PTKs). To examine whether R-PTKs might participate i...

journal_title：Mechanisms of development

authors： Ruiz JC,Robertson EJ

更新日期：1994-05-01 00:00:00

abstract：:T-box genes constitute a conserved multi-gene family with important roles in many developmental processes. In this report, we describe the cloning and expression analysis of a novel mouse T-box gene, Tbx20. Expression is prominent in the extraembryonic mesoderm, in the developing heart, the eye anlage and motor neuron...

journal_title：Mechanisms of development

authors： Kraus F,Haenig B,Kispert A

更新日期：2001-01-01 00:00:00

abstract：:Drosophila immunity and embryogenesis appear to be linked by an evolutionarily ancient signalling pathway, which includes the Rel-domain transcription factors Dif and dorsal, respectively, as well as a common inhibitor, cactus. Previous genetic screens have centered on maternal mutants that disrupt the dorsal pathway....

journal_title：Mechanisms of development

authors： Corbo JC,Levine M

更新日期：1996-04-01 00:00:00

abstract：:The germ cell nuclear factor (GCNF, NR6A1) is a nuclear orphan receptor that functions as a transcriptional repressor and is transiently expressed in mammalian carcinoma cells during retinoic acid (RA) induced neuronal differentiation. During Xenopus laevis development, the spatiotemporal expression pattern of embryon...

journal_title：Mechanisms of development

authors： Barreto G,Borgmeyer U,Dreyer C

更新日期：2003-04-01 00:00:00

abstract：:The actin cytoskeleton is implicated in many cellular processes, such as cell adhesion, locomotion, contraction and cytokinesis, which are central to any development. The extent of polymerization, cross-linking, and bundling of actin is regulated by several actin-binding proteins. Knock-out mutations in these proteins...

journal_title：Mechanisms of development

authors： Ponte E,Rivero F,Fechheimer M,Noegel A,Bozzaro S

更新日期：2000-03-01 00:00:00

abstract：:We have recently identified a new G protein-coupled receptor, msr/apj, whose transcripts are detected in the endothelium of the primary blood vessels and the newly forming heart (Mech. Dev. 1999;84:199). Its expression during formation of the embryonic vasculature incited us to investigate whether expression of the re...

journal_title：Mechanisms of development

authors： Saint-Geniez M,Masri B,Malecaze F,Knibiehler B,Audigier Y

更新日期：2002-01-01 00:00:00

abstract：:We present a complete staging table of normal development for the lungless salamander, Hemidactylium scutatum (Caudata: Plethodontidae). Terrestrial egg clutches from naturally ovipositing females were collected and maintained at 15 °C in the laboratory. Observations, photographs, and time-lapse movies of embryos were...

journal_title：Mechanisms of development

authors： Hurney CA,Babcock SK,Shook DR,Pelletier TM,Turner SD,Maturo J,Cogbill S,Snow MC,Kinch K

更新日期：2015-05-01 00:00:00

abstract：:During heart development, cells of the endocardial cushions undergo an epithelial-mesenchymal transformation and migrate into the surrounding extracellular matrix. This event is required for the normal formation of valves and chamber septation. Coincident with this phenotypic change is the expression of the serine pro...

journal_title：Mechanisms of development

authors： Majka SM,McGuire PG

更新日期：1997-11-01 00:00:00

abstract：:We have characterised the transdifferentiation of human HepG2 (hepatoma) cells to pancreatic cells following introduction of an activated version of the pancreatic transcription factor Pdx1 (XlHbox8-VP16). The following questions are addressed: (1) are all types of pancreatic cells produced? (2) is the requirement for...

journal_title：Mechanisms of development

authors： Li WC,Horb ME,Tosh D,Slack JM

更新日期：2005-06-01 00:00:00

abstract：:We have isolated nine putative odorant receptor genes from the chick, named COR1 to COR9, that belong to the large multigene family of olfactory G protein-coupled receptors found in the fish, rat, mouse, dog, and human. By combining genomic DNA blot analysis, low stringency library screenings, and several PCR analyses...

journal_title：Mechanisms of development

authors： Nef S,Allaman I,Fiumelli H,De Castro E,Nef P

更新日期：1996-03-01 00:00:00

abstract：:Here we present the cloning of a full-length zebrafish pdgfr-alpha cDNA as well as the expression of this gene during zebrafish embryogenesis. We show that zebrafish pdgfr-alpha mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation. Spatially restricted ex...

journal_title：Mechanisms of development

authors： Liu L,Chong SW,Balasubramaniyan NV,Korzh V,Ge R

更新日期：2002-08-01 00:00:00

abstract：:The full length sequence of the Xenopus integrin alpha 5 subunit is reported. Analysis of cloned cDNA fragments reveals that alternative polyadenylation of alpha 5 mRNA occurs in the embryo. Furthermore, a variant form of the alpha 5 mRNA is expressed which encodes an integrin alpha 5 subunit with a truncated cytoplas...

journal_title：Mechanisms of development

authors： Joos TO,Whittaker CA,Meng F,DeSimone DW,Gnau V,Hausen P

更新日期：1995-04-01 00:00:00

abstract：:C-terminal binding protein (CtBP) is an evolutionarily and functionally conserved transcriptional corepressor known to integrate diverse signals to regulate transcription. Drosophila CtBP (dCtBP) regulates tissue specification and segmentation during early embryogenesis. Here, we investigated the roles of dCtBP during...

journal_title：Mechanisms of development

authors： Stern MD,Aihara H,Roccaro GA,Cheung L,Zhang H,Negeri D,Nibu Y

更新日期：2009-01-01 00:00:00

abstract：:Using an in silico (electronic database) subtraction, we identified a new member of the Ret Finger Protein-Like gene family, Rfpl4. Rfpl4 encodes a 287 amino acid putative E3 ubiquitin-protein ligase with a RING finger-like domain and a B30.2 motif. Reverse transcriptase polymerase chain reaction and Northern blot ana...

journal_title：Mechanisms of development

authors： Rajkovic A,Lee JH,Yan C,Matzuk MM

更新日期：2002-03-01 00:00:00

abstract：:We have identified ramshackle (ram) as a dominant suppressor of hedgehog loss-of-function in the developing Drosophila eye. We have characterized the gene and it encodes a double bromodomain protein with eight WD40 repeats. The Ram protein is localized predominantly to polytene chromosome interbands and is required fo...

journal_title：Mechanisms of development

authors： D'Costa A,Reifegerste R,Sierra S,Moses K

更新日期：2006-08-01 00:00:00

abstract：:The cloning of a Pax6 orthologue from the sepiolid squid Euprymna scolopes and its developmental expression pattern are described. The data are consistent with the presence of a single gene encoding a protein with highly conserved DNA-binding paired and homeodomains. A detailed expression analysis by in situ hybridiza...

journal_title：Mechanisms of development

authors： Hartmann B,Lee PN,Kang YY,Tomarev S,de Couet HG,Callaerts P

更新日期：2003-02-01 00:00:00

abstract：:In Drosophila, the homeotic gene Distal-less (Dll) has a fundamental role in the establishment of the identity of ventral appendages such as the leg and antenna. This study reports the expression pattern of Dll in the genital disc, the requirement of Dll activity for the development of the terminalia and the activatio...

journal_title：Mechanisms of development

authors： Gorfinkiel N,Sánchez L,Guerrero I

更新日期：1999-08-01 00:00:00

abstract：:Factors controlling the differentiation of the multipotent embryonic lung endoderm and mesoderm are poorly understood. Recent evidence that Delta-like 1 (Dll1) and other genes in the Notch/Delta signaling pathway are expressed in the embryonic mouse lung suggests that this pathway is important for cell fate decisions ...

journal_title：Mechanisms of development

authors： Post LC,Ternet M,Hogan BL

更新日期：2000-11-01 00:00:00

abstract：:In chick embryos, naso-temporal polarity of the retina becomes established before Hamburger-Hamilton stage 10. To examine the plasticity of the early eye anlage, double-temporal eyes were made using stage 10-11 (E1.5) chick embryos and stage 8-9 quail embryos. In vivo and in vitro experiments revealed that these doubl...

journal_title：Mechanisms of development

authors： Mueller BK,Dütting D,Haase A,Feucht A,Macchi P

更新日期：1998-06-01 00:00:00

abstract：:Imitation Switch (ISWI) is a member of the SWI2/SNF2 superfamily of ATP-dependent chromatin remodelers, which regulate transcription and maintain chromatin structure by mobilizing nucleosomes using the energy of ATP. Four distinct ISWI complexes have been identified in Xenopus oocytes. The developmental role of Xenopu...

journal_title：Mechanisms of development

authors： Dirscherl SS,Henry JJ,Krebs JE

更新日期：2005-11-01 00:00:00

abstract：:We describe a zebrafish gene, Ziro3, which is highly homologous to Xenopus and mouse iroquois3. Ziro3 expression starts during gastrulation in the dorsal axial mesoderm that develops into the notochord. Later, the expression is limited to the chordo-neural hinge in the tailbud. Ziro3 expression also occurs in the cent...

journal_title：Mechanisms of development

authors： Tan JT,Korzh V,Gong Z

更新日期：1999-09-01 00:00:00

abstract：:We have identified a Drosophila gene encoding a putative receptor tyrosine kinase by screening a genomic DNA library with a DNA probe for a Drosophila homolog of fibroblast growth factor receptors. The newly isolated gene codes for a transmembrane protein most similar in sequence to a mammalian proto-oncogene ret; thu...

journal_title：Mechanisms of development

authors： Sugaya R,Ishimaru S,Hosoya T,Saigo K,Emori Y

更新日期：1994-02-01 00:00:00

abstract：:The cAMP signaling system has been postulated to be involved in embryogenesis of many animal species, however, little is known about its role in embryonic axis formation in vertebrates. In this study, the role of the cAMP signaling pathway in patterning the body plan of the Xenopus embryo was investigated by expressin...

journal_title：Mechanisms of development

authors： Kim MJ,Han JK

更新日期：1999-12-01 00:00:00

abstract：:The fork head domain-containing gene family (Fox) comprises over 20 members in mammals and is defined by a conserved 110 amino-acid motif containing a winged helix structure DNA-binding domain. The members of this gene family have been implicated as key regulators of embryogenesis, cell cycling, cell lineage restricti...

journal_title：Mechanisms of development

authors： Tribioli C,Robledo RF,Lufkin T

更新日期：2002-10-01 00:00:00

abstract：:The recent development of transgenic methods for the frog Xenopus laevis provides the opportunity to study later developmental events, such as organogenesis, at the molecular level. Our studies have focused on the development of the tadpole gut, where tissue specific promoters have yet to be identified. We have used m...

journal_title：Mechanisms of development

authors： Beck CW,Slack JM

更新日期：1999-11-01 00:00:00

abstract：:Noelins are secreted glycoproteins with important developmental functions in frogs and birds. Here, we present the expression pattern of the mouse homolog of Noelin-1/2 at E8-10 of development and compare this pattern to other vertebrates. Expression was observed in the neural plate and neural crest, as well as in the...

journal_title：Mechanisms of development

authors： Moreno TA,Bronner-Fraser M

更新日期：2002-11-01 00:00:00

abstract：:By means of subtractive and differential hybridization techniques we have identified a novel murine gene (1A13) the expression of which is developmentally regulated in the mouse brain. Comparison of the nucleotide and predicted protein sequence revealed closest relationship of 1A13 to human CoREST, a transcriptional c...

journal_title：Mechanisms of development

authors： Tontsch S,Zach O,Bauer HC

更新日期：2001-10-01 00:00:00

abstract：:The phylogenetic location of hemichordates is unique because they seem to fill an evolutionary gap between echinoderms and chordates. We report here characterization of Pf-otx, a hemichordate ortholog of otx, with its embryonic and larval expression pattern. Pf-otx is initially expressed in the vegetal plate of the bl...

journal_title：Mechanisms of development

authors： Harada Y,Okai N,Taguchi S,Tagawa K,Humphreys T,Satoh N

更新日期：2000-03-01 00:00:00

abstract：:Haploinsufficiency for the HMG-box transcription factor SOX2 results in abnormalities of the human ventral forebrain and its derivative structures. These defects include anophthalmia (absence of eye), microphthalmia (small eye) and hypothalamic hamartoma (HH), an overgrowth of the ventral hypothalamus. To determine ho...

journal_title：Mechanisms of development

authors： Langer L,Taranova O,Sulik K,Pevny L

更新日期：2012-03-01 00:00:00

abstract：:Early in the development of the imaginal wing disc of Drosophila, the LIM-HD gene tailup (islet), together with the HD genes of the iroquois complex, specify the notum territory of the disc. Later, tailup has been shown to act as a prepattern gene that antagonizes formation of sensory bristles on the notum of this fly...

journal_title：Mechanisms of development

authors： de Navascués J,Modolell J

更新日期：2010-09-01 00:00:00