Regulation of urokinase expression in the developing avian heart: a role for the Ets-2 transcription factor.

abstract：:The Drosophila pointed gene encodes two ETS transcriptional activators, pointedP1 and pointedP2, sharing a common C-terminal ETS domain. In the embryonic central nervous system pointedP2 is required for midline glial cell differentiation, whereas, in the eye, pointedP2 is essential for photoreceptor cell differentiati...

journal_title：Mechanisms of development

authors： Albagli O,Klaes A,Ferreira E,Leprince D,Klämbt C

更新日期：1996-09-01 00:00:00

abstract：:The Fused (Fu) serine-threonine kinase and the Suppressor of fused (Su(fu)) product are part of the Hedgehog (Hh) signaling pathway both in embryos and in imaginal discs. In wing imaginal discs, the Hh signal induces Cubitus interruptus (Ci) accumulation and activates patched (ptc) and decapentaplegic (dpp) expression...

journal_title：Mechanisms of development

authors： Alves G,Limbourg-Bouchon B,Tricoire H,Brissard-Zahraoui J,Lamour-Isnard C,Busson D

更新日期：1998-11-01 00:00:00

abstract：:Here we report the use of double-stranded RNA (dsRNA) and morpholino technologies to specifically 'knock down' gene expression in early postimplantation mouse embryos. Sequence specific interference mediated by either dsRNA or by morpholino has been a useful tool for studying gene function in several organisms. Howeve...

journal_title：Mechanisms of development

authors： Mellitzer G,Hallonet M,Chen L,Ang SL

更新日期：2002-10-01 00:00:00

abstract：:A hallmark of germline cells throughout the animal kingdom is their ability to execute meiosis. However, despite its prime importance, little is known about how germline progenitors acquire this ability. In Drosophila, the primordial germ cells (PGCs) are characterized by the inheritance of germ plasm, which contains ...

journal_title：Mechanisms of development

authors： Mukai M,Hayashi Y,Kitadate Y,Shigenobu S,Arita K,Kobayashi S

更新日期：2007-08-01 00:00:00

abstract：:The mouse and human Hox complex consists of 39 genes in four linkage groups (A-D). Although the structure and expression patterns of most of these genes have been reported, the 5' members of the Hox C linkage group have been only partially characterized. Herein we report the primary and genomic structure of the mouse ...

journal_title：Mechanisms of development

authors： Hostikka SL,Capecchi MR

更新日期：1998-01-01 00:00:00

abstract：:Retinoic acid plays important roles in development, growth and differentiation by regulating the expression of target genes. A new retinoic acid-inducible gene, Stra6, has been identified in P19 embryonal carcinoma cells using a subtractive hybridization cDNA cloning technique. Stra6 codes for a very hydrophobic membr...

journal_title：Mechanisms of development

authors： Bouillet P,Sapin V,Chazaud C,Messaddeq N,Décimo D,Dollé P,Chambon P

更新日期：1997-05-01 00:00:00

abstract：:We report the cloning and expression of a novel murine forkhead/winged helix family member--Foxn4--that is expressed during neural development in the retina, the ventral hindbrain and spinal cord and dorsal midbrain. Retinal Foxn4 expression is associated with the zone of proliferating progenitor cells. In the mouse m...

journal_title：Mechanisms of development

authors： Gouge A,Holt J,Hardy AP,Sowden JC,Smith HK

更新日期：2001-09-01 00:00:00

abstract：:Nemo-like kinases define a novel family of serine/threonine kinases that are involved in integrating multiple signaling pathways. They are conserved regulators of Wnt/Wingless pathways, which may coordinate Wnt with TGFbeta-mediated signaling. Drosophila nemo was identified through its involvement in epithelial planar...

journal_title：Mechanisms of development

authors： Mirkovic I,Charish K,Gorski SM,McKnight K,Verheyen EM

更新日期：2002-11-01 00:00:00

abstract：:Six genes are vertebrate homologues of the homeobox-containing gene sine oculis, which plays an essential role in controlling Drosophila compound eye development. Here we report the identification and expression patterns of all three subfamilies of Xenopus Six genes. Two Six2 subfamily genes (Six1, Six2) showed very s...

journal_title：Mechanisms of development

authors： Ghanbari H,Seo HC,Fjose A,Brändli AW

更新日期：2001-03-01 00:00:00

abstract：:Nanos family members have been shown to act as translational repressors in the Drosophila and Caenorhabditis elegans germline, but direct evidence is missing for a similar function in vertebrates. Using a tethered function assay, we show that Xenopus Nanos1 is a translational repressor and that association with the RN...

journal_title：Mechanisms of development

authors： Lai F,Zhou Y,Luo X,Fox J,King ML

更新日期：2011-01-01 00:00:00

abstract：:DmFoxF is a novel Drosophila fork head domain factor, which is expressed in the visceral mesoderm of the embryo. Our data suggest that DmFoxF is the fly orthologue of the vertebrates FOXF1 and FOXF2 transcription factors. DmFoxF shares homology with FOXF1 and FOXF2 in its fork head domain, and it is able to specifical...

journal_title：Mechanisms of development

authors： Pérez Sánchez C,Casas-Tintó S,Sánchez L,Rey-Campos J,Granadino B

更新日期：2002-02-01 00:00:00

abstract：:Haploinsufficiency for the HMG-box transcription factor SOX2 results in abnormalities of the human ventral forebrain and its derivative structures. These defects include anophthalmia (absence of eye), microphthalmia (small eye) and hypothalamic hamartoma (HH), an overgrowth of the ventral hypothalamus. To determine ho...

journal_title：Mechanisms of development

authors： Langer L,Taranova O,Sulik K,Pevny L

更新日期：2012-03-01 00:00:00

abstract：:The transgenic sequences in the mouse line TKZ751 are demethylated on a DBA/2 inbred strain background but become highly methylated at postimplantation stages in offspring of a cross with a BALB/c female. In the reciprocal cross the transgene remains demethylated suggesting that imprinted BALB/c methylation modifiers ...

journal_title：Mechanisms of development

authors： Pickard B,Dean W,Engemann S,Bergmann K,Fuermann M,Jung M,Reis A,Allen N,Reik W,Walter J

更新日期：2001-05-01 00:00:00

abstract：:Msg1 and Mrg1 are founding members of a gene family which exhibit distinct patterns of gene expression during mouse embryogenesis. Sequence analysis reveals that these genes are unlike any other gene identified to date, but they share two near-identical sequence domains. The Msg1 and Mrg1 expression profiles during ea...

journal_title：Mechanisms of development

authors： Dunwoodie SL,Rodriguez TA,Beddington RS

更新日期：1998-03-01 00:00:00

abstract：:The localization of RNAs at the vegetal cortex in Xenopus oocytes is a complex process, involving at least two different pathways. The early, or messenger transport organizer (METRO), pathway, localizes RNAs such as Xlsirts, Xcat2 and Xwnt11 during stages 1 and 2 of oogenesis, while the late pathway localizes RNAs suc...

journal_title：Mechanisms of development

authors： Kloc M,Etkin LD

更新日期：1998-04-01 00:00:00

abstract：:The normal embryogenesis of marine animals is typically confined to a species-specific range of temperatures. Within that temperature range development results in a consistent, or canalized, phenotype, whereas above and below the range abnormal phenotypes are produced. This study reveals a high temperature threshold, ...

journal_title：Mechanisms of development

authors： Irvine SQ,McNulty KB,Siler EM,Jacobson RE

更新日期：2019-06-01 00:00:00

abstract：:To examine the role of the Oct-6 gene in Schwann cell differentiation we have cloned and characterized the chicken and zebrafish homologues of the mouse Oct-6 gene. While highly homologous in the Pit1-Oct1/2-Unc86 (POU) domain, sequence similarities are limited outside this domain. Both genes are intronless and both p...

journal_title：Mechanisms of development

authors： Levavasseur F,Mandemakers W,Visser P,Broos L,Grosveld F,Zivkovic D,Meijer D

更新日期：1998-06-01 00:00:00

abstract：:DEADSouth was selected in a screen for localized RNAs in Xenopus oocytes. In situ hybridization analysis shows that DEADSouth localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with germ plasm during early embryogenesis. These results lend further support for the general conc...

journal_title：Mechanisms of development

authors： MacArthur H,Houston DW,Bubunenko M,Mosquera L,King ML

更新日期：2000-07-01 00:00:00

abstract：:The embryonic fins and the tip of adult fins of teleost fish are supported by rows of straight, unmineralized fibrils called actinotrichia. The proximal ends of the actinotrichia are bundled and the mineralized bones called lepidotrichia are made along them. Since malformation in actinotrichia causes wavy fin bones, t...

journal_title：Mechanisms of development

authors： Kuroda J,Iwane AH,Kondo S

更新日期：2018-10-01 00:00:00

abstract：:Vegetally localized RNAs in Xenopus oocytes have been implicated in the establishment of the primary germ layers and the formation and development of the primordial germ cells. fatvg mRNA is localized through the late pathway to the vegetal cortex. Like Vg1 mRNA fatvg is distributed throughout the entire cortex; howev...

journal_title：Mechanisms of development

authors： Chan AP,Kloc M,Bilinski S,Etkin LD

更新日期：2001-01-01 00:00:00

abstract：:The maturation of T cells is an intricate process involving the interaction of developing thymocytes with discrete microenvironments within the thymus. Numerous studies have indicated that distinct thymic compartments provide signals required for each stage of thymocyte maturation. In this study we performed a compreh...

journal_title：Mechanisms of development

authors： Vergara-Silva A,Schaefer KL,Berg LJ

更新日期：2002-12-01 00:00:00

abstract：:We describe the cloning, expression pattern and functional overexpression analysis of Xotx5b, a new member of the Otx gene family in Xenopus laevis. Early expression of Xotx5b resembles that of Xotx2, being detected in the organizer region at early gastrula stage, and, shortly after, also in anterior neuroectoderm. Du...

journal_title：Mechanisms of development

authors： Vignali R,Colombetti S,Lupo G,Zhang W,Stachel S,Harland RM,Barsacchi G

更新日期：2000-08-01 00:00:00

abstract：:We isolated a novel gene by a differential-display RT-PCR method comparing basal disk tissue and peduncle tissue in a species of Hydra, Pelmatohydra robusta, and we referred to it as anklet. The putative anklet product has a signal sequence in its N-terminus, and it has one MAC/PF domain and one EGF domain. In normal ...

journal_title：Mechanisms of development

authors： Amimoto Y,Kodama R,Kobayakawa Y

更新日期：2006-05-01 00:00:00

abstract：:We have investigated in detail the expression patterns of two Gata genes, cGata2 and cGata3, during early chick development. In addition to confirming previously described expression of these two genes in developing brain, kidney and blood islands, this study reveals several important novel expression domains during v...

journal_title：Mechanisms of development

authors： Sheng G,Stern CD

更新日期：1999-09-01 00:00:00

abstract：:In the Drosophila embryonic CNS several subtypes of glial cells develop, which arrange themselves at characteristic positions and presumably fulfil specific functions. The mechanisms leading to the specification and differentiation of glial subtypes are largely unknown. By DiI labelling in glia-specific Gal4 lines we ...

journal_title：Mechanisms of development

authors： Beckervordersandforth RM,Rickert C,Altenhein B,Technau GM

更新日期：2008-05-01 00:00:00

abstract：:The products of the trithorax gene are required to stably maintain homeotic gene expression patterns established during embryo-genesis by the action of the transiently expressed segmentation genes. We have determined the intron/exon structure of the trx gene and the large alternatively spliced trx RNAs, which are capa...

journal_title：Mechanisms of development

authors： Stassen MJ,Bailey D,Nelson S,Chinwalla V,Harte PJ

更新日期：1995-08-01 00:00:00

abstract：:Mitochondrial large rRNA (mtlrRNA) and small rRNA (mtsrRNA) have been identified as components of germinal granules in Drosophila. We have previously reported that mtlrRNA is present on the germinal granules in Xenopus embryos. Here we report that mtsrRNA is also a common component of the germinal granules. Extra-mito...

journal_title：Mechanisms of development

authors： Kashikawa M,Amikura R,Kobayashi S

更新日期：2001-03-01 00:00:00

abstract：:The maintenance of pluripotential embryonic stem (ES) cells is dependent on the cytokine LIF. This report documents the mRNA expression profiles of LIF and the two components of the LIF-receptor complex, LIF-R and gp130, during early mouse embryogenesis. These mRNAs were undetectable in 1- or 2-cell embryos, but all w...

journal_title：Mechanisms of development

authors： Nichols J,Davidson D,Taga T,Yoshida K,Chambers I,Smith A

更新日期：1996-07-01 00:00:00

abstract：:Early in the development of the imaginal wing disc of Drosophila, the LIM-HD gene tailup (islet), together with the HD genes of the iroquois complex, specify the notum territory of the disc. Later, tailup has been shown to act as a prepattern gene that antagonizes formation of sensory bristles on the notum of this fly...

journal_title：Mechanisms of development

authors： de Navascués J,Modolell J

更新日期：2010-09-01 00:00:00

abstract：:We previously showed that otx2 activates ectopic formation of the Xenopus cement gland only in ventrolateral ectoderm, defining a region of the embryo permissive for cement gland formation. In this paper, we explore the molecular identity of this permissive area. One candidate permissive factor is BMP4, whose putative...

journal_title：Mechanisms of development

authors： Gammill LS,Sive H

更新日期：2000-04-01 00:00:00