Xotx5b, a new member of the Otx gene family, may be involved in anterior and eye development in Xenopus laevis.


:We describe the cloning, expression pattern and functional overexpression analysis of Xotx5b, a new member of the Otx gene family in Xenopus laevis. Early expression of Xotx5b resembles that of Xotx2, being detected in the organizer region at early gastrula stage, and, shortly after, also in anterior neuroectoderm. During neurula stages Xotx5b exhibits a changing and dynamic pattern of expression. After neural tube closure, Xotx5b is expressed in the eye and pineal gland, both involved in photoreception. Overexpression of Xotx5b has a similar effect to that of Xotx2, producing posterior truncations and inducing ectopic cement gland and neural tissue in whole embryos. In animal cap assays, Xotx5b and Xotx2 are both able to activate XAG, to strongly suppress the expression of the epidermal marker XK81, and to reciprocally activate each other. Finally, in einsteck transplantation assays, Xotx5b is able to respecify a tail/trunk organizer to a head organizer.


Mech Dev


Vignali R,Colombetti S,Lupo G,Zhang W,Stachel S,Harland RM,Barsacchi G




Has Abstract


2000-08-01 00:00:00














  • Expression of a cysteine-rich protein (CRP) encoding gene during early development of the trout.

    abstract::Members of the cysteine-rich protein (CRP) define a subclass of LIM-only proteins implicated mainly in muscle differentiation. Until now, very little is known concerning the expression of CRP encoding genes during vertebrate development. We describe here the isolation of a trout (Oncorhynchus mykiss) gene encoding a c...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Delalande JM,Rescan PY

    更新日期:1998-08-01 00:00:00

  • Stimulation of circus movement by activin, bFGF and TGF-beta 2 in isolated animal cap cells of Xenopus laevis.

    abstract::Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dep...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Minoura I,Nakamura H,Tashiro K,Shiokawa K

    更新日期:1995-01-01 00:00:00

  • Neural and eye-specific defects associated with loss of the imitation switch (ISWI) chromatin remodeler in Xenopus laevis.

    abstract::Imitation Switch (ISWI) is a member of the SWI2/SNF2 superfamily of ATP-dependent chromatin remodelers, which regulate transcription and maintain chromatin structure by mobilizing nucleosomes using the energy of ATP. Four distinct ISWI complexes have been identified in Xenopus oocytes. The developmental role of Xenopu...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Dirscherl SS,Henry JJ,Krebs JE

    更新日期:2005-11-01 00:00:00

  • Innate immune cells are dispensable for regenerative growth of imaginal discs.

    abstract::Following tissue damage the immune response, including inflammation, has been considered an inevitable condition to build the host defense against invading pathogens. The recruitment of innate immune leukocytes to injured tissue is observed in both vertebrates and invertebrates. However, it is still not conclusive whe...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Katsuyama T,Paro R

    更新日期:2013-02-01 00:00:00

  • Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other.

    abstract::The Polycomb group genes in Drosophila are involved in the stable and inheritable repression of gene expression. The Polycomb group proteins probably operate as multimeric complexes that bind to chromatin. To investigate molecular mechanisms of stable repression of gene activity in vertebrates we have begun to study X...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Reijnen MJ,Hamer KM,den Blaauwen JL,Lambrechts C,Schoneveld I,van Driel R,Otte AP

    更新日期:1995-09-01 00:00:00

  • Protein expression pattern and analysis of differentially expressed peptides during various stages of tail regeneration in Hemidactylus flaviviridis.

    abstract::Epimorphic regeneration is a process allowing the animal to regain its lost structure which depends on the resident pluripotent stem cells as well as de-differentiation of existing cells to form multi-potent stem cells. Many studies have been done to understand the appendage regeneration mechanism. The animal model us...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Murawala H,Ranadive I,Patel S,Desai I,Balakrishnan S

    更新日期:2018-04-01 00:00:00

  • Normal table of embryonic development in the four-toed salamander, Hemidactylium scutatum.

    abstract::We present a complete staging table of normal development for the lungless salamander, Hemidactylium scutatum (Caudata: Plethodontidae). Terrestrial egg clutches from naturally ovipositing females were collected and maintained at 15 °C in the laboratory. Observations, photographs, and time-lapse movies of embryos were...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Hurney CA,Babcock SK,Shook DR,Pelletier TM,Turner SD,Maturo J,Cogbill S,Snow MC,Kinch K

    更新日期:2015-05-01 00:00:00

  • Regulation of runt transcription by Drosophila segmentation genes.

    abstract::The runt gene plays an important role in the genetic hierarchy that generates the segmented body pattern during the early stages of Drosophila embryogenesis. We studied mRNA expression in mutant embryos in order to investigate the regulation of runt transcription during these stages. We used sensitive whole-mount in s...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Klingler M,Gergen JP

    更新日期:1993-09-01 00:00:00

  • A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells.

    abstract::We have identified a Drosophila gene encoding a putative receptor tyrosine kinase by screening a genomic DNA library with a DNA probe for a Drosophila homolog of fibroblast growth factor receptors. The newly isolated gene codes for a transmembrane protein most similar in sequence to a mammalian proto-oncogene ret; thu...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Sugaya R,Ishimaru S,Hosoya T,Saigo K,Emori Y

    更新日期:1994-02-01 00:00:00

  • Understanding the somitogenesis clock: what's missing?

    abstract::The segmentation of vertebrate embryos depends on a complex genetic network that generates highly dynamic gene expression. Many of the elements of the network have been identified, but their interaction and their influence on segmentation remain poorly understood. A few mathematical models have been proposed to explai...

    journal_title:Mechanisms of development

    pub_type: 杂志文章,评审


    authors: Cinquin O

    更新日期:2007-08-01 00:00:00

  • Roles of basal keratinocytes in actinotrichia formation.

    abstract::The embryonic fins and the tip of adult fins of teleost fish are supported by rows of straight, unmineralized fibrils called actinotrichia. The proximal ends of the actinotrichia are bundled and the mineralized bones called lepidotrichia are made along them. Since malformation in actinotrichia causes wavy fin bones, t...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Kuroda J,Iwane AH,Kondo S

    更新日期:2018-10-01 00:00:00

  • Expression of PTTG and prc1 genes during telencephalic neurogenesis.

    abstract::We present the first time/space analysis using in situ hybridization for PTTG and prc1 genes during development of the mouse telencephalon. During the stages E11.5-E13.5 PTTG and prc1 are expressed in most tissues of the embryo. Within the telencephalon, PTTG and prc1 are found exclusively inside of the ventricular zo...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Tarabykin V,Britanova O,Fradkov A,Voss A,Katz LS,Lukyanov S,Gruss P

    更新日期:2000-04-01 00:00:00

  • caudal is required for gnathal and thoracic patterning and for posterior elongation in the intermediate-germband cricket Gryllus bimaculatus.

    abstract::Although the molecular mechanisms directing anteroposterior patterning of the Drosophila embryo (long-germband mode) are well understood, how these mechanisms were evolved from an ancestral mode of insect embryogenesis remains largely unknown. In order to gain insight into mechanisms of evolution in insect embryogenes...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Shinmyo Y,Mito T,Matsushita T,Sarashina I,Miyawaki K,Ohuchi H,Noji S

    更新日期:2005-02-01 00:00:00

  • Pancreas development and the Polycomb group protein complexes.

    abstract::The dual nature of pancreatic tissue permits both endocrine and exocrine functions. Enzymatic secretions by the exocrine pancreas help digestive processes while the pancreatic hormones regulate glucose homeostasis and energy metabolism. Pancreas organogenesis is defined by a conserved array of signaling pathways that ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章,评审


    authors: Dumasia NP,Pethe PS

    更新日期:2020-12-01 00:00:00

  • Pax6 in the sepiolid squid Euprymna scolopes: evidence for a role in eye, sensory organ and brain development.

    abstract::The cloning of a Pax6 orthologue from the sepiolid squid Euprymna scolopes and its developmental expression pattern are described. The data are consistent with the presence of a single gene encoding a protein with highly conserved DNA-binding paired and homeodomains. A detailed expression analysis by in situ hybridiza...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Hartmann B,Lee PN,Kang YY,Tomarev S,de Couet HG,Callaerts P

    更新日期:2003-02-01 00:00:00

  • Species-specific activation of EGF receptor signaling underlies evolutionary diversity in the dorsal appendage number of the genus Drosophila eggshells.

    abstract::In Drosophila melanogaster, the patterning of dorsal appendages on the eggshell is strictly controlled by EGFR signaling. However, the number of dorsal appendages is remarkably diverse among Drosophila species. For example, D. melanogaster and D. virilis have two and four dorsal appendages, respectively. Here we show ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Nakamura Y,Matsuno K

    更新日期:2003-08-01 00:00:00

  • Expansion of the polycomb system and evolution of complexity.

    abstract::Polycomb group (PcG) proteins regulate and maintain expression pattern of genes set early during development. Although originally isolated as regulators of homeotic genes, PcG members play a key role in epigenetic mechanisms that maintain the expression state of a large number of genes. All members of the two polycomb...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Sowpati DT,Ramamoorthy S,Mishra RK

    更新日期:2015-11-01 00:00:00

  • Forces driving cell sorting in the amphibian embryo.

    abstract::Adhesion differences are the main driver of cell sorting and related processes such as boundary formation or tissue positioning. In the early amphibian embryo, graded variations in cadherin density and localized expression of adhesion-modulating factors are associated with regional differences in adhesive properties i...

    journal_title:Mechanisms of development

    pub_type: 杂志文章,评审


    authors: Winklbauer R,Parent SE

    更新日期:2017-04-01 00:00:00

  • Dorsal dermis development depends on a signal from the dorsal neural tube, which can be substituted by Wnt-1.

    abstract::To investigate the origin and nature of the signals responsible for specification of the dermatomal lineage, excised axial organs in 2-day-old chick embryos were replaced by grafts of the dorsal neural tube, or the ventral neural tube plus the notochord, or aggregates of cells engineered to produce Sonic hedgehog (Shh...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Olivera-Martinez I,Thélu J,Teillet MA,Dhouailly D

    更新日期:2001-02-01 00:00:00

  • Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach.

    abstract::In the process of cloning murine proteins capable of binding to a regulatory module of the Ncam promoter, we isolated a novel homeobox gene, Barx1, the first vertebrate member of the structural subclass defined by Drosophila BarH1. Here we report its sequence, chromosomal localisation and embryonic expression pattern....

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Tissier-Seta JP,Mucchielli ML,Mark M,Mattei MG,Goridis C,Brunet JF

    更新日期:1995-05-01 00:00:00

  • The Tomita collection of medaka pigmentation mutants as a resource for understanding neural crest cell development.

    abstract::All body pigment cells in vertebrates are derived from the neural crest. In fish the neural crest can generate up to six different types of pigment cells, as well as various non-pigmented derivatives. In mouse and zebrafish, extensive collections of pigmentation mutants have enabled dissection of many aspects of pigme...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Kelsh RN,Inoue C,Momoi A,Kondoh H,Furutani-Seiki M,Ozato K,Wakamatsu Y

    更新日期:2004-07-01 00:00:00

  • ventral veins lacking is required for specification of the tritocerebrum in embryonic brain development of Drosophila.

    abstract::The homeotic or Hox genes encode a network of conserved transcription factors which provide axial positional information and control segment morphology in development and evolution. During embryonic brain development of Drosophila, the Hox gene labial (lab) is essential for tritocerebral neuromere specification; lab l...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Meier S,Sprecher SG,Reichert H,Hirth F

    更新日期:2006-01-01 00:00:00

  • Partial respecification of nasotemporal polarity in double-temporal chick and chimeric chick-quail eyes.

    abstract::In chick embryos, naso-temporal polarity of the retina becomes established before Hamburger-Hamilton stage 10. To examine the plasticity of the early eye anlage, double-temporal eyes were made using stage 10-11 (E1.5) chick embryos and stage 8-9 quail embryos. In vivo and in vitro experiments revealed that these doubl...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Mueller BK,Dütting D,Haase A,Feucht A,Macchi P

    更新日期:1998-06-01 00:00:00

  • Latin American contributions to the neural crest field.

    abstract::The neural crest (NC) is one of the most fascinating structures during embryonic development. Unique to vertebrate embryos, these cells give rise to important components of the craniofacial skeleton, such as the jaws and skull, as well as melanocytes and ganglia of the peripheral nervous system. Worldwide, several gro...

    journal_title:Mechanisms of development

    pub_type: 杂志文章,评审


    authors: Pescador GS,Trentin AG,Garcez RC

    更新日期:2018-10-01 00:00:00

  • Expanded retina territory by midbrain transformation upon overexpression of Six6 (Optx2) in Xenopus embryos.

    abstract::During vertebrate eye development, the expression of the homeobox gene Six6 is restricted to the neural retina and is initiated later than Rx and Pax6 in the presumptive retina field. We show here that overexpression of mouse Six6 in Xenopus embryos can induce transformation of competent tissue of the anterior neural ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Bernier G,Panitz F,Zhou X,Hollemann T,Gruss P,Pieler T

    更新日期:2000-05-01 00:00:00

  • Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development.

    abstract::Cell fate specification during inner ear development is dependent upon regional gene expression within the otic vesicle. One of the earliest cell fate determination steps in this system is the specification of neural precursors, and regulators of this process include the Atonal-related basic helix-loop-helix genes, Ng...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Friedman RA,Makmura L,Biesiada E,Wang X,Keithley EM

    更新日期:2005-05-01 00:00:00

  • Expression pattern of cLhx2b, cZic1 and cZic3 in the developing chick diencephalon.

    abstract::The diencephalon is the caudal part of the developing forebrain that gives rise to the epithalamus, thalamus, hypothalamus and retina. The mature diencephalon is functionally and anatomically parceled into well-defined nuclei. In an effort to understand how this region of the brain develops we examined the expression ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Lim Y,Golden JA

    更新日期:2002-07-01 00:00:00

  • Cell type dependent transcription regulation by chick homeodomain proteins.

    abstract::Five chick homeodomain proteins (CHOXs), CHOX-1.7, -1.1, -1.4, -4.2 and -2.6, had different transcription-regulating activities in a chick cultured cell line, LMH. In particular, CHOX-1.7 highly activated transcription when NP6 was used as the target site whereas CHOX-1.4 did not. This was mainly due to differences in...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Sasaki H,Yamamoto M,Kuroiwa A

    更新日期:1992-03-01 00:00:00

  • Planarian Gtsix3, a member of the Six/so gene family, is expressed in brain branches but not in eye cells.

    abstract::Six/sine oculis (Six/so) class genes, with representatives in vertebrates and invertebrates, include members with key developmental roles in the anterior part of the central nervous system (CNS) and eye. Having characterized the role of the first planarian gene of the Six/so family in eye development, we attempted to ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Pineda D,Saló E

    更新日期:2002-12-01 00:00:00

  • Ectopic expression of the Drosophila tramtrack gene results in multiple embryonic defects, including repression of even-skipped and fushi tarazu.

    abstract::The tramtrack (ttk) gene of Drosophila encodes 69-kDa and 88-kDa proteins through alternative splicing of the primary ttk transcript. The two proteins share a common amino-terminal sequence, but contain different carboxy-terminal portions, each of which has a distinct zinc finger domain with a unique DNA binding speci...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Read D,Levine M,Manley JL

    更新日期:1992-09-01 00:00:00