CtBP is required for proper development of peripheral nervous system in Drosophila.


:C-terminal binding protein (CtBP) is an evolutionarily and functionally conserved transcriptional corepressor known to integrate diverse signals to regulate transcription. Drosophila CtBP (dCtBP) regulates tissue specification and segmentation during early embryogenesis. Here, we investigated the roles of dCtBP during development of the peripheral nervous system (PNS). Our study includes a detailed quantitative analysis of how altered dCtBP activity affects the formation of adult mechanosensory bristles. We found that dCtBP loss-of-function resulted in a series of phenotypes with the most prevalent being supernumerary bristles. These dCtBP phenotypes are more complex than those caused by Hairless, a known dCtBP-interacting factor that regulates bristle formation. The emergence of additional bristles correlated with the appearance of extra sensory organ precursor (SOP) cells in earlier stages, suggesting that dCtBP may directly or indirectly inhibit SOP cell fates. We also found that development of a subset of bristles was regulated by dCtBP associated with U-shaped through the PxDLS dCtBP-interacting motif. Furthermore, the double bristle with sockets phenotype induced by dCtBP mutations suggests the involvement of this corepressor in additional molecular pathways independent of both Hairless and U-shaped. We therefore propose that dCtBP is part of a gene circuitry that controls the patterning and differentiation of the fly PNS via multiple mechanisms.


Mech Dev


Stern MD,Aihara H,Roccaro GA,Cheung L,Zhang H,Negeri D,Nibu Y




Has Abstract


2009-01-01 00:00:00














  • Innate immune cells are dispensable for regenerative growth of imaginal discs.

    abstract::Following tissue damage the immune response, including inflammation, has been considered an inevitable condition to build the host defense against invading pathogens. The recruitment of innate immune leukocytes to injured tissue is observed in both vertebrates and invertebrates. However, it is still not conclusive whe...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Katsuyama T,Paro R

    更新日期:2013-02-01 00:00:00

  • Epigenetic mechanisms and boundaries in the regulation of mammalian Hox clusters.

    abstract::Hox gene expression imparts segment identity to body structures along the anterior-posterior axis and is tightly governed by higher order chromatin mechanisms. Chromatin regulatory features of the homeotic complex are best defined in Drosophila melanogaster, where multiple cis-regulatory elements have been identified ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Srivastava S,Dhawan J,Mishra RK

    更新日期:2015-11-01 00:00:00

  • DEADSouth is a germ plasm specific DEAD-box RNA helicase in Xenopus related to eIF4A.

    abstract::DEADSouth was selected in a screen for localized RNAs in Xenopus oocytes. In situ hybridization analysis shows that DEADSouth localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with germ plasm during early embryogenesis. These results lend further support for the general conc...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: MacArthur H,Houston DW,Bubunenko M,Mosquera L,King ML

    更新日期:2000-07-01 00:00:00

  • MRG-1, a mortality factor-related chromodomain protein, is required maternally for primordial germ cells to initiate mitotic proliferation in C. elegans.

    abstract::We identified MRG-1, a Caenorhabditis elegans chromodomain-containing protein that is similar to the human mortality factor-related gene 15 product (MRG15). RNA-mediated interference (RNAi) of mrg-1 resulted in complete absence of the germline in both hermaphrodite and male adults. Examination of the expression of PGL...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Fujita M,Takasaki T,Nakajima N,Kawano T,Shimura Y,Sakamoto H

    更新日期:2002-06-01 00:00:00

  • Keratinocyte expression of transgenic hepatocyte growth factor affects melanocyte development, leading to dermal melanocytosis.

    abstract::Using the epidermis-specific cytokeratin 14 promoter to deliver HGF exclusively from epidermal keratinocytes, we have examined the potential of hepatocyte growth factor (HGF) secreted from the normal environment to control morphogenesis. The transgenic mice displayed a significant increase of the number of melanocytes...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Kunisada T,Yamazaki H,Hirobe T,Kamei S,Omoteno M,Tagaya H,Hemmi H,Koshimizu U,Nakamura T,Hayashi SI

    更新日期:2000-06-01 00:00:00

  • Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development.

    abstract::The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF-6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras t...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Kanai-Azuma M,Mattick JS,Kaibuchi K,Wood SA

    更新日期:2000-03-01 00:00:00

  • Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction.

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    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Sheth B,Fontaine JJ,Ponza E,McCallum A,Page A,Citi S,Louvard D,Zahraoui A,Fleming TP

    更新日期:2000-10-01 00:00:00

  • Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation.

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    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Walton KD,Wagner KU,Rucker EB 3rd,Shillingford JM,Miyoshi K,Hennighausen L

    更新日期:2001-12-01 00:00:00

  • Characterization of zebrafish smad1, smad2 and smad5: the amino-terminus of smad1 and smad5 is required for specific function in the embryo.

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    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Müller F,Blader P,Rastegar S,Fischer N,Knöchel W,Strähle U

    更新日期:1999-10-01 00:00:00

  • Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development.

    abstract::In mammals, the Ror-family receptor tyrosine kinases consist of two structurally related proteins, Ror1 and Ror2, characterized by the extracellular Frizzled-like cysteine-rich domain and membrane proximal kringle domains. As an attempt to gain insights into their roles in mouse development, expression patterns of Ror...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Matsuda T,Nomi M,Ikeya M,Kani S,Oishi I,Terashima T,Takada S,Minami Y

    更新日期:2001-07-01 00:00:00

  • The suppressor of forked gene of Drosophila, which encodes a homologue of human CstF-77K involved in mRNA 3'-end processing, is required for progression through mitosis.

    abstract::The Suppressor of forked (Su(f)) protein of Drosophila melanogaster is a homologue of the 77K subunit of human cleavage stimulation factor required for cleavage of pre-mRNAs before addition of poly(A). We have previously shown that the Su(f) protein is not ubiquitously distributed: it accumulates in dividing cells at ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Audibert A,Simonelig M

    更新日期:1999-04-01 00:00:00

  • Mesenchymal-to-epithelial transition of intercalating cells in Drosophila renal tubules depends on polarity cues from epithelial neighbours.

    abstract::The intercalation of mesenchymal cells into epithelia, through mesenchymal-to-epithelial transition (MET), underlies organogenesis, for example, in nephrogenesis, and tissue regeneration, during cell renewal and wound repair. Despite its importance, surprisingly little is known about the mechanisms that bring about ME...

    journal_title:Mechanisms of development

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    authors: Campbell K,Casanova J,Skaer H

    更新日期:2010-07-01 00:00:00

  • Xotx5b, a new member of the Otx gene family, may be involved in anterior and eye development in Xenopus laevis.

    abstract::We describe the cloning, expression pattern and functional overexpression analysis of Xotx5b, a new member of the Otx gene family in Xenopus laevis. Early expression of Xotx5b resembles that of Xotx2, being detected in the organizer region at early gastrula stage, and, shortly after, also in anterior neuroectoderm. Du...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Vignali R,Colombetti S,Lupo G,Zhang W,Stachel S,Harland RM,Barsacchi G

    更新日期:2000-08-01 00:00:00

  • In vivo time-lapse imaging in medaka--n-heptanol blocks contractile rhythmical movements.

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    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Rembold M,Wittbrodt J

    更新日期:2004-07-01 00:00:00

  • A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish.

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    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Neave B,Holder N,Patient R

    更新日期:1997-03-01 00:00:00

  • Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo.

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    journal_title:Mechanisms of development

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    authors: Maruoka Y,Ohbayashi N,Hoshikawa M,Itoh N,Hogan BL,Furuta Y

    更新日期:1998-06-01 00:00:00

  • Expression of the novel basic-helix-loop-helix transcription factor cMespo in presomitic mesoderm of chicken embryos.

    abstract::We have identified a novel chicken gene, cMespo, which encodes a basic-helix-loop-helix (bHLH) protein with sequence homology to a subgroup of bHLH transcription factors that have been implicated in somitogenesis. cMespo transcripts are first found in the primitive streak of gastrulating chick embryos (HH stage 4) and...

    journal_title:Mechanisms of development

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    authors: Buchberger A,Bonneick S,Arnold H

    更新日期:2000-10-01 00:00:00

  • Pax6 in the sepiolid squid Euprymna scolopes: evidence for a role in eye, sensory organ and brain development.

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    journal_title:Mechanisms of development

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    authors: Hartmann B,Lee PN,Kang YY,Tomarev S,de Couet HG,Callaerts P

    更新日期:2003-02-01 00:00:00

  • Involvement of fibroblast growth factor (FGF)18-FGF8 signaling in specification of left-right asymmetry and brain and limb development of the chick embryo.

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    journal_title:Mechanisms of development

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    authors: Ohuchi H,Kimura S,Watamoto M,Itoh N

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  • Dynamic expression of alternate splice forms of D-cbl during embryogenesis.

    abstract::The Cbl family of proteins act as E3 ubiquitin-protein ligases and have been associated with the down regulation of a variety of receptor tyrosine kinases. Cbl proteins associate with many different cell signalling molecules suggesting that they may have functions outside of the RING finger-mediated ubiquitin ligase a...

    journal_title:Mechanisms of development

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    authors: Hime GR,Abud HE,Garner B,Harris KL,Robertson H

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  • Transcription of XLPOU3, a brain-specific gene, during Xenopus laevis early embryogenesis.

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    journal_title:Mechanisms of development

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    authors: Baltzinger M,Relaix F,Remy P

    更新日期:1996-08-01 00:00:00

  • Subtypes of glial cells in the Drosophila embryonic ventral nerve cord as related to lineage and gene expression.

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    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Beckervordersandforth RM,Rickert C,Altenhein B,Technau GM

    更新日期:2008-05-01 00:00:00

  • Diverse modes of Drosophila tracheal fusion cell transcriptional regulation.

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    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Jiang L,Pearson JC,Crews ST

    更新日期:2010-05-01 00:00:00

  • Suboptimal 5' and 3' splice sites regulate alternative splicing of Drosophila melanogaster myosin heavy chain transcripts in vitro.

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    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Hodges D,Bernstein SI

    更新日期:1992-05-01 00:00:00

  • Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein.

    abstract::Retinoic acid plays important roles in development, growth and differentiation by regulating the expression of target genes. A new retinoic acid-inducible gene, Stra6, has been identified in P19 embryonal carcinoma cells using a subtractive hybridization cDNA cloning technique. Stra6 codes for a very hydrophobic membr...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Bouillet P,Sapin V,Chazaud C,Messaddeq N,Décimo D,Dollé P,Chambon P

    更新日期:1997-05-01 00:00:00

  • Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal.

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    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Grosshans J,Schnorrer F,Nüsslein-Volhard C

    更新日期:1999-03-01 00:00:00

  • TGF-beta2 neutralization inhibits proliferation and activates apoptosis of cerebellar granule cell precurors in the developing cerebellum.

    abstract::Transforming growth factor beta 2 (TGF-beta2) plays a critical role in growth, differentiation and cell death, but its function in the developing cerebellum is still uncertain. In this study we analyzed the effects of TGF-beta2 on ex vivo developing cerebellar slice cultures. Proliferation of granule cell precursors p...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Elvers M,Pfeiffer J,Kaltschmidt C,Kaltschmidt B

    更新日期:2005-04-01 00:00:00

  • Cloning and developmental expression of Baf57 in Xenopus laevis.

    abstract::Mammalian and Drosophila homologues of Baf57 have been previously isolated as being a subunit of SWI/SNF-like chromatin remodeling complexes. Here, we report the cloning and developmental expression of Xenopus Baf57. We isolated XBaf57 by using an expression cloning approach to identify novel modulators of Xenopus Sma...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Domingos PM,Obukhanych TV,Altmann CR,Hemmati-Brivanlou A

    更新日期:2002-08-01 00:00:00

  • Apoptotic forces in tissue morphogenesis.

    abstract::It is now well established that apoptosis is induced in response to mechanical strain. Indeed, increasing compressive forces induces apoptosis in confined spheroids of tumour cells, whereas releasing stress reduces apoptosis in spheroids cultivated in free suspension (Cheng et al., 2009). Apoptosis can also be induced...

    journal_title:Mechanisms of development

    pub_type: 杂志文章,评审


    authors: Ambrosini A,Gracia M,Proag A,Rayer M,Monier B,Suzanne M

    更新日期:2017-04-01 00:00:00

  • Differential expression and function of cadherin-like proteins in the sea urchin embryo.

    abstract::Cadherins are Ca(+2)-dependent cell surface proteins involved in the specification of the adhesive properties of cells. They are supposed to play a critical role in morphogenesis and pattern formation. In this paper we show that in the sea urchin embryo there are at least two different cadherins of relative molecular ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Ghersi G,Salamone M,Dolo V,Levi G,Vittorelli ML

    更新日期:1993-04-01 00:00:00