Developmental expression of the hemichordate otx ortholog.

abstract：:Nanos family members have been shown to act as translational repressors in the Drosophila and Caenorhabditis elegans germline, but direct evidence is missing for a similar function in vertebrates. Using a tethered function assay, we show that Xenopus Nanos1 is a translational repressor and that association with the RN...

journal_title：Mechanisms of development

authors： Lai F,Zhou Y,Luo X,Fox J,King ML

更新日期：2011-01-01 00:00:00

abstract：:Endoreduplication cycles that lead to an increase of DNA ploidy and cell size occur in distinct spatial and temporal patterns during Drosophila development. Only little is known about the regulation of these modified cell cycles. We have investigated fore- and hindgut development and we present evidence that the Droso...

journal_title：Mechanisms of development

authors： Fuss B,Meissner T,Bauer R,Lehmann C,Eckardt F,Hoch M

更新日期：2001-01-01 00:00:00

abstract：:Haploinsufficiency for the HMG-box transcription factor SOX2 results in abnormalities of the human ventral forebrain and its derivative structures. These defects include anophthalmia (absence of eye), microphthalmia (small eye) and hypothalamic hamartoma (HH), an overgrowth of the ventral hypothalamus. To determine ho...

journal_title：Mechanisms of development

authors： Langer L,Taranova O,Sulik K,Pevny L

更新日期：2012-03-01 00:00:00

abstract：:Nuclear orphan receptors are DNA binding proteins that share the domain structure of the nuclear hormone receptor superfamily, although ligands are unknown. We have identified an orphan receptor in Xenopus laevis and named it xGCNF based on its high degree of sequence homology to the previously described murine germ c...

journal_title：Mechanisms of development

authors： Joos TO,David R,Dreyer C

更新日期：1996-11-01 00:00:00

abstract：:Compelling evidence from in vivo model systems within the past decade shows that the APP family of proteins is important for synaptic development and function in the central and peripheral nervous systems. The synaptic role promises to be complex and multifaceted for several reasons. The three family members have over...

journal_title：Mechanisms of development

authors： Caldwell JH,Klevanski M,Saar M,Müller UC

更新日期：2013-06-01 00:00:00

abstract：:Tubby is a mouse gene that may provide a model for adult-onset obesity in humans. It is a member of a four gene family in mammals that collectively encode the Tubby-like proteins (TULPs), putative transcription factors which share similar 260 amino acid 'tubby domains' at their C-termini. The mammalian genome also enc...

journal_title：Mechanisms of development

authors： Ronshaugen M,McGinnis N,Inglis D,Chou D,Zhao J,McGinnis W

更新日期：2002-09-01 00:00:00

abstract：:Dystroglycan is a transmembrane receptor protein that provides a structural linkage between extracellular matrix components and cytoskeletal proteins. It was originally characterized as a member of dystrophin associated protein complex in muscle but, unlike other proteins of this complex, mutations in the dystroglycan...

journal_title：Mechanisms of development

authors： Lunardi A,Dente L

更新日期：2002-12-01 00:00:00

abstract：:Blood vessel maturation, which is characterized by the investment of vascular smooth muscle cells (vSMCs) around developing blood vessels, begins when vessels remodel into a hierarchy of proximal arteries and proximal veins that branch into smaller distal capillaries. The ultimate result of maturation is formation of ...

journal_title：Mechanisms of development

authors： Padget RL,Mohite SS,Hoog TG,Justis BS,Green BE,Udan RS

更新日期：2019-04-01 00:00:00

abstract：:The Dan gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in vertebrates. Xenopus DAN, as with Cerberus and Gremlin, was demonstrated to block bone morphogenetic protein (BMP) signaling by binding BMPs, and to be capable of inducing a...

journal_title：Mechanisms of development

authors： Ogita J,Isogai E,Sudo H,Sakiyama S,Nakagawara A,Koseki H

更新日期：2001-12-01 00:00:00

abstract：:We have characterised the transdifferentiation of human HepG2 (hepatoma) cells to pancreatic cells following introduction of an activated version of the pancreatic transcription factor Pdx1 (XlHbox8-VP16). The following questions are addressed: (1) are all types of pancreatic cells produced? (2) is the requirement for...

journal_title：Mechanisms of development

authors： Li WC,Horb ME,Tosh D,Slack JM

更新日期：2005-06-01 00:00:00

abstract：:Three homeobox genes, one from Drosophila melanogaster (Drosophila Hmx gene) and two from mouse (murine Hmx2 and Hmx3) were isolated and the full-length cDNAs and corresponding genomic structures were characterized. The striking homeodomain similarity encoded by these three genes to previously identified genes in sea ...

journal_title：Mechanisms of development

authors： Wang W,Lo P,Frasch M,Lufkin T

更新日期：2000-12-01 00:00:00

abstract：:The Fused (Fu) serine-threonine kinase and the Suppressor of fused (Su(fu)) product are part of the Hedgehog (Hh) signaling pathway both in embryos and in imaginal discs. In wing imaginal discs, the Hh signal induces Cubitus interruptus (Ci) accumulation and activates patched (ptc) and decapentaplegic (dpp) expression...

journal_title：Mechanisms of development

authors： Alves G,Limbourg-Bouchon B,Tricoire H,Brissard-Zahraoui J,Lamour-Isnard C,Busson D

更新日期：1998-11-01 00:00:00

abstract：:During vertebrate eye development, the expression of the homeobox gene Six6 is restricted to the neural retina and is initiated later than Rx and Pax6 in the presumptive retina field. We show here that overexpression of mouse Six6 in Xenopus embryos can induce transformation of competent tissue of the anterior neural ...

journal_title：Mechanisms of development

authors： Bernier G,Panitz F,Zhou X,Hollemann T,Gruss P,Pieler T

更新日期：2000-05-01 00:00:00

abstract：:The neural crest (NC) is one of the most fascinating structures during embryonic development. Unique to vertebrate embryos, these cells give rise to important components of the craniofacial skeleton, such as the jaws and skull, as well as melanocytes and ganglia of the peripheral nervous system. Worldwide, several gro...

journal_title：Mechanisms of development

authors： Pescador GS,Trentin AG,Garcez RC

更新日期：2018-10-01 00:00:00

abstract：:Drosophila tracheal fusion cells play multiple important roles in guiding and facilitating tracheal branch fusion. Mechanistic understanding of how fusion cells function during development requires deciphering their transcriptional circuitry. In this paper, three genes with distinct patterns of fusion cell expression ...

journal_title：Mechanisms of development

authors： Jiang L,Pearson JC,Crews ST

更新日期：2010-05-01 00:00:00

abstract：:The expression pattern of the receptor tyrosine kinase gene EphB3 was examined during the early stages of chick embryogenesis, and is described in this report. In the gastrula, EphB3 is expressed in epiblast cells adjacent to and entering the anterior portion of the primitive streak; expression is extinguished once ce...

journal_title：Mechanisms of development

authors： Baker RK,Vanderboom AK,Bell GW,Antin PB

更新日期：2001-06-01 00:00:00

abstract：:During the third larval instar, the steroid moulting hormone ecdysone activates three temporally distinct puff sets on the D. melanogaster salivary gland polytene chromosome: the so-called intermoult, early and late puffs. Hormonal regulation of intermoult puffs is quite complex and, so far, largely not understood. In...

journal_title：Mechanisms of development

authors： D'Avino PP,Crispi S,Polito LC,Furia M

更新日期：1995-02-01 00:00:00

abstract：:During heart development, cells of the endocardial cushions undergo an epithelial-mesenchymal transformation and migrate into the surrounding extracellular matrix. This event is required for the normal formation of valves and chamber septation. Coincident with this phenotypic change is the expression of the serine pro...

journal_title：Mechanisms of development

authors： Majka SM,McGuire PG

更新日期：1997-11-01 00:00:00

abstract：:Recent work identified an apoptotic program in gastrulation stage Xenopus embryos (Anderson, J.A., Lewellyn, A.L., Maller, J.L., 1997. Mol. Biol. Cell 8, 1195-1206; Stack, J.H., Newport, J.W., 1997. Development 124, 3185-3195). Here, we characterize in detail this maternal cell death program, which is set up at fertil...

journal_title：Mechanisms of development

authors： Hensey C,Gautier J

更新日期：1997-12-01 00:00:00

abstract：:Unlike gap genes in the trunk region of Drosophila embryos, gap genes in the head were presumed not to regulate each other's transcription. Here, we show that in tailless (tll) loss-of-function mutants the empty spiracles (ems) expression domain in the head expands, whereas it retracts in tll gain-of-function embryos....

journal_title：Mechanisms of development

authors： Hartmann B,Reichert H,Walldorf U

更新日期：2001-12-01 00:00:00

abstract：:Myogenin and CMD1, the chicken homologue of MyoD, transactivate the promoter of the alpha-subunit of the acetylcholine receptor (AChR) in chicken fibroblasts. The expression of these three genes was followed by in situ hybridization. In two-day-old embryos the CMD1 gene is expressed shortly before the AChR alpha-subun...

journal_title：Mechanisms of development

authors： Piette J,Huchet M,Duclert A,Fujisawa-Sehara A,Changeux JP

更新日期：1992-03-01 00:00:00

abstract：:We isolated and characterized embryonic lethal mutations in piragua (prg). The prg locus encodes a protein with an amino terminus Zinc Finger-Associated-Domain (ZAD) and nine C2H2 zinc fingers (ZF). prg mRNA and protein expression during embryogenesis is dynamic with widespread maternal contribution, and subsequent ex...

journal_title：Mechanisms of development

authors： Nazario-Yepiz NO,Riesgo-Escovar JR

更新日期：2017-04-01 00:00:00

abstract：:Epimorphic regeneration is a process allowing the animal to regain its lost structure which depends on the resident pluripotent stem cells as well as de-differentiation of existing cells to form multi-potent stem cells. Many studies have been done to understand the appendage regeneration mechanism. The animal model us...

journal_title：Mechanisms of development

authors： Murawala H,Ranadive I,Patel S,Desai I,Balakrishnan S

更新日期：2018-04-01 00:00:00

abstract：:We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is exp...

journal_title：Mechanisms of development

authors： Sumanas S,Ekker SC

更新日期：2001-05-01 00:00:00

abstract：:Fetal liver is the major embryonic hematopoietic organ and is extrinsically colonized by circulating hematopoietic stem cells (HSCs). Integrin beta-1 expression on HSCs is crucial for colonization, suggesting that interaction of Integrin beta-1 with extra-cellular matrix (ECM) factors promotes HSC adherence to fetal l...

journal_title：Mechanisms of development

authors： Sugiyama D,Kulkeaw K,Mizuochi C

更新日期：2013-02-01 00:00:00

abstract：:Nk(x)-type homeobox genes are an evolutionarily conserved family that regulate diverse developmental processes. Here we describe a novel Drosophila gene, Nk6, which encodes an Nk-type transcription factor most homologous to vertebrate Nkx6.1 and Nkx6.2. The homeodomains and NK decapeptide domains of all three proteins...

journal_title：Mechanisms of development

authors： Uhler J,Garbern J,Yang L,Kamholz J,Mellerick DM

更新日期：2002-08-01 00:00:00

abstract：:This is the first in situ hybridization analysis of expression of a tumor necrosis factor (TNF) receptor associated factor (TRAF) during development. TRAF4 is observed throughout mouse embryogenesis, most notably during ontogenesis of the central (CNS) and peripheral (PNS) nervous system, and of nervous tissues of sen...

journal_title：Mechanisms of development

authors： Masson R,Régnier CH,Chenard MP,Wendling C,Mattei MG,Tomasetto C,Rio MC

更新日期：1998-02-01 00:00:00

abstract：:In order to analyze the expression pattern of the 5'-nucleotidase (5nt) gene in Dictyostelium, we made a fusion construct in which the 5nt promoter directed the expression of beta-galactosidase gene. The reporter gene was not active in vegetative amoebae but was expressed during the aggregation stage. At the slug stag...

journal_title：Mechanisms of development

authors： Ubeidat M,Eristi CM,Rutherford CL

更新日期：2002-01-01 00:00:00

abstract：:The recent determination and annotation of the entire euchromatic sequence of the Drosophila melanogaster genome predicted the existence of about 13600 different genes (Science 287 (2000) 2185; http://www.fruitfly.org/annot/index.html). In parallel, the Berkeley Drosophila Genome Project (BDGP) has undertaken systemat...

journal_title：Mechanisms of development

authors： Bourbon HM,Gonzy-Treboul G,Peronnet F,Alin MF,Ardourel C,Benassayag C,Cribbs D,Deutsch J,Ferrer P,Haenlin M,Lepesant JA,Noselli S,Vincent A

更新日期：2002-01-01 00:00:00

abstract：:The homeobox gene superfamily is highly conserved during evolution. These genes act as transcription factors during several important developmental processes through their 60 amino acid homeodomains that recognize and bind to the regulatory region of their target genes. We isolated a novel homeobox gene designated Tex...

journal_title：Mechanisms of development

authors： Lai YL,Li H,Chiang HS,Hsieh-Li HM

更新日期：2002-05-01 00:00:00