Abstract:
:During vertebrate eye development, the expression of the homeobox gene Six6 is restricted to the neural retina and is initiated later than Rx and Pax6 in the presumptive retina field. We show here that overexpression of mouse Six6 in Xenopus embryos can induce transformation of competent tissue of the anterior neural plate into retinal tissue. In Six6 injected embryos, the molecular identity of the presumptive midbrain and rostral hindbrain regions was lost, as shown by the absence of XEn-2 and Xpax2 expression, being replaced by the ectopic expression of the retinal markers Xpax6 and Xrx. When allowed to grow further, Six6 injected embryos developed ectopic eye-like structures in the rostral brain and showed a transformation of the midbrain into retina. Similar results were obtained upon overexpression of Six3 or Xsix3, revealing a possible redundance of Six3 and Six6 activities. Taken together, results obtained suggest that during normal retina development, the relatively late expressed Six6 gene becomes part of a network of retinal homeobox genes that are linked together by positive feedback loops. Furthermore, our results demonstrate that the primitive neural ectoderm of the future midbrain and rostral hindbrain is competent to form retinal tissue.
journal_name
Mech Devjournal_title
Mechanisms of developmentauthors
Bernier G,Panitz F,Zhou X,Hollemann T,Gruss P,Pieler Tdoi
10.1016/s0925-4773(00)00271-9subject
Has Abstractpub_date
2000-05-01 00:00:00pages
59-69issue
1-2eissn
0925-4773issn
1872-6356pii
S0925477300002719journal_volume
93pub_type
杂志文章abstract::A hallmark of germline cells throughout the animal kingdom is their ability to execute meiosis. However, despite its prime importance, little is known about how germline progenitors acquire this ability. In Drosophila, the primordial germ cells (PGCs) are characterized by the inheritance of germ plasm, which contains ...
journal_title:Mechanisms of development
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:Mechanisms of development
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journal_title:Mechanisms of development
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/j.mod.2008.10.004
更新日期:2009-01-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/0925-4773(94)90041-8
更新日期:1994-09-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
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journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/s0925-4773(02)00289-7
更新日期:2002-11-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
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journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/j.mod.2004.08.005
更新日期:2005-01-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/0925-4773(95)00422-x
更新日期:1995-09-01 00:00:00
abstract::To elucidate roles of fibroblast growth factors (FGF)18 during vertebrate development, we examined expression patterns of Fgf18 in chick embryos and observed effects of FGF18 protein on the Hensen's node, isthmus, and limb buds. Fgf18 is expressed on the right side of the node before the expression of Fgf8 starts. FGF...
journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/s0925-4773(00)00331-2
更新日期:2000-07-01 00:00:00
abstract::Here we present the cloning of a full-length zebrafish pdgfr-alpha cDNA as well as the expression of this gene during zebrafish embryogenesis. We show that zebrafish pdgfr-alpha mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation. Spatially restricted ex...
journal_title:Mechanisms of development
pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/j.mod.2013.09.005
更新日期:2014-02-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章,评审
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更新日期:2020-12-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/0925-4773(93)90001-e
更新日期:1993-08-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/s0925-4773(00)00424-x
更新日期:2000-10-01 00:00:00
abstract::We have characterised a short (30 base pair) element from the Xenopus Wnt-5a promoter which is nearly identical to one located in the human Wnt-5a promoter, and has the same position relative to the transcription start site. When placed in front of a LacZ gene, this element can reproduce the same expression pattern ob...
journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/s0925-4773(99)00091-x
更新日期:1999-07-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
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journal_title:Mechanisms of development
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更新日期:2005-09-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/j.mod.2004.10.001
更新日期:2005-02-01 00:00:00
abstract::In mammals, the Ror-family receptor tyrosine kinases consist of two structurally related proteins, Ror1 and Ror2, characterized by the extracellular Frizzled-like cysteine-rich domain and membrane proximal kringle domains. As an attempt to gain insights into their roles in mouse development, expression patterns of Ror...
journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/s0925-4773(01)00383-5
更新日期:2001-07-01 00:00:00
abstract::Normal sexual differentiation in the genital organs is essential for the animal species that use sexual reproduction. Although it is known that doublesex (dsx) is required for the sexual development of the genitalia in various insect species, the direct target genes responsible for the sexual differentiation of the ge...
journal_title:Mechanisms of development
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章,评审
doi:10.1016/s0925-4773(01)00395-1
更新日期:2001-07-01 00:00:00
abstract::Cadherins are Ca(+2)-dependent cell surface proteins involved in the specification of the adhesive properties of cells. They are supposed to play a critical role in morphogenesis and pattern formation. In this paper we show that in the sea urchin embryo there are at least two different cadherins of relative molecular ...
journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/0925-4773(93)90054-2
更新日期:1993-04-01 00:00:00
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journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/s0925-4773(98)00009-4
更新日期:1998-02-01 00:00:00
abstract::We have cloned a chick homologue of Drosophila dachshund (dac), termed Dach1. Dach1 is the orthologue of mouse and human Dac/Dach (hereafter referred to as Dach1). We show that chick Dach1 is expressed in a variety of sites during embryonic development, including the eye and ear. Previous work has demonstrated the exi...
journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/s0925-4773(01)00611-6
更新日期:2002-02-01 00:00:00
abstract::We describe the sequence and expression pattern of Sp5, a novel member of the vertebrate Sp1 transcription factor gene family which consists of at least five members. This gene family is characterized by a highly conserved domain which is formed by three Zn fingers, which bind to the GC box or the GT/CACC box in the p...
journal_title:Mechanisms of development
pub_type: 杂志文章
doi:10.1016/s0925-4773(00)00544-x
更新日期:2001-03-01 00:00:00
abstract::Early in the development of the imaginal wing disc of Drosophila, the LIM-HD gene tailup (islet), together with the HD genes of the iroquois complex, specify the notum territory of the disc. Later, tailup has been shown to act as a prepattern gene that antagonizes formation of sensory bristles on the notum of this fly...
journal_title:Mechanisms of development
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00