Interaction of gap genes in the Drosophila head: tailless regulates expression of empty spiracles in early embryonic patterning and brain development.

abstract：:This study compares by immunogold labeling the ultrastructural localization of a hexameric 22S glycoprotein, called toposome, with that of hyalin in unfertilized eggs and cells of hatched sea urchin blastulae. Nearly all hyalin is present in the electron translucent compartment of the cortical granules and in the tran...

journal_title：Mechanisms of development

authors： Gratwohl EK,Kellenberger E,Lorand L,Noll H

更新日期：1991-02-01 00:00:00

abstract：:The dual nature of pancreatic tissue permits both endocrine and exocrine functions. Enzymatic secretions by the exocrine pancreas help digestive processes while the pancreatic hormones regulate glucose homeostasis and energy metabolism. Pancreas organogenesis is defined by a conserved array of signaling pathways that ...

journal_title：Mechanisms of development

authors： Dumasia NP,Pethe PS

更新日期：2020-12-01 00:00:00

abstract：:We describe the identification and detailed expression pattern of a second Drosophila Sox gene, SoxNeuro (SoxN), highly related to mammalian group B Sox1, 2, 3 genes. SoxN is expressed in a highly dynamic pattern during embyogenesis, being associated with the development of the central nervous system (CNS), from the e...

journal_title：Mechanisms of development

authors： Crémazy F,Berta P,Girard F

更新日期：2000-05-01 00:00:00

abstract：:In situ hybridization of mouse embryo whole mounts and sagittal sections revealed a tissue- and stage-specific expression pattern of the transcriptionally regulated serum and glucocorticoid-inducible protein kinase (sgk) during embryogenesis. Sgk expression is first observed at embryonic day 8.5 (E8.5) in the decidua ...

journal_title：Mechanisms of development

authors： Lee E,Lein ES,Firestone GL

更新日期：2001-05-01 00:00:00

abstract：:To investigate the origin and nature of the signals responsible for specification of the dermatomal lineage, excised axial organs in 2-day-old chick embryos were replaced by grafts of the dorsal neural tube, or the ventral neural tube plus the notochord, or aggregates of cells engineered to produce Sonic hedgehog (Shh...

journal_title：Mechanisms of development

authors： Olivera-Martinez I,Thélu J,Teillet MA,Dhouailly D

更新日期：2001-02-01 00:00:00

abstract：:ADAM19 is a member of the meltrin subfamily of ADAM metalloproteases. In Xenopus, ADAM19 is present as a maternal transcript. Zygotic expression starts during gastrulation and is apparent in the dorsal blastopore lip. ADAM19 expression through neurulation and tailbud formation becomes enriched in dorsal structures suc...

journal_title：Mechanisms of development

authors： Neuner R,Cousin H,McCusker C,Coyne M,Alfandari D

更新日期：2009-03-01 00:00:00

abstract：:The homeotic gene abdominal-A (abd-A) is normally expressed in parasegments 7 to 13. We find that the initial distribution of the product is approximately uniform within this domain, but the subsequent elaboration of the expression pattern results in differences between, as well as within, parasegments. We have invest...

journal_title：Mechanisms of development

authors： Macías A,Pelaz S,Morata G

更新日期：1994-04-01 00:00:00

abstract：:Dystroglycan is a transmembrane receptor protein that provides a structural linkage between extracellular matrix components and cytoskeletal proteins. It was originally characterized as a member of dystrophin associated protein complex in muscle but, unlike other proteins of this complex, mutations in the dystroglycan...

journal_title：Mechanisms of development

authors： Lunardi A,Dente L

更新日期：2002-12-01 00:00:00

abstract：:Mutations in the renin-angiotensin system (RAS) genes are associated with congenital anomalies of the kidney and urinary tract (CAKUT). As angiotensin (Ang) II, the principal effector peptide growth factor of the RAS, stimulates ureteric bud (UB) branching in whole intact embryonic (E) metanephroi, defects in UB morph...

journal_title：Mechanisms of development

authors： Song R,Preston G,Yosypiv IV

更新日期：2011-09-01 00:00:00

abstract：:We have made a null mutation in the mouse activin beta B gene by deleting the portion of the gene encoding the proteolytic cleavage site and the majority of the coding region for the mature processed protein. Mice homozygous for this mutation complete embryogenesis and are completely viable. Approximately 40% of the h...

journal_title：Mechanisms of development

authors： Schrewe H,Gendron-Maguire M,Harbison ML,Gridley T

更新日期：1994-07-01 00:00:00

abstract：:We investigated the expression pattern of the endothelin-A receptor and endothelin 1 genes, the mutations of which affect the development of the mesectodermal derivatives of the neural crest. We show here that endothelin 1 is expressed by the environment of the cephalic neural crest cells invading branchial arches. La...

journal_title：Mechanisms of development

authors： Nataf V,Grapin-Botton A,Champeval D,Amemiya A,Yanagisawa M,Le Douarin NM

更新日期：1998-07-01 00:00:00

abstract：:We describe the expression of three Runt-related RUNX genes (previously termed AML, Cbfa, or Pebp2alpha) Runx1 and Runx3 during the development of teeth and other craniofacial tissues and compare them to Runx2 expression reported earlier. All three genes were expressed in mesenchymal condensates. Runx1 was expressed i...

journal_title：Mechanisms of development

authors： Yamashiro T,Aberg T,Levanon D,Groner Y,Thesleff I

更新日期：2002-12-01 00:00:00

abstract：:The transcription factor scleraxis (SCX) is expressed throughout tendon development and plays a key role in directing tendon wound healing. However, little is known regarding its role in fetal or young postnatal tendons, stages in development that are known for their enhanced regenerative capabilities. Here we used RN...

journal_title：Mechanisms of development

authors： Paterson YZ,Evans N,Kan S,Cribbs A,Henson FMD,Guest DJ

更新日期：2020-09-01 00:00:00

abstract：:Transcription of the human interphotoreceptor retinoid binding protein (IRBP) gene is strictly tissue specific, being restricted to retinal photoreceptors and pinealocytes. We have previously demonstrated that a sequence named A element, in the IRBP promoter is essential for IRBP gene transcription in vivo. Here we de...

journal_title：Mechanisms of development

authors： Bobola N,Briata P,Ilengo C,Rosatto N,Craft C,Corte G,Ravazzolo R

更新日期：1999-04-01 00:00:00

abstract：:Increases in Na/K-ATPase activity occur concurrently with the onset of cavitation and are associated with increases in Na(+)-pump subunit mRNA and protein expression. We have hypothesized that the alpha1-isozyme of the Na/K-ATPase is required to mediate blastocyst formation. We have tested this hypothesis by character...

journal_title：Mechanisms of development

authors： Barcroft LC,Moseley AE,Lingrel JB,Watson AJ

更新日期：2004-05-01 00:00:00

abstract：:Maleless (mle) is essential in Drosophila melanogaster males both in somatic cells and in germ cells. In somatic cells mle is necessary for X-chromosome dosage compensation. The role of mle in the germline is unknown. We have analyzed the expression pattern and localization of MLE, the other MSLs and acetylated isofor...

journal_title：Mechanisms of development

authors： Rastelli L,Kuroda MI

更新日期：1998-02-01 00:00:00

abstract：:Cortactin is a Src substrate that interacts with F-actin and can stimulate actin polymerization by direct interaction with the Arp2/3 complex. We have isolated complete loss-of-function mutants of the single Drosophila cortactin gene. Mutants are viable and fertile, showing that cortactin is not an essential gene. How...

journal_title：Mechanisms of development

authors： Somogyi K,Rørth P

更新日期：2004-01-01 00:00:00

abstract：:High expression of the B1 Sox genes, Sox2 and Sox3, is associated with the development of definitive neural primordia, the neural plates, in early stage embryos. However, in the caudal lateral epiblast (CLE) where axial stem cells reside, Sox2 and Sox3 are expressed at low levels, together with Brachyury. Because axia...

journal_title：Mechanisms of development

authors： Yoshida M,Uchikawa M,Rizzoti K,Lovell-Badge R,Takemoto T,Kondoh H

更新日期：2014-05-01 00:00:00

abstract：:The forkhead type Brain Factor 2 from mouse and chicken help pattern the forebrain, optic vesicle and kidney. We have isolated a Xenopus homolog (Xbf2) and found that during gastrulation it is expressed in the dorsolateral mesoderm, where it helps specify this territory by downregulating BMP-4 and its downstream genes...

journal_title：Mechanisms of development

authors： Gómez-Skarmeta JL,de la Calle-Mustienes E,Modolell J,Mayor R

更新日期：1999-01-01 00:00:00

abstract：:DmFoxF is a novel Drosophila fork head domain factor, which is expressed in the visceral mesoderm of the embryo. Our data suggest that DmFoxF is the fly orthologue of the vertebrates FOXF1 and FOXF2 transcription factors. DmFoxF shares homology with FOXF1 and FOXF2 in its fork head domain, and it is able to specifical...

journal_title：Mechanisms of development

authors： Pérez Sánchez C,Casas-Tintó S,Sánchez L,Rey-Campos J,Granadino B

更新日期：2002-02-01 00:00:00

abstract：:The cloning of a Pax6 orthologue from the sepiolid squid Euprymna scolopes and its developmental expression pattern are described. The data are consistent with the presence of a single gene encoding a protein with highly conserved DNA-binding paired and homeodomains. A detailed expression analysis by in situ hybridiza...

journal_title：Mechanisms of development

authors： Hartmann B,Lee PN,Kang YY,Tomarev S,de Couet HG,Callaerts P

更新日期：2003-02-01 00:00:00

abstract：:During the development of the proventriculus (glandular stomach) of the chicken embryo, the endodermal epithelium invades into the surrounding mesenchyme and forms glands. The glandular epithelial cells produce pepsinogen, while the non-glandular (luminal) epithelial cells secrete mucus. Sonic hedgehog is expressed un...

journal_title：Mechanisms of development

authors： Fukuda K,Kameda T,Saitoh K,Iba H,Yasugi S

更新日期：2003-07-01 00:00:00

abstract：:The fork head domain-containing gene family (Fox) comprises over 20 members in mammals and is defined by a conserved 110 amino-acid motif containing a winged helix structure DNA-binding domain. The members of this gene family have been implicated as key regulators of embryogenesis, cell cycling, cell lineage restricti...

journal_title：Mechanisms of development

authors： Tribioli C,Robledo RF,Lufkin T

更新日期：2002-10-01 00:00:00

abstract：:Active repression of gene expression mediated by unliganded nuclear receptors plays crucial roles in early development of vertebrates. N-CoR (nuclear receptor co-repressor) is the first identified co-repressor that can repress retinoic acid (RA) inducible gene transcription in the absence of RA. Previously, N-CoR was ...

journal_title：Mechanisms of development

authors： Xu F,Li K,Tian M,Hu P,Song W,Chen J,Gao X,Zhao Q

更新日期：2009-10-01 00:00:00

abstract：:Tribolium castaneum is a well-characterised model insect, whose short germ-band mode of embryonic development is characteristic of many insect species and differs from the exhaustively studied Drosophila. Mechanisms of early neurogenesis, however, show significant conservation with Drosophila, as a characteristic patt...

journal_title：Mechanisms of development

authors： Kux K,Kiparaki M,Delidakis C

更新日期：2013-04-01 00:00:00

abstract：:In Xenopus and zebrafish, BMP2, 4 and 7 have been implicated, after the onset of zygotic expression, in inducing and maintaining ventro-lateral cell fate during early development. We provide evidence here that a maternally expressed bone morphogenetic protein (BMP), Radar, may control early ventral specification in ze...

journal_title：Mechanisms of development

authors： Goutel C,Kishimoto Y,Schulte-Merker S,Rosa F

更新日期：2000-12-01 00:00:00

abstract：:To elucidate roles of fibroblast growth factors (FGF)18 during vertebrate development, we examined expression patterns of Fgf18 in chick embryos and observed effects of FGF18 protein on the Hensen's node, isthmus, and limb buds. Fgf18 is expressed on the right side of the node before the expression of Fgf8 starts. FGF...

journal_title：Mechanisms of development

authors： Ohuchi H,Kimura S,Watamoto M,Itoh N

更新日期：2000-07-01 00:00:00

abstract：:The study of distal lung morphogenesis and vascular development would be greatly facilitated by an in vitro or ex vivo experimental model. In this study we show that the growth of mouse embryonic day 12.5 lung rudiments implanted underneath the kidney capsules of syngeneic or immunodeficient hosts follows closely lung...

journal_title：Mechanisms of development

authors： Vu TH,Alemayehu Y,Werb Z

更新日期：2003-03-01 00:00:00

abstract：:A key role for phosphorylation of Smad2 by TGFβ superfamily ligands in the axial patterning of early embryos is well established. The regulation and role of Smad2 signaling in post-neurula embryonic patterning, however, is less well understood. While a variety of TGFβ superfamily ligands are implicated in various stag...

journal_title：Mechanisms of development

authors： Ho DM,Yeo CY,Whitman M

更新日期：2010-09-01 00:00:00

abstract：:The odd-skipped (odd) gene encodes a zinc finger protein that represses other segmentation genes in the early Drosophila embryo. Though odd is initially expressed in a striped pattern that reflects its function within the segmentation hierarchy, it is also expressed in a variety of patterns during later stages of embr...

journal_title：Mechanisms of development

authors： Ward EJ,Coulter DE

更新日期：2000-09-01 00:00:00