Pax6 in the sepiolid squid Euprymna scolopes: evidence for a role in eye, sensory organ and brain development.

Abstract:

:The cloning of a Pax6 orthologue from the sepiolid squid Euprymna scolopes and its developmental expression pattern are described. The data are consistent with the presence of a single gene encoding a protein with highly conserved DNA-binding paired and homeodomains. A detailed expression analysis by in situ hybridization and immunodetection revealed Pax6 mRNA and protein with predominantly nuclear localization in the developing eye, olfactory organ, brain lobes (optic lobe, olfactory lobe, peduncle lobe, superior frontal lobe and dorsal basal lobe), arms and mantle, suggestive of a role in eye, brain, and sensory organ development.

journal_name

Mech Dev

authors

Hartmann B,Lee PN,Kang YY,Tomarev S,de Couet HG,Callaerts P

doi

10.1016/s0925-4773(02)00456-2

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

177-83

issue

2

eissn

0925-4773

issn

1872-6356

pii

S0925477302004562

journal_volume

120

pub_type

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