Species-specific activation of EGF receptor signaling underlies evolutionary diversity in the dorsal appendage number of the genus Drosophila eggshells.

abstract：:Mice with targeted disruption of the TGF beta 2 gene display defects in epithelial-mesenchymal tissue interactions in several tissues including the developing cochlea. Specifically, the region of the spiral limbus and the overlying interdental cells, structures putatively involved in endolymphatic fluid homeostasis, d...

journal_title：Mechanisms of development

authors： Paradies NE,Sanford LP,Doetschman T,Friedman RA

更新日期：1998-12-01 00:00:00

abstract：:Mitochondrial large rRNA (mtlrRNA) and small rRNA (mtsrRNA) have been identified as components of germinal granules in Drosophila. We have previously reported that mtlrRNA is present on the germinal granules in Xenopus embryos. Here we report that mtsrRNA is also a common component of the germinal granules. Extra-mito...

journal_title：Mechanisms of development

authors： Kashikawa M,Amikura R,Kobayashi S

更新日期：2001-03-01 00:00:00

abstract：:DCC (deleted in colon cancer), Neogenin and UNC-5 are all members of the immunoglobulin superfamily of transmembrane receptors which are believed to play a role in axon guidance by binding to their ligands, the Netrin/UNC-40 family of secreted molecules (Cell. Mol. Life Sci. 56 (1999) 62; Curr. Opin. Genet. Dev. 7 (19...

journal_title：Mechanisms of development

authors： Hjorth JT,Gad J,Cooper H,Key B

更新日期：2001-11-01 00:00:00

abstract：:We describe the structural organization of a gene, termed XFDL 141/156, that is transiently activated during early Xenopus development. XFDL 141/156 is first transcribed at the midblastula transition (MBT) and during early gastrulation events. A roughly 200 nucleotide fragment immediately 5' to the transcription start...

journal_title：Mechanisms of development

authors： Bellefroid E,Bourguignon C,Bouwmeester T,Rausch O,Blumberg B,Pieler T

更新日期：1997-04-01 00:00:00

abstract：:In the last years, several reports have established the notion that metabolism is not just a housekeeping process, but instead an active effector of physiological changes. The idea that the metabolic status may rule a wide range of phenomena in cell biology is starting to be broadly accepted. Thus, current development...

journal_title：Mechanisms of development

authors： Gándara L,Wappner P

更新日期：2018-12-01 00:00:00

abstract：:In this paper we analyze the expression in follicular cells and regulation of the vitelline membrane protein gene we identified in region 32E of the second chromosome of D. melanogaster (VMP32E). We report germ line transformation results obtained with different kinds of gene fusion leading to the identification of a ...

journal_title：Mechanisms of development

authors： Gargiulo G,Gigliotti S,Malva C,Graziani F

更新日期：1991-11-01 00:00:00

abstract：:The Drosophila wing is a classical model for studying the generation of developmental patterns. Previous studies have suggested that vein primordia form at boundaries between discrete sectors of gene expression along the antero-posterior (A/P) axis in the larval wing imaginal disc. Observation that the vein marker rho...

journal_title：Mechanisms of development

authors： Crozatier M,Glise B,Khemici V,Vincent A

更新日期：2003-05-01 00:00:00

abstract：:Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dep...

journal_title：Mechanisms of development

authors： Minoura I,Nakamura H,Tashiro K,Shiokawa K

更新日期：1995-01-01 00:00:00

abstract：:In order to analyze the expression pattern of the 5'-nucleotidase (5nt) gene in Dictyostelium, we made a fusion construct in which the 5nt promoter directed the expression of beta-galactosidase gene. The reporter gene was not active in vegetative amoebae but was expressed during the aggregation stage. At the slug stag...

journal_title：Mechanisms of development

authors： Ubeidat M,Eristi CM,Rutherford CL

更新日期：2002-01-01 00:00:00

abstract：:The vertebrate hindbrain is composed of a series of lineage-restricted segments termed rhombomeres. Segment-specific gene expression drives unique programs of neuronal differentiation. Two critical embryonic signaling pathways, Fibroblast Growth Factor (FGF) and Retinoic Acid (RA), regulate early embryonic rhombomere ...

journal_title：Mechanisms of development

authors： Selland LG,Koch S,Laraque M,Waskiewicz AJ

更新日期：2018-04-01 00:00:00

abstract：:The forkhead type Brain Factor 2 from mouse and chicken help pattern the forebrain, optic vesicle and kidney. We have isolated a Xenopus homolog (Xbf2) and found that during gastrulation it is expressed in the dorsolateral mesoderm, where it helps specify this territory by downregulating BMP-4 and its downstream genes...

journal_title：Mechanisms of development

authors： Gómez-Skarmeta JL,de la Calle-Mustienes E,Modolell J,Mayor R

更新日期：1999-01-01 00:00:00

abstract：:The expression pattern of the receptor tyrosine kinase gene EphB3 was examined during the early stages of chick embryogenesis, and is described in this report. In the gastrula, EphB3 is expressed in epiblast cells adjacent to and entering the anterior portion of the primitive streak; expression is extinguished once ce...

journal_title：Mechanisms of development

authors： Baker RK,Vanderboom AK,Bell GW,Antin PB

更新日期：2001-06-01 00:00:00

abstract：:Cell fate specification during inner ear development is dependent upon regional gene expression within the otic vesicle. One of the earliest cell fate determination steps in this system is the specification of neural precursors, and regulators of this process include the Atonal-related basic helix-loop-helix genes, Ng...

journal_title：Mechanisms of development

authors： Friedman RA,Makmura L,Biesiada E,Wang X,Keithley EM

更新日期：2005-05-01 00:00:00

abstract：:Cadherins are Ca(+2)-dependent cell surface proteins involved in the specification of the adhesive properties of cells. They are supposed to play a critical role in morphogenesis and pattern formation. In this paper we show that in the sea urchin embryo there are at least two different cadherins of relative molecular ...

journal_title：Mechanisms of development

authors： Ghersi G,Salamone M,Dolo V,Levi G,Vittorelli ML

更新日期：1993-04-01 00:00:00

abstract：:Three homeobox genes, one from Drosophila melanogaster (Drosophila Hmx gene) and two from mouse (murine Hmx2 and Hmx3) were isolated and the full-length cDNAs and corresponding genomic structures were characterized. The striking homeodomain similarity encoded by these three genes to previously identified genes in sea ...

journal_title：Mechanisms of development

authors： Wang W,Lo P,Frasch M,Lufkin T

更新日期：2000-12-01 00:00:00

abstract：:We have identified a short segment of the mouse Pax-6 gene 5' flanking region that is necessary and sufficient for reporter construct expression in components of the eye derived from non-neural ectoderm. This transcriptional control element has a highly conserved nucleotide sequence over 341 bp and is located approxim...

journal_title：Mechanisms of development

authors： Williams SC,Altmann CR,Chow RL,Hemmati-Brivanlou A,Lang RA

更新日期：1998-05-01 00:00:00

abstract：:Exogenously applied retinoic acid given at the early stages of gastrulation causes abnormal development of the caudal midbrain and anterior hindbrain in vertebrate embryos. We describe the limits of the brain regions that are affected using neuroanatomical criteria in the zebrafish embryo. Analysis of the reticulospin...

journal_title：Mechanisms of development

authors： Hill J,Clarke JD,Vargesson N,Jowett T,Holder N

更新日期：1995-03-01 00:00:00

abstract：:A hallmark of germline cells throughout the animal kingdom is their ability to execute meiosis. However, despite its prime importance, little is known about how germline progenitors acquire this ability. In Drosophila, the primordial germ cells (PGCs) are characterized by the inheritance of germ plasm, which contains ...

journal_title：Mechanisms of development

authors： Mukai M,Hayashi Y,Kitadate Y,Shigenobu S,Arita K,Kobayashi S

更新日期：2007-08-01 00:00:00

abstract：:Deflecting biomineralized crystals attached to vestibular hair cells are necessary for maintaining balance. Zebrafish (Danio rerio) are useful organisms to study these biomineralized crystals called otoliths, as many required genes are homologous to human otoconial development. We sought to identify and characterize t...

journal_title：Mechanisms of development

authors： Thiessen KD,Grzegorski SJ,Chin Y,Higuchi LN,Wilkinson CJ,Shavit JA,Kramer KL

更新日期：2019-06-01 00:00:00

abstract：:The recent development of transgenic methods for the frog Xenopus laevis provides the opportunity to study later developmental events, such as organogenesis, at the molecular level. Our studies have focused on the development of the tadpole gut, where tissue specific promoters have yet to be identified. We have used m...

journal_title：Mechanisms of development

authors： Beck CW,Slack JM

更新日期：1999-11-01 00:00:00

abstract：:The Retinal homeobox gene (Rx; also Rax) plays a crucial role in the early development of the vertebrate eye. Germline deletion of Rx in mice results in the failure of optic vesicle formation, leading to anophthalmia. Recent research using conditional mouse knockout models provides some clues to the role of Rx in eye ...

journal_title：Mechanisms of development

authors： Rodgers HM,Huffman VJ,Voronina VA,Lewandoski M,Mathers PH

更新日期：2018-06-01 00:00:00

abstract：:Mll, Brg1 and Brm are vertebrate homologues of Drosophila trithorax group (trxG) genes. We isolated chicken Mll cDNA clones, and examined patterns of Mll, Brg1 and Brm expression in chick embryos. All three genes were expressed from embryonic stage 2 onwards. Mll transcripts were just detectable in all tissues by in s...

journal_title：Mechanisms of development

authors： Schofield J,Isaac A,Golovleva I,Crawley A,Goodwin G,Tickle C,Brickell P

更新日期：1999-01-01 00:00:00

abstract：:We have cloned a chick homologue of Drosophila dachshund (dac), termed Dach1. Dach1 is the orthologue of mouse and human Dac/Dach (hereafter referred to as Dach1). We show that chick Dach1 is expressed in a variety of sites during embryonic development, including the eye and ear. Previous work has demonstrated the exi...

journal_title：Mechanisms of development

authors： Heanue TA,Davis RJ,Rowitch DH,Kispert A,McMahon AP,Mardon G,Tabin CJ

更新日期：2002-02-01 00:00:00

abstract：:We describe the expression of three Runt-related RUNX genes (previously termed AML, Cbfa, or Pebp2alpha) Runx1 and Runx3 during the development of teeth and other craniofacial tissues and compare them to Runx2 expression reported earlier. All three genes were expressed in mesenchymal condensates. Runx1 was expressed i...

journal_title：Mechanisms of development

authors： Yamashiro T,Aberg T,Levanon D,Groner Y,Thesleff I

更新日期：2002-12-01 00:00:00

abstract：:The process of gastrulation is a pivotal step in the formation of the vertebrate body plan. The primary function of gastrulation is the correct placement of precursor tissues for subsequent morphogenesis. There is now mounting evidence that the body plan is established through inductive interactions between germ layer...

journal_title：Mechanisms of development

authors： Tam PP,Behringer RR

更新日期：1997-11-01 00:00:00

abstract：:Tubby is a mouse gene that may provide a model for adult-onset obesity in humans. It is a member of a four gene family in mammals that collectively encode the Tubby-like proteins (TULPs), putative transcription factors which share similar 260 amino acid 'tubby domains' at their C-termini. The mammalian genome also enc...

journal_title：Mechanisms of development

authors： Ronshaugen M,McGinnis N,Inglis D,Chou D,Zhao J,McGinnis W

更新日期：2002-09-01 00:00:00

abstract：:The adrenergic differentiation of sympathetic neurons is controlled by complex interactions with the embryonic environment. To provide a basis for the experimental analysis of these interactions, the expression of the adrenergic marker enzyme tyrosine hydroxylase (TH) was analyzed by immunohistochemistry and in situ h...

journal_title：Mechanisms of development

authors： Ernsberger U,Patzke H,Tissier-Seta JP,Reh T,Goridis C,Rohrer H

更新日期：1995-07-01 00:00:00

abstract：:Recent studies have shown that aberrantly expressed gastrin-releasing peptide (GRP) and its receptor (GRP-R) critically regulate tumor cell differentiation in colon cancers developing in humans and mice. This finding suggested that the ability of GRP/GRP-R to promote a well-differentiated phenotype in colon cancer mig...

journal_title：Mechanisms of development

authors： Carroll RE,Matkowskyj K,Saunthararajah Y,Sekosan M,Battey JF,Benya RV

更新日期：2002-05-01 00:00:00

abstract：:Endothelial to mesenchymal transition (EMT) that occurs during cardiac outflow tract (OFT) development is critical for formation of the semilunar valves. Fibulin-1 (Fbln1) is an extracellular matrix protein that is present at several sites of EMT, including the OFT (i.e., E9.5-10.5). The aim of this study was to deter...

journal_title：Mechanisms of development

authors： Harikrishnan K,Cooley MA,Sugi Y,Barth JL,Rasmussen LM,Kern CB,Argraves KM,Argraves WS

更新日期：2015-05-01 00:00:00

abstract：:pebble (pbl) is required for cytokinesis during postblastoderm mitoses (Hime, G., Saint, R., 1992. Zygotic expression of the pebble locus is required for cytokinesis during the postblastoderm mitoses of Drosophila. Development 114, 165-171; Lehner, C.F., 1992. The pebble gene is required for cytokinesis in Drosophila....

journal_title：Mechanisms of development

authors： Prokopenko SN,Saint R,Bellen HJ

更新日期：2000-02-01 00:00:00