The novel transcription factor gene Sp5 exhibits a dynamic and highly restricted expression pattern during mouse embryogenesis.

abstract：:We identified MRG-1, a Caenorhabditis elegans chromodomain-containing protein that is similar to the human mortality factor-related gene 15 product (MRG15). RNA-mediated interference (RNAi) of mrg-1 resulted in complete absence of the germline in both hermaphrodite and male adults. Examination of the expression of PGL...

journal_title：Mechanisms of development

authors： Fujita M,Takasaki T,Nakajima N,Kawano T,Shimura Y,Sakamoto H

更新日期：2002-06-01 00:00:00

abstract：:To elucidate roles of fibroblast growth factors (FGF)18 during vertebrate development, we examined expression patterns of Fgf18 in chick embryos and observed effects of FGF18 protein on the Hensen's node, isthmus, and limb buds. Fgf18 is expressed on the right side of the node before the expression of Fgf8 starts. FGF...

journal_title：Mechanisms of development

authors： Ohuchi H,Kimura S,Watamoto M,Itoh N

更新日期：2000-07-01 00:00:00

abstract：:The polyhomeotic (ph) gene of Drosophila is a member of the Polycomb group of genes and encodes a chromatin protein required for negative regulation of homeotic genes and other loci, in particular the ph locus itself. We have studied the genetic control of ph transcription during development. Early ph expression is un...

journal_title：Mechanisms of development

authors： Fauvarque MO,Zuber V,Dura JM

更新日期：1995-08-01 00:00:00

abstract：:Mammalian Krüppel-like transcription factors include 12 zinc finger proteins (KLF1-12) that are involved in regulation of cell proliferation and differentiation during morphogenesis and development (Trends Biochem. Sci., 24 (1999) 236). Structural considerations have segregated KLF6 and KLF7 into a separate sub-group,...

journal_title：Mechanisms of development

authors： Laub F,Aldabe R,Ramirez F,Friedman S

更新日期：2001-08-01 00:00:00

abstract：:We have identified a short segment of the mouse Pax-6 gene 5' flanking region that is necessary and sufficient for reporter construct expression in components of the eye derived from non-neural ectoderm. This transcriptional control element has a highly conserved nucleotide sequence over 341 bp and is located approxim...

journal_title：Mechanisms of development

authors： Williams SC,Altmann CR,Chow RL,Hemmati-Brivanlou A,Lang RA

更新日期：1998-05-01 00:00:00

abstract：:We investigated the expression pattern of the endothelin-A receptor and endothelin 1 genes, the mutations of which affect the development of the mesectodermal derivatives of the neural crest. We show here that endothelin 1 is expressed by the environment of the cephalic neural crest cells invading branchial arches. La...

journal_title：Mechanisms of development

authors： Nataf V,Grapin-Botton A,Champeval D,Amemiya A,Yanagisawa M,Le Douarin NM

更新日期：1998-07-01 00:00:00

abstract：:The tumor-suppressor protein p53 belongs to a small gene family that includes p63 and p73. While p53 and p73 regulate cell cycle progression and apoptosis, the major role of p63 appears to be in promoting ectodermal proliferation and differentiation. In this report we describe the cloning of a Xenopus orthologue of ma...

journal_title：Mechanisms of development

authors： Lu P,Barad M,Vize PD

更新日期：2001-04-01 00:00:00

abstract：:In C. elegans development, unfavorable growth conditions lead a larva to an arrested and enduring form called a dauer. To elucidate components upstream of DAF-7/TGF-beta in this control pathway, we isolated a mutant that was defective in daf-7 promoter::gfp reporter expression and showed an arrested (dauer-constitutiv...

journal_title：Mechanisms of development

authors： Murakami M,Koga M,Ohshima Y

更新日期：2001-11-01 00:00:00

abstract：:Maleless (mle) is essential in Drosophila melanogaster males both in somatic cells and in germ cells. In somatic cells mle is necessary for X-chromosome dosage compensation. The role of mle in the germline is unknown. We have analyzed the expression pattern and localization of MLE, the other MSLs and acetylated isofor...

journal_title：Mechanisms of development

authors： Rastelli L,Kuroda MI

更新日期：1998-02-01 00:00:00

abstract：:The Polycomb group genes in Drosophila are involved in the stable and inheritable repression of gene expression. The Polycomb group proteins probably operate as multimeric complexes that bind to chromatin. To investigate molecular mechanisms of stable repression of gene activity in vertebrates we have begun to study X...

journal_title：Mechanisms of development

authors： Reijnen MJ,Hamer KM,den Blaauwen JL,Lambrechts C,Schoneveld I,van Driel R,Otte AP

更新日期：1995-09-01 00:00:00

abstract：:In Drosophila melanogaster, the patterning of dorsal appendages on the eggshell is strictly controlled by EGFR signaling. However, the number of dorsal appendages is remarkably diverse among Drosophila species. For example, D. melanogaster and D. virilis have two and four dorsal appendages, respectively. Here we show ...

journal_title：Mechanisms of development

authors： Nakamura Y,Matsuno K

更新日期：2003-08-01 00:00:00

abstract：:The gene expression patterns of primordial germ cells (PGCs) and embryonic stem cells were analyzed by a modified serial analysis of gene expression. During the process, we cloned a novel gene, PGC7, which was preferentially expressed in PGCs. Immunohistochemical analysis revealed that PGC7 was specifically expressed ...

journal_title：Mechanisms of development

authors： Sato M,Kimura T,Kurokawa K,Fujita Y,Abe K,Masuhara M,Yasunaga T,Ryo A,Yamamoto M,Nakano T

更新日期：2002-04-01 00:00:00

abstract：:The actin cytoskeleton is implicated in many cellular processes, such as cell adhesion, locomotion, contraction and cytokinesis, which are central to any development. The extent of polymerization, cross-linking, and bundling of actin is regulated by several actin-binding proteins. Knock-out mutations in these proteins...

journal_title：Mechanisms of development

authors： Ponte E,Rivero F,Fechheimer M,Noegel A,Bozzaro S

更新日期：2000-03-01 00:00:00

abstract：:The availability of the draft sequence of the chicken genome will undoubtedly propel an already important vertebrate research model, the domestic chicken, to a new level. This review describes aspects of chicken natural history and cross-disciplinary biological value. The diversity of extant genetic variants available...

journal_title：Mechanisms of development

authors： Delany ME

更新日期：2004-09-01 00:00:00

abstract：:Hairless is a dominant loss of function mutation in Drosophila affecting the formation of adult sensory organs. In the mutants, neuronal precursor cells do not differentiate, suggesting that Hairless might be involved in specifying or realizing neuronal fate in the fly, similar to the 'pro-neural' genes of the achaete...

journal_title：Mechanisms of development

authors： Maier D,Stumm G,Kuhn K,Preiss A

更新日期：1992-08-01 00:00:00

abstract：:T-box genes constitute a conserved multi-gene family with important roles in many developmental processes. In this report, we describe the cloning and expression analysis of a novel mouse T-box gene, Tbx20. Expression is prominent in the extraembryonic mesoderm, in the developing heart, the eye anlage and motor neuron...

journal_title：Mechanisms of development

authors： Kraus F,Haenig B,Kispert A

更新日期：2001-01-01 00:00:00

abstract：:Avian neural crest cells migrate on precise pathways to their target areas where they form a wide variety of cellular derivatives, including neurons, glia, pigment cells and skeletal components. In one portion of their pathway, trunk neural crest cells navigate in the somitic mesoderm in a segmental fashion, invading ...

journal_title：Mechanisms of development

authors： Krull CE

更新日期：2001-07-01 00:00:00

abstract：:The maturation of T cells is an intricate process involving the interaction of developing thymocytes with discrete microenvironments within the thymus. Numerous studies have indicated that distinct thymic compartments provide signals required for each stage of thymocyte maturation. In this study we performed a compreh...

journal_title：Mechanisms of development

authors： Vergara-Silva A,Schaefer KL,Berg LJ

更新日期：2002-12-01 00:00:00

abstract：:Nemo-like kinases define a novel family of serine/threonine kinases that are involved in integrating multiple signaling pathways. They are conserved regulators of Wnt/Wingless pathways, which may coordinate Wnt with TGFbeta-mediated signaling. Drosophila nemo was identified through its involvement in epithelial planar...

journal_title：Mechanisms of development

authors： Mirkovic I,Charish K,Gorski SM,McKnight K,Verheyen EM

更新日期：2002-11-01 00:00:00

abstract：:In order to analyze the expression pattern of the 5'-nucleotidase (5nt) gene in Dictyostelium, we made a fusion construct in which the 5nt promoter directed the expression of beta-galactosidase gene. The reporter gene was not active in vegetative amoebae but was expressed during the aggregation stage. At the slug stag...

journal_title：Mechanisms of development

authors： Ubeidat M,Eristi CM,Rutherford CL

更新日期：2002-01-01 00:00:00

abstract：:Ppp6c, which encodes the catalytic subunit of phosphoprotein phosphatase 6 (PP6), is conserved among eukaryotes from yeast to humans. In mammalian cells, PP6 targets IκBε for degradation, activates DNA-dependent protein kinase to trigger DNA repair, and is reportedly required for normal mitosis. Recently, Ppp6c mutati...

journal_title：Mechanisms of development

authors： Ogoh H,Tanuma N,Matsui Y,Hayakawa N,Inagaki A,Sumiyoshi M,Momoi Y,Kishimoto A,Suzuki M,Sasaki N,Ohuchi T,Nomura M,Teruya Y,Yasuda K,Watanabe T,Shima H

更新日期：2016-02-01 00:00:00

abstract：:The idea has been put forward that molecules and mechanisms acting during development are re-used during regeneration in the adult, for example in response to traumatic injury in order to re-establish the functional integrity of neuronal circuits. Members of the Eph family of receptor tyrosine kinases and their 'ligan...

journal_title：Mechanisms of development

authors： Knöll B,Isenmann S,Kilic E,Walkenhorst J,Engel S,Wehinger J,Bähr M,Drescher U

更新日期：2001-08-01 00:00:00

abstract：:In the developing eye of Drosophila the protein kinase D-Raf controls the specification of the R7 photoreceptor cells. We show that overexpression of wild-type D-Raf inhibits the formation of R7 cells in a dose-dependent manner. Conversely, overexpression of mutant D-Raf proteins in which the conserved S388 is replace...

journal_title：Mechanisms of development

authors： Rommel C,Radziwill G,Moelling K,Hafen E

更新日期：1997-06-01 00:00:00

abstract：:ZT3, isolated from a murine muscle cell cDNA library by a low-stringency hybridization, encodes a zinc finger domain containing factor with a transcript of 5.0 kb. A 3' 2.5 kb partial nucleotide sequence contains an ORF of 1.5 kb where 17 canonical C2H2 zinc finger domains organized in tandem were identified. It maps ...

journal_title：Mechanisms of development

authors： Polimeni M,Giorgi S,De Gregorio L,Dragani TA,Molinaro M,Cossu G,Bouché M

更新日期：1996-01-01 00:00:00

abstract：:Wnt-4 signaling plays a critical role in kidney development and is associated with the epithelial conversion of the metanephric mesenchyme. Furthermore, secreted Frizzled-related proteins (sFRPs) that can bind Wnts are normally expressed in the developing metanephros, and function in other systems as modulators of Wnt...

journal_title：Mechanisms of development

authors： Yoshino K,Rubin JS,Higinbotham KG,Uren A,Anest V,Plisov SY,Perantoni AO

更新日期：2001-04-01 00:00:00

abstract：:The Drosophila pointed gene encodes two ETS transcriptional activators, pointedP1 and pointedP2, sharing a common C-terminal ETS domain. In the embryonic central nervous system pointedP2 is required for midline glial cell differentiation, whereas, in the eye, pointedP2 is essential for photoreceptor cell differentiati...

journal_title：Mechanisms of development

authors： Albagli O,Klaes A,Ferreira E,Leprince D,Klämbt C

更新日期：1996-09-01 00:00:00

abstract：:Drosophila tracheal fusion cells play multiple important roles in guiding and facilitating tracheal branch fusion. Mechanistic understanding of how fusion cells function during development requires deciphering their transcriptional circuitry. In this paper, three genes with distinct patterns of fusion cell expression ...

journal_title：Mechanisms of development

authors： Jiang L,Pearson JC,Crews ST

更新日期：2010-05-01 00:00:00

abstract：:C-terminal binding protein (CtBP) is an evolutionarily and functionally conserved transcriptional corepressor known to integrate diverse signals to regulate transcription. Drosophila CtBP (dCtBP) regulates tissue specification and segmentation during early embryogenesis. Here, we investigated the roles of dCtBP during...

journal_title：Mechanisms of development

authors： Stern MD,Aihara H,Roccaro GA,Cheung L,Zhang H,Negeri D,Nibu Y

更新日期：2009-01-01 00:00:00

abstract：:Nanos family members have been shown to act as translational repressors in the Drosophila and Caenorhabditis elegans germline, but direct evidence is missing for a similar function in vertebrates. Using a tethered function assay, we show that Xenopus Nanos1 is a translational repressor and that association with the RN...

journal_title：Mechanisms of development

authors： Lai F,Zhou Y,Luo X,Fox J,King ML

更新日期：2011-01-01 00:00:00

abstract：:The normal embryogenesis of marine animals is typically confined to a species-specific range of temperatures. Within that temperature range development results in a consistent, or canalized, phenotype, whereas above and below the range abnormal phenotypes are produced. This study reveals a high temperature threshold, ...

journal_title：Mechanisms of development

authors： Irvine SQ,McNulty KB,Siler EM,Jacobson RE

更新日期：2019-06-01 00:00:00