The expression patterns of endothelin-A receptor and endothelin 1 in the avian embryo.

abstract：:Mammalian embryos develop in coordination with extraembryonic tissues, which support embryonic development by implanting embryos into the uterus, supplying nutrition, providing a confined niche, and also providing patterning signals to embryos. Here, we show that in mouse embryos, the expansion of the amniotic cavity ...

journal_title：Mechanisms of development

authors： Imuta Y,Koyama H,Shi D,Eiraku M,Fujimori T,Sasaki H

更新日期：2014-05-01 00:00:00

abstract：:The putative vertebrate morphogen retinoic acid (RA) has been shown to induce expression of many mammalian homeobox genes in cell lines, suggesting expression of this gene family in developing vertebrate embryos may be controlled in part by RA. Using the teratocarcinoma cell line F9 as a model system, we have studied ...

journal_title：Mechanisms of development

authors： Langston AW,Gudas LJ

更新日期：1992-09-01 00:00:00

abstract：:Fetal liver is the major embryonic hematopoietic organ and is extrinsically colonized by circulating hematopoietic stem cells (HSCs). Integrin beta-1 expression on HSCs is crucial for colonization, suggesting that interaction of Integrin beta-1 with extra-cellular matrix (ECM) factors promotes HSC adherence to fetal l...

journal_title：Mechanisms of development

authors： Sugiyama D,Kulkeaw K,Mizuochi C

更新日期：2013-02-01 00:00:00

abstract：:Adhesion differences are the main driver of cell sorting and related processes such as boundary formation or tissue positioning. In the early amphibian embryo, graded variations in cadherin density and localized expression of adhesion-modulating factors are associated with regional differences in adhesive properties i...

journal_title：Mechanisms of development

authors： Winklbauer R,Parent SE

更新日期：2017-04-01 00:00:00

abstract：:We present the first time/space analysis using in situ hybridization for PTTG and prc1 genes during development of the mouse telencephalon. During the stages E11.5-E13.5 PTTG and prc1 are expressed in most tissues of the embryo. Within the telencephalon, PTTG and prc1 are found exclusively inside of the ventricular zo...

journal_title：Mechanisms of development

authors： Tarabykin V,Britanova O,Fradkov A,Voss A,Katz LS,Lukyanov S,Gruss P

更新日期：2000-04-01 00:00:00

abstract：:Recent work identified an apoptotic program in gastrulation stage Xenopus embryos (Anderson, J.A., Lewellyn, A.L., Maller, J.L., 1997. Mol. Biol. Cell 8, 1195-1206; Stack, J.H., Newport, J.W., 1997. Development 124, 3185-3195). Here, we characterize in detail this maternal cell death program, which is set up at fertil...

journal_title：Mechanisms of development

authors： Hensey C,Gautier J

更新日期：1997-12-01 00:00:00

abstract：:We report the characterization of a zebrafish DnaJ-like protein, homologue to the human Hsp40 protein hdj1, that we named zf-Hsp40. We have studied its expression during fin regeneration and we show that zf-Hsp40 mRNA level is drastically increased in all ray segments beneath the regenerated part, or blastema, in resp...

journal_title：Mechanisms of development

authors： Tawk M,Joulie C,Vriz S

更新日期：2000-12-01 00:00:00

abstract：:Cell-cell interactions during embryogenesis have been shown to be important for establishing developmental fates in a number of organisms such as Drosophila and Caenorhabditis. One class of genes shown to mediate this process are receptor-protein tyrosine kinases (R-PTKs). To examine whether R-PTKs might participate i...

journal_title：Mechanisms of development

authors： Ruiz JC,Robertson EJ

更新日期：1994-05-01 00:00:00

abstract：:ADAMs are multidomain cell surface proteins that function in receptor-ligand processing, cell adhesion and fusion, and signaling. SpADAM, a single copy sea urchin ADAM gene with a 3072 bp open reading frame, is expressed during embryonic and larval development. The deduced SpADAM protein is 1023 amino acids long and i...

journal_title：Mechanisms of development

authors： Rise M,Burke RD

更新日期：2002-09-01 00:00:00

abstract：:A model of the trans-regulation of the Drosophila pair-rule segmentation gene, paired (prd), has been derived from the observed alterations in the distribution of prd transcripts during early embryogenesis in single and double pair-rule mutants. Important aspects of the model include the following features and implica...

journal_title：Mechanisms of development

authors： Baumgartner S,Noll M

更新日期：1990-12-01 00:00:00

abstract：:Deflecting biomineralized crystals attached to vestibular hair cells are necessary for maintaining balance. Zebrafish (Danio rerio) are useful organisms to study these biomineralized crystals called otoliths, as many required genes are homologous to human otoconial development. We sought to identify and characterize t...

journal_title：Mechanisms of development

authors： Thiessen KD,Grzegorski SJ,Chin Y,Higuchi LN,Wilkinson CJ,Shavit JA,Kramer KL

更新日期：2019-06-01 00:00:00

abstract：:Active repression of gene expression mediated by unliganded nuclear receptors plays crucial roles in early development of vertebrates. N-CoR (nuclear receptor co-repressor) is the first identified co-repressor that can repress retinoic acid (RA) inducible gene transcription in the absence of RA. Previously, N-CoR was ...

journal_title：Mechanisms of development

authors： Xu F,Li K,Tian M,Hu P,Song W,Chen J,Gao X,Zhao Q

更新日期：2009-10-01 00:00:00

abstract：:Haploinsufficiency for the HMG-box transcription factor SOX2 results in abnormalities of the human ventral forebrain and its derivative structures. These defects include anophthalmia (absence of eye), microphthalmia (small eye) and hypothalamic hamartoma (HH), an overgrowth of the ventral hypothalamus. To determine ho...

journal_title：Mechanisms of development

authors： Langer L,Taranova O,Sulik K,Pevny L

更新日期：2012-03-01 00:00:00

abstract：:Four genes - deltaA, deltaB, deltaC and deltaD - coding for homologues of the Notch ligand Delta have been discovered in zebrafish (Haddon et al., 1998b). We report here the cDNA sequence and expression pattern of deltaC. Its closest relatives are deltaB and Xenopus X-Delta-2. Unlike deltaA, deltaB, and deltaD, deltaC...

journal_title：Mechanisms of development

authors： Smithers L,Haddon C,Jiang YJ,Lewis J

更新日期：2000-01-01 00:00:00

abstract：:The study of distal lung morphogenesis and vascular development would be greatly facilitated by an in vitro or ex vivo experimental model. In this study we show that the growth of mouse embryonic day 12.5 lung rudiments implanted underneath the kidney capsules of syngeneic or immunodeficient hosts follows closely lung...

journal_title：Mechanisms of development

authors： Vu TH,Alemayehu Y,Werb Z

更新日期：2003-03-01 00:00:00

abstract：:Nk(x)-type homeobox genes are an evolutionarily conserved family that regulate diverse developmental processes. Here we describe a novel Drosophila gene, Nk6, which encodes an Nk-type transcription factor most homologous to vertebrate Nkx6.1 and Nkx6.2. The homeodomains and NK decapeptide domains of all three proteins...

journal_title：Mechanisms of development

authors： Uhler J,Garbern J,Yang L,Kamholz J,Mellerick DM

更新日期：2002-08-01 00:00:00

abstract：:The Drosophila wing is a classical model for studying the generation of developmental patterns. Previous studies have suggested that vein primordia form at boundaries between discrete sectors of gene expression along the antero-posterior (A/P) axis in the larval wing imaginal disc. Observation that the vein marker rho...

journal_title：Mechanisms of development

authors： Crozatier M,Glise B,Khemici V,Vincent A

更新日期：2003-05-01 00:00:00

abstract：:DEADSouth was selected in a screen for localized RNAs in Xenopus oocytes. In situ hybridization analysis shows that DEADSouth localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with germ plasm during early embryogenesis. These results lend further support for the general conc...

journal_title：Mechanisms of development

authors： MacArthur H,Houston DW,Bubunenko M,Mosquera L,King ML

更新日期：2000-07-01 00:00:00

abstract：:Sexual reproduction in the ciliate Tetrahymena follows a complex developmental program involving the sequential regulation of dozens of genes. Genes that are up-regulated during post-zygotic development in Tetrahymena were isolated by subtractive hybridization. Anlagen stage induced gene 1 (ASI1) encodes a 2.8 kb tran...

journal_title：Mechanisms of development

authors： Udani RA,Karrer KM

更新日期：2002-10-01 00:00:00

abstract：:The spatial and temporal expression of seven Drosophila protein tyrosine phosphatase genes during oogenesis was examined by whole mount in-situ hybridization of antisense RNA probes to ovaries. Our observations indicate diverse expression patterns consistent with multiple roles for protein tyrosine phosphatases in the...

journal_title：Mechanisms of development

authors： Fitzpatrick KA,Gorski SM,Ursuliak Z,Price JV

更新日期：1995-10-01 00:00:00

abstract：:Tubby is a mouse gene that may provide a model for adult-onset obesity in humans. It is a member of a four gene family in mammals that collectively encode the Tubby-like proteins (TULPs), putative transcription factors which share similar 260 amino acid 'tubby domains' at their C-termini. The mammalian genome also enc...

journal_title：Mechanisms of development

authors： Ronshaugen M,McGinnis N,Inglis D,Chou D,Zhao J,McGinnis W

更新日期：2002-09-01 00:00:00

abstract：:The gastrointestinal tract is subdivided into regions with different roles in digestion and absorption. How this patterning is established is unknown. We now report that the pancreatic-duodenal homeobox 1 gene (pdx1) is also expressed in cells of the distal stomach. Positive cells include subpopulations of the three m...

journal_title：Mechanisms of development

authors： Larsson LI,Madsen OD,Serup P,Jonsson J,Edlund H

更新日期：1996-12-01 00:00:00

abstract：:Ppp6c, which encodes the catalytic subunit of phosphoprotein phosphatase 6 (PP6), is conserved among eukaryotes from yeast to humans. In mammalian cells, PP6 targets IκBε for degradation, activates DNA-dependent protein kinase to trigger DNA repair, and is reportedly required for normal mitosis. Recently, Ppp6c mutati...

journal_title：Mechanisms of development

authors： Ogoh H,Tanuma N,Matsui Y,Hayakawa N,Inagaki A,Sumiyoshi M,Momoi Y,Kishimoto A,Suzuki M,Sasaki N,Ohuchi T,Nomura M,Teruya Y,Yasuda K,Watanabe T,Shima H

更新日期：2016-02-01 00:00:00

abstract：:We describe the expression of three Runt-related RUNX genes (previously termed AML, Cbfa, or Pebp2alpha) Runx1 and Runx3 during the development of teeth and other craniofacial tissues and compare them to Runx2 expression reported earlier. All three genes were expressed in mesenchymal condensates. Runx1 was expressed i...

journal_title：Mechanisms of development

authors： Yamashiro T,Aberg T,Levanon D,Groner Y,Thesleff I

更新日期：2002-12-01 00:00:00

abstract：:The gene crumbs (crb) of Drosophila encodes a transmembrane protein with 30 EGF-like and four laminin A G-domain-like repeats in its extracellular domain. Loss-of-function mutations lead to severe disorganization and degeneration of ectodermally derived embryonic epithelia. In embryos homozygous for crb8F105, an amorp...

journal_title：Mechanisms of development

authors： Wodarz A,Grawe F,Knust E

更新日期：1993-12-01 00:00:00

abstract：:In the last years, several reports have established the notion that metabolism is not just a housekeeping process, but instead an active effector of physiological changes. The idea that the metabolic status may rule a wide range of phenomena in cell biology is starting to be broadly accepted. Thus, current development...

journal_title：Mechanisms of development

authors： Gándara L,Wappner P

更新日期：2018-12-01 00:00:00

abstract：:Increases in Na/K-ATPase activity occur concurrently with the onset of cavitation and are associated with increases in Na(+)-pump subunit mRNA and protein expression. We have hypothesized that the alpha1-isozyme of the Na/K-ATPase is required to mediate blastocyst formation. We have tested this hypothesis by character...

journal_title：Mechanisms of development

authors： Barcroft LC,Moseley AE,Lingrel JB,Watson AJ

更新日期：2004-05-01 00:00:00

abstract：:Many proteins involved in signal transduction and cell adhesion are characterized by the presence of an extracellular domain with repeated copies of a leucine-rich motif (LRR). Here we report the isolation and characterization of a novel gene, tlr (for Toll-like receptor), which encodes a protein containing multiple L...

journal_title：Mechanisms of development

authors： Chiang C,Beachy PA

更新日期：1994-09-01 00:00:00

abstract：:The tumor-suppressor protein p53 belongs to a small gene family that includes p63 and p73. While p53 and p73 regulate cell cycle progression and apoptosis, the major role of p63 appears to be in promoting ectodermal proliferation and differentiation. In this report we describe the cloning of a Xenopus orthologue of ma...

journal_title：Mechanisms of development

authors： Lu P,Barad M,Vize PD

更新日期：2001-04-01 00:00:00

abstract：:The maturation of T cells is an intricate process involving the interaction of developing thymocytes with discrete microenvironments within the thymus. Numerous studies have indicated that distinct thymic compartments provide signals required for each stage of thymocyte maturation. In this study we performed a compreh...

journal_title：Mechanisms of development

authors： Vergara-Silva A,Schaefer KL,Berg LJ

更新日期：2002-12-01 00:00:00