Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning.

abstract：:dkk-1 has recently been identified as a secreted protein in Xenopus laevis which is sufficient and necessary to cause head induction by antagonizing Wnt signalling (Glinka et al., 1998, Nature 391, 357-362). Consistent with such a role dkk-1 is expressed in the Spemann organizer of the early frog gastrula. Later, expr...

journal_title：Mechanisms of development

authors： Grotewold L,Theil T,Rüther U

更新日期：1999-12-01 00:00:00

abstract：:pebble (pbl) is required for cytokinesis during postblastoderm mitoses (Hime, G., Saint, R., 1992. Zygotic expression of the pebble locus is required for cytokinesis during the postblastoderm mitoses of Drosophila. Development 114, 165-171; Lehner, C.F., 1992. The pebble gene is required for cytokinesis in Drosophila....

journal_title：Mechanisms of development

authors： Prokopenko SN,Saint R,Bellen HJ

更新日期：2000-02-01 00:00:00

abstract：:The mouse and human Hox complex consists of 39 genes in four linkage groups (A-D). Although the structure and expression patterns of most of these genes have been reported, the 5' members of the Hox C linkage group have been only partially characterized. Herein we report the primary and genomic structure of the mouse ...

journal_title：Mechanisms of development

authors： Hostikka SL,Capecchi MR

更新日期：1998-01-01 00:00:00

abstract：:Xenopus embryos in solutions containing suramin show a dose-dependent decrease in the formation of dorsoanterior structures. Continuous treatment with 1 mM suramin produces embryos without mesodermal derivatives but with mesenchymal cells. Brief immersions of 20 min were used to determine the most sensitive stages and...

journal_title：Mechanisms of development

authors： Cardellini P,Polo C,Coral S

更新日期：1994-01-01 00:00:00

abstract：:This study compares by immunogold labeling the ultrastructural localization of a hexameric 22S glycoprotein, called toposome, with that of hyalin in unfertilized eggs and cells of hatched sea urchin blastulae. Nearly all hyalin is present in the electron translucent compartment of the cortical granules and in the tran...

journal_title：Mechanisms of development

authors： Gratwohl EK,Kellenberger E,Lorand L,Noll H

更新日期：1991-02-01 00:00:00

abstract：:We have isolated a Xenopus homologue of the zinc finger/homeodomain-containing transcriptional repressor Smad-interacting protein-1 (SIP1) from mouse. XSIP1 is activated at the early gastrula stage and transcription occurs throughout embryogenesis. At the beginning of gastrulation, XSIP1 is strongly expressed in prosp...

journal_title：Mechanisms of development

authors： van Grunsven LA,Papin C,Avalosse B,Opdecamp K,Huylebroeck D,Smith JC,Bellefroid EJ

更新日期：2000-06-01 00:00:00

abstract：:We previously showed that otx2 activates ectopic formation of the Xenopus cement gland only in ventrolateral ectoderm, defining a region of the embryo permissive for cement gland formation. In this paper, we explore the molecular identity of this permissive area. One candidate permissive factor is BMP4, whose putative...

journal_title：Mechanisms of development

authors： Gammill LS,Sive H

更新日期：2000-04-01 00:00:00

abstract：:In bovine preimplantation development, female embryos progress at lower rates and originate smaller blastocysts than male counterparts. Although sex-specific gene expression patterns are reported, when and how sex dimorphism is established is not clear. Differences among female and male early development can be useful...

journal_title：Mechanisms of development

authors： Oliveira CS,Saraiva NZ,de Lima MR,Oliveira LZ,Serapião RV,Garcia JM,Borges CA,Camargo LS

更新日期：2016-02-01 00:00:00

abstract：:The Drosophila genes eyeless, eyes absent, sine oculis and dachshund cooperate as components of a network to control retinal determination. Vertebrate homologues of these genes have been identified and implicated in the control of cell fate. We present the cloning and characterization of mouse Dach2, a homologue of da...

journal_title：Mechanisms of development

authors： Davis RJ,Shen W,Sandler YI,Heanue TA,Mardon G

更新日期：2001-04-01 00:00:00

abstract：:During the third larval instar, the steroid moulting hormone ecdysone activates three temporally distinct puff sets on the D. melanogaster salivary gland polytene chromosome: the so-called intermoult, early and late puffs. Hormonal regulation of intermoult puffs is quite complex and, so far, largely not understood. In...

journal_title：Mechanisms of development

authors： D'Avino PP,Crispi S,Polito LC,Furia M

更新日期：1995-02-01 00:00:00

abstract：:In the mammary gland Bcl-x is the most abundant cell survival factor from the Bcl-2 family. Since Bcl-x null mice die around day 12 of embryogenesis, the relevance of this protein in organ development and function is poorly understood. In erythroid cells bcl-x gene expression is controlled by cytokines and the transcr...

journal_title：Mechanisms of development

authors： Walton KD,Wagner KU,Rucker EB 3rd,Shillingford JM,Miyoshi K,Hennighausen L

更新日期：2001-12-01 00:00:00

abstract：:We analyse the role of the empty spiracles (ems) gene in embryonic brain and ventral nerve cord development. ems is differentially expressed in the neurectoderm of the anterior head versus the trunk region of early embryos. A distal enhancer region drives expression in the deutocerebral brain anlage and a proximal enh...

journal_title：Mechanisms of development

authors： Hartmann B,Hirth F,Walldorf U,Reichert H

更新日期：2000-02-01 00:00:00

abstract：:Mice with targeted disruption of the TGF beta 2 gene display defects in epithelial-mesenchymal tissue interactions in several tissues including the developing cochlea. Specifically, the region of the spiral limbus and the overlying interdental cells, structures putatively involved in endolymphatic fluid homeostasis, d...

journal_title：Mechanisms of development

authors： Paradies NE,Sanford LP,Doetschman T,Friedman RA

更新日期：1998-12-01 00:00:00

abstract：:We have identified a short segment of the mouse Pax-6 gene 5' flanking region that is necessary and sufficient for reporter construct expression in components of the eye derived from non-neural ectoderm. This transcriptional control element has a highly conserved nucleotide sequence over 341 bp and is located approxim...

journal_title：Mechanisms of development

authors： Williams SC,Altmann CR,Chow RL,Hemmati-Brivanlou A,Lang RA

更新日期：1998-05-01 00:00:00

abstract：:We report the cloning and expression of a novel murine forkhead/winged helix family member--Foxn4--that is expressed during neural development in the retina, the ventral hindbrain and spinal cord and dorsal midbrain. Retinal Foxn4 expression is associated with the zone of proliferating progenitor cells. In the mouse m...

journal_title：Mechanisms of development

authors： Gouge A,Holt J,Hardy AP,Sowden JC,Smith HK

更新日期：2001-09-01 00:00:00

abstract：:The Suppressor of forked (Su(f)) protein of Drosophila melanogaster is a homologue of the 77K subunit of human cleavage stimulation factor required for cleavage of pre-mRNAs before addition of poly(A). We have previously shown that the Su(f) protein is not ubiquitously distributed: it accumulates in dividing cells at ...

journal_title：Mechanisms of development

authors： Audibert A,Simonelig M

更新日期：1999-04-01 00:00:00

abstract：:In mouse Otx2 plays essential roles in anterior-posterior axis formation and head development in anterior visceral endoderm and anterior mesendoderm. The Otx2 expression in these sites is regulated by VE and CM enhancers at the 5' proximal to the translation start site, and we proposed that these enhancers would have ...

journal_title：Mechanisms of development

authors： Kurokawa D,Ohmura T,Akasaka K,Aizawa S

更新日期：2012-01-01 00:00:00

abstract：:In multicellular organisms, very little is known about the role of mRNA stability in development, and few proteins involved in degradation pathways have been characterized. We have identified the Drosophila homologue of XRN1, which is the major cytoplasmic 5'-3' exoribonuclease in Saccharomyces cerevisiae. The protein...

journal_title：Mechanisms of development

authors： Till DD,Linz B,Seago JE,Elgar SJ,Marujo PE,Elias ML,Arraiano CM,McClellan JA,McCarthy JE,Newbury SF

更新日期：1998-12-01 00:00:00

abstract：:There has been rapid progress recently in the identification of signalling pathways regulating tooth development. It has become apparent that signalling networks involved in Drosophila development and development of mammalian organs such as the limb are also used in tooth development. Teeth are epithelial appendages f...

journal_title：Mechanisms of development

authors： Thesleff I,Sharpe P

更新日期：1997-10-01 00:00:00

abstract：:Endothelial to mesenchymal transition (EMT) that occurs during cardiac outflow tract (OFT) development is critical for formation of the semilunar valves. Fibulin-1 (Fbln1) is an extracellular matrix protein that is present at several sites of EMT, including the OFT (i.e., E9.5-10.5). The aim of this study was to deter...

journal_title：Mechanisms of development

authors： Harikrishnan K,Cooley MA,Sugi Y,Barth JL,Rasmussen LM,Kern CB,Argraves KM,Argraves WS

更新日期：2015-05-01 00:00:00

abstract：:Recent studies have shown that aberrantly expressed gastrin-releasing peptide (GRP) and its receptor (GRP-R) critically regulate tumor cell differentiation in colon cancers developing in humans and mice. This finding suggested that the ability of GRP/GRP-R to promote a well-differentiated phenotype in colon cancer mig...

journal_title：Mechanisms of development

authors： Carroll RE,Matkowskyj K,Saunthararajah Y,Sekosan M,Battey JF,Benya RV

更新日期：2002-05-01 00:00:00

abstract：:Exogenously applied retinoic acid given at the early stages of gastrulation causes abnormal development of the caudal midbrain and anterior hindbrain in vertebrate embryos. We describe the limits of the brain regions that are affected using neuroanatomical criteria in the zebrafish embryo. Analysis of the reticulospin...

journal_title：Mechanisms of development

authors： Hill J,Clarke JD,Vargesson N,Jowett T,Holder N

更新日期：1995-03-01 00:00:00

abstract：:A key role for phosphorylation of Smad2 by TGFβ superfamily ligands in the axial patterning of early embryos is well established. The regulation and role of Smad2 signaling in post-neurula embryonic patterning, however, is less well understood. While a variety of TGFβ superfamily ligands are implicated in various stag...

journal_title：Mechanisms of development

authors： Ho DM,Yeo CY,Whitman M

更新日期：2010-09-01 00:00:00

abstract：:Growth is confined within a size that is normal for each species, revealing that somehow an organism 'knows' when this size has been reached. Within a species, growth is also variable, but despite this, proportion and structure are maintained. Perhaps, the key element in the control of size is the control of cell numb...

journal_title：Mechanisms of development

authors： Hidalgo A,ffrench-Constant C

更新日期：2003-11-01 00:00:00

abstract：:The existence of a common endodermal progenitor cell to both pancreas and liver is suggested by anatomy of the development of pancreatic and liver buds in embryogenesis. Here we review the large body of evidence that pancreas to liver and liver to pancreas cell differentiation can also occur in adult life. The publish...

journal_title：Mechanisms of development

authors： Grompe M

更新日期：2003-01-01 00:00:00

abstract：:We report the expression pattern of a murine homolog of the Xenopus laevis T-box gene Eomesodermin. mEomes expression is first detected in the extra-embryonic ectoderm prior to gastrulation, and persists there until head-fold stages. In the embryo proper, mEomes is expressed throughout the early primitive streak, nasc...

journal_title：Mechanisms of development

authors： Ciruna BG,Rossant J

更新日期：1999-03-01 00:00:00

abstract：:Here we report the use of double-stranded RNA (dsRNA) and morpholino technologies to specifically 'knock down' gene expression in early postimplantation mouse embryos. Sequence specific interference mediated by either dsRNA or by morpholino has been a useful tool for studying gene function in several organisms. Howeve...

journal_title：Mechanisms of development

authors： Mellitzer G,Hallonet M,Chen L,Ang SL

更新日期：2002-10-01 00:00:00

abstract：:Development of oligodendrocytes, myelin-forming glia in the central nervous system (CNS), proceeds on a protracted schedule. Specification of oligodendrocyte progenitor cells (OPCs) begins early in development, whereas their terminal differentiation occurs at late embryonic and postnatal periods. However, for oligoden...

journal_title：Mechanisms of development

authors： Hashimoto R,Hori K,Owa T,Miyashita S,Dewa K,Masuyama N,Sakai K,Hayase Y,Seto Y,Inoue YU,Inoue T,Ichinohe N,Kawaguchi Y,Akiyama H,Koizumi S,Hoshino M

更新日期：2016-05-01 00:00:00

abstract：:The transcription factor scleraxis (SCX) is expressed throughout tendon development and plays a key role in directing tendon wound healing. However, little is known regarding its role in fetal or young postnatal tendons, stages in development that are known for their enhanced regenerative capabilities. Here we used RN...

journal_title：Mechanisms of development

authors： Paterson YZ,Evans N,Kan S,Cribbs A,Henson FMD,Guest DJ

更新日期：2020-09-01 00:00:00

abstract：:All body pigment cells in vertebrates are derived from the neural crest. In fish the neural crest can generate up to six different types of pigment cells, as well as various non-pigmented derivatives. In mouse and zebrafish, extensive collections of pigmentation mutants have enabled dissection of many aspects of pigme...

journal_title：Mechanisms of development

authors： Kelsh RN,Inoue C,Momoi A,Kondoh H,Furutani-Seiki M,Ozato K,Wakamatsu Y

更新日期：2004-07-01 00:00:00