Exogenous retinoic acid causes specific alterations in the development of the midbrain and hindbrain of the zebrafish embryo including positional respecification of the Mauthner neuron.

abstract：:Blood vessel maturation, which is characterized by the investment of vascular smooth muscle cells (vSMCs) around developing blood vessels, begins when vessels remodel into a hierarchy of proximal arteries and proximal veins that branch into smaller distal capillaries. The ultimate result of maturation is formation of ...

journal_title：Mechanisms of development

authors： Padget RL,Mohite SS,Hoog TG,Justis BS,Green BE,Udan RS

更新日期：2019-04-01 00:00:00

abstract：:In a large-scale gene expression screen 1765 randomly picked cDNAs were analyzed by whole-mount in situ hybridization in Xenopus embryos. Two hundred and seventy three unique, differentially expressed genes were identified, 204 of which are novel in Xenopus. Partial DNA sequences and expression patterns were documente...

journal_title：Mechanisms of development

authors： Gawantka V,Pollet N,Delius H,Vingron M,Pfister R,Nitsch R,Blumenstock C,Niehrs C

更新日期：1998-10-01 00:00:00

abstract：:Germ-line mutations of LKB1 and PTEN tumor suppressor genes underlie the phenotypically related Peutz-Jeghers syndrome (PJS) and Cowden disease (CD), respectively. To analyze possible developmental roles of PTEN and LKB1, we have studied their mRNA expression during mouse embryonic development (E7-17.5) by in situ hyb...

journal_title：Mechanisms of development

authors： Luukko K,Ylikorkala A,Tiainen M,Mäkelä TP

更新日期：1999-05-01 00:00:00

abstract：:We have isolated nine putative odorant receptor genes from the chick, named COR1 to COR9, that belong to the large multigene family of olfactory G protein-coupled receptors found in the fish, rat, mouse, dog, and human. By combining genomic DNA blot analysis, low stringency library screenings, and several PCR analyses...

journal_title：Mechanisms of development

authors： Nef S,Allaman I,Fiumelli H,De Castro E,Nef P

更新日期：1996-03-01 00:00:00

abstract：:We describe the identification and expression pattern of Xenopus frizzled 4 (Xfz4) gene during early development. Xfz4 protein presents characteristic features of a frizzled family member. The mature protein sequence of Xfz4 is 93% identical to murine Mfz4. Xfz4 is a maternal mRNA, its expression level remains constan...

journal_title：Mechanisms of development

authors： Shi DL,Boucaut JC

更新日期：2000-06-01 00:00:00

abstract：:Transcription of the human interphotoreceptor retinoid binding protein (IRBP) gene is strictly tissue specific, being restricted to retinal photoreceptors and pinealocytes. We have previously demonstrated that a sequence named A element, in the IRBP promoter is essential for IRBP gene transcription in vivo. Here we de...

journal_title：Mechanisms of development

authors： Bobola N,Briata P,Ilengo C,Rosatto N,Craft C,Corte G,Ravazzolo R

更新日期：1999-04-01 00:00:00

abstract：:SIP1 encodes a DNA-binding transcription factor that regulates multiple developmental processes, as highlighted by the pleiotropic defects observed in Mowat-Wilson syndrome, which results from mutations in this gene. Further, in adults, dysregulated SIP1 expression has been implicated in both cancer and fibrotic disea...

journal_title：Mechanisms of development

authors： Manthey AL,Lachke SA,FitzGerald PG,Mason RW,Scheiblin DA,McDonald JH,Duncan MK

更新日期：2014-02-01 00:00:00

abstract：:Haploinsufficiency for the HMG-box transcription factor SOX2 results in abnormalities of the human ventral forebrain and its derivative structures. These defects include anophthalmia (absence of eye), microphthalmia (small eye) and hypothalamic hamartoma (HH), an overgrowth of the ventral hypothalamus. To determine ho...

journal_title：Mechanisms of development

authors： Langer L,Taranova O,Sulik K,Pevny L

更新日期：2012-03-01 00:00:00

abstract：:A pool of beta 1-integrin, ready to be inserted into the cleavage membranes, is present in the cytoplasm of the Xenopus egg, while its plasma membrane is devoid of this membrane protein (Gawantka et al., 1992). The underlying mechanisms that lead to this specific pattern of beta 1-integrin distribution in the egg have...

journal_title：Mechanisms of development

authors： Müller AH,Gawantka V,Ding X,Hausen P

更新日期：1993-07-01 00:00:00

abstract：:The intercalation of mesenchymal cells into epithelia, through mesenchymal-to-epithelial transition (MET), underlies organogenesis, for example, in nephrogenesis, and tissue regeneration, during cell renewal and wound repair. Despite its importance, surprisingly little is known about the mechanisms that bring about ME...

journal_title：Mechanisms of development

authors： Campbell K,Casanova J,Skaer H

更新日期：2010-07-01 00:00:00

abstract：:An important question in oocyte-mediated nuclear reprogramming is whether gene expression of the donor nucleus changes randomly or follows a pattern. Since cloned embryos are very heterogeneous and arrest frequently during preimplantation development, a random scenario is generally accepted. In the present study, we r...

journal_title：Mechanisms of development

authors： Cavaleri FM,Balbach ST,Gentile L,Jauch A,Böhm-Steuer B,Han YM,Schöler HR,Boiani M

更新日期：2008-01-01 00:00:00

abstract：:In this paper we analyze the expression in follicular cells and regulation of the vitelline membrane protein gene we identified in region 32E of the second chromosome of D. melanogaster (VMP32E). We report germ line transformation results obtained with different kinds of gene fusion leading to the identification of a ...

journal_title：Mechanisms of development

authors： Gargiulo G,Gigliotti S,Malva C,Graziani F

更新日期：1991-11-01 00:00:00

abstract：:The development of multi-cellular organisms is regulated by the ordered definition of gene expression programmes that govern cell proliferation and differentiation. Although differential gene activity is mainly controlled by transcription factors, it is also dependent upon the underlying chromatin structure, which can...

journal_title：Mechanisms of development

authors： Czvitkovich S,Sauer S,Peters AH,Deiner E,Wolf A,Laible G,Opravil S,Beug H,Jenuwein T

更新日期：2001-09-01 00:00:00

abstract：:The spatial and temporal analysis of GATA-3 expression pattern in the human embryo revealed its expression in new anatomical sites. These include the endoderm of the primitive foregut, pharynx and allantois, the branchial arches and the mesenchymal cells surrounding the stomach and dorsal aorta. On the other hand, hum...

journal_title：Mechanisms of development

authors： Debacker C,Catala M,Labastie MC

更新日期：1999-07-01 00:00:00

abstract：:The vertebrate hindbrain is composed of a series of lineage-restricted segments termed rhombomeres. Segment-specific gene expression drives unique programs of neuronal differentiation. Two critical embryonic signaling pathways, Fibroblast Growth Factor (FGF) and Retinoic Acid (RA), regulate early embryonic rhombomere ...

journal_title：Mechanisms of development

authors： Selland LG,Koch S,Laraque M,Waskiewicz AJ

更新日期：2018-04-01 00:00:00

abstract：:We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is exp...

journal_title：Mechanisms of development

authors： Sumanas S,Ekker SC

更新日期：2001-05-01 00:00:00

abstract：:The germ cell nuclear factor (GCNF, NR6A1) is a nuclear orphan receptor that functions as a transcriptional repressor and is transiently expressed in mammalian carcinoma cells during retinoic acid (RA) induced neuronal differentiation. During Xenopus laevis development, the spatiotemporal expression pattern of embryon...

journal_title：Mechanisms of development

authors： Barreto G,Borgmeyer U,Dreyer C

更新日期：2003-04-01 00:00:00

abstract：:Commissureless (Comm) is a novel transmembrane molecule necessary both for commissural axons to cross the midline of the Drosophila central nervous system and normal synaptogenesis. Comm is able to reduce cell surface levels of Roundabout (Robo), a receptor for the midline repellent Slit, on commissural axons and unkn...

journal_title：Mechanisms of development

authors： Georgiou M,Tear G

更新日期：2003-09-01 00:00:00

abstract：:Recent studies have shown that aberrantly expressed gastrin-releasing peptide (GRP) and its receptor (GRP-R) critically regulate tumor cell differentiation in colon cancers developing in humans and mice. This finding suggested that the ability of GRP/GRP-R to promote a well-differentiated phenotype in colon cancer mig...

journal_title：Mechanisms of development

authors： Carroll RE,Matkowskyj K,Saunthararajah Y,Sekosan M,Battey JF,Benya RV

更新日期：2002-05-01 00:00:00

abstract：:The Ras protein activates at least three different pathways during early development. Two of them regulate mesodermal gene expression and the third is thought to participate in the control of actin cytoskeleton dynamics via the Ral protein. From a yeast two-hybrid screen of a Xenopus maternal cDNA library, we identifi...

journal_title：Mechanisms of development

authors： Lebreton S,Boissel L,Iouzalen N,Moreau J

更新日期：2004-12-01 00:00:00

abstract：:Dystroglycan is a transmembrane receptor protein that provides a structural linkage between extracellular matrix components and cytoskeletal proteins. It was originally characterized as a member of dystrophin associated protein complex in muscle but, unlike other proteins of this complex, mutations in the dystroglycan...

journal_title：Mechanisms of development

authors： Lunardi A,Dente L

更新日期：2002-12-01 00:00:00

abstract：:Mammalian cell culture studies have shown that several members of the nuclear receptor super family such as glucocorticoid receptor, retinoic acid receptor and thyroid hormone receptor can repress the activity of AP-1 proteins by a mechanism that does not require the nuclear receptor to bind to DNA directly, but that ...

journal_title：Mechanisms of development

authors： Gritzan U,Weiss C,Brennecke J,Bohmann D

更新日期：2002-07-01 00:00:00

abstract：:The vertebrate neural tube develops by two distinct mechanisms. Anteriorly, in the brain and future trunk (cervicothoracic) region, 'primary neurulation' occurs, where an epithelial sheet rolls or bends into a tube. Posteriorly, in the future lumbar and tail region, the neural tube forms by 'secondary neurulation', wh...

journal_title：Mechanisms of development

authors： Lowery LA,Sive H

更新日期：2004-10-01 00:00:00

abstract：:During Drosophila embryogenesis, the attachment of somatic muscles to epidermal tendon cells requires heterodimeric PS-integrin proteins (alpha- and beta-subunits). The alpha-subunits are expressed complementarily, either tendon cell- or muscle-specific, whereas the beta-integrin subunit is expressed in both tissues. ...

journal_title：Mechanisms of development

authors： Chanana B,Graf R,Koledachkina T,Pflanz R,Vorbrüggen G

更新日期：2007-07-01 00:00:00

abstract：:In C. elegans development, unfavorable growth conditions lead a larva to an arrested and enduring form called a dauer. To elucidate components upstream of DAF-7/TGF-beta in this control pathway, we isolated a mutant that was defective in daf-7 promoter::gfp reporter expression and showed an arrested (dauer-constitutiv...

journal_title：Mechanisms of development

authors： Murakami M,Koga M,Ohshima Y

更新日期：2001-11-01 00:00:00

abstract：:Using a Drosophila cell-free system, we have analyzed the regulation of alternative splicing of Drosophila muscle myosin heavy chain (MHC) transcripts. Splicing of MHC 3' end transcripts results in exclusion of adult-specific alternative exon 18, as is observed in embryonic and larval muscle in vivo. Mutations that st...

journal_title：Mechanisms of development

authors： Hodges D,Bernstein SI

更新日期：1992-05-01 00:00:00

abstract：:We report the expression pattern of a murine homolog of the Xenopus laevis T-box gene Eomesodermin. mEomes expression is first detected in the extra-embryonic ectoderm prior to gastrulation, and persists there until head-fold stages. In the embryo proper, mEomes is expressed throughout the early primitive streak, nasc...

journal_title：Mechanisms of development

authors： Ciruna BG,Rossant J

更新日期：1999-03-01 00:00:00

abstract：:Mutations in the renin-angiotensin system (RAS) genes are associated with congenital anomalies of the kidney and urinary tract (CAKUT). As angiotensin (Ang) II, the principal effector peptide growth factor of the RAS, stimulates ureteric bud (UB) branching in whole intact embryonic (E) metanephroi, defects in UB morph...

journal_title：Mechanisms of development

authors： Song R,Preston G,Yosypiv IV

更新日期：2011-09-01 00:00:00

abstract：:This study compares by immunogold labeling the ultrastructural localization of a hexameric 22S glycoprotein, called toposome, with that of hyalin in unfertilized eggs and cells of hatched sea urchin blastulae. Nearly all hyalin is present in the electron translucent compartment of the cortical granules and in the tran...

journal_title：Mechanisms of development

authors： Gratwohl EK,Kellenberger E,Lorand L,Noll H

更新日期：1991-02-01 00:00:00

abstract：:The Dan gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in vertebrates. Xenopus DAN, as with Cerberus and Gremlin, was demonstrated to block bone morphogenetic protein (BMP) signaling by binding BMPs, and to be capable of inducing a...

journal_title：Mechanisms of development

authors： Ogita J,Isogai E,Sudo H,Sakiyama S,Nakagawara A,Koseki H

更新日期：2001-12-01 00:00:00