RLIP mediates downstream signalling from RalB to the actin cytoskeleton during Xenopus early development.

abstract：:We describe the identification and expression pattern of Xenopus frizzled 4 (Xfz4) gene during early development. Xfz4 protein presents characteristic features of a frizzled family member. The mature protein sequence of Xfz4 is 93% identical to murine Mfz4. Xfz4 is a maternal mRNA, its expression level remains constan...

journal_title：Mechanisms of development

authors： Shi DL,Boucaut JC

更新日期：2000-06-01 00:00:00

abstract：:In multicellular organisms, very little is known about the role of mRNA stability in development, and few proteins involved in degradation pathways have been characterized. We have identified the Drosophila homologue of XRN1, which is the major cytoplasmic 5'-3' exoribonuclease in Saccharomyces cerevisiae. The protein...

journal_title：Mechanisms of development

authors： Till DD,Linz B,Seago JE,Elgar SJ,Marujo PE,Elias ML,Arraiano CM,McClellan JA,McCarthy JE,Newbury SF

更新日期：1998-12-01 00:00:00

abstract：:To examine the role of the Oct-6 gene in Schwann cell differentiation we have cloned and characterized the chicken and zebrafish homologues of the mouse Oct-6 gene. While highly homologous in the Pit1-Oct1/2-Unc86 (POU) domain, sequence similarities are limited outside this domain. Both genes are intronless and both p...

journal_title：Mechanisms of development

authors： Levavasseur F,Mandemakers W,Visser P,Broos L,Grosveld F,Zivkovic D,Meijer D

更新日期：1998-06-01 00:00:00

abstract：:In mammals, the SWI/SNF complex is involved in chromatin remodelling in a wide range of cellular events for which regulatory factors require access to DNA. In the present study, we analyzed in early postimplantation mouse embryos the expression pattern of BRM (SNF2alpha) and BRG1 (SNF2beta), which are both ATPase subu...

journal_title：Mechanisms of development

authors： Dauvillier S,Ott MO,Renard JP,Legouy E

更新日期：2001-03-01 00:00:00

abstract：:The cloning of a Pax6 orthologue from the sepiolid squid Euprymna scolopes and its developmental expression pattern are described. The data are consistent with the presence of a single gene encoding a protein with highly conserved DNA-binding paired and homeodomains. A detailed expression analysis by in situ hybridiza...

journal_title：Mechanisms of development

authors： Hartmann B,Lee PN,Kang YY,Tomarev S,de Couet HG,Callaerts P

更新日期：2003-02-01 00:00:00

abstract：:Nk(x)-type homeobox genes are an evolutionarily conserved family that regulate diverse developmental processes. Here we describe a novel Drosophila gene, Nk6, which encodes an Nk-type transcription factor most homologous to vertebrate Nkx6.1 and Nkx6.2. The homeodomains and NK decapeptide domains of all three proteins...

journal_title：Mechanisms of development

authors： Uhler J,Garbern J,Yang L,Kamholz J,Mellerick DM

更新日期：2002-08-01 00:00:00

abstract：:Mammalian Krüppel-like transcription factors include 12 zinc finger proteins (KLF1-12) that are involved in regulation of cell proliferation and differentiation during morphogenesis and development (Trends Biochem. Sci., 24 (1999) 236). Structural considerations have segregated KLF6 and KLF7 into a separate sub-group,...

journal_title：Mechanisms of development

authors： Laub F,Aldabe R,Ramirez F,Friedman S

更新日期：2001-08-01 00:00:00

abstract：:The expression pattern of K(+) currents is the principal regulator of electrical activity during development of the nervous and muscular system. We report here a study showing the expression pattern of HERG K(+) currents-encoding (erg) genes in various nervous and muscular tissues at different stages of quail embryo d...

journal_title：Mechanisms of development

authors： Crociani O,Cherubini A,Piccini E,Polvani S,Costa L,Fontana L,Hofmann G,Rosati B,Wanke E,Olivotto M,Arcangeli A

更新日期：2000-07-01 00:00:00

abstract：:This study compares by immunogold labeling the ultrastructural localization of a hexameric 22S glycoprotein, called toposome, with that of hyalin in unfertilized eggs and cells of hatched sea urchin blastulae. Nearly all hyalin is present in the electron translucent compartment of the cortical granules and in the tran...

journal_title：Mechanisms of development

authors： Gratwohl EK,Kellenberger E,Lorand L,Noll H

更新日期：1991-02-01 00:00:00

abstract：:The Suppressor of forked (Su(f)) protein of Drosophila melanogaster is a homologue of the 77K subunit of human cleavage stimulation factor required for cleavage of pre-mRNAs before addition of poly(A). We have previously shown that the Su(f) protein is not ubiquitously distributed: it accumulates in dividing cells at ...

journal_title：Mechanisms of development

authors： Audibert A,Simonelig M

更新日期：1999-04-01 00:00:00

abstract：:An enhancer sequence found in the Protease Nexin-1 (PN-1) gene was shown to drive lacZ expression specifically at the met-/mesencephalic junction in transgenic mouse embryos. A functional study of this enhancer has been performed to better understand the mechanisms regulating isthmic gene expression. An octamer-bindin...

journal_title：Mechanisms of development

authors： Mihailescu D,Küry P,Monard D

更新日期：1999-06-01 00:00:00

abstract：:The Drosophila wing is a classical model for studying the generation of developmental patterns. Previous studies have suggested that vein primordia form at boundaries between discrete sectors of gene expression along the antero-posterior (A/P) axis in the larval wing imaginal disc. Observation that the vein marker rho...

journal_title：Mechanisms of development

authors： Crozatier M,Glise B,Khemici V,Vincent A

更新日期：2003-05-01 00:00:00

abstract：:We describe the structural organization of a gene, termed XFDL 141/156, that is transiently activated during early Xenopus development. XFDL 141/156 is first transcribed at the midblastula transition (MBT) and during early gastrulation events. A roughly 200 nucleotide fragment immediately 5' to the transcription start...

journal_title：Mechanisms of development

authors： Bellefroid E,Bourguignon C,Bouwmeester T,Rausch O,Blumberg B,Pieler T

更新日期：1997-04-01 00:00:00

abstract：:We performed a systematic screen for mutations affecting the trajectory of axons visualized by immunohistochemical staining of Medaka embryos with anti-acetylated tubulin antibody. Among the mutations identified, yanagi (yan) and kazura (kaz) mutations caused specific defects in projection of the posterior lateral lin...

journal_title：Mechanisms of development

authors： Yasuoka A,Hirose Y,Yoda H,Aihara Y,Suwa H,Niwa K,Sasado T,Morinaga C,Deguchi T,Henrich T,Iwanami N,Kunimatsu S,Abe K,Kondoh H,Furutani-Seiki M

更新日期：2004-07-01 00:00:00

abstract：:We describe the cloning, expression pattern and functional overexpression analysis of Xotx5b, a new member of the Otx gene family in Xenopus laevis. Early expression of Xotx5b resembles that of Xotx2, being detected in the organizer region at early gastrula stage, and, shortly after, also in anterior neuroectoderm. Du...

journal_title：Mechanisms of development

authors： Vignali R,Colombetti S,Lupo G,Zhang W,Stachel S,Harland RM,Barsacchi G

更新日期：2000-08-01 00:00:00

abstract：:Mammalian embryos develop in coordination with extraembryonic tissues, which support embryonic development by implanting embryos into the uterus, supplying nutrition, providing a confined niche, and also providing patterning signals to embryos. Here, we show that in mouse embryos, the expansion of the amniotic cavity ...

journal_title：Mechanisms of development

authors： Imuta Y,Koyama H,Shi D,Eiraku M,Fujimori T,Sasaki H

更新日期：2014-05-01 00:00:00

abstract：:In Drosophila, the homeotic gene Distal-less (Dll) has a fundamental role in the establishment of the identity of ventral appendages such as the leg and antenna. This study reports the expression pattern of Dll in the genital disc, the requirement of Dll activity for the development of the terminalia and the activatio...

journal_title：Mechanisms of development

authors： Gorfinkiel N,Sánchez L,Guerrero I

更新日期：1999-08-01 00:00:00

abstract：:The gene crumbs (crb) of Drosophila encodes a transmembrane protein with 30 EGF-like and four laminin A G-domain-like repeats in its extracellular domain. Loss-of-function mutations lead to severe disorganization and degeneration of ectodermally derived embryonic epithelia. In embryos homozygous for crb8F105, an amorp...

journal_title：Mechanisms of development

authors： Wodarz A,Grawe F,Knust E

更新日期：1993-12-01 00:00:00

abstract：:The segmentation of vertebrate embryos depends on a complex genetic network that generates highly dynamic gene expression. Many of the elements of the network have been identified, but their interaction and their influence on segmentation remain poorly understood. A few mathematical models have been proposed to explai...

journal_title：Mechanisms of development

authors： Cinquin O

更新日期：2007-08-01 00:00:00

abstract：:The transgenic sequences in the mouse line TKZ751 are demethylated on a DBA/2 inbred strain background but become highly methylated at postimplantation stages in offspring of a cross with a BALB/c female. In the reciprocal cross the transgene remains demethylated suggesting that imprinted BALB/c methylation modifiers ...

journal_title：Mechanisms of development

authors： Pickard B,Dean W,Engemann S,Bergmann K,Fuermann M,Jung M,Reis A,Allen N,Reik W,Walter J

更新日期：2001-05-01 00:00:00

abstract：:We have made a null mutation in the mouse activin beta B gene by deleting the portion of the gene encoding the proteolytic cleavage site and the majority of the coding region for the mature processed protein. Mice homozygous for this mutation complete embryogenesis and are completely viable. Approximately 40% of the h...

journal_title：Mechanisms of development

authors： Schrewe H,Gendron-Maguire M,Harbison ML,Gridley T

更新日期：1994-07-01 00:00:00

abstract：:Xenopus embryos in solutions containing suramin show a dose-dependent decrease in the formation of dorsoanterior structures. Continuous treatment with 1 mM suramin produces embryos without mesodermal derivatives but with mesenchymal cells. Brief immersions of 20 min were used to determine the most sensitive stages and...

journal_title：Mechanisms of development

authors： Cardellini P,Polo C,Coral S

更新日期：1994-01-01 00:00:00

abstract：:Induction of the retinoic acid receptor beta 2 (RAR beta 2) gene by retinoic acid (RA) is mediated by a RA response element (RARE), which represents a high affinity binding site for RAR/RXR heterodimers acting at this site as RA-inducible transcription activators. In RA resistant RAC65 cells, RAR beta 2 induction is b...

journal_title：Mechanisms of development

authors： Shen S,van der Saag PT,Kruijer W

更新日期：1993-03-01 00:00:00

abstract：:In endothelial cells that form capillary-like structures in vitro a variety of genes is upregulated as we have demonstrated previously. In addition to well known genes, we also identified genes never described in endothelial cells before. Here, we report the further characterization of one selected gene called cystein...

journal_title：Mechanisms of development

authors： Glienke J,Sturz A,Menrad A,Thierauch KH

更新日期：2002-12-01 00:00:00

abstract：:In mammals, the Ror-family receptor tyrosine kinases consist of two structurally related proteins, Ror1 and Ror2, characterized by the extracellular Frizzled-like cysteine-rich domain and membrane proximal kringle domains. As an attempt to gain insights into their roles in mouse development, expression patterns of Ror...

journal_title：Mechanisms of development

authors： Matsuda T,Nomi M,Ikeya M,Kani S,Oishi I,Terashima T,Takada S,Minami Y

更新日期：2001-07-01 00:00:00

abstract：:Homeodomain transcription factor CnNK-2 seems to play a major role in foot formation in Hydra. Recently, we reported in vitro evidence indicating that CnNK-2 has autoregulatory features and regulates expression of the morphogenetic peptide pedibin. We proposed that CnNK-2 and pedibin synergistically orchestrate foot d...

journal_title：Mechanisms of development

authors： Siebert S,Thomsen S,Reimer MM,Bosch TC

更新日期：2005-09-01 00:00:00

abstract：:In the mammary gland Bcl-x is the most abundant cell survival factor from the Bcl-2 family. Since Bcl-x null mice die around day 12 of embryogenesis, the relevance of this protein in organ development and function is poorly understood. In erythroid cells bcl-x gene expression is controlled by cytokines and the transcr...

journal_title：Mechanisms of development

authors： Walton KD,Wagner KU,Rucker EB 3rd,Shillingford JM,Miyoshi K,Hennighausen L

更新日期：2001-12-01 00:00:00

abstract：:Drosophila tracheal fusion cells play multiple important roles in guiding and facilitating tracheal branch fusion. Mechanistic understanding of how fusion cells function during development requires deciphering their transcriptional circuitry. In this paper, three genes with distinct patterns of fusion cell expression ...

journal_title：Mechanisms of development

authors： Jiang L,Pearson JC,Crews ST

更新日期：2010-05-01 00:00:00

abstract：:The polyhomeotic (ph) gene of Drosophila is a member of the Polycomb group of genes and encodes a chromatin protein required for negative regulation of homeotic genes and other loci, in particular the ph locus itself. We have studied the genetic control of ph transcription during development. Early ph expression is un...

journal_title：Mechanisms of development

authors： Fauvarque MO,Zuber V,Dura JM

更新日期：1995-08-01 00:00:00

abstract：:Retinoic acid plays important roles in development, growth and differentiation by regulating the expression of target genes. A new retinoic acid-inducible gene, Stra6, has been identified in P19 embryonal carcinoma cells using a subtractive hybridization cDNA cloning technique. Stra6 codes for a very hydrophobic membr...

journal_title：Mechanisms of development

authors： Bouillet P,Sapin V,Chazaud C,Messaddeq N,Décimo D,Dollé P,Chambon P

更新日期：1997-05-01 00:00:00