Embryonic expression of Krüppel-like factor 6 in neural and non-neural tissues.

abstract：:Early in the development of the imaginal wing disc of Drosophila, the LIM-HD gene tailup (islet), together with the HD genes of the iroquois complex, specify the notum territory of the disc. Later, tailup has been shown to act as a prepattern gene that antagonizes formation of sensory bristles on the notum of this fly...

journal_title：Mechanisms of development

authors： de Navascués J,Modolell J

更新日期：2010-09-01 00:00:00

abstract：:Mice with targeted disruption of the TGF beta 2 gene display defects in epithelial-mesenchymal tissue interactions in several tissues including the developing cochlea. Specifically, the region of the spiral limbus and the overlying interdental cells, structures putatively involved in endolymphatic fluid homeostasis, d...

journal_title：Mechanisms of development

authors： Paradies NE,Sanford LP,Doetschman T,Friedman RA

更新日期：1998-12-01 00:00:00

abstract：:ADAMs are multidomain cell surface proteins that function in receptor-ligand processing, cell adhesion and fusion, and signaling. SpADAM, a single copy sea urchin ADAM gene with a 3072 bp open reading frame, is expressed during embryonic and larval development. The deduced SpADAM protein is 1023 amino acids long and i...

journal_title：Mechanisms of development

authors： Rise M,Burke RD

更新日期：2002-09-01 00:00:00

abstract：:Nemo-like kinases define a novel family of serine/threonine kinases that are involved in integrating multiple signaling pathways. They are conserved regulators of Wnt/Wingless pathways, which may coordinate Wnt with TGFbeta-mediated signaling. Drosophila nemo was identified through its involvement in epithelial planar...

journal_title：Mechanisms of development

authors： Mirkovic I,Charish K,Gorski SM,McKnight K,Verheyen EM

更新日期：2002-11-01 00:00:00

abstract：:The gene crumbs (crb) of Drosophila encodes a transmembrane protein with 30 EGF-like and four laminin A G-domain-like repeats in its extracellular domain. Loss-of-function mutations lead to severe disorganization and degeneration of ectodermally derived embryonic epithelia. In embryos homozygous for crb8F105, an amorp...

journal_title：Mechanisms of development

authors： Wodarz A,Grawe F,Knust E

更新日期：1993-12-01 00:00:00

abstract：:Using a Drosophila cell-free system, we have analyzed the regulation of alternative splicing of Drosophila muscle myosin heavy chain (MHC) transcripts. Splicing of MHC 3' end transcripts results in exclusion of adult-specific alternative exon 18, as is observed in embryonic and larval muscle in vivo. Mutations that st...

journal_title：Mechanisms of development

authors： Hodges D,Bernstein SI

更新日期：1992-05-01 00:00:00

abstract：:The foot of the simple metazoan Hydra is a highly dynamic body region of constant tissue movement, cell proliferation, determination and differentiation. Previously, two genes have been shown to participate in the development and differentiation of this body region: homeodomain factor CnNK-2 and signal peptide pedibin...

journal_title：Mechanisms of development

authors： Thomsen S,Till A,Wittlieb J,Beetz C,Khalturin K,Bosch TC

更新日期：2004-02-01 00:00:00

abstract：:Factors controlling the differentiation of the multipotent embryonic lung endoderm and mesoderm are poorly understood. Recent evidence that Delta-like 1 (Dll1) and other genes in the Notch/Delta signaling pathway are expressed in the embryonic mouse lung suggests that this pathway is important for cell fate decisions ...

journal_title：Mechanisms of development

authors： Post LC,Ternet M,Hogan BL

更新日期：2000-11-01 00:00:00

abstract：:There has been rapid progress recently in the identification of signalling pathways regulating tooth development. It has become apparent that signalling networks involved in Drosophila development and development of mammalian organs such as the limb are also used in tooth development. Teeth are epithelial appendages f...

journal_title：Mechanisms of development

authors： Thesleff I,Sharpe P

更新日期：1997-10-01 00:00:00

abstract：:HNF1 (Hepatic Nuclear Factor 1) and vHNF1 are transcriptional regulators containing a highly divergent homeodomain. The first was initially found in liver nuclear extracts and is crucial for the transcription of albumin and many other hepatocyte specific genes, while the second was found in dedifferentiated hepatoma c...

journal_title：Mechanisms of development

authors： Ott MO,Rey-Campos J,Cereghini S,Yaniv M

更新日期：1991-12-01 00:00:00

abstract：:Four genes - deltaA, deltaB, deltaC and deltaD - coding for homologues of the Notch ligand Delta have been discovered in zebrafish (Haddon et al., 1998b). We report here the cDNA sequence and expression pattern of deltaC. Its closest relatives are deltaB and Xenopus X-Delta-2. Unlike deltaA, deltaB, and deltaD, deltaC...

journal_title：Mechanisms of development

authors： Smithers L,Haddon C,Jiang YJ,Lewis J

更新日期：2000-01-01 00:00:00

abstract：:Imitation Switch (ISWI) is a member of the SWI2/SNF2 superfamily of ATP-dependent chromatin remodelers, which regulate transcription and maintain chromatin structure by mobilizing nucleosomes using the energy of ATP. Four distinct ISWI complexes have been identified in Xenopus oocytes. The developmental role of Xenopu...

journal_title：Mechanisms of development

authors： Dirscherl SS,Henry JJ,Krebs JE

更新日期：2005-11-01 00:00:00

abstract：:The induction of sensory organ placodes, in particular the lens placode, represents the paradigm for induction. We show that medaka Sox3 is expressed in the neuroectoderm and in the placodes of all sensory organs prior to placode formation and subsequently in placode-derived tissues. Ectopic Sox3 expression leads to e...

journal_title：Mechanisms of development

authors： Köster RW,Kühnlein RP,Wittbrodt J

更新日期：2000-07-01 00:00:00

abstract：:The leucine zipper transcription factor TSC-22 (TGF-beta1 Stimulated Clone-22) was first isolated from a mouse osteoblast cell line as an immediate-early target gene of TGF-beta1. However, work with other cell lines, as well as with a Drosophila homolog, bunched, suggests that it is an effector gene of various growth ...

journal_title：Mechanisms of development

authors： Dohrmann CE,Belaoussoff M,Raftery LA

更新日期：1999-06-01 00:00:00

abstract：:In sea urchin development, micromere descendants play important roles in skeletogenesis and induction of gastrulation. We previously reported that the T-brain homolog of sea urchin Hemicentrotus pulcherrimus, HpTb expresses specifically in micromere descendants and is required for induction of gastrulation and skeleto...

journal_title：Mechanisms of development

authors： Ochiai H,Sakamoto N,Momiyama A,Akasaka K,Yamamoto T

更新日期：2008-01-01 00:00:00

abstract：:Development of oligodendrocytes, myelin-forming glia in the central nervous system (CNS), proceeds on a protracted schedule. Specification of oligodendrocyte progenitor cells (OPCs) begins early in development, whereas their terminal differentiation occurs at late embryonic and postnatal periods. However, for oligoden...

journal_title：Mechanisms of development

authors： Hashimoto R,Hori K,Owa T,Miyashita S,Dewa K,Masuyama N,Sakai K,Hayase Y,Seto Y,Inoue YU,Inoue T,Ichinohe N,Kawaguchi Y,Akiyama H,Koizumi S,Hoshino M

更新日期：2016-05-01 00:00:00

abstract：:A new family of homeodomain proteins has recently been identified that includes extradenticle, ceh-20 and three mammalian proteins Pbx1, Pbx2 and Pbx3. We show here that two members of this family, Pbx1 and Pbx2 bind cooperatively to DNA with both Hoxb-7 and Hoxb-8. Engrailed-2 modulates the DNA binding activity of th...

journal_title：Mechanisms of development

authors： van Dijk MA,Peltenburg LT,Murre C

更新日期：1995-07-01 00:00:00

abstract：:Nuclear orphan receptors are DNA binding proteins that share the domain structure of the nuclear hormone receptor superfamily, although ligands are unknown. We have identified an orphan receptor in Xenopus laevis and named it xGCNF based on its high degree of sequence homology to the previously described murine germ c...

journal_title：Mechanisms of development

authors： Joos TO,David R,Dreyer C

更新日期：1996-11-01 00:00:00

abstract：:Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dep...

journal_title：Mechanisms of development

authors： Minoura I,Nakamura H,Tashiro K,Shiokawa K

更新日期：1995-01-01 00:00:00

abstract：:Hairless is a dominant loss of function mutation in Drosophila affecting the formation of adult sensory organs. In the mutants, neuronal precursor cells do not differentiate, suggesting that Hairless might be involved in specifying or realizing neuronal fate in the fly, similar to the 'pro-neural' genes of the achaete...

journal_title：Mechanisms of development

authors： Maier D,Stumm G,Kuhn K,Preiss A

更新日期：1992-08-01 00:00:00

abstract：:We have identified a short segment of the mouse Pax-6 gene 5' flanking region that is necessary and sufficient for reporter construct expression in components of the eye derived from non-neural ectoderm. This transcriptional control element has a highly conserved nucleotide sequence over 341 bp and is located approxim...

journal_title：Mechanisms of development

authors： Williams SC,Altmann CR,Chow RL,Hemmati-Brivanlou A,Lang RA

更新日期：1998-05-01 00:00:00

abstract：:Haploid spermatids undergo extensive cellular, molecular and morphological changes to form spermatozoa during spermiogenesis. Abnormalities in these steps can lead to serious male fertility problems, from oligospermia to complete azoospermia. CHD5 is a chromatin-remodeling nuclear protein expressed almost exclusively ...

journal_title：Mechanisms of development

authors： Zhuang T,Hess RA,Kolla V,Higashi M,Raabe TD,Brodeur GM

更新日期：2014-02-01 00:00:00

abstract：:Active repression of gene expression mediated by unliganded nuclear receptors plays crucial roles in early development of vertebrates. N-CoR (nuclear receptor co-repressor) is the first identified co-repressor that can repress retinoic acid (RA) inducible gene transcription in the absence of RA. Previously, N-CoR was ...

journal_title：Mechanisms of development

authors： Xu F,Li K,Tian M,Hu P,Song W,Chen J,Gao X,Zhao Q

更新日期：2009-10-01 00:00:00

abstract：:The study of distal lung morphogenesis and vascular development would be greatly facilitated by an in vitro or ex vivo experimental model. In this study we show that the growth of mouse embryonic day 12.5 lung rudiments implanted underneath the kidney capsules of syngeneic or immunodeficient hosts follows closely lung...

journal_title：Mechanisms of development

authors： Vu TH,Alemayehu Y,Werb Z

更新日期：2003-03-01 00:00:00

abstract：:The actin cytoskeleton is implicated in many cellular processes, such as cell adhesion, locomotion, contraction and cytokinesis, which are central to any development. The extent of polymerization, cross-linking, and bundling of actin is regulated by several actin-binding proteins. Knock-out mutations in these proteins...

journal_title：Mechanisms of development

authors： Ponte E,Rivero F,Fechheimer M,Noegel A,Bozzaro S

更新日期：2000-03-01 00:00:00

abstract：:The Retinal homeobox gene (Rx; also Rax) plays a crucial role in the early development of the vertebrate eye. Germline deletion of Rx in mice results in the failure of optic vesicle formation, leading to anophthalmia. Recent research using conditional mouse knockout models provides some clues to the role of Rx in eye ...

journal_title：Mechanisms of development

authors： Rodgers HM,Huffman VJ,Voronina VA,Lewandoski M,Mathers PH

更新日期：2018-06-01 00:00:00

abstract：:A pool of beta 1-integrin, ready to be inserted into the cleavage membranes, is present in the cytoplasm of the Xenopus egg, while its plasma membrane is devoid of this membrane protein (Gawantka et al., 1992). The underlying mechanisms that lead to this specific pattern of beta 1-integrin distribution in the egg have...

journal_title：Mechanisms of development

authors： Müller AH,Gawantka V,Ding X,Hausen P

更新日期：1993-07-01 00:00:00

abstract：:The localization of RNAs at the vegetal cortex in Xenopus oocytes is a complex process, involving at least two different pathways. The early, or messenger transport organizer (METRO), pathway, localizes RNAs such as Xlsirts, Xcat2 and Xwnt11 during stages 1 and 2 of oogenesis, while the late pathway localizes RNAs suc...

journal_title：Mechanisms of development

authors： Kloc M,Etkin LD

更新日期：1998-04-01 00:00:00

abstract：:The recent development of transgenic methods for the frog Xenopus laevis provides the opportunity to study later developmental events, such as organogenesis, at the molecular level. Our studies have focused on the development of the tadpole gut, where tissue specific promoters have yet to be identified. We have used m...

journal_title：Mechanisms of development

authors： Beck CW,Slack JM

更新日期：1999-11-01 00:00:00

abstract：:Germ-line mutations of LKB1 and PTEN tumor suppressor genes underlie the phenotypically related Peutz-Jeghers syndrome (PJS) and Cowden disease (CD), respectively. To analyze possible developmental roles of PTEN and LKB1, we have studied their mRNA expression during mouse embryonic development (E7-17.5) by in situ hyb...

journal_title：Mechanisms of development

authors： Luukko K,Ylikorkala A,Tiainen M,Mäkelä TP

更新日期：1999-05-01 00:00:00