Control of foot differentiation in Hydra: in vitro evidence that the NK-2 homeobox factor CnNK-2 autoregulates its own expression and uses pedibin as target gene.

abstract：:Regulatory genes directing embryonic development are expressed in complex patterns. The Drosophila homeobox gene fushi tarazu (ftz) is expressed in a striped pattern that is controlled by several discrete and large cis- regulatory elements. One key cis-element is the ftz proximal enhancer which is required for stripe ...

journal_title：Mechanisms of development

authors： Yu Y,Yussa M,Song J,Hirsch J,Pick L

更新日期：1999-05-01 00:00:00

abstract：:In multicellular organisms, very little is known about the role of mRNA stability in development, and few proteins involved in degradation pathways have been characterized. We have identified the Drosophila homologue of XRN1, which is the major cytoplasmic 5'-3' exoribonuclease in Saccharomyces cerevisiae. The protein...

journal_title：Mechanisms of development

authors： Till DD,Linz B,Seago JE,Elgar SJ,Marujo PE,Elias ML,Arraiano CM,McClellan JA,McCarthy JE,Newbury SF

更新日期：1998-12-01 00:00:00

abstract：:We report the expression pattern of a murine homolog of the Xenopus laevis T-box gene Eomesodermin. mEomes expression is first detected in the extra-embryonic ectoderm prior to gastrulation, and persists there until head-fold stages. In the embryo proper, mEomes is expressed throughout the early primitive streak, nasc...

journal_title：Mechanisms of development

authors： Ciruna BG,Rossant J

更新日期：1999-03-01 00:00:00

abstract：:We describe the structural organization of a gene, termed XFDL 141/156, that is transiently activated during early Xenopus development. XFDL 141/156 is first transcribed at the midblastula transition (MBT) and during early gastrulation events. A roughly 200 nucleotide fragment immediately 5' to the transcription start...

journal_title：Mechanisms of development

authors： Bellefroid E,Bourguignon C,Bouwmeester T,Rausch O,Blumberg B,Pieler T

更新日期：1997-04-01 00:00:00

abstract：:In situ hybridization of mouse embryo whole mounts and sagittal sections revealed a tissue- and stage-specific expression pattern of the transcriptionally regulated serum and glucocorticoid-inducible protein kinase (sgk) during embryogenesis. Sgk expression is first observed at embryonic day 8.5 (E8.5) in the decidua ...

journal_title：Mechanisms of development

authors： Lee E,Lein ES,Firestone GL

更新日期：2001-05-01 00:00:00

abstract：:In the Drosophila embryo the nuclear localisation of Dorsal, a member of the Rel family, is regulated by an extracellular signal, which is transmitted to the interior of the egg cell by a cascade of proteins involving the novel protein Tube and the protein kinase Pelle. Here we analyse the activation mechanism of Tube...

journal_title：Mechanisms of development

authors： Grosshans J,Schnorrer F,Nüsslein-Volhard C

更新日期：1999-03-01 00:00:00

abstract：:Cell-cell interactions during embryogenesis have been shown to be important for establishing developmental fates in a number of organisms such as Drosophila and Caenorhabditis. One class of genes shown to mediate this process are receptor-protein tyrosine kinases (R-PTKs). To examine whether R-PTKs might participate i...

journal_title：Mechanisms of development

authors： Ruiz JC,Robertson EJ

更新日期：1994-05-01 00:00:00

abstract：:Growth is confined within a size that is normal for each species, revealing that somehow an organism 'knows' when this size has been reached. Within a species, growth is also variable, but despite this, proportion and structure are maintained. Perhaps, the key element in the control of size is the control of cell numb...

journal_title：Mechanisms of development

authors： Hidalgo A,ffrench-Constant C

更新日期：2003-11-01 00:00:00

abstract：:dkk-1 has recently been identified as a secreted protein in Xenopus laevis which is sufficient and necessary to cause head induction by antagonizing Wnt signalling (Glinka et al., 1998, Nature 391, 357-362). Consistent with such a role dkk-1 is expressed in the Spemann organizer of the early frog gastrula. Later, expr...

journal_title：Mechanisms of development

authors： Grotewold L,Theil T,Rüther U

更新日期：1999-12-01 00:00:00

abstract：:During the final stages of embryogenesis, the Drosophila embryo exhibits a dorsal hole covered by a simple epithelium of large cells termed the amnioserosa (AS). Dorsal closure is the process whereby this hole is closed through the coordination of cellular activities within both the AS and the epidermis. Genetic analy...

journal_title：Mechanisms of development

authors： Fernández BG,Arias AM,Jacinto A

更新日期：2007-11-01 00:00:00

abstract：:In C. elegans development, unfavorable growth conditions lead a larva to an arrested and enduring form called a dauer. To elucidate components upstream of DAF-7/TGF-beta in this control pathway, we isolated a mutant that was defective in daf-7 promoter::gfp reporter expression and showed an arrested (dauer-constitutiv...

journal_title：Mechanisms of development

authors： Murakami M,Koga M,Ohshima Y

更新日期：2001-11-01 00:00:00

abstract：:Gastrulation in vertebrates is a highly dynamic process driven by convergent extension movements of internal mesodermal cells, under the regulatory activity of the Spemann-Mangold or gastrula organizer. In a large-scale screen for genes expressed in the organizer, we have isolated a novel gene, termed Xmc, an acronym ...

journal_title：Mechanisms of development

authors： Frazzetto G,Klingbeil P,Bouwmeester T

更新日期：2002-04-01 00:00:00

abstract：:The actin cytoskeleton is implicated in many cellular processes, such as cell adhesion, locomotion, contraction and cytokinesis, which are central to any development. The extent of polymerization, cross-linking, and bundling of actin is regulated by several actin-binding proteins. Knock-out mutations in these proteins...

journal_title：Mechanisms of development

authors： Ponte E,Rivero F,Fechheimer M,Noegel A,Bozzaro S

更新日期：2000-03-01 00:00:00

abstract：:We present the first time/space analysis using in situ hybridization for PTTG and prc1 genes during development of the mouse telencephalon. During the stages E11.5-E13.5 PTTG and prc1 are expressed in most tissues of the embryo. Within the telencephalon, PTTG and prc1 are found exclusively inside of the ventricular zo...

journal_title：Mechanisms of development

authors： Tarabykin V,Britanova O,Fradkov A,Voss A,Katz LS,Lukyanov S,Gruss P

更新日期：2000-04-01 00:00:00

abstract：:The homeotic or Hox genes encode a network of conserved transcription factors which provide axial positional information and control segment morphology in development and evolution. During embryonic brain development of Drosophila, the Hox gene labial (lab) is essential for tritocerebral neuromere specification; lab l...

journal_title：Mechanisms of development

authors： Meier S,Sprecher SG,Reichert H,Hirth F

更新日期：2006-01-01 00:00:00

abstract：:In mouse Otx2 plays essential roles in anterior-posterior axis formation and head development in anterior visceral endoderm and anterior mesendoderm. The Otx2 expression in these sites is regulated by VE and CM enhancers at the 5' proximal to the translation start site, and we proposed that these enhancers would have ...

journal_title：Mechanisms of development

authors： Kurokawa D,Ohmura T,Akasaka K,Aizawa S

更新日期：2012-01-01 00:00:00

abstract：:Noelins are secreted glycoproteins with important developmental functions in frogs and birds. Here, we present the expression pattern of the mouse homolog of Noelin-1/2 at E8-10 of development and compare this pattern to other vertebrates. Expression was observed in the neural plate and neural crest, as well as in the...

journal_title：Mechanisms of development

authors： Moreno TA,Bronner-Fraser M

更新日期：2002-11-01 00:00:00

abstract：:In chick embryos, naso-temporal polarity of the retina becomes established before Hamburger-Hamilton stage 10. To examine the plasticity of the early eye anlage, double-temporal eyes were made using stage 10-11 (E1.5) chick embryos and stage 8-9 quail embryos. In vivo and in vitro experiments revealed that these doubl...

journal_title：Mechanisms of development

authors： Mueller BK,Dütting D,Haase A,Feucht A,Macchi P

更新日期：1998-06-01 00:00:00

abstract：:Epimorphic regeneration is a process allowing the animal to regain its lost structure which depends on the resident pluripotent stem cells as well as de-differentiation of existing cells to form multi-potent stem cells. Many studies have been done to understand the appendage regeneration mechanism. The animal model us...

journal_title：Mechanisms of development

authors： Murawala H,Ranadive I,Patel S,Desai I,Balakrishnan S

更新日期：2018-04-01 00:00:00

abstract：:Tribolium castaneum is a well-characterised model insect, whose short germ-band mode of embryonic development is characteristic of many insect species and differs from the exhaustively studied Drosophila. Mechanisms of early neurogenesis, however, show significant conservation with Drosophila, as a characteristic patt...

journal_title：Mechanisms of development

authors： Kux K,Kiparaki M,Delidakis C

更新日期：2013-04-01 00:00:00

abstract：:In the process of cloning murine proteins capable of binding to a regulatory module of the Ncam promoter, we isolated a novel homeobox gene, Barx1, the first vertebrate member of the structural subclass defined by Drosophila BarH1. Here we report its sequence, chromosomal localisation and embryonic expression pattern....

journal_title：Mechanisms of development

authors： Tissier-Seta JP,Mucchielli ML,Mark M,Mattei MG,Goridis C,Brunet JF

更新日期：1995-05-01 00:00:00

abstract：:The polyhomeotic (ph) gene of Drosophila is a member of the Polycomb group of genes and encodes a chromatin protein required for negative regulation of homeotic genes and other loci, in particular the ph locus itself. We have studied the genetic control of ph transcription during development. Early ph expression is un...

journal_title：Mechanisms of development

authors： Fauvarque MO,Zuber V,Dura JM

更新日期：1995-08-01 00:00:00

abstract：:The mouse and human Hox complex consists of 39 genes in four linkage groups (A-D). Although the structure and expression patterns of most of these genes have been reported, the 5' members of the Hox C linkage group have been only partially characterized. Herein we report the primary and genomic structure of the mouse ...

journal_title：Mechanisms of development

authors： Hostikka SL,Capecchi MR

更新日期：1998-01-01 00:00:00

abstract：:Msg1 and Mrg1 are founding members of a gene family which exhibit distinct patterns of gene expression during mouse embryogenesis. Sequence analysis reveals that these genes are unlike any other gene identified to date, but they share two near-identical sequence domains. The Msg1 and Mrg1 expression profiles during ea...

journal_title：Mechanisms of development

authors： Dunwoodie SL,Rodriguez TA,Beddington RS

更新日期：1998-03-01 00:00:00

abstract：:The process of gastrulation is a pivotal step in the formation of the vertebrate body plan. The primary function of gastrulation is the correct placement of precursor tissues for subsequent morphogenesis. There is now mounting evidence that the body plan is established through inductive interactions between germ layer...

journal_title：Mechanisms of development

authors： Tam PP,Behringer RR

更新日期：1997-11-01 00:00:00

abstract：:We have sequenced and defined the expression during rat embryogenesis of the protocadherin fat, the murine homologue of a Drosophila tumour suppressor gene. As previously described for human fat, the sequence encodes a large protocadherin with 34 cadherin repeats, five epidermal growth factor (EGF)-like repeats contai...

journal_title：Mechanisms of development

authors： Ponassi M,Jacques TS,Ciani L,ffrench Constant C

更新日期：1999-02-01 00:00:00

abstract：:Wnt-4 signaling plays a critical role in kidney development and is associated with the epithelial conversion of the metanephric mesenchyme. Furthermore, secreted Frizzled-related proteins (sFRPs) that can bind Wnts are normally expressed in the developing metanephros, and function in other systems as modulators of Wnt...

journal_title：Mechanisms of development

authors： Yoshino K,Rubin JS,Higinbotham KG,Uren A,Anest V,Plisov SY,Perantoni AO

更新日期：2001-04-01 00:00:00

abstract：:In the mammary gland Bcl-x is the most abundant cell survival factor from the Bcl-2 family. Since Bcl-x null mice die around day 12 of embryogenesis, the relevance of this protein in organ development and function is poorly understood. In erythroid cells bcl-x gene expression is controlled by cytokines and the transcr...

journal_title：Mechanisms of development

authors： Walton KD,Wagner KU,Rucker EB 3rd,Shillingford JM,Miyoshi K,Hennighausen L

更新日期：2001-12-01 00:00:00

abstract：:Drosophila tracheal fusion cells play multiple important roles in guiding and facilitating tracheal branch fusion. Mechanistic understanding of how fusion cells function during development requires deciphering their transcriptional circuitry. In this paper, three genes with distinct patterns of fusion cell expression ...

journal_title：Mechanisms of development

authors： Jiang L,Pearson JC,Crews ST

更新日期：2010-05-01 00:00:00

abstract：:Haploid spermatids undergo extensive cellular, molecular and morphological changes to form spermatozoa during spermiogenesis. Abnormalities in these steps can lead to serious male fertility problems, from oligospermia to complete azoospermia. CHD5 is a chromatin-remodeling nuclear protein expressed almost exclusively ...

journal_title：Mechanisms of development

authors： Zhuang T,Hess RA,Kolla V,Higashi M,Raabe TD,Brodeur GM

更新日期：2014-02-01 00:00:00