ventral veins lacking is required for specification of the tritocerebrum in embryonic brain development of Drosophila.


:The homeotic or Hox genes encode a network of conserved transcription factors which provide axial positional information and control segment morphology in development and evolution. During embryonic brain development of Drosophila, the Hox gene labial (lab) is essential for tritocerebral neuromere specification; lab loss of function results in tritocerebral cells that fail to adopt a neuronal identity, causing axonal pathfinding defects. Here we present evidence that the POU-homeodomain DNA-binding protein ventral veins lacking (vvl) acts genetically downstream of lab in the specification of the tritocerebral neuromere. In the embryonic brain, vvl expression is seen in all brain neuromeres, including the tritocerebral lab domain. Lab mutant analysis shows that vvl expression in the tritocerebrum is dependent on lab activity. Loss-of-function analysis focussed on the tritocerebrum reveals that inactivation of vvl results in patterning defects which are comparable to the brain phenotype caused by null mutation of lab. In the absence of vvl, mutant tritocerebral cells are generated and positioned correctly, but these cells fail to express neuronal markers indicating defects in neuronal differentiation. Moreover, longitudinal axon pathways in the tritocerebrum are severely reduced or absent and the tritocerebral commissure is missing in the vvl mutant brain. Genetic rescue experiments show that vvl is able to partially replace lab in the specification of the tritocerebral neuromere. Our results indicate that vvl acts downstream of the Hox gene lab and regulates specific aspects of neuronal differentiation within the tritocerebral neuromere during embryonic brain development of Drosophila.


Mech Dev


Meier S,Sprecher SG,Reichert H,Hirth F




Has Abstract


2006-01-01 00:00:00














  • In vivo time-lapse imaging in medaka--n-heptanol blocks contractile rhythmical movements.

    abstract::Medaka is an ideal model system for developmental studies as it combines the advantages of powerful genetics and classical embryology. Due to the accessibility, transparency and fast development, embryogenesis and morphogenesis can be followed in vivo. Microscopic time-lapse imaging, however, requires the immobilizati...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Rembold M,Wittbrodt J

    更新日期:2004-07-01 00:00:00

  • Cellular specificity of expression and regulation of Drosophila vitelline membrane protein 32E gene in the follicular epithelium: identification of cis-acting elements.

    abstract::In this paper we analyze the expression in follicular cells and regulation of the vitelline membrane protein gene we identified in region 32E of the second chromosome of D. melanogaster (VMP32E). We report germ line transformation results obtained with different kinds of gene fusion leading to the identification of a ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Gargiulo G,Gigliotti S,Malva C,Graziani F

    更新日期:1991-11-01 00:00:00

  • The battle of the sexes.

    abstract::The sex determining gene, Sry, determines the sex of the organism by initiating development of a testis rather than an ovary from the cells of the bipotential gonad. In the 10 years since the discovery of Sry, new genes and cellular pathways that operate in the establishment of the gonadal primordium and the initiatio...

    journal_title:Mechanisms of development

    pub_type: 杂志文章,评审


    authors: Capel B

    更新日期:2000-03-15 00:00:00

  • Structure and expression patterns of Drosophila TULP and TUSP, members of the tubby-like gene family.

    abstract::Tubby is a mouse gene that may provide a model for adult-onset obesity in humans. It is a member of a four gene family in mammals that collectively encode the Tubby-like proteins (TULPs), putative transcription factors which share similar 260 amino acid 'tubby domains' at their C-termini. The mammalian genome also enc...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Ronshaugen M,McGinnis N,Inglis D,Chou D,Zhao J,McGinnis W

    更新日期:2002-09-01 00:00:00

  • New insights into saccular development and vascular formation in lung allografts under the renal capsule.

    abstract::The study of distal lung morphogenesis and vascular development would be greatly facilitated by an in vitro or ex vivo experimental model. In this study we show that the growth of mouse embryonic day 12.5 lung rudiments implanted underneath the kidney capsules of syngeneic or immunodeficient hosts follows closely lung...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Vu TH,Alemayehu Y,Werb Z

    更新日期:2003-03-01 00:00:00

  • MYB and CBP: physiological relevance of a biochemical interaction.

    abstract::Drosophila melanogaster possesses a single gene, Dm myb, that is closely related to the vertebrate family of Myb genes, which encode transcription factors involved in regulatory decisions affecting cell proliferation, differentiation and apoptosis. In proliferating cells, the Dm myb gene product, DMyb, promotes both S...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Fung SM,Ramsay G,Katzen AL

    更新日期:2003-06-01 00:00:00

  • Regulation of polyhomeotic transcription may involve local changes in chromatin activity in Drosophila.

    abstract::The polyhomeotic (ph) gene of Drosophila is a member of the Polycomb group of genes and encodes a chromatin protein required for negative regulation of homeotic genes and other loci, in particular the ph locus itself. We have studied the genetic control of ph transcription during development. Early ph expression is un...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Fauvarque MO,Zuber V,Dura JM

    更新日期:1995-08-01 00:00:00

  • Expression of ret in the chicken embryo suggests roles in regionalisation of the vagal neural tube and somites and in development of multiple neural crest and placodal lineages.

    abstract::In a screen for receptor tyrosine kinase genes regionally expressed in the developing hindbrain, we cloned and characterised the chicken ret gene. Data derived from studies of congenital human disease and from disruption of murine ret have demonstrated roles for ret in development of the kidney and enteric nervous sys...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Robertson K,Mason I

    更新日期:1995-11-01 00:00:00

  • Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning.

    abstract::In a large-scale gene expression screen 1765 randomly picked cDNAs were analyzed by whole-mount in situ hybridization in Xenopus embryos. Two hundred and seventy three unique, differentially expressed genes were identified, 204 of which are novel in Xenopus. Partial DNA sequences and expression patterns were documente...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Gawantka V,Pollet N,Delius H,Vingron M,Pfister R,Nitsch R,Blumenstock C,Niehrs C

    更新日期:1998-10-01 00:00:00

  • Platelet-derived growth factor receptor alpha (pdgfr-alpha) gene in zebrafish embryonic development.

    abstract::Here we present the cloning of a full-length zebrafish pdgfr-alpha cDNA as well as the expression of this gene during zebrafish embryogenesis. We show that zebrafish pdgfr-alpha mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation. Spatially restricted ex...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Liu L,Chong SW,Balasubramaniyan NV,Korzh V,Ge R

    更新日期:2002-08-01 00:00:00

  • Control of foot differentiation in Hydra: phylogenetic footprinting indicates interaction of head, bud and foot patterning systems.

    abstract::Homeodomain transcription factor CnNK-2 seems to play a major role in foot formation in Hydra. Recently, we reported in vitro evidence indicating that CnNK-2 has autoregulatory features and regulates expression of the morphogenetic peptide pedibin. We proposed that CnNK-2 and pedibin synergistically orchestrate foot d...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Siebert S,Thomsen S,Reimer MM,Bosch TC

    更新日期:2005-09-01 00:00:00

  • Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis.

    abstract::The maintenance of pluripotential embryonic stem (ES) cells is dependent on the cytokine LIF. This report documents the mRNA expression profiles of LIF and the two components of the LIF-receptor complex, LIF-R and gp130, during early mouse embryogenesis. These mRNAs were undetectable in 1- or 2-cell embryos, but all w...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Nichols J,Davidson D,Taga T,Yoshida K,Chambers I,Smith A

    更新日期:1996-07-01 00:00:00

  • Mice homozygous for a null mutation of activin beta B are viable and fertile.

    abstract::We have made a null mutation in the mouse activin beta B gene by deleting the portion of the gene encoding the proteolytic cleavage site and the majority of the coding region for the mature processed protein. Mice homozygous for this mutation complete embryogenesis and are completely viable. Approximately 40% of the h...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Schrewe H,Gendron-Maguire M,Harbison ML,Gridley T

    更新日期:1994-07-01 00:00:00

  • Expression of the T-box gene Eomesodermin during early mouse development.

    abstract::We report the expression pattern of a murine homolog of the Xenopus laevis T-box gene Eomesodermin. mEomes expression is first detected in the extra-embryonic ectoderm prior to gastrulation, and persists there until head-fold stages. In the embryo proper, mEomes is expressed throughout the early primitive streak, nasc...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Ciruna BG,Rossant J

    更新日期:1999-03-01 00:00:00

  • The role of the BR-C locus on the expression of genes located at the ecdysone-regulated 3C puff of Drosophila melanogaster.

    abstract::During the third larval instar, the steroid moulting hormone ecdysone activates three temporally distinct puff sets on the D. melanogaster salivary gland polytene chromosome: the so-called intermoult, early and late puffs. Hormonal regulation of intermoult puffs is quite complex and, so far, largely not understood. In...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: D'Avino PP,Crispi S,Polito LC,Furia M

    更新日期:1995-02-01 00:00:00

  • Interaction of gap genes in the Drosophila head: tailless regulates expression of empty spiracles in early embryonic patterning and brain development.

    abstract::Unlike gap genes in the trunk region of Drosophila embryos, gap genes in the head were presumed not to regulate each other's transcription. Here, we show that in tailless (tll) loss-of-function mutants the empty spiracles (ems) expression domain in the head expands, whereas it retracts in tll gain-of-function embryos....

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Hartmann B,Reichert H,Walldorf U

    更新日期:2001-12-01 00:00:00

  • Protein expression pattern and analysis of differentially expressed peptides during various stages of tail regeneration in Hemidactylus flaviviridis.

    abstract::Epimorphic regeneration is a process allowing the animal to regain its lost structure which depends on the resident pluripotent stem cells as well as de-differentiation of existing cells to form multi-potent stem cells. Many studies have been done to understand the appendage regeneration mechanism. The animal model us...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Murawala H,Ranadive I,Patel S,Desai I,Balakrishnan S

    更新日期:2018-04-01 00:00:00

  • piragua encodes a zinc finger protein required for development in Drosophila.

    abstract::We isolated and characterized embryonic lethal mutations in piragua (prg). The prg locus encodes a protein with an amino terminus Zinc Finger-Associated-Domain (ZAD) and nine C2H2 zinc fingers (ZF). prg mRNA and protein expression during embryogenesis is dynamic with widespread maternal contribution, and subsequent ex...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Nazario-Yepiz NO,Riesgo-Escovar JR

    更新日期:2017-04-01 00:00:00

  • Dynamic expression of alternate splice forms of D-cbl during embryogenesis.

    abstract::The Cbl family of proteins act as E3 ubiquitin-protein ligases and have been associated with the down regulation of a variety of receptor tyrosine kinases. Cbl proteins associate with many different cell signalling molecules suggesting that they may have functions outside of the RING finger-mediated ubiquitin ligase a...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Hime GR,Abud HE,Garner B,Harris KL,Robertson H

    更新日期:2001-04-01 00:00:00

  • In vitro transdifferentiation of hepatoma cells into functional pancreatic cells.

    abstract::We have characterised the transdifferentiation of human HepG2 (hepatoma) cells to pancreatic cells following introduction of an activated version of the pancreatic transcription factor Pdx1 (XlHbox8-VP16). The following questions are addressed: (1) are all types of pancreatic cells produced? (2) is the requirement for...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Li WC,Horb ME,Tosh D,Slack JM

    更新日期:2005-06-01 00:00:00

  • Expression of Drosophila trithorax-group homologues in chick embryos.

    abstract::Mll, Brg1 and Brm are vertebrate homologues of Drosophila trithorax group (trxG) genes. We isolated chicken Mll cDNA clones, and examined patterns of Mll, Brg1 and Brm expression in chick embryos. All three genes were expressed from embryonic stage 2 onwards. Mll transcripts were just detectable in all tissues by in s...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Schofield J,Isaac A,Golovleva I,Crawley A,Goodwin G,Tickle C,Brickell P

    更新日期:1999-01-01 00:00:00

  • XMam1, Xenopus Mastermind1, induces neural gene expression in a Notch-independent manner.

    abstract::Mastermind, which is a Notch signal component, is a nuclear protein and is thought to contribute to the transactivation of target genes. Previously we showed that XMam1, Xenopus Mastermind1, was essential in the transactivation of a Notch target gene, XESR-1, and was involved in primary neurogenesis. To examine the fu...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Katada T,Ito M,Kojima Y,Miyatani S,Kinoshita T

    更新日期:2006-11-01 00:00:00

  • Function of ets genes is conserved between vertebrates and Drosophila.

    abstract::The Drosophila pointed gene encodes two ETS transcriptional activators, pointedP1 and pointedP2, sharing a common C-terminal ETS domain. In the embryonic central nervous system pointedP2 is required for midline glial cell differentiation, whereas, in the eye, pointedP2 is essential for photoreceptor cell differentiati...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Albagli O,Klaes A,Ferreira E,Leprince D,Klämbt C

    更新日期:1996-09-01 00:00:00

  • Tissue distribution of PEBBLE RNA and pebble protein during Drosophila embryonic development.

    abstract::pebble (pbl) is required for cytokinesis during postblastoderm mitoses (Hime, G., Saint, R., 1992. Zygotic expression of the pebble locus is required for cytokinesis during the postblastoderm mitoses of Drosophila. Development 114, 165-171; Lehner, C.F., 1992. The pebble gene is required for cytokinesis in Drosophila....

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Prokopenko SN,Saint R,Bellen HJ

    更新日期:2000-02-01 00:00:00

  • Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model.

    abstract::The tetrapod vertebral column has become increasingly complex during evolution as an adaptation to a terrestrial life. At the same time, the evolution of the vertebral formula became subject to developmental constraints acting on the size of the cervical and thoraco-lumbar regions. In the course of our studies concern...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Woltering JM,Duboule D

    更新日期:2015-11-01 00:00:00

  • Characterization of zebrafish smad1, smad2 and smad5: the amino-terminus of smad1 and smad5 is required for specific function in the embryo.

    abstract::Members of the TGFbeta superfamily of signalling molecules play important roles in mesendoderm induction and dorsoventral patterning of the vertebrate embryo. We cloned three intracellular mediators of TGFbeta signalling, smad1, 2 and 5, from the zebrafish. The three smad genes are expressed ubiquitously at the onset ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Müller F,Blader P,Rastegar S,Fischer N,Knöchel W,Strähle U

    更新日期:1999-10-01 00:00:00

  • Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein.

    abstract::Retinoic acid plays important roles in development, growth and differentiation by regulating the expression of target genes. A new retinoic acid-inducible gene, Stra6, has been identified in P19 embryonal carcinoma cells using a subtractive hybridization cDNA cloning technique. Stra6 codes for a very hydrophobic membr...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Bouillet P,Sapin V,Chazaud C,Messaddeq N,Décimo D,Dollé P,Chambon P

    更新日期:1997-05-01 00:00:00

  • Egfr signaling controls the size of the stem cell precursor pool in the Drosophila ovary.

    abstract::In many animals, germline progenitors are kept undifferentiated to give rise to germline stem cells (GSCs), enabling continuous production of gametes throughout animal life. In the Drosophila ovary, GSCs arise from a subset of primordial germ cells (PGCs) that stay undifferentiated even after gametogenesis has started...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Matsuoka S,Hiromi Y,Asaoka M

    更新日期:2013-04-01 00:00:00

  • The Ste20-like kinase misshapen functions together with Bicaudal-D and dynein in driving nuclear migration in the developing drosophila eye.

    abstract::Nuclear translocation, driven by the motility apparatus consisting of the cytoplasmic dynein motor and microtubules, is essential for cell migration during embryonic development. Bicaudal-D (Bic-D), an evolutionarily conserved dynein-interacting protein, is required for developmental control of nuclear migration in Dr...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Houalla T,Hien Vuong D,Ruan W,Suter B,Rao Y

    更新日期:2005-01-01 00:00:00

  • Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo.

    abstract::In mammals, 16 members of the Fgf family have so far been described with diverse roles in embryonic cell growth and differentiation. Here, we report the expression from early streak stage to midgestation of two newly-identified murine genes, Fgf17 and Fgf18, that are most closely related to Fgf8 (63.7% and 56.8% ident...

    journal_title:Mechanisms of development

    pub_type: 杂志文章


    authors: Maruoka Y,Ohbayashi N,Hoshikawa M,Itoh N,Hogan BL,Furuta Y

    更新日期:1998-06-01 00:00:00