Expression domains of murine ephrin-A5 in the pituitary and hypothalamus.

Abstract:

:Using in situ hybridization on whole-mounts and sections of mouse embryos we have visualized the pattern of expression for the Eph receptor ligand ephrin-A5. Non neuronal expression domains include the ectoderm of the branchial arches, the ectoderm and mesenchyme surrounding the dorsal root ganglia, the intervertebral discs, maxillary and mandibulary mesenchymal elements as well as the nasal mesenchyme and ectoderm. Within the developing nervous system, ephrin-A5 expression is very dynamic. Besides the midbrain it is also expressed in the hypothalamus, and the neurohypophysis that we studied here in more detail. Hypothalamus expression of ephrin-A5 demarks distinct nuclei, persists throughout embryonic development, and can be seen also in the adult.

journal_name

Mech Dev

authors

Zarbalis K,Wurst W

doi

10.1016/s0925-4773(00)00252-5

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

165-8

issue

1-2

eissn

0925-4773

issn

1872-6356

pii

S0925477300002525

journal_volume

93

pub_type

杂志文章
  • Hairless, a Drosophila gene involved in neural development, encodes a novel, serine rich protein.

    abstract::Hairless is a dominant loss of function mutation in Drosophila affecting the formation of adult sensory organs. In the mutants, neuronal precursor cells do not differentiate, suggesting that Hairless might be involved in specifying or realizing neuronal fate in the fly, similar to the 'pro-neural' genes of the achaete...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/0925-4773(92)90006-6

    authors: Maier D,Stumm G,Kuhn K,Preiss A

    更新日期:1992-08-01 00:00:00

  • Specific modification of heparan sulphate is required for normal cerebral cortical development.

    abstract::Proteoglycans are cell surface and extracellular matrix molecules to which long, unbranched glycosaminoglycan side chains are attached. Heparan sulphate, a type of glycosaminoglycan chain, has been proposed as a co-factor necessary for signalling by a range of growth factors. Here we provide evidence that loss of 2-O-...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/j.mod.2003.08.008

    authors: McLaughlin D,Karlsson F,Tian N,Pratt T,Bullock SL,Wilson VA,Price DJ,Mason JO

    更新日期:2003-12-01 00:00:00

  • Expression of ret in the chicken embryo suggests roles in regionalisation of the vagal neural tube and somites and in development of multiple neural crest and placodal lineages.

    abstract::In a screen for receptor tyrosine kinase genes regionally expressed in the developing hindbrain, we cloned and characterised the chicken ret gene. Data derived from studies of congenital human disease and from disruption of murine ret have demonstrated roles for ret in development of the kidney and enteric nervous sys...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/0925-4773(95)00449-1

    authors: Robertson K,Mason I

    更新日期:1995-11-01 00:00:00

  • Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species.

    abstract::The enteric nervous system (ENS) derives from migratory neural crest cells that colonize the developing gut tube, giving rise to an integrated network of neurons and glial cells, which together regulate important aspects of gut function, including coordinating the smooth muscle contractions of the gut wall. The absenc...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/j.mod.2008.04.006

    authors: Heanue TA,Pachnis V

    更新日期:2008-08-01 00:00:00

  • Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster.

    abstract::In multicellular organisms, very little is known about the role of mRNA stability in development, and few proteins involved in degradation pathways have been characterized. We have identified the Drosophila homologue of XRN1, which is the major cytoplasmic 5'-3' exoribonuclease in Saccharomyces cerevisiae. The protein...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(98)00173-7

    authors: Till DD,Linz B,Seago JE,Elgar SJ,Marujo PE,Elias ML,Arraiano CM,McClellan JA,McCarthy JE,Newbury SF

    更新日期:1998-12-01 00:00:00

  • Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus.

    abstract::The dorsal thalamus (DT) is a pivotal region in the vertebrate brain that relays inputs from the peripheral sensory organs to higher cognitive centers. It consists of clusters of neurons with relevant functions, called brain nuclei. However, the mechanisms underlying development of the DT, including specification of t...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/j.mod.2003.09.001

    authors: Hashimoto-Torii K,Motoyama J,Hui CC,Kuroiwa A,Nakafuku M,Shimamura K

    更新日期:2003-10-01 00:00:00

  • Expression pattern of cLhx2b, cZic1 and cZic3 in the developing chick diencephalon.

    abstract::The diencephalon is the caudal part of the developing forebrain that gives rise to the epithalamus, thalamus, hypothalamus and retina. The mature diencephalon is functionally and anatomically parceled into well-defined nuclei. In an effort to understand how this region of the brain develops we examined the expression ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(02)00091-6

    authors: Lim Y,Golden JA

    更新日期:2002-07-01 00:00:00

  • Regulation of mesodermal precursor production by low-level expression of B1 Sox genes in the caudal lateral epiblast.

    abstract::High expression of the B1 Sox genes, Sox2 and Sox3, is associated with the development of definitive neural primordia, the neural plates, in early stage embryos. However, in the caudal lateral epiblast (CLE) where axial stem cells reside, Sox2 and Sox3 are expressed at low levels, together with Brachyury. Because axia...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/j.mod.2014.01.003

    authors: Yoshida M,Uchikawa M,Rizzoti K,Lovell-Badge R,Takemoto T,Kondoh H

    更新日期:2014-05-01 00:00:00

  • Drosophila nemo is an essential gene involved in the regulation of programmed cell death.

    abstract::Nemo-like kinases define a novel family of serine/threonine kinases that are involved in integrating multiple signaling pathways. They are conserved regulators of Wnt/Wingless pathways, which may coordinate Wnt with TGFbeta-mediated signaling. Drosophila nemo was identified through its involvement in epithelial planar...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(02)00289-7

    authors: Mirkovic I,Charish K,Gorski SM,McKnight K,Verheyen EM

    更新日期:2002-11-01 00:00:00

  • Graded expression patterns of ephrin-As in the superior colliculus after lesion of the adult mouse optic nerve.

    abstract::The idea has been put forward that molecules and mechanisms acting during development are re-used during regeneration in the adult, for example in response to traumatic injury in order to re-establish the functional integrity of neuronal circuits. Members of the Eph family of receptor tyrosine kinases and their 'ligan...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(01)00431-2

    authors: Knöll B,Isenmann S,Kilic E,Walkenhorst J,Engel S,Wehinger J,Bähr M,Drescher U

    更新日期:2001-08-01 00:00:00

  • The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification.

    abstract::The Retinal homeobox gene (Rx; also Rax) plays a crucial role in the early development of the vertebrate eye. Germline deletion of Rx in mice results in the failure of optic vesicle formation, leading to anophthalmia. Recent research using conditional mouse knockout models provides some clues to the role of Rx in eye ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/j.mod.2018.04.003

    authors: Rodgers HM,Huffman VJ,Voronina VA,Lewandoski M,Mathers PH

    更新日期:2018-06-01 00:00:00

  • Respecification of ectoderm and altered Nodal expression in sea urchin embryos after cobalt and nickel treatment.

    abstract::In the sea urchin embryo, Nodal is the earliest known signal to play a role in the specification of the oral ectodermal territory. Nodal, a TGF-beta ligand, is first expressed in the presumptive oral ectoderm at approximately 7 H of development. Nodal overexpression produces a distinctive bell-shaped phenotype with ex...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/j.mod.2009.01.005

    authors: Agca C,Klein WH,Venuti JM

    更新日期:2009-05-01 00:00:00

  • Differentiation dependent expression in muscle cells of ZT3, a novel zinc finger factor differentially expressed in embryonic and adult tissues.

    abstract::ZT3, isolated from a murine muscle cell cDNA library by a low-stringency hybridization, encodes a zinc finger domain containing factor with a transcript of 5.0 kb. A 3' 2.5 kb partial nucleotide sequence contains an ORF of 1.5 kb where 17 canonical C2H2 zinc finger domains organized in tandem were identified. It maps ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/0925-4773(95)00465-3

    authors: Polimeni M,Giorgi S,De Gregorio L,Dragani TA,Molinaro M,Cossu G,Bouché M

    更新日期:1996-01-01 00:00:00

  • Fibulin-1 suppresses endothelial to mesenchymal transition in the proximal outflow tract.

    abstract::Endothelial to mesenchymal transition (EMT) that occurs during cardiac outflow tract (OFT) development is critical for formation of the semilunar valves. Fibulin-1 (Fbln1) is an extracellular matrix protein that is present at several sites of EMT, including the OFT (i.e., E9.5-10.5). The aim of this study was to deter...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/j.mod.2014.12.005

    authors: Harikrishnan K,Cooley MA,Sugi Y,Barth JL,Rasmussen LM,Kern CB,Argraves KM,Argraves WS

    更新日期:2015-05-01 00:00:00

  • The expression of tyrosine hydroxylase and the transcription factors cPhox-2 and Cash-1: evidence for distinct inductive steps in the differentiation of chick sympathetic precursor cells.

    abstract::The adrenergic differentiation of sympathetic neurons is controlled by complex interactions with the embryonic environment. To provide a basis for the experimental analysis of these interactions, the expression of the adrenergic marker enzyme tyrosine hydroxylase (TH) was analyzed by immunohistochemistry and in situ h...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/0925-4773(95)00396-i

    authors: Ernsberger U,Patzke H,Tissier-Seta JP,Reh T,Goridis C,Rohrer H

    更新日期:1995-07-01 00:00:00

  • The germ cell nuclear factor is required for retinoic acid signaling during Xenopus development.

    abstract::The germ cell nuclear factor (GCNF, NR6A1) is a nuclear orphan receptor that functions as a transcriptional repressor and is transiently expressed in mammalian carcinoma cells during retinoic acid (RA) induced neuronal differentiation. During Xenopus laevis development, the spatiotemporal expression pattern of embryon...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(03)00018-2

    authors: Barreto G,Borgmeyer U,Dreyer C

    更新日期:2003-04-01 00:00:00

  • Zebrafish otolith biomineralization requires polyketide synthase.

    abstract::Deflecting biomineralized crystals attached to vestibular hair cells are necessary for maintaining balance. Zebrafish (Danio rerio) are useful organisms to study these biomineralized crystals called otoliths, as many required genes are homologous to human otoconial development. We sought to identify and characterize t...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/j.mod.2019.04.001

    authors: Thiessen KD,Grzegorski SJ,Chin Y,Higuchi LN,Wilkinson CJ,Shavit JA,Kramer KL

    更新日期:2019-06-01 00:00:00

  • xGCNF, a nuclear orphan receptor is expressed during neurulation in Xenopus laevis.

    abstract::Nuclear orphan receptors are DNA binding proteins that share the domain structure of the nuclear hormone receptor superfamily, although ligands are unknown. We have identified an orphan receptor in Xenopus laevis and named it xGCNF based on its high degree of sequence homology to the previously described murine germ c...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(96)00599-0

    authors: Joos TO,David R,Dreyer C

    更新日期:1996-11-01 00:00:00

  • Identification and localization of M-CoREST (1A13), a mouse homologue of the human transcriptional co-repressor CoREST, in the developing mouse CNS.

    abstract::By means of subtractive and differential hybridization techniques we have identified a novel murine gene (1A13) the expression of which is developmentally regulated in the mouse brain. Comparison of the nucleotide and predicted protein sequence revealed closest relationship of 1A13 to human CoREST, a transcriptional c...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(01)00477-4

    authors: Tontsch S,Zach O,Bauer HC

    更新日期:2001-10-01 00:00:00

  • Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouse.

    abstract::To examine the role of the Oct-6 gene in Schwann cell differentiation we have cloned and characterized the chicken and zebrafish homologues of the mouse Oct-6 gene. While highly homologous in the Pit1-Oct1/2-Unc86 (POU) domain, sequence similarities are limited outside this domain. Both genes are intronless and both p...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(98)00067-7

    authors: Levavasseur F,Mandemakers W,Visser P,Broos L,Grosveld F,Zivkovic D,Meijer D

    更新日期:1998-06-01 00:00:00

  • Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila.

    abstract::Many proteins involved in signal transduction and cell adhesion are characterized by the presence of an extracellular domain with repeated copies of a leucine-rich motif (LRR). Here we report the isolation and characterization of a novel gene, tlr (for Toll-like receptor), which encodes a protein containing multiple L...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/0925-4773(94)90041-8

    authors: Chiang C,Beachy PA

    更新日期:1994-09-01 00:00:00

  • A zebrafish homologue of deleted in colorectal cancer (zdcc) is expressed in the first neuronal clusters of the developing brain.

    abstract::DCC (deleted in colon cancer), Neogenin and UNC-5 are all members of the immunoglobulin superfamily of transmembrane receptors which are believed to play a role in axon guidance by binding to their ligands, the Netrin/UNC-40 family of secreted molecules (Cell. Mol. Life Sci. 56 (1999) 62; Curr. Opin. Genet. Dev. 7 (19...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(01)00513-5

    authors: Hjorth JT,Gad J,Cooper H,Key B

    更新日期:2001-11-01 00:00:00

  • Control of foot differentiation in Hydra: in vitro evidence that the NK-2 homeobox factor CnNK-2 autoregulates its own expression and uses pedibin as target gene.

    abstract::The foot of the simple metazoan Hydra is a highly dynamic body region of constant tissue movement, cell proliferation, determination and differentiation. Previously, two genes have been shown to participate in the development and differentiation of this body region: homeodomain factor CnNK-2 and signal peptide pedibin...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/j.mod.2003.12.001

    authors: Thomsen S,Till A,Wittlieb J,Beetz C,Khalturin K,Bosch TC

    更新日期:2004-02-01 00:00:00

  • Dynamic expression of alternate splice forms of D-cbl during embryogenesis.

    abstract::The Cbl family of proteins act as E3 ubiquitin-protein ligases and have been associated with the down regulation of a variety of receptor tyrosine kinases. Cbl proteins associate with many different cell signalling molecules suggesting that they may have functions outside of the RING finger-mediated ubiquitin ligase a...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(01)00292-1

    authors: Hime GR,Abud HE,Garner B,Harris KL,Robertson H

    更新日期:2001-04-01 00:00:00

  • Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning.

    abstract::The gastrointestinal tract is subdivided into regions with different roles in digestion and absorption. How this patterning is established is unknown. We now report that the pancreatic-duodenal homeobox 1 gene (pdx1) is also expressed in cells of the distal stomach. Positive cells include subpopulations of the three m...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(96)00609-0

    authors: Larsson LI,Madsen OD,Serup P,Jonsson J,Edlund H

    更新日期:1996-12-01 00:00:00

  • Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development.

    abstract::The vertebrate hindbrain is composed of a series of lineage-restricted segments termed rhombomeres. Segment-specific gene expression drives unique programs of neuronal differentiation. Two critical embryonic signaling pathways, Fibroblast Growth Factor (FGF) and Retinoic Acid (RA), regulate early embryonic rhombomere ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/j.mod.2018.02.005

    authors: Selland LG,Koch S,Laraque M,Waskiewicz AJ

    更新日期:2018-04-01 00:00:00

  • High temperature limits on developmental canalization in the ascidian Ciona intestinalis.

    abstract::The normal embryogenesis of marine animals is typically confined to a species-specific range of temperatures. Within that temperature range development results in a consistent, or canalized, phenotype, whereas above and below the range abnormal phenotypes are produced. This study reveals a high temperature threshold, ...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/j.mod.2019.04.002

    authors: Irvine SQ,McNulty KB,Siler EM,Jacobson RE

    更新日期:2019-06-01 00:00:00

  • Exogenous retinoic acid causes specific alterations in the development of the midbrain and hindbrain of the zebrafish embryo including positional respecification of the Mauthner neuron.

    abstract::Exogenously applied retinoic acid given at the early stages of gastrulation causes abnormal development of the caudal midbrain and anterior hindbrain in vertebrate embryos. We describe the limits of the brain regions that are affected using neuroanatomical criteria in the zebrafish embryo. Analysis of the reticulospin...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/0925-4773(94)00321-d

    authors: Hill J,Clarke JD,Vargesson N,Jowett T,Holder N

    更新日期:1995-03-01 00:00:00

  • CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo.

    abstract::In endothelial cells that form capillary-like structures in vitro a variety of genes is upregulated as we have demonstrated previously. In addition to well known genes, we also identified genes never described in endothelial cells before. Here, we report the further characterization of one selected gene called cystein...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(02)00355-6

    authors: Glienke J,Sturz A,Menrad A,Thierauch KH

    更新日期:2002-12-01 00:00:00

  • Sox neuro, a new Drosophila Sox gene expressed in the developing central nervous system.

    abstract::We describe the identification and detailed expression pattern of a second Drosophila Sox gene, SoxNeuro (SoxN), highly related to mammalian group B Sox1, 2, 3 genes. SoxN is expressed in a highly dynamic pattern during embyogenesis, being associated with the development of the central nervous system (CNS), from the e...

    journal_title:Mechanisms of development

    pub_type: 杂志文章

    doi:10.1016/s0925-4773(00)00268-9

    authors: Crémazy F,Berta P,Girard F

    更新日期:2000-05-01 00:00:00