A zebrafish homologue of deleted in colorectal cancer (zdcc) is expressed in the first neuronal clusters of the developing brain.

abstract：:Using an in silico (electronic database) subtraction, we identified a new member of the Ret Finger Protein-Like gene family, Rfpl4. Rfpl4 encodes a 287 amino acid putative E3 ubiquitin-protein ligase with a RING finger-like domain and a B30.2 motif. Reverse transcriptase polymerase chain reaction and Northern blot ana...

journal_title：Mechanisms of development

authors： Rajkovic A,Lee JH,Yan C,Matzuk MM

更新日期：2002-03-01 00:00:00

abstract：:Active repression of gene expression mediated by unliganded nuclear receptors plays crucial roles in early development of vertebrates. N-CoR (nuclear receptor co-repressor) is the first identified co-repressor that can repress retinoic acid (RA) inducible gene transcription in the absence of RA. Previously, N-CoR was ...

journal_title：Mechanisms of development

authors： Xu F,Li K,Tian M,Hu P,Song W,Chen J,Gao X,Zhao Q

更新日期：2009-10-01 00:00:00

abstract：:The synchronous development of a sibling group of Rhynchosciara larvae enables us to follow the relationship between the local transcription and extrareplication of C3 and C8 DNA puffs. Although DNA amplification at these two loci takes place during the last cycle of DNA duplication in salivary gland chromosomes, a di...

journal_title：Mechanisms of development

authors： Santelli RV,Machado-Santelli GM,Pueyo MT,Navarro-Cattapan LD,Lara FJ

更新日期：1991-12-01 00:00:00

abstract：:Sexual reproduction in the ciliate Tetrahymena follows a complex developmental program involving the sequential regulation of dozens of genes. Genes that are up-regulated during post-zygotic development in Tetrahymena were isolated by subtractive hybridization. Anlagen stage induced gene 1 (ASI1) encodes a 2.8 kb tran...

journal_title：Mechanisms of development

authors： Udani RA,Karrer KM

更新日期：2002-10-01 00:00:00

abstract：:The intercalation of mesenchymal cells into epithelia, through mesenchymal-to-epithelial transition (MET), underlies organogenesis, for example, in nephrogenesis, and tissue regeneration, during cell renewal and wound repair. Despite its importance, surprisingly little is known about the mechanisms that bring about ME...

journal_title：Mechanisms of development

authors： Campbell K,Casanova J,Skaer H

更新日期：2010-07-01 00:00:00

abstract：:In sea urchin development, micromere descendants play important roles in skeletogenesis and induction of gastrulation. We previously reported that the T-brain homolog of sea urchin Hemicentrotus pulcherrimus, HpTb expresses specifically in micromere descendants and is required for induction of gastrulation and skeleto...

journal_title：Mechanisms of development

authors： Ochiai H,Sakamoto N,Momiyama A,Akasaka K,Yamamoto T

更新日期：2008-01-01 00:00:00

abstract：:The central nervous system (CNS) is vascularized by a dense capillary network that is critical to deliver oxygen and nutrients, and remove carbon dioxide and waste products, from the neural tissue. These blood vessels contain a series of properties, termed the blood-brain barrier (BBB), which distinguishes them from v...

journal_title：Mechanisms of development

authors： Blanchette M,Daneman R

更新日期：2015-11-01 00:00:00

abstract：:The spatial and temporal expression of seven Drosophila protein tyrosine phosphatase genes during oogenesis was examined by whole mount in-situ hybridization of antisense RNA probes to ovaries. Our observations indicate diverse expression patterns consistent with multiple roles for protein tyrosine phosphatases in the...

journal_title：Mechanisms of development

authors： Fitzpatrick KA,Gorski SM,Ursuliak Z,Price JV

更新日期：1995-10-01 00:00:00

abstract：:Egr1 is a highly conserved zinc finger protein which plays important roles in many aspects of vertebrate development and in the adult. The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization. Egr1 mRNA is first detec...

journal_title：Mechanisms of development

authors： Close R,Toro S,Martial JA,Muller M

更新日期：2002-10-01 00:00:00

abstract：:SIP1 encodes a DNA-binding transcription factor that regulates multiple developmental processes, as highlighted by the pleiotropic defects observed in Mowat-Wilson syndrome, which results from mutations in this gene. Further, in adults, dysregulated SIP1 expression has been implicated in both cancer and fibrotic disea...

journal_title：Mechanisms of development

authors： Manthey AL,Lachke SA,FitzGerald PG,Mason RW,Scheiblin DA,McDonald JH,Duncan MK

更新日期：2014-02-01 00:00:00

abstract：:pebble (pbl) is required for cytokinesis during postblastoderm mitoses (Hime, G., Saint, R., 1992. Zygotic expression of the pebble locus is required for cytokinesis during the postblastoderm mitoses of Drosophila. Development 114, 165-171; Lehner, C.F., 1992. The pebble gene is required for cytokinesis in Drosophila....

journal_title：Mechanisms of development

authors： Prokopenko SN,Saint R,Bellen HJ

更新日期：2000-02-01 00:00:00

abstract：:We have isolated nine putative odorant receptor genes from the chick, named COR1 to COR9, that belong to the large multigene family of olfactory G protein-coupled receptors found in the fish, rat, mouse, dog, and human. By combining genomic DNA blot analysis, low stringency library screenings, and several PCR analyses...

journal_title：Mechanisms of development

authors： Nef S,Allaman I,Fiumelli H,De Castro E,Nef P

更新日期：1996-03-01 00:00:00

abstract：:The Mix/Bix family of Pax-like homeodomain transcription factors is expressed early in vertebrate development and play important roles in endoderm and mesoderm formation. Like other Pax-related homeodomain proteins, the Mix/Bix family binds DNA as monomers or dimers and dimerization is mediated by the homeodomain. Whi...

journal_title：Mechanisms of development

authors： Doherty JR,Zhu H,Kuliyev E,Mead PE

更新日期：2006-01-01 00:00:00

abstract：:The development of skeletal muscle in vertebrate embryos is controlled by a transcriptional cascade involving the four myogenic regulatory factors. In the somites of the mouse embryo the order of expression is thought to be Myf5, Myogenin, Mrf4 and MyoD. We have re-examined the expression pattern of Mrf4 and show that...

journal_title：Mechanisms of development

authors： Summerbell D,Halai C,Rigby PW

更新日期：2002-09-01 00:00:00

abstract：:During vertebrate eye development, the expression of the homeobox gene Six6 is restricted to the neural retina and is initiated later than Rx and Pax6 in the presumptive retina field. We show here that overexpression of mouse Six6 in Xenopus embryos can induce transformation of competent tissue of the anterior neural ...

journal_title：Mechanisms of development

authors： Bernier G,Panitz F,Zhou X,Hollemann T,Gruss P,Pieler T

更新日期：2000-05-01 00:00:00

abstract：:The Retinal homeobox gene (Rx; also Rax) plays a crucial role in the early development of the vertebrate eye. Germline deletion of Rx in mice results in the failure of optic vesicle formation, leading to anophthalmia. Recent research using conditional mouse knockout models provides some clues to the role of Rx in eye ...

journal_title：Mechanisms of development

authors： Rodgers HM,Huffman VJ,Voronina VA,Lewandoski M,Mathers PH

更新日期：2018-06-01 00:00:00

abstract：:The availability of the draft sequence of the chicken genome will undoubtedly propel an already important vertebrate research model, the domestic chicken, to a new level. This review describes aspects of chicken natural history and cross-disciplinary biological value. The diversity of extant genetic variants available...

journal_title：Mechanisms of development

authors： Delany ME

更新日期：2004-09-01 00:00:00

abstract：:The full length sequence of the Xenopus integrin alpha 5 subunit is reported. Analysis of cloned cDNA fragments reveals that alternative polyadenylation of alpha 5 mRNA occurs in the embryo. Furthermore, a variant form of the alpha 5 mRNA is expressed which encodes an integrin alpha 5 subunit with a truncated cytoplas...

journal_title：Mechanisms of development

authors： Joos TO,Whittaker CA,Meng F,DeSimone DW,Gnau V,Hausen P

更新日期：1995-04-01 00:00:00

abstract：:In order to analyze the expression pattern of the 5'-nucleotidase (5nt) gene in Dictyostelium, we made a fusion construct in which the 5nt promoter directed the expression of beta-galactosidase gene. The reporter gene was not active in vegetative amoebae but was expressed during the aggregation stage. At the slug stag...

journal_title：Mechanisms of development

authors： Ubeidat M,Eristi CM,Rutherford CL

更新日期：2002-01-01 00:00:00

abstract：:In the Drosophila embryo the nuclear localisation of Dorsal, a member of the Rel family, is regulated by an extracellular signal, which is transmitted to the interior of the egg cell by a cascade of proteins involving the novel protein Tube and the protein kinase Pelle. Here we analyse the activation mechanism of Tube...

journal_title：Mechanisms of development

authors： Grosshans J,Schnorrer F,Nüsslein-Volhard C

更新日期：1999-03-01 00:00:00

abstract：:Following tissue damage the immune response, including inflammation, has been considered an inevitable condition to build the host defense against invading pathogens. The recruitment of innate immune leukocytes to injured tissue is observed in both vertebrates and invertebrates. However, it is still not conclusive whe...

journal_title：Mechanisms of development

authors： Katsuyama T,Paro R

更新日期：2013-02-01 00:00:00

abstract：:Nk(x)-type homeobox genes are an evolutionarily conserved family that regulate diverse developmental processes. Here we describe a novel Drosophila gene, Nk6, which encodes an Nk-type transcription factor most homologous to vertebrate Nkx6.1 and Nkx6.2. The homeodomains and NK decapeptide domains of all three proteins...

journal_title：Mechanisms of development

authors： Uhler J,Garbern J,Yang L,Kamholz J,Mellerick DM

更新日期：2002-08-01 00:00:00

abstract：:We have recently identified a new G protein-coupled receptor, msr/apj, whose transcripts are detected in the endothelium of the primary blood vessels and the newly forming heart (Mech. Dev. 1999;84:199). Its expression during formation of the embryonic vasculature incited us to investigate whether expression of the re...

journal_title：Mechanisms of development

authors： Saint-Geniez M,Masri B,Malecaze F,Knibiehler B,Audigier Y

更新日期：2002-01-01 00:00:00

abstract：:The cAMP signaling system has been postulated to be involved in embryogenesis of many animal species, however, little is known about its role in embryonic axis formation in vertebrates. In this study, the role of the cAMP signaling pathway in patterning the body plan of the Xenopus embryo was investigated by expressin...

journal_title：Mechanisms of development

authors： Kim MJ,Han JK

更新日期：1999-12-01 00:00:00

abstract：:We have investigated the mechanisms by which the epithelial apicolateral junctional complex (AJC) is generated during trophectoderm differentiation in the mouse blastocyst using molecular, structural and functional analyses. The mature AJC comprises an apical tight junction (TJ), responsible for intercellular sealing ...

journal_title：Mechanisms of development

authors： Sheth B,Fontaine JJ,Ponza E,McCallum A,Page A,Citi S,Louvard D,Zahraoui A,Fleming TP

更新日期：2000-10-01 00:00:00

abstract：:This study utilizes morphological and mechanistic endpoints to characterize the onset of bilateral atresia of the vas deferens in a recently derived cystic fibrosis (CF) rat model. Embryonic reproductive structures, including Wolffian (mesonephric) duct, Mullerian (paramesonephric) duct, mesonephric tubules, and gonad...

journal_title：Mechanisms of development

authors： Plyler ZE,Birket SE,Schultz BD,Hong JS,Rowe SM,Petty CF,Crowley MR,Crossman DK,Schoeb TR,Sorscher EJ

更新日期：2019-02-01 00:00:00

abstract：:Basic helix-loop-helix (bHLH) proteins of the Achaete/Scute (Ac/Sc) family are required for neurogenesis in both Drosophila and vertebrates. These transcription factors are commonly referred to as 'proneural' factors, as they promote neural fate in many contexts. Although Ac/Sc proteins have been studied in Hydra, jel...

journal_title：Mechanisms of development

authors： Doonan R,Hatzold J,Raut S,Conradt B,Alfonso A

更新日期：2008-09-01 00:00:00

abstract：:Development of oligodendrocytes, myelin-forming glia in the central nervous system (CNS), proceeds on a protracted schedule. Specification of oligodendrocyte progenitor cells (OPCs) begins early in development, whereas their terminal differentiation occurs at late embryonic and postnatal periods. However, for oligoden...

journal_title：Mechanisms of development

authors： Hashimoto R,Hori K,Owa T,Miyashita S,Dewa K,Masuyama N,Sakai K,Hayase Y,Seto Y,Inoue YU,Inoue T,Ichinohe N,Kawaguchi Y,Akiyama H,Koizumi S,Hoshino M

更新日期：2016-05-01 00:00:00

abstract：:The recessive mutant mouse jumonji (jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygotes with a Balb/cA and 129/Ola mixed background. Here, we show that no neural tube defects are observed with a Balb/cA background. We also found hypoplasia of the liver, thymus and spl...

journal_title：Mechanisms of development

authors： Motoyama J,Kitajima K,Kojima M,Kondo S,Takeuchi T

更新日期：1997-08-01 00:00:00

abstract：:The Bar homeobox genes play an essential role during nervous system and eye development in Drosophila. We isolated a medaka Bar gene closely related to the Drosophila and mammalian Bar genes. In the medaka embryo, OlBar is expressed from gastrula stages onwards, in a region demarcating the presumptive prosencephalic-m...

journal_title：Mechanisms of development

authors： Poggi L,Carl M,Vignali R,Barsacchi G,Wittbrodt J

更新日期：2002-06-01 00:00:00