Abstract：
:In the sea urchin embryo, Nodal is the earliest known signal to play a role in the specification of the oral ectodermal territory. Nodal, a TGF-beta ligand, is first expressed in the presumptive oral ectoderm at approximately 7 H of development. Nodal overexpression produces a distinctive bell-shaped phenotype with expanded oral ectoderm, which resembles the oralized phenotype obtained as a result of nickel (Ni) treatment. To date, a detailed analysis of gene expression in Ni-treated embryos has not been undertaken. Because treatment with cobalt (Co) produces similar results to those seen with Ni treatment in other systems, we were interested in determining how Co influences sea urchin embryonic development. Here we report that Co also induces oralization of the ectoderm, and the effects of Ni and Co depend on functional Nodal signaling. Although both metals upregulate nodal gene expression, they do not initiate nodal transcription precociously. Analysis of the perturbation of Nodal receptor function suggests that Ni and Co contribute to nodal upregulation in the absence of nodal autoregulation, but cannot fully oralize the ectoderm in the absence of Nodal signaling.
journal_name
Mech Devjournal_title
Mechanisms of developmentauthors
Agca C,Klein WH,Venuti JMdoi
10.1016/j.mod.2009.01.005subject
Has Abstractpub_date
2009-05-01 00:00:00pages
430-42issue
5-6eissn
0925-4773issn
1872-6356pii
S0925-4773(09)00006-9journal_volume
126pub_type
杂志文章abstract：:Hsp47 is a heat-shock protein which interacts with newly synthesize procollagen chains in the endoplasmic reticulum (ER) of collagen-secreting cells and is thought to assist in procollagen triple helix assembly and subsequent transport to the cis-Golgi. This is supported by studies which have reported that genes encod...
journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/s0925-4773(96)00626-0
更新日期：1997-01-01 00:00:00
abstract：:Skeletal muscle regeneration requires processes different from developmental myogenesis. One important difference is a requirement of inflammatory reactions prior to regenerative myogenesis, by which injured muscle fibers must be eliminated to make new myotubes. In this study, we show that efficient elimination of inj...
journal_title：Mechanisms of development
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
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更新日期：2004-12-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/j.mod.2003.08.008
更新日期：2003-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0925-4773(01)00549-4
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/s0925-4773(00)00252-5
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journal_title：Mechanisms of development
pub_type： 杂志文章
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更新日期：1994-10-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/0925-4773(96)00584-9
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/s0925-4773(97)00082-8
更新日期：1997-08-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
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更新日期：2005-11-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/s0925-4773(99)00011-8
更新日期：1999-04-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/0925-4773(92)90025-f
更新日期：1992-11-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/s0925-4773(96)00563-1
更新日期：1996-08-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/s0925-4773(02)00091-6
更新日期：2002-07-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/0925-4773(92)90012-9
更新日期：1992-03-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/s0925-4773(02)00289-7
更新日期：2002-11-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/s0925-4773(01)00282-9
更新日期：2001-04-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
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journal_title：Mechanisms of development
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/j.mod.2008.10.005
更新日期：2009-01-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章,评审
doi：10.1016/j.mod.2003.06.004
更新日期：2003-11-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
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journal_title：Mechanisms of development
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/0925-4773(93)90041-u
更新日期：1993-05-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
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更新日期：2001-06-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/s0925-4773(00)00432-9
更新日期：2000-11-01 00:00:00
abstract：:The bHLH protein eHAND is a sensitive marker for cardiovascular precursors in the Xenopus embryo. The earliest site of expression is a broad domain within the lateral plate mesoderm of the tailbud embryo. This domain comprises precursors that contribute to the posterior cardinal veins in later stages. Surprisingly, ex...
journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/s0925-4773(98)00010-0
更新日期：1998-02-01 00:00:00
abstract：:The synchronous development of a sibling group of Rhynchosciara larvae enables us to follow the relationship between the local transcription and extrareplication of C3 and C8 DNA puffs. Although DNA amplification at these two loci takes place during the last cycle of DNA duplication in salivary gland chromosomes, a di...
journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/0925-4773(91)90072-e
更新日期：1991-12-01 00:00:00
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journal_title：Mechanisms of development
pub_type： 杂志文章
doi：10.1016/s0925-4773(01)00383-5
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