An oncogenic form of human raf can specify terminal body pattern in Drosophila.

abstract：:Members of the TGFbeta superfamily of signalling molecules play important roles in mesendoderm induction and dorsoventral patterning of the vertebrate embryo. We cloned three intracellular mediators of TGFbeta signalling, smad1, 2 and 5, from the zebrafish. The three smad genes are expressed ubiquitously at the onset ...

journal_title：Mechanisms of development

authors： Müller F,Blader P,Rastegar S,Fischer N,Knöchel W,Strähle U

更新日期：1999-10-01 00:00:00

abstract：:Here we present the cloning of a full-length zebrafish pdgfr-alpha cDNA as well as the expression of this gene during zebrafish embryogenesis. We show that zebrafish pdgfr-alpha mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation. Spatially restricted ex...

journal_title：Mechanisms of development

authors： Liu L,Chong SW,Balasubramaniyan NV,Korzh V,Ge R

更新日期：2002-08-01 00:00:00

abstract：:Using the epidermis-specific cytokeratin 14 promoter to deliver HGF exclusively from epidermal keratinocytes, we have examined the potential of hepatocyte growth factor (HGF) secreted from the normal environment to control morphogenesis. The transgenic mice displayed a significant increase of the number of melanocytes...

journal_title：Mechanisms of development

authors： Kunisada T,Yamazaki H,Hirobe T,Kamei S,Omoteno M,Tagaya H,Hemmi H,Koshimizu U,Nakamura T,Hayashi SI

更新日期：2000-06-01 00:00:00

abstract：:We describe the structural organization of a gene, termed XFDL 141/156, that is transiently activated during early Xenopus development. XFDL 141/156 is first transcribed at the midblastula transition (MBT) and during early gastrulation events. A roughly 200 nucleotide fragment immediately 5' to the transcription start...

journal_title：Mechanisms of development

authors： Bellefroid E,Bourguignon C,Bouwmeester T,Rausch O,Blumberg B,Pieler T

更新日期：1997-04-01 00:00:00

abstract：:HNF1 (Hepatic Nuclear Factor 1) and vHNF1 are transcriptional regulators containing a highly divergent homeodomain. The first was initially found in liver nuclear extracts and is crucial for the transcription of albumin and many other hepatocyte specific genes, while the second was found in dedifferentiated hepatoma c...

journal_title：Mechanisms of development

authors： Ott MO,Rey-Campos J,Cereghini S,Yaniv M

更新日期：1991-12-01 00:00:00

abstract：:XLPOU3 is a member of the Xenopus POU domain family of genes, encoding a class of homeodomain-containing transcription factors implicated in cell differentiation during development. Here we describe the isolation and characterisation of XLPOU3b, an allelic genomic counterpart of the XLPOU3 cDNA previously described (B...

journal_title：Mechanisms of development

authors： Baltzinger M,Relaix F,Remy P

更新日期：1996-08-01 00:00:00

abstract：:In mammals, 16 members of the Fgf family have so far been described with diverse roles in embryonic cell growth and differentiation. Here, we report the expression from early streak stage to midgestation of two newly-identified murine genes, Fgf17 and Fgf18, that are most closely related to Fgf8 (63.7% and 56.8% ident...

journal_title：Mechanisms of development

authors： Maruoka Y,Ohbayashi N,Hoshikawa M,Itoh N,Hogan BL,Furuta Y

更新日期：1998-06-01 00:00:00

abstract：:The notochord is a structure present in all chordates and its development requires the transcription of Brachyury. While previous studies have shown that Brachyury is essential for notochord formation in vertebrate embryos, this gene is also expressed during the embryogenesis of nonchordate deuterostomes, hemichordate...

journal_title：Mechanisms of development

authors： Satoh G,Harada Y,Satoh N

更新日期：2000-09-01 00:00:00

abstract：:In order to dissect the MHC class I H-2K gene regulatory sequences, we p reviously generated transgenic mice containing various H-2K/lacZ fusion genes. However contrary to transgenes where H-2K sequences were fused to other coding sequences, none of the lacZ fusion transgenes was widely ex pressed like H-2K gene. We n...

journal_title：Mechanisms of development

authors： Cohen-Tannoudji M,Vandormael-Pournin S,Drezen J,Mercier P,Babinet C,Morello D

更新日期：2000-01-01 00:00:00

abstract：:The polyhomeotic (ph) gene of Drosophila is a member of the Polycomb group of genes and encodes a chromatin protein required for negative regulation of homeotic genes and other loci, in particular the ph locus itself. We have studied the genetic control of ph transcription during development. Early ph expression is un...

journal_title：Mechanisms of development

authors： Fauvarque MO,Zuber V,Dura JM

更新日期：1995-08-01 00:00:00

abstract：:Noelins are secreted glycoproteins with important developmental functions in frogs and birds. Here, we present the expression pattern of the mouse homolog of Noelin-1/2 at E8-10 of development and compare this pattern to other vertebrates. Expression was observed in the neural plate and neural crest, as well as in the...

journal_title：Mechanisms of development

authors： Moreno TA,Bronner-Fraser M

更新日期：2002-11-01 00:00:00

abstract：:Factors controlling the differentiation of the multipotent embryonic lung endoderm and mesoderm are poorly understood. Recent evidence that Delta-like 1 (Dll1) and other genes in the Notch/Delta signaling pathway are expressed in the embryonic mouse lung suggests that this pathway is important for cell fate decisions ...

journal_title：Mechanisms of development

authors： Post LC,Ternet M,Hogan BL

更新日期：2000-11-01 00:00:00

abstract：:The spatial and temporal expression of seven Drosophila protein tyrosine phosphatase genes during oogenesis was examined by whole mount in-situ hybridization of antisense RNA probes to ovaries. Our observations indicate diverse expression patterns consistent with multiple roles for protein tyrosine phosphatases in the...

journal_title：Mechanisms of development

authors： Fitzpatrick KA,Gorski SM,Ursuliak Z,Price JV

更新日期：1995-10-01 00:00:00

abstract：:In sea urchin development, micromere descendants play important roles in skeletogenesis and induction of gastrulation. We previously reported that the T-brain homolog of sea urchin Hemicentrotus pulcherrimus, HpTb expresses specifically in micromere descendants and is required for induction of gastrulation and skeleto...

journal_title：Mechanisms of development

authors： Ochiai H,Sakamoto N,Momiyama A,Akasaka K,Yamamoto T

更新日期：2008-01-01 00:00:00

abstract：:The zebrafish biklf gene encodes a novel Krüppel-like transcription factor containing three contiguous zinc fingers at the C-terminus. Expression of biklf is detected from the shield stage onward in the developing prechordal plate, and as a 'baseball seam'-like lateral stripe beginning at the end of gastrulation. The ...

journal_title：Mechanisms of development

authors： Kawahara A,Dawid IB

更新日期：2000-10-01 00:00:00

abstract：:Blood vessel maturation, which is characterized by the investment of vascular smooth muscle cells (vSMCs) around developing blood vessels, begins when vessels remodel into a hierarchy of proximal arteries and proximal veins that branch into smaller distal capillaries. The ultimate result of maturation is formation of ...

journal_title：Mechanisms of development

authors： Padget RL,Mohite SS,Hoog TG,Justis BS,Green BE,Udan RS

更新日期：2019-04-01 00:00:00

abstract：:In many animals, germline progenitors are kept undifferentiated to give rise to germline stem cells (GSCs), enabling continuous production of gametes throughout animal life. In the Drosophila ovary, GSCs arise from a subset of primordial germ cells (PGCs) that stay undifferentiated even after gametogenesis has started...

journal_title：Mechanisms of development

authors： Matsuoka S,Hiromi Y,Asaoka M

更新日期：2013-04-01 00:00:00

abstract：:An enhancer sequence found in the Protease Nexin-1 (PN-1) gene was shown to drive lacZ expression specifically at the met-/mesencephalic junction in transgenic mouse embryos. A functional study of this enhancer has been performed to better understand the mechanisms regulating isthmic gene expression. An octamer-bindin...

journal_title：Mechanisms of development

authors： Mihailescu D,Küry P,Monard D

更新日期：1999-06-01 00:00:00

abstract：:The homeotic or Hox genes encode a network of conserved transcription factors which provide axial positional information and control segment morphology in development and evolution. During embryonic brain development of Drosophila, the Hox gene labial (lab) is essential for tritocerebral neuromere specification; lab l...

journal_title：Mechanisms of development

authors： Meier S,Sprecher SG,Reichert H,Hirth F

更新日期：2006-01-01 00:00:00

abstract：:We describe the cloning, expression pattern and functional overexpression analysis of Xotx5b, a new member of the Otx gene family in Xenopus laevis. Early expression of Xotx5b resembles that of Xotx2, being detected in the organizer region at early gastrula stage, and, shortly after, also in anterior neuroectoderm. Du...

journal_title：Mechanisms of development

authors： Vignali R,Colombetti S,Lupo G,Zhang W,Stachel S,Harland RM,Barsacchi G

更新日期：2000-08-01 00:00:00

abstract：:To understand the mechanisms regulating the tissue non-specific alkaline phosphatase (TNAP) activity during development, we characterized cis-transcriptional regulatory elements. In embryonic cells and tissues, TNAP expression was driven preferentially by the exon 1A (E1A) promoter, one of the two promoters previously...

journal_title：Mechanisms of development

authors： Escalante-Alcalde D,Recillas-Targa F,Hernández-García D,Castro-Obregón S,Terao M,Garattini E,Covarrubias L

更新日期：1996-06-01 00:00:00

abstract：:Six/sine oculis (Six/so) class genes, with representatives in vertebrates and invertebrates, include members with key developmental roles in the anterior part of the central nervous system (CNS) and eye. Having characterized the role of the first planarian gene of the Six/so family in eye development, we attempted to ...

journal_title：Mechanisms of development

authors： Pineda D,Saló E

更新日期：2002-12-01 00:00:00

abstract：:XLPOU91, a POU-homeobox gene is expressed in a narrow window during early Xenopus development. We show that ectopic expression of XLPOU91 RNA causes severe posterior truncations in embryos without inhibiting the formation of Spemann's organizer. Ectopic XLPOU91 expression also inhibits mesoderm induction by fibroblast...

journal_title：Mechanisms of development

authors： Henig C,Elias S,Frank D

更新日期：1998-02-01 00:00:00

abstract：:Branching morphogenesis is a developmental process characteristic of many organ systems. Specifically, during renal branching morphogenesis, its been postulated that the final number of nephrons formed is one key clinical factor in the development of hypertension in adulthood. As it has been established that BMPs regu...

journal_title：Mechanisms of development

authors： Nikopoulos GN,Martins JF,Adams TL,Karaczyn A,Adams D,Vary C,Oxburgh L,Verdi JM

更新日期：2009-05-01 00:00:00

abstract：:dkk-1 has recently been identified as a secreted protein in Xenopus laevis which is sufficient and necessary to cause head induction by antagonizing Wnt signalling (Glinka et al., 1998, Nature 391, 357-362). Consistent with such a role dkk-1 is expressed in the Spemann organizer of the early frog gastrula. Later, expr...

journal_title：Mechanisms of development

authors： Grotewold L,Theil T,Rüther U

更新日期：1999-12-01 00:00:00

abstract：:Dickkopf-1 (dkk-1) is member of a novel family of secreted proteins and functions in head induction during Xenopus embryogenesis, acting as a potent inhibitor of Wnt signalling. Here we report: (1) the isolation of two additional murine members of the dkk family, dkk-2 and dkk-3; and (2) analysis of adult and embryoni...

journal_title：Mechanisms of development

authors： Monaghan AP,Kioschis P,Wu W,Zuniga A,Bock D,Poustka A,Delius H,Niehrs C

更新日期：1999-09-01 00:00:00

abstract：:Hsp47 is a heat-shock protein which interacts with newly synthesize procollagen chains in the endoplasmic reticulum (ER) of collagen-secreting cells and is thought to assist in procollagen triple helix assembly and subsequent transport to the cis-Golgi. This is supported by studies which have reported that genes encod...

journal_title：Mechanisms of development

authors： Lele Z,Krone PH

更新日期：1997-01-01 00:00:00

abstract：:We have sequenced and defined the expression during rat embryogenesis of the protocadherin fat, the murine homologue of a Drosophila tumour suppressor gene. As previously described for human fat, the sequence encodes a large protocadherin with 34 cadherin repeats, five epidermal growth factor (EGF)-like repeats contai...

journal_title：Mechanisms of development

authors： Ponassi M,Jacques TS,Ciani L,ffrench Constant C

更新日期：1999-02-01 00:00:00

abstract：:We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is exp...

journal_title：Mechanisms of development

authors： Sumanas S,Ekker SC

更新日期：2001-05-01 00:00:00

abstract：:The neural crest (NC) is one of the most fascinating structures during embryonic development. Unique to vertebrate embryos, these cells give rise to important components of the craniofacial skeleton, such as the jaws and skull, as well as melanocytes and ganglia of the peripheral nervous system. Worldwide, several gro...

journal_title：Mechanisms of development

authors： Pescador GS,Trentin AG,Garcez RC

更新日期：2018-10-01 00:00:00